Roxera ndi woimira gulu la mankhwala omwe amakhudza metabolidi ya lipid. Chofunikira chachikulu cha Roxers ndi rosuvastatin, chomwe chimalepheretsa enzyme yomwe imatembenuza cholesterol.
Momwe ntchito rosuvastatin ndi hepatocytes, momwe cholesterol imapangidwira ndipo zigawo za atherogenic za lipoproteins zimawonongeka. Njira yogwiritsira ntchito ndikuwonjezera kuchuluka kwa ma endeptor kumapeto kwa hepatocytes a LDL, potero amapereka kuwonjezeka kwa chidwi ndi kuwonongeka kwa LDL, motero kuletsa kaphatikizidwe ka atherogenic lipoproteins.
Chifukwa cha Roxer, cholesterol, ma atherogenic complexes, triglycerides (TAGs) amachepetsa, ndipo kuchuluka kwa anti-atherogenic tizigawo ta lipoproteins kumachulukanso.
A kutchulidwa achire zotsatira amapezeka sabata pambuyo kuyambika kwa makonzedwe. Mkati mwa milungu inayi ya chithandizo, mankhwala okwanira amakwaniritsidwa, malinga ngati mankhwalawo amamwa.
Mankhwala ayenera kuperekedwa ndi dokotala kuganizira za munthu wodwala.
Kudzilanga nokha ndi Roxeroy kungayambitse zovuta zambiri, kuphatikizapo rhabdomyolysis ndi kulephera kwaimpso.
Pharmacokinetics ndi pharmacodynamics
Mankhwalawa ali ndioaoailil pawiri. Kusintha ndi kugwiritsa ntchito mankhwalawa kumachitika ndi ma cell a chiwindi.
Pafupifupi 90% ya Roxers yolumikizidwa ndi mapuloteni a plasma, makamaka ndi albumin. Pharmacokinetics sasintha mukamamwa pafupipafupi.
Pafupifupi 90% ya rosuvastatin amataya mawonekedwe ake oyambira kudzera mgawo. Gawo laling'ono la mankhwalawa limapangidwa mu mafupa aimpso.
Zisonyezo zakusankhidwa kwa Roxers ndi:
- chachikulu hypercholesterolemia;
- kusagwirizana kwa lipids;
- genetic hypercholesterolemia;
- hypertriglyceridemia;
- atherosulinosis;
- Ngati mankhwala a matenda oyamba ndi matenda amtima pachimake kwa odwala popanda matenda a matenda a mtima, koma ali pachiwopsezo chachikulu.
Mankhwala amapezeka mu mawonekedwe a mapiritsi okhala ndi chipolopolo choteteza.
Piritsi limodzi limakhala ndi mlingo wotsatira: ma milligram asanu, ma milligram 10, ma milligram 15, ma milligram 20, milligram 30, ma milligram 40.
Mlingo amasankhidwa kutengera mtundu ndi zovuta za matendawa. The achire zotsatira zimatengera mlingo ndi pafupipafupi mankhwala.
Mitundu ndi ma genetic a mankhwalawa amasiyanitsidwa. M'mayeso azachipatala, mtundu wa a Mongoloid, poyerekeza ndi Caucasoid, adawonetsa kuwonjezeka kwa plosma ya rosuvastatin.
Mapiritsi a Roxer ali ndi lactose chakudya, chifukwa cha izi mankhwala saloledwa kwa odwala omwe ali ndi kuchepa kwa lactase, komanso carbohydrate malabsorption syndrome.
Chifukwa cha chizungulire, kupweteka mutu ndi zina zoyipa, kuyang'anira mosamala ndi kusamala ndikofunikira poyendetsa makinawo ndikuwongolera njira zowonetsetsa.
Kukhazikika komanso koyenera kwa mankhwalawa kumalepheretsa kusintha kosakhudzana. Ndikofunika kumwa mankhwalawa mulingo woyenera kuti musapanikize kwambiri pachiwindi ndi impso, chifukwa mu izi ziwalo zimachitika kagayidwe ka rosuvastatin.
