Mtundu wachiwiri wa matenda ashuga, pakudza nthawi yomwe insulin yanu sikokwanira, ndipo wodwala ali ndi chisankho: yambani mankhwala a insulin kapena mapiritsi omwe amalimbikitsa kuphatikiza kwa mahomoni ake, mwachitsanzo, Maninil. Mankhwalawa ndi akale kwambiri pagulu lawo, chifukwa chogwira ntchito mopitilira pake akuti "golidi" muyezo wowerengetsa matenda ashuga.
Pakadali pano, ndemanga zokhudzana ndi mankhwalawa sizabwino kwambiri, madokotala ambiri amakonda kupereka mankhwala amakono ochepetsa shuga kwa odwala matenda ashuga. Maninil chithandizo sichiwonetsedwa kwa odwala onse. Kumayambiriro kwa matendawa, adzachita zoipa zambiri kuposa zabwino. Chifukwa chake, mankhwalawa amagulitsidwa molingana ndi mankhwala omwe adalembedwa ndi adotolo atalandira zotsatira zoyesedwa zotsimikizira kupezeka kwa zisonyezo zotengera Maninil.
Buku lamalangizo
Mankhwala okhala pamapiritsi a Maninyl ndi glibenclamide, yomwe ndi sulfonylurea yotengedwa ndipo ndi ya m'badwo wachiwiri. Kwa nthawi yoyamba glibenclamide idayamba kugwiritsidwa ntchito pazachipatala kale mu 1969. Gliclazide, glipizide ndi glycidone nawonso ndi amtundu womwewo. M'badwo wachitatu ndi glimepiride wamakono. Manilin amapangidwa ndi kampani yaku Germany ya Berlin-Chemie. Pakati pa anzawo, mankhwalawa amawonekera chifukwa chogwira bwino kwambiri, mtengo wotsika, komanso chiwopsezo chachikulu cha kapamba.
| Machitidwe | Zimakhudza matenda ashuga ochokera mbali ziwiri:
Kuphatikiza pa kuthana ndi zovuta zomwe zimapezeka mu shuga, Maninil amatsitsa magazi lipids, ndi cardiprotector ofooka, ndipo ali ndi antiarrhythmic. Mbiri yakuchitapo kanthu kuchokera ku malangizo ogwiritsira ntchito: kuchuluka kwa maola a 2,5 pa fomu yanthawi zonse, maola 1.5 kwa ma micron, nthawi yonse yogwira ntchito ikufika mpaka maola 24, ndiye kuti chinthucho chimagawika m'chiwindi. Zogulitsa za Cleavage sizisonkhana m'thupi, koma zimathiridwa mu mkodzo ndi bile. |
| Zizindikiro zogwiritsidwa ntchito | 2 mtundu wa matenda ashuga. Mankhwalawa amatha kuphatikizidwa ndi othandizira a hypoglycemic ochokera m'magulu ena. Zotumphukira za Sulfonylurea sizingatengedwe popewa mankhwala osokoneza bongo. |
| Contraindication |
Malinga ndi malangizo othandizirana kwambiri a matenda a shuga kapena matenda oopsa omwe angayambitse, Maninil amasinthidwa kwakanthawi ndi insulin. Kuyenderana ndi mowa: Mlingo waung'ono wa mowa sungabweretse mavuto, uchidakwa kapena kuledzera ungayambitse hypoglycemia yoopsa. |
| Zitha kukhala zovuta | Zotsatira zoyipa kwambiri ndizo hypoglycemia. Zitha kuchitika chifukwa cha kudya mopitirira muyeso, kudya kwambiri, kudya zolimbitsa thupi nthawi yayitali. Insulin imalepheretsa kuchepa kwa lipids, chifukwa chake mukatenga Maninil, kulemera kwa wodwalayo kumatha kuwonjezeka. Osakwana 1% ya odwala, chithandizo chimayendetsedwa ndi matupi awo sagwirizana ndi kupsinjika, komanso matenda am'mimba, limodzi ndi mseru, kutsekula m'mimba, kuwonda kapena kupweteka m'mimba. Kusokonezeka kwa chiwindi, chifuwa chachikulu, kusintha kwa magazi kumakhala kocheperako. Malangizo ogwiritsira ntchito amachenjeza kuti kutenga Maninil kumatha kukulitsa chidwi cha khungu kuti khungu la ultraviolet liperekedwe, motero, odwala omwe amamwa mankhwalawa. Analetsa kuyang'ana dzuwa nthawi yayitali. |
