Malamulo otenga Glimecomb ndi analogues

Glimecomb amatanthauza mankhwala omwe amagwiritsidwa ntchito pa matenda a shuga a 2.

Chidacho chili ndi katundu wophatikizidwa wa hypoglycemic.

Mutatha kumwa mankhwalawa, matenda a shuga m'magazi a wodwalayo amadziwika.

Zambiri, kapangidwe ndi mawonekedwe ake amasulidwe

Mankhwala omwe amatchulidwa amachokera ku hypoglycemic wothandizira omwe amamwa pakamwa. Chidacho chimakhala ndi kuphatikiza. Kuphatikiza pa kutsitsa shuga, Glimecomb ili ndi kapamba wambiri. Nthawi zina, mankhwalawa amakhala ndi mphamvu yowonjezera.

Kukonzekera kumakhala ndi Metformin hydrochloride mu 500 mg ndi Gliclazide - 40 mg, komanso ma exbitored sorbitol ndi croscarmellose sodium. Pochepa, magnesium stearate ndi povidone amapezeka mumankhwala.

Mankhwalawa amapezeka mu mawonekedwe a mapiritsi a cylindrical mumayera oyera, kirimu kapena chikasu. Kwa mapiritsi, kuguba ndi kololedwa. Mapiritsi ali ndi chiopsezo komanso zokongoletsa.

Glimecomb imagulitsidwa pama mapiritsi 10 mumatumba a blister. Phukusi limodzi lili ndi 6 mapaketi.

Pharmacology ndi pharmacokinetics

Glimecomb ndi mankhwala osakanikirana omwe amaphatikiza ma hypoglycemic othandizira a gulu la Biguanide ndi zotumphukira za sulfonylurea.

Wothandizirayo amadziwika ndi zotsatira za pancreatic ndi extrapancreatic.

Gliclazide ndi imodzi mwazinthu zazikulu zamankhwala. Ndizotuluka kuchokera ku sulfonylurea.

Katunduyo amathandizira:

• yogwira insulin;
• kuchepa kwa magazi ndende;
• kuchepetsa kupendekera kwa mapulateleti, komwe kumalepheretsa mapangidwe azigazi m'mitsempha;
• matenda a mtima kukhathamira.

Gliclazide linalake ndipo tikulephera kupezeka kwa microthrombosis. Nthawi yayitali kugwiritsa ntchito mankhwalawa odwala matenda ashuga nephropathy, kuchepa kwa proteinuria (kukhalapo kwa mapuloteni mu mkodzo).

Gliclazide imakhudza kulemera kwa wodwala yemwe amamwa mankhwalawo. Ndi zakudya zoyenera odwala omwe ali ndi matenda osokoneza bongo omwe amatenga Glimecomb, kuwonda kumadziwika.

Metformin, yomwe ndi gawo la mankhwalawo, amatanthauza gulu lalikulu. Vutoli limachepetsa kuchuluka kwa shuga m'magazi, limathandizira kufooketsa njira yopopera shuga m'mimba ndi matumbo. Metformin imathandizira kufulumizitsa njira yogwiritsira ntchito glucose kuchokera ku minofu ya thupi.

Mankhwala amachepetsa cholesterol, otsika kachulukidwe lipoproteins. Pankhaniyi, Metformin sikukhudza kuchuluka kwa lipoproteins a kachulukidwe kosiyanasiyana. Monga Glyclazide, amachepetsa kulemera kwa wodwalayo. Zilibe mphamvu pakakhala insulin m'magazi. Zilibe kuthandiza kuti mawonekedwe a hypoglycemic asinthe. Gliclazide ndi metformin zimasunthidwa mosiyanasiyana kuchokera kwa wodwala. Gliclazide imadziwika ndi mayamwidwe apamwamba kuposa a Metformin.

Mulingo wokulirapo wa Gliclazide m'magazi umafikiridwa patatha maola atatu kuchokera nthawi yomwe munayamba kumwa mankhwalawo. Thupi limachotsedwa kudzera mu impso (70%) komanso matumbo (12%). Kutha kwa theka moyo kumafika maola 20.

The bioavailability wa Metformin ndi 60%. Vutoli limadziunjikira m'magazi ofiira. Hafu ya moyo ndi maola 6. Kuchoka m'thupi kumachitika kudzera mu impso, komanso matumbo (30%).

Zizindikiro ndi contraindication

Mankhwalawa amalimbikitsidwa kwa odwala matenda ashuga omwe ali ndi matenda a shuga 2 ngati:

• chithandizo cham'mbuyomu ndi zakudya komanso kuchita masewera olimbitsa thupi sizinakhale ndi ntchito yoyenera;
• pakufunika kubwezeretsa mankhwala omwe amaphatikizidwa kale pogwiritsa ntchito Gliclazide ndi Metformin mwa odwala omwe ali ndi shuga wamagazi okhazikika.

