Blocktran GT ndi mankhwala omwe nthawi zambiri amadzipatsa kuthamanga kwa magazi. Kufunikira kwakukulu kwa mankhwalawa chifukwa cha mlingo woyenera komanso mtengo wotsika mtengo.
Dzinalo Losayenerana
Dzinja wamba lodziwika bwino la mankhwalawo ndi Losartan.
Blocktran GT ndi mankhwala omwe nthawi zambiri amadzipatsa kuthamanga kwa magazi.
ATX
Malinga ndi gulu la mankhwala, ATX: C09DA01.
Losartan wophatikizidwa ndi okodzetsa.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amamasulidwa ngati mapiritsi ozungulira, omwe aliwonse amaphatikizika ndi zokutira zosalala. Mtundu wa chipolopolo ukhoza kukhala wapinki, pali utoto wofiirira.
Potengera mankhwala, gawo lalikulu limaseweredwa ndi zinthu zomwe zimagwira ntchito:
- losartan potaziyamu;
- hydrochlorothiazide.
Mndandanda wazinthu zothandizira ukuphatikizapo:
- ma cellcose a microcrystalline;
- lactose monohydrate;
- wowuma mbatata;
- povidone;
- magnesium wakuba;
- sodium wowuma glycolate;
- colloidal silicon dioxide.
Kuphatikizika kwa losartan ndi hydrochlorothiazide kumathandizira kutsitsa magazi.
Chipolopolo cha piritsi chimakhala ndi izi:
- polydextrose;
- hypromellose;
- talc;
- unyolo wapakatikati triglycerides;
- titanium dioxide;
- dextrin;
- utoto carmine wofiira madzi sungunuka (E120).
Zotsatira za pharmacological
Kuphatikizika kwa losartan ndi hydrochlorothiazide kumakhala ndi katundu wowonjezera wa antihypertensive. Chifukwa cha izi, kuchepa kwa kuthamanga kwa magazi kumachitika mwachangu kwambiri kuposa momwe mumagwiritsira ntchito gawo lililonse palokha. Kukhalapo kwa diuretic zotsatira kumapangitsa:
- kukondoweza kwa kupanga aldosterone;
- kuchuluka kwa plasma retin;
- kuchuluka kwa angiotensin II;
- yafupika ma seramu potaziyamu.
Chifukwa cha zomwe zili losartan, mankhwalawa ndi a gulu la angiotensin 2 receptor antagonists. Sikuletsa kinase II (enzyme iyi ndi yomwe imapangitsa kuti bradykinin iwonongeke.
Mankhwalawa samayambitsa kutsekeka kwa mahomoni ena ndi ma ion njira zomwe zimakhudza kugwira ntchito kwa mtima.
The yogwira thunthu limasinthasintha zingapo mu dongosolo la magazi nthawi imodzi:
- amachepetsa kuthamanga kwa magazi ndi kukakamiza mu kufalikira kwa m'mapapo;
- amachepetsa ndende ya norepinephrine ndi aldosterone mu madzi a m'magazi;
- amachepetsa kuchuluka kwa OPSS;
- ali ndi diuretic zotsatira;
- amachepetsa pambuyo;
- amathandizira kukulitsa kulolerana kwa odwala omwe ali ndi vuto la mtima losalephera kuchita zolimbitsa thupi.
Poterepa, mankhwalawa samayambitsa kutsekeka kwa mahomoni ena ndi ma ion njira zomwe zimakhudza kugwira ntchito kwa mtima.
Hydrochlorothiazide imatha kukhala ndi antihypertensive komanso okodzetsa. Mchitidwe wake umalimbikitsidwa kupatsanso ma elekitiroma a electrolyte omwe ali mu aimpso distal tubules. Kuwonjezeka kwa ndende ya uric acid. Pambuyo pakukonzekera pakamwa, chigawochi chimayamba kugwira ntchito patatha maola awiri. Mphamvu yayitali imatheka pambuyo maola 4. Kutalika kwa nthawi kumatha kusintha kuchokera maola 6 mpaka 12.
Pharmacokinetics
Mphamvu ya antihypertensive pambuyo pa mlingo umodzi wa mankhwalawo imafika pazomwe itatha maola 6. Maola 24 otsatira, zotsatira zimachepa pang'onopang'ono. Chilolezo cha plasma cha mankhwalawo ndi metabolite wake ndi 600 ml / min ndi 50 ml / min, motsatana.
Kutulutsa kwazinthu zomwe zimagwira ntchito kumachitika kudzera mu impso ndi matumbo (pamodzi ndi bile).
Kutulutsa kwazinthu zomwe zimagwira ntchito kumachitika kudzera mu impso ndi matumbo (pamodzi ndi bile).