Dokotala wopezekapo sayenera kungosankha mlingo woyenera, komanso mitundu yosiyanasiyana ya mankhwala pakati pawo. Izi ndichifukwa choti odwala ambiri omwe ali ndi atherosulinosis amakhalanso ndi matenda a mtima.
Malangizo ogwiritsira ntchito mankhwalawa
Roxer amatengedwa malinga ndi malingaliro omwe alembedwe azomwe amagwiritsira ntchito.
Mankhwalawa adapangira pakamwa. Sizoletsedwa kutafuna ndikupera mankhwalawo. Piritsi imayenera kutengedwa momwe ilili yoyambirira, kutsukidwa ndi madzi ambiri. Kulandila nthawi iliyonse, mosasamala kanthu zakudya.
Mphamvu ya mankhwalawa imawonedwa pokhapokha ngati zakudya zapadera zimatsatiridwa. Kumayambiriro kwa mankhwalawa, ma milligram asanu a mankhwala amaperekedwa tsiku lililonse. Mukamasankha regimen, muyezo wa cholesterol wa plasma umawaganiziranso ndikuwunika chiopsezo cha zovuta zamtima. Kuphatikiza apo, samalani ndi chiopsezo chanu chazotsatira zoyipa.
Mutha kuonjezera mlingo pambuyo pa mwezi kuyambira chiyambi cha chithandizo. Mlingo wa 40 mg ndiwofukidwa ndi zotsatira zingapo poyerekeza ndi Mlingo wochepa wazinthu. Kuchulukitsa kwa mankhwalawa kumaloledwa kwa mwezi umodzi ndipo kumachitika kokha mwa odwala omwe ali ndi digiri ya hypercholesterolemia ndipo ali pachiwopsezo chachikulu chodzakhala ndi mavuto amtima. Chithandizo chikuchitika moyang'aniridwa ndi dokotala.
Pakatha mwezi umodzi chithandizo kapena vuto la kusintha kwa mankhwalawa, ndikofunikira kuyambitsa mbiri ya lipid. Kwa odwala omwe ali ndi vuto limodzi laimpso kulephera (chilolezo cha creatinine ndi ochepera mamililita 30 pamphindi), kugwiritsa ntchito mankhwala monga mankhwala sikuloledwa.
Rosuvastatin sangathe kulembedwa kwa odwala omwe ali ndi matenda a chiwindi panthawi yovuta. Odwala a zaka zopitilira 65 ayenera kuti ayambe kumwa ndi zochepa.
Zochita Zosiyana ndi Zopinga Roxers
Zotsatira zoyipa zimadalira mlingo wa mankhwalawo komanso zomwe wodwalayo ali nazo.
Zotsatira zoyipa zimayikidwa malinga ndi kuchuluka kwa zomwe zimachitika komanso zomwe zimawonekera.
Zomwe zimachitika kawirikawiri zimaphatikizapo hypersensitivity reaction (Quincke's edema, urticaria, anaphylactic shock); mutu Chizungulire polyneuropathy; kuphwanya zochitika kukumbukira. Kuphwanya kwam'mimba thirakiti la kudzimbidwa, kutsatiridwa ndi matenda am'mimba, nseru ndi kusanza, kupweteka ndi kusamva bwino m'mimba siziphatikizidwa; chiwindi dystrophy, hepatitis kwambiri icteric syndrome; Stevens-Johnson syndrome; kupweteka kwa minofu; myopathy ndi kuwonongeka kwa minofu minofu; kupweteka kwa molumikizana kutayika kwa mapuloteni mu mkodzo; kutayika kwa maselo ofiira a mkodzo; asthenic chikhalidwe; chithokomiro chithokomiro.
Chifukwa cha kuwopsa kwa mankhwalawa, wopanga akuwonetsa zoletsa zingapo pakugwiritsa ntchito Roxers. Zolepheretsa zazikulu ndiz:
- The yogwira hepatitis kapena zina hepatic matenda.
- Kulephera kwakukulu kwaimpso.