Mankhwalawa amadziwika ndi mndandanda wambiri wa zotsutsana, zomwe:

• kukhalapo kwa matenda a shuga 1;
• tsankho lake pazigawo za mankhwala;
• kuphwanya impso ntchito;
• mimba
• kulephera kwa chiwindi;
• lactic acidosis;
• kulephera kwa mtima;
• matenda a shuga;
• kuyamwa
• matenda osiyanasiyana;
• myocardial infarction;
• matenda a porphyrin;
• matenda a shuga;
• kuchitapo kanthu kwa opareshoni;
• nthawi yomwe wodwalayo amaphunzira maphunziro a x-ray ndi mayeso pogwiritsa ntchito ma radioisotopes poyambitsa zinthu zosiyanitsa ndi ayodini m'thupi (ndizoletsedwa kutenga masiku awiri isanachitike komanso pambuyo pa maphunziro awa);
• kuvulala kwakukulu;
• kugwedezeka komwe kumayambitsa maziko a mtima ndi matenda a impso;
• kulephera kupuma;
• kuledzera;
• shuga wamagazi ochepa (hypoglycemia);
• matenda oopsa a impso;
• uchidakwa wambiri;
• kupsa kwambiri thupi;
• Kutsatira odwala omwe ali ndi hypocaloric zakudya;
• kutenga miconazole;
• matenda ashuga ketoacidosis.

Malangizo ogwiritsira ntchito ndi malangizo apadera

Mlingo wa mankhwalawa ndiwothandiza kwa wodwala aliyense. Ndikulimbikitsidwa kumwa mapiritsi atatu patsiku. M'masiku otsatirawo amathandizira, kuwonjezereka kwa mlingo kumatheka, kutengera zomwe zimawonetsa shuga m'magazi a wodwala komanso kuchuluka kwa matenda ake. Kwa Glimecomb, mlingo waukulu ndi mapiritsi 5 patsiku.

Mankhwala tikulimbikitsidwa kuti kumwedwa m'mawa ndi madzulo. Mankhwalawa amatengedwa nthawi yakudya kapena itatha.

Chipangizocho sichikulimbikitsidwa kwa odwala azaka zopitilira 60, ogwira ntchito movutikira. Pogwira ntchito molimbika komanso kutenga Glimecomb mwa okalamba, lactic acidosis imatha kukula.

Mimba ndi imodzi mwazomwe zimayambitsa kumwa mankhwalawa. Mimba ikachitika, komanso musanakonzekere, ndikofunikira kusintha mankhwalawa ndi insulin.

Kuyamwitsa kumapangitsanso chifukwa choponderezedwa pazinthu zambiri za mankhwala mkaka wamawere. Ndikofunika kusiya kudyetsa kwa nthawi yayitali kumwa Glimecomb ndi amayi kapena kusiya kumwa mankhwalawo pakupatsa msambo.

Mosamala, ndikofunikira kumwa mankhwalawa kwa odwala omwe ali ndi:

• malungo;
• mavuto a chithokomiro;
• adrenal kusowa.

Mankhwalawa amaletsedwa kwa odwala omwe ali ndi matenda a chiwindi, komanso kuwonongeka kwaimpso, limodzi ndi mantha, kufooka kwa thupi ndi zina zoopsa.

Mankhwalawa amatengedwa pokhapokha ngati amadya zakudya zochepa zopatsa mphamvu zamafuta ochepa. M'masiku oyambirira a chithandizo, kuyendetsa shuga kumakhala kofunikira. Mankhwala othandizira ndi mankhwalawa amachitika kokha mwa odwala omwe amalandila zakudya zonse.

Sulfonylureas, yomwe ndi gawo la mankhwalawa, imatha kupangitsa hypoglycemia. Imachitika ndi otsika kalori zakudya ndi zolimbitsa thupi. Ndikofunikira nthawi zonse kusintha mlingo wa mankhwalawa, makamaka odwala okalamba.

Hypoglycemia imatha kudwala odwala akamatenga:

• mowa wa ethyl;
• mankhwala osapweteka a antiidal.

Kusala kudya kumathandizanso kukhala ndi vuto la hypoglycemia mwa odwala, ndipo mankhwala osokoneza bongo monga reserpine omwe amakhala ndi clonidine amawaphimba.

Panthawi ya opaleshoni ya opaleshoni odwala, ngati atenthedwa, kuvulala, matenda a malungo, komanso myalgia, lactic acidosis, kusiya kwa mankhwalawo kumafunika.