Zizindikiro zogwiritsidwa ntchito
Mankhwalawa amalembera zotsatirazi:
- Matenda oopsa. Mankhwalawa amagwiritsidwa ntchito pochizira ndi prophylactic.
- Hypertrophy ya kumanzere kwamitsempha. Mankhwalawa akuwonetsedwa popewa matenda amtima.
Contraindication
Kugwiritsa ntchito mankhwalawa popanda mankhwala a dokotala kumakhumudwitsidwa kwambiri. Pali zotsutsana zingapo:
- Hypersensitivity chimodzi kapena zingapo zomwe zikuchokera;
- zaka za ana mpaka zaka 18 (zomwe zikuchitika pakhungu la ana sizinaphunzire);
- kukhalapo kwa shuga-galactose malabsorption syndrome, kuperewera kwa lactase kapena tsankho lactose;
- nthawi ya pakati komanso nthawi yoyamwitsa;
- mbiri yayikulu ya matenda a chiwindi, cholestasis;
- Matenda a Addison;
- kusowa kwamadzi;
- kwambiri ochepa hypotension;
- matenda a impso (ngati chilolezo cha creatinine ndiochepera 30 ml / min);
- anuria
- Hypokalemia Refractory;
- Hyperkalemia
- matenda ashuga a shuga ndi ovuta kuwongolera.
Ndi chisamaliro
Pamaso pa matenda ena pakufunika kusankha kochita kusamala mosamala kwambiri. Nthawi yomweyo, dokotala amayang'aniridwa pafupipafupi kuti adziwe momwe wodwalayo alili. Mosamala, mapiritsi amatchulidwa mu milandu yotsatirayi:
- stenosis (mitral ndi aortic);
- kuchira pambuyo kupatsidwa impso;
- hypertrophic cardiomyopathy;
- kukhalapo kwa mtima kulephera;
- chachikulu hyperaldosteronism;
- matenda amisala;
- angioedema.
Momwe mungatengere Blocktran GT
Mapiritsi alipo pakamwa. Chakudya sichimakhudza ma pharmacokinetics, chifukwa chake, mankhwalawa amawonongeka nthawi iliyonse yoyenera: musanadye, musanadye, kapena pambuyo pake.
Mlingo wofanana watsiku ndi tsiku umaonedwa kuti piritsi limodzi, amatengedwa kamodzi. Frequency - 1 nthawi patsiku.
Nthawi zina, voliyumu iyi siyingabweretse kufunika kwa achire, ndiye, moyang'aniridwa ndi dokotala, ndizotheka kuti muonjezere kuchuluka kwa mapiritsi awiri patsiku. Voliyumu iyi iyenera kugawidwa pawiri. Nthawi zambiri, odwala omwe ali ndi matenda oopsa amatha kuchita zinthu ngati izi.
Ndi matenda ashuga
Mankhwalawa odwala matenda a shuga ayenera kuwunika momwe wodwalayo alili.
Kuchokera kumachitidwe amanjenje ndi ziwalo zam'maganizo, kutopa kochulukirapo ndikotheka.
Zotsatira zoyipa za Blocktran GT
Zotsatira zoyipa zobwera chifukwa chogwiritsa ntchito mankhwalawa zimatha kufanana ndi magulu osiyanasiyana amthupi. Mawonetsero ofooka amapezeka m'masiku oyamba kumwa mapiritsi, amathetsedwa pang'onopang'ono.
Matumbo
Infrequent ndi kudzimbidwa ndi kupweteka pamimba. Kutheka kotakasuka, kamwa yowuma, gastritis, sialadenitis, kapamba, hyponatremia.
Hematopoietic ziwalo
Kuchokera kuzinthu zoyenda mozungulira komanso zamitsempha yamagazi, kuchepa kwa magazi kumapezeka kwambiri mwa odwala. Leukopenia, agranulocytosis, thrombocytopenia, ndi purpura sizimachitika kawirikawiri.
Pakati mantha dongosolo
Kuchokera kwamankhwala amanjenje ndi ziwalo zam'maganizo, kutopa kochulukirapo, asthenia, chizungulire, kusowa tulo komanso kupweteka pamutu ndikotheka.
Pafupipafupi, kugona, kufooka, nkhawa, zotumphukira za m'mimba, kusokonezeka kwa kukumbukira, kugunda kwa malekezero, kukhumudwa, kusokonezeka kwa kulawa, kulira ndi tinnitus, conjunctivitis, ndi kusazindikira.
Mwa zina mwazotsatira zoyipa zomwe zimakhudzana ndi dongosolo la kwamikodzo, matenda amtundu wa kwamkodzo amatchedwa.