| Kuopsa kwa hypoglycemia | Mu malangizo, kuthekera kwa kutsika kwa shuga kukuyerekeza ndi 0,5%. Nthawi zambiri hypoglycemia imayendetsedwa ndi kunjenjemera, njala, thukuta limachulukirachulukira, tachycardia, nkhawa. Vutolo likamakulirakulira, wodwalayo amasiya kuwongolera zochita, ndiye kuti chikumbumtima chasokonezeka. Ngati mankhwala sanayambike munthawi yake, chikomokere cha hypoglycemic chimayamba. Odwala omwe amakhala ndi hypoglycemia kapena diabetesic neuropathy, Zizindikiro zimayamba kutchulidwa, motero zimakhala zowopsa. Ngati hypoglycemia ikukayikiridwa, ndizoletsedwa kutenga Maninil, kuyendetsa galimoto ndikuchita zinthu zomwe zimafuna chidwi chapadera. |
| Kugwirizana ndi mankhwala ena | Hormonal, hypoglycemic, hypotensive, antifungal, antitumor mankhwala, antidepressants, maantibayotiki, NSAIDs ndi mankhwala ena amatha kuthana ndi Maninil. Mndandanda wathunthu umapezeka pofotokoza mwatsatanetsatane mankhwala omwe amaphatikizidwa piritsi lililonse la mapiritsi. Ndi kayendetsedwe kawo munthawi yomweyo, kusintha kwa maninil kungafunike onse kuti akuwonjezere ndi kuchepa. Mankhwala onse omwe amamwa iyenera kuvomerezedwa ndi dokotala kapena endocrinologist. |
| Kutulutsa Fomu | Mapiritsi a pinki osiyanasiyana. Mu Maninil 1.75 ndi 3.5 glibenclamide ili ndi ma micronized mawonekedwe, ndiko kuti, tinthu tating'onoting'ono tomwe timakhala piritsi timatsitsidwa, zomwe zimathandizira kuyamwa. Maninil 5 ali ndi 5 mg ya glibenclamide yokhazikika. Micronization ya glibenclamide imachulukitsa kukhala bioavailability (kuyambira 29-69 mpaka 100%), zomwe zikutanthauza kuti zimakupatsani mwayi woti mumwe mankhwala ochepa. |
| Kupanga | Glibenclamide 1.75; 3.5; 5 mg Zowonjezera: utoto, lactose, silicon dioksidi, hydroxyethyl cellulose, wowuma, magnesium stearate, 5 talc ndi gelatin ku Maninil. |
| Zofunika posungira | Kutentha mpaka 25 ° C, mankhwalawa amasungabe katundu wake kwa zaka zitatu kuyambira nthawi yopanga. |
Malamulo Ovomerezeka
Maninyl ndi zotumphukira zina za sulfonylurea ndizosavomerezeka chifukwa cha matenda opatsirana a shuga. Pakadali pano, kutulutsidwa kwa insulini kwayamba kale, kuti muwonjezere mothandizidwa ndi mapiritsi amatanthauza kukweza insulin, kulimbitsa njala, kupeza ma kilogalamu atsopano amafuta. Kuphatikiza apo, kapamba, wolimbikitsidwa ndi glibenclamide, adzakakamizidwa kugwira ntchito kuvala, motero amasiya kugwira ntchito m'mbuyomu, ndipo wodwalayo amakakamizidwa kuti asinthane ndi insulin.
Kumayambiriro kwa matendawa, zakudya, masewera ndi metformin nthawi zambiri amakhazikitsidwa. Mapiritsi a Maninil amayamba kutengedwa pambuyo pa zaka zingapo za matenda (pafupifupi zaka 8), pamene metformin pamlingo wokwanira sapereka chindapusa chokwanira cha matenda ashuga. Musanayambe kumwa, ndikofunika kuonetsetsa kuti kuphatikiza kwa insulini sikokwanira pakupereka mayeso a C-peptide. Zitha kuzindikirika kuti kusowa kwa insulin kuli ndi vuto lalikulu la shuga, koma zolakwika zakudya komanso kulemera kwambiri.
Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale
- Matenda a shuga -95%
- Kuthetsa kwa mitsempha thrombosis - 70%
- Kuthetsa kwa kugunda kwamtima kwamphamvu -90%
- Kuthana ndi kuthamanga kwa magazi - 92%
- Kuwonjezeka kwa mphamvu masana, kukonza kugona usiku -97%
Madokotala ena amafuna kuti asiye mankhwala ndi Maninil. Kuti achulukitse kuchepa kwa maselo a pancreatic cell, Metformin ikagwira ntchito mokwanira, amalimbikitsa kuti insulini iyambike nthawi yomweyo.