Mankhwalawa angakhudze kuyendetsa. Chisamaliro chiyenera kutengedwa.

Amayenera kusiya kumwa Glimecomb masiku awiri asanafike komanso atalowa m'thupi la wodwalayo wothandizira wa radiopaque ndi ayodini.

Zotsatira zoyipa ndi bongo

Mwa zina zoyipa zomwe zimachitika chifukwa chogwiritsa ntchito mankhwalawa ndizotheka:

• hypoglycemia ndi thukuta kwambiri, kufooka, chizungulire, njala, ndi kukomoka;
• lactic acidosis ndi kugona, kutsika magazi, kufooka, kupweteka kwam'mimba, myalgia;
• nseru
• kuchepa magazi
• mavuto amawonedwe;
• urticaria;
• mziwindi vasculitis;
• kutsegula m'mimba
• kuyabwa
• hemolytic anemia;
• kuyabwa
• erythropenia;
• Nthawi zina, chiwindi;
• kulephera kwa chiwindi.

Zizindikiro zofala kwambiri za bongo ndi hypoglycemia ndi lactic acidosis. Zizindikiro zonsezi zimafunikira chithandizo kuchipatala. M'njira zonsezi, mankhwalawa amaletsedwa. Poyamba, wodwala amalandila chithandizo, hemodialysis imachitidwa.

Ndi hypoglycemia yofatsa komanso yolimbitsa thupi, ndizokwanira kuti odwala atenge yankho la shuga mkati. Woopsa mawonekedwe, shuga amaperekedwa kwa wodwalayo (40%). Njira ina ikhoza kukhala glucagon, yoyendetsedwa yonse ndi minyewa. Kuperekanso chithandizo kumachitika ndi wodwalayo akudya chakudya chopatsa thanzi.

Kuyanjana Ndi Mankhwala Ndi Analogi

Mankhwalawa amalumikizana ndi mankhwala ena motere:

• kuchuluka kwa hypoglycemic kumalimbikitsidwa akaphatikizidwa ndi enalapril, cimetidine, miconazole, clofibrate, ethionamide, anabolic steroids, cyclophosphamide, tetracycline, reserpine ndi othandizira ena omwe ali ndi vuto la hypoglycemic;
• amachepetsa hypoglycemic zotsatira pamene atengedwa limodzi ndi Clonidine, Phenytoin, Acetazolamide, Furosemide, Danazole, Morphine, Glucagon, Rifampicin, nicotinic acid mu mlingo waukulu, estrogen, mchere wa lithiamu, njira yolerera pakamwa;
• ntchito munthawi yomweyo nifedipine amachepetsa kuchoka kwa metformin;
• Co-makonzedwe ndi cationic mankhwala kumawonjezera pazipita ndende ya metformin m'magazi ndi 60%;
• kumawonjezera ndende ya metformin mgwirizano wa mankhwala ndi furosemide.

Glimecomb ili ndi ma fanizo ndi mawu ofanana:

• Glidiab;
• Glyformin;
• Glidiab MB;
• Kutalika kwa Gliformin;
• Metglib;
• Fomu;
• Glyclazide MB;
• Diabetesalong;
• Gliclazide-Akos.

Piritsi ya kanema ikuwonetsa zizindikiro ndi chithandizo cha matenda ashuga:

Maganizo a akatswiri ndi odwala

Kuchokera pakuwunika kwa odwala, titha kunena kuti Glimecomb amachepetsa shuga m'magazi ndipo amaloledwa bwino, komabe, madokotala amalimbikitsa chisamaliro chake chifukwa cha zovuta zingapo.

Glimecomb ndi chithandizo chothandiza kwa matenda ashuga amtundu wa 2. Koma poganizira zambiri zake, tikulimbikitsidwa kuti zilembedwe mosamala kwa odwala angapo. Makamaka okalamba.

Anna Zheleznova, wazaka 45, endocrinologist

Mankhwala abwino othandizira shuga. Ndidatenga kwa mwezi umodzi, palibe mavuto, ngakhale pali ambiri mwa malangizo. Ndidakondwera ndi mtengo.

Chikondi, wazaka 57

Kwa nthawi yayitali ndakhala ndikudwala matenda a shuga. Ndimalola Glimecomb. Mankhwalawa ndiabwino komanso osakwera mtengo kwambiri. Amachepetsa shuga bwino. Chofunikira ndi kudya bwino komanso kudya moyenera.

Alexandra, wazaka 51

Mankhwala omwe amafotokozedwawu amawagawa pogwiritsa ntchito mankhwala. Mtengo wake umachokera ku ma ruble 440-580. Mtengo wa anzanu ena apabanja umachokera ku ruble 82 mpaka 423.