Kuchokera kwamikodzo
Mwa zina mwazotsatira zoyipa zomwe zimakhudzana ndi kwamikodzo imatchedwa matenda a kwamikodzo, kuchepa kwamphamvu kwa amuna, ntchito yaimpso, komanso kuwoneka pokodza kwamkodzo. Hydrochlorothiazide nthawi zina amatha kuyambitsa glucosuria, interstitial nephritis.
Kuchokera ku kupuma
Odwala ena amadandaula za kuchulukana kwammphuno, chifuwa ndi zizindikiro za matenda omwe akukhudza chapamwamba kupuma thirakiti (pakati pawo sinusitis ndi pharyngitis). Kuwonetsera kotereku nthawi zambiri kumatsatiridwa ndi kutentha.
Zomwe zimakonda kwambiri ndi rhinitis, bronchitis, kupuma movutikira, mapapu a edema, chibayo.
Pa khungu
Kumwa mankhwalawa kumatha kuyambitsa khungu louma, photosensitivity, hyperemia, thukuta kwambiri la thupi, poizoni wa khungu, khungu mawonekedwe a systemic lupus erythematosus.
Kuchokera ku minculoskeletal system
Kukoka, kupweteka msana, myalgia, kupweteka m'miyendo ndi chifuwa nthawi zambiri kumadziwika. Arthralgia, fibromyalgia ndi nyamakazi amaonedwa ngati mawonekedwe osowa.
Kuchokera pamankhwala am'mimba atatha kumwa mankhwalawa, kupweteka kumadziwika nthawi zambiri.
Kuchokera pamtima
Zotsatira zoyipa zamankhwala zingakhale:
- kuchuluka kwa mtima;
- orthostatic hypotension;
- arrhythmia;
- angina pectoris;
- bradycardia;
- necrotizing vasculitis;
- kupweteka mumtima.
Matupi omaliza
Thupi lawo siligwirizana ndi Hypersensitivity zimachitika ku chinthu china cha mankhwala. Imakhala ndi kuyabwa, urticaria, zidzolo, angioedema.
Zokhudza mphamvu pakuwongolera njira
Munthawi yamankhwala omwe mumalandira ndi odwala, odwala amatha kukumana ndi zovuta monga kugona, kuchepa kwa chidwi ndi kuzungulira kwa chizungulire komanso kusazindikira. Pachifukwa ichi, chisamaliro chimayenera kuthandizidwa poyendetsa galimoto ndikuchita nawo masewera oopsa.
Malangizo apadera
Blocktran imatha kuwonjezera kuchuluka kwa serum creatinine ndi urea wamagazi. Kusintha kumeneku kumachitika kawirikawiri kwa odwala omwe apezeka ndi stenosis a impso kapena a impso.
Thupi lawo siligwirizana ndi Hypersensitivity zimachitika ku chinthu china cha mankhwala.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwala, palibe chidziwitso cha mankhwalawa pa thanzi ndi chikhalidwe cha mwana wosabadwayo. Mwanjira imeneyi, mankhwalawa amakhudza RAAS, omwe mu chiphunzitsocho angayambitse kukulira m'mimba ndi kufa kwa fetal mukamamwa mankhwalawa mu 2nd ndi 3 trimester ya mimba.
Ngati n`kofunika kugwiritsa ntchito mankhwalawa akazi akunyumba, madokotala amalimbikitsa kusokoneza mkaka wa m`mawere, chifukwa mkaka wa m'mawere muli ochepa losartan.
Kusankhidwa kwa ana aBtrtran GT
Zambiri pakugwiritsa ntchito mankhwalawa muubwana sizikupezeka. Pachifukwa ichi, ana sapatsidwa mankhwala.
Gwiritsani ntchito mu ukalamba
Chifukwa cha mayeso azachipatala, panalibe chowopsa mukamamwa mulingo woyenera wa mankhwalawa. Kulera mlingo sikulimbikitsidwa.
Akatswiri amaletsa kugwiritsa ntchito mankhwalawa panthawi yoyamwitsa.
The ntchito aimpso kuwonongeka
Nthawi zina, kumwa mankhwalawa kunadzetsa vuto la impso. Izi zikufotokozedwa ndikuletsa kwa RAAS, komwe kumachitika mutamwa mapiritsi. Ma pathologies amenewo anali osakhalitsa ndipo adayimitsidwa atasiya kumwa mankhwala.
Mosamala, mankhwalawa amayenera kuperekedwa kwa anthu omwe akudwala aimpso.
Kugwiritsa ntchito kwa vuto la chiwindi
Zotsatira zamaphunziro a pharmacological, kuwonjezeka kofulumira kwa losartan m'magazi a odwala omwe adapezeka ndi matenda a chiwindi. Pazifukwa izi, mlingo wa chiwindi choperewera umachepa.