- Myopathy
- Kulandila ndi cytostatic cyclosporin.
- Kugwiritsa ntchito munthawi yomweyo ndi ma fiber.
- Nthawi ya pakati ndi kuyamwa.
- Lactose tsankho.
- Zaka za ana.
- Aliyense tsankho kwa mankhwala.
Kumwa mankhwala pa mimba ndi mkaka wa m`mawere kwathunthu contraindicated. Contraindication imalumikizidwa ndi ntchito yayikulu ya teratogenic ya chinthu.
Rosuvastatin amatsutsana mwa anthu osakwana zaka 18. Mosamala, mankhwalawa amayenera kuperekedwa kwa okalamba.
Mankhwala osankha omwe amagwiritsidwa ntchito amapangidwira kukanika kwa impso, popeza rosuvastatin amakhala ndi nephrotoxic. Mukamamwa mankhwala opitilira 30 mg patsiku, muyenera kuwunika impso nthawi zonse.
Mankhwala ndi myotoxic. Kuwonongeka kwa myalgia ndi minofu kunazindikirika kuphatikizidwa ndi mankhwala ena otsitsa a lipid. Wodwala akakhala ndi ululu wamisempha, kufooka, kukokana komanso kuphatikizika ndi mankhwala ambiri, dokotala wopezekapo ayenera kudziwika nthawi yomweyo. Ndikofunikanso kudziwa mwachangu kuchuluka kwa creatine phosphokinase m'mwazi.
Chithandizo cha mankhwalawa chimayimitsidwa ndikuwonjezeka kwakuthwa kwa creatine phosphokinase kapena kupitirira kwa chizindikiro cha kupweteka kwa minofu, kupindika komanso kufooka.
Kuyanjana kwa Roxers ndi mankhwala ena
Roxers amadziwika ndi kucheza kwina ndi mankhwala ena.
Mukamagwiritsa ntchito mankhwalawa ndi othandizira ena, kuyanjana komwe kungachitike pakati pawo kuyenera kuganiziridwanso.
Ndi mankhwala otsatirawa, mankhwalawa ali ndi mphamvu inayake ya pharmacokinetic:
- Antimetabolite "Tsisklosporin". Ndi kugwiritsa ntchito mankhwala pamodzi, kuwonjezereka kwakuchuluka kwa kuchuluka kwa rosuvastatin mu plasma kumadziwika.
- Warfarin. Mankhwala omwe amapezeka munthawi yomweyo amadzetsa mavuto kwa wodwala. Kuphatikizidwa kwa makulidwe ophatikizana ndi ma anticoagulants kumawonjezera kuchuluka kwa rosuvastatin ndikuwonjezera kawiri konse padziko lonse lapansi.
- Ezetimibe. Kugwiritsa ntchito munthawi yomweyo mankhwalawa sikuwonjezera kuchuluka kwa magazi. Koma ezetimibe angakulitse chiopsezo cha myotoxic reaction.
- Mankhwala ena otsitsa lipid. Ndi makonzedwe omwewo, kuwonetseredwa kwapadera kwa Rosuvastatin mu plasma kumadziwika. Kuphatikiza koteroko kumawonjezera mwayi wokhala ndi matenda a minofu.
- Mankhwala ochepetsa mphamvu ya ma antiretroviral: human immunodeficiency virusase protease inhibitors. Kuphatikiza koteroko kumawonjezera kuchuluka kwa plasma ya rosuvastatin.
- Maantacid. Kuphatikizidwa kwa rosuvastatin ndi maacacid, omwe akuphatikiza aluminiyamu ndi magnesium hydroxide, kumabweretsa kutsika kwa plasma ya rosuvastatin ndi oposa theka. Kuti muchepetse kufanana, ma antacid amaperekedwa patatha maola awiri atatha kumwa kwa rosuvastatin.
- Antibiotic Erythromycin. Munthawi yomweyo makonzedwe kumabweretsa kuchepa ndende ya rosuvastatin. chifukwa cha kuchuluka kwamatumbo.