Overdose wa Blocktran GT
Kuchulukitsa kwa mankhwala omwe dokotala amakupatsani nthawi zambiri kumabweretsa mankhwala osokoneza bongo. Amadziwika ndi mawonekedwe a kuthamanga magazi, tachycardia, bradycardia. Kuchuluka kwa hydrochlorothiazide kumayambitsa hypochloremia, hypokalemia, hyponatremia. Mwina kuchuluka kwa mndandanda.
Zotsatira zamaphunziro a pharmacological, kuwonjezeka kofulumira kwa losartan m'magazi a odwala omwe adapezeka ndi matenda a chiwindi.
Kuti khazikitse mkhalidwe wa wodwalayo, madokotala amachita kukakamiza ndipo amachita zozizwitsa. Pankhaniyi, hemodialysis siyothandiza.
Kuchita ndi mankhwala ena
Angiotensin II receptor antagonist nthawi zina amadziwika kuti ndi gawo la zovuta mankhwala. Pankhaniyi, mankhwalawa amalumikizana mosiyanasiyana ndi mankhwala ena:
- Kuphatikiza ndi Aliskiren sikulimbikitsidwa chifukwa cha chiwopsezo cha kukulitsa ma pathologies mu ntchito ya impso komanso hypotension yayikulu.
- Ndi zoletsa zoletsa za ACE. Nthawi zambiri pamakhala kuoneka ngati kulephera kwa impso, syncope, hypotension yayikulu kapena hyperkalemia.
- Kugwiritsa ntchito pamodzi ndi sympatholytics kapena antihypertgency othandizira kumabweretsa kupititsa patsogolo limodzi kwa machitidwe a mankhwala.
- Pogwiritsa ntchito potaziyamu wothandiza kuchepetsa, odwala ambiri amakula potaziyamu wambiri m'thupi.
- Ndi fluconazole ndi rifampicin, zotsatira za losartan zimachepetsedwa.
- Ndi barbiturates ndi narcotic analgesics. Pali chiopsezo chachikulu cha orthostatic hypotension.
- Ndi mankhwala a hypoglycemic. Kusintha kwa Mlingo ndikofunikira, popeza kugwiritsa ntchito bwino mankhwalawa kumachepetsedwa.
Kuyenderana ndi mowa
Kutenga mapiritsi ndikosayenera kwambiri kuphatikiza ndi zakumwa zoledzeretsa. Zochita zoterezi zimatha kubweretsa zovuta zoyipa. Hydrochlorothiazide pamaso pa ethanol imatha kuyambitsa orthostatic hypotension.
Analogi
Mankhwalawa ali ndi ma fanizo angapo omwe amapangidwa ndi makampani aku Russia ndi akunja. Zina mwa izo ndi majeniki ndi mankhwala omwe ali ndi zotsatira zofananira:
- Vazotens H;
- Lorista N;
- Gizaar Forte;
- Presartan H;
- Simartan-N;
- Gizortan.
Kupita kwina mankhwala
Mutha kugula mankhwala ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Mankhwala ochokera pagulu la angiotensin II receptor antagonists amapezeka kokha pamankhwala.
Mtengo wa Blocktran GT
Mtengo wa mankhwalawa umatengera kuchuluka kwa mapiritsi. Mtengo pafupifupi wa mafakisi ku Moscow amachokera ku ma ruble 220. pa paketi (mapiritsi 30).
Zosungidwa zamankhwala
Malo osungirako mankhwalawo akhale ouma, otetezedwa ku dzuwa. Kutentha - kopanda kuposa + 25 ° ะก.
Tsiku lotha ntchito
Potengera momwe mankhwalawo amasungidwira, moyo wa alumali wa mapiritsiwa umafika miyezi 24 kuchokera tsiku lotulutsidwa. Pambuyo pa nthawi iyi, mankhwalawa amaletsedwa kotheratu.
Wopanga
Mankhwalawa amapangidwa ndi Pharmstandard-Leksredstva OJSC. Kampani yopanga mankhwala ili ku Kursk pa adilesi: st. 2 Aggregate, 1a / 18.
Ndemanga ya blocktran GT
Alexander, wazaka 48, Volgograd
Mankhwalawa adatengedwa ngati gawo lachithandizo chokwanira pambuyo povutika ndi matenda oopsa. M'masiku oyambilira, kupweteka mutu komanso kutopa pang'ono kunabuka. Dotolo adalangiza kuti asakane kulandira. Mu sabata yachiwiri, zoyipa zake zidayima. Maphunzirowa anali atakwaniritsidwa.
Tatyana, wazaka 39, Khabarovsk
Ndakhala ndikuvutika ndi kuthamanga kwa magazi kwazaka zambiri. Mankhwalawa amachita mwachangu komanso moyenera. Izi zisanachitike, adotolo adalembera mapiritsi ena, koma sanabweretse zotsatira.