- Kuphatikiza kulera kwa pakamwa ndi mitundu ina ya mankhwala a mahomoni. Kugwiritsa ntchito limodzi ndi rosuvastatin kumawonjezera kuchuluka kwa zinthu zomwe zimagwira m'magazi m'magazi a m'magazi. Kuti muchepetse izi, kusintha kwa mlingo kumachitika pambuyo pake.
- Mtima glycosides.
Kugwirizana ndi mankhwala omwe ali pamwambawa ndikotsika. Kusankhidwa nthawi yomweyo kuyenera kutsimikiziridwa molingana ndi machitidwe a wodwala.
Mankhwala pamsika woweta
Mankhwalawa atha kugulidwa ku pharmacy iliyonse ku Russia ndi mayiko a CIS.
Mankhwalawa amapezeka pamsika woweta popanda mankhwala.
Mtengo wake umatengera mlingo wa mankhwalawo.
Lero mtengo umasiyanasiyana:
- Mapiritsi okhala ndi muyeso wa 5 mg pa 90 ma PC. - 1056 ma ruble;
- Mapiritsi okhala ndi mulingo wa 10 mg pa 30 ma PC. ndi ma PC 90. - 461 rub. ndi 999 ma ruble. motero;
- mapiritsi okhala ndi mulingo wa 15 mg wa 30 ndi 90 ma PC. - 404 rub. ndi 1225 rubles. motero;
- Mapiritsi okhala ndi mulingo wa 20 mg pa 30 ma PC. pafupifupi 690 rub.
Pamsika wa pharmacological wa Russia pali zambiri zofananira za Roxers. Analogue ndi mankhwala okhala ndi chinthu chofanana. Mankhwala apadziko lonse a Rosuvastatin ndiye mankhwala othandizira pama mankhwala ambiri pamsika wa Russia. Dzina lakelo la mankhwalawo litha kusiyanasiyana.
Mankhwalawa amapangidwa ndi nkhawa yaku Slovenia "Krka". Komanso opanga ambiri, kuphatikizapo apakhomo, akuchita nawo maphunziro a rosuvastatin. Kuphatikiza apo, palinso nthumwi zina za gulu la statin.
Kukonzekera kwamagulu okhudzana (Atorvastatin, Rosuvastatin Canon, Tevastor, ndi ena otere) ndiofanizira pamachitidwe amachitidwe amachitidwe. Kusankhidwa kwa mankhwala ena kumatengera mawonekedwe a wodwalayo.
Roxer ali ndi ndemanga zingapo za odwala omwe amamwa mankhwalawa.
Ndemanga zambiri nthawi zambiri zimakhala zabwino, kupatula ngati pachitika zovuta. Ndemanga za Roxera ndizovuta pakagwiritsidwe ntchito ka nthawi yayitali.
Nthawi zambiri zotsatira zoyipa za thupi zimachitika chifukwa choti wodwalayo amamwa mowa, amalamula kuti amwe mankhwalawo payekha kapena kupitirira muyeso womwe umalimbikitsidwa. Kuunikiridwa koteroko kwa mankhwalawa sicholinga ndipo sikungakhale chifukwa chodalirika chokana kumwa mankhwalawo.
Ndi mwanzeru makonzedwe, mankhwalawa ayenera kuthandiza wodwalayo. Ndi lipid-kuchepetsa mphamvu ya mankhwala omwe amatha kuchepetsa cholesterol komanso chiopsezo cha atherosulinosis ndi zovuta zake. Zotsatira zoyenera kumwa mankhwalawa ndizochepa kwambiri poyerekeza ndi momwe achire angakhalire.
Ndikofunikira kuphatikiza kumwa kwa mitundu yonse ya mankhwala ochepetsa lipid ndi zakudya zabwino komanso moyo wosuntha.
Njira yolumikizirana yolimbana ndi matenda amtima komanso kuwonetsa kwa atherosulinosis ndi yothandiza kwambiri komanso yoyenera.
Statins akufotokozedwa mu kanema munkhaniyi.