Sankhani
Mlingo wofunikira umasankhidwa payekhapayekha kwa wodwala aliyense. M'badwo wa anthu odwala matenda ashuga, kuwuma kwawo komanso kuchuluka kwa ziphuphuzo kumawerengedwa. Mlingo woyamba malinga ndi malangizo ndi 1,75 mg. Imakhwima pang'onopang'ono kamodzi pa sabata mpaka glycemia ikafika. Mlingo wocheperako (<3.5 mg) amatengedwa musanadye kadzutsa; Mlingo waukulu umagawidwa m'mawa ndi madzulo. Popewa usiku hypoglycemia, kumwa mankhwalawa kumachepera kawiri kuposa mlingo wa m'mawa. Kuti mupeze mlingo woyenera, mapiritsiwo amatha kugawidwa limodzi ndi mzere wa zoopsa.
| Kutulutsa Fomu | Mlingo woyambira mapiritsi | Mulingo woyenera mapiritsi | Nthawi yolandila |
| Maninil 1.75 | 1-2 | 6 | Tisanadye kaye |
| Maninil 3.5 | 0,5-1 | 3 | |
| Maninil 5 | 0,5-1 | 3 | Mu mphindi 30 |
Potsitsa mlingo, insulin ingapangikebe. Zakudya zama carb ochepa, kuchepa thupi kunenepa, kuchita masewera olimbitsa thupi pafupipafupi kumathandizira kuchepetsa mlingo. Kuyesa kulipirira shuga yokhala ndi shuga ndi mlingo wambiri, osangobweretsa chithandizo cha insulin, komanso kungayambitse hypoglycemia.
Kulandila kwa Metformin
Kuthandizira pa nthawi yomweyo ndi metformin (Glucofage, Siofor, etc.) ndi Maninil ndikuloledwa. Mankhwalawa amaphatikizika bwino ndikupereka mphamvu yochepetsera shuga. Kuti athandizire kuyendetsa mapiritsi ndi kuchepetsa mwayi wopezekapo, mapiritsi ophatikizidwa amapangidwa: Glucovans, Glibomet, Bagomet Plus, Metglib. Amakhala ndi 2,5 kapena 5 mg ya glibenclamide ndi 400-500 mg wa metformin.
Maninil Akapanda Kuchepetsa shuga
Maninil amagwira ntchito bola ma cell a pancreatic beta ali moyo. Chiwonongeko chawo chikadzakhala chofunikira (nthawi zambiri> 80%), kumwa mapiritsi aliwonse omwe amachepetsa shuga kulibe phindu. Inali panthawiyi kuti shuga yosadalira insulini idayamba kudalira insulin. Kuyambira pano, odwala amafunika kutenga jakisoni wa insulin moyo wonse. Kuchepetsa ndi kuyamba kwa mankhwala a insulini ndikuwopseza moyo. Palibe mahomoni ake, shuga wamagazi amawonjezeka kwambiri, ndipo khungu la ketoacidotic limachitika.
Mitu ya mankhwalawa
Kuphatikiza pa Maninil waku Germany, mutha kupeza pa Russian Glibenclamide. Kampani ya Atoll ikuigulitsa, mtengo wa piritsi 50 ndi ma ruble 26-50. Kupanga ndi kulongedza mapiritsi kumakhala m'dera la Samara, koma mankhwala omwe akutengedwa amachokera ku India. Malinga ndi anthu odwala matenda ashuga, chithandizo ndi Maninil chimaperekedwa bwino ndipo chimachepetsa shuga moyenera kuposa ndi mankhwala apakhomo. Ngati mukuwona kuti mankhwalawa ndiwotsika mtengo (mtengo wake ndi ma ruble a 120-170 pama mapiritsi 120) ndipo ali mu mankhwala onse, kusintha Maninil ndi ma analogu kulibe ntchito.
Maninil kapena Diabeteson - ndibwino bwanji?
Mankhwalawa ndi a gulu limodzi ndi m'badwo, koma ali ndi zinthu zosiyanasiyana zogwira ntchito: Maninil - glibenclamide, Diabeteson - glyclazide.
Kusiyana kwawo:
- Diabeteson simalimbikitsa kutulutsa kwa insulin kwa nthawi yayitali, chifukwa chake chiopsezo cha hypoglycemia, kufinya thupi, komanso kunenepa kwambiri ndizochepa.
- Maninil ndi wamphamvu. Nthawi zina, ndi iye yekha amene amatha kupeza shuga wabwinobwino.
- Diabeteson ibwezeretsa kupanga insulin mwachangu chifukwa chakuwonjezeka kwa shuga, Maninil amagwira gawo lachiwiri. Ngati mumamwa gliclazide, shuga atatha kudya amayamba kutsika mofulumira.
- Malinga ndi ena, a shuga ndi otetezeka mtima.
Kusiyanaku ndikofunika kwambiri, chifukwa chake, odwala omwe amatenga mapiritsi ochepa Mlingo wambiri, zimapangitsa kuti Maninil akhale ndi Diabeteson.
Nkhani yathu yatsatanetsatane ya mankhwala a Diabeteson, werengani apa -//diabetiya.ru/lechimsya/diabeton-mv-60.html
Ndemanga za mankhwala
Kwazaka zambiri kugwiritsa ntchito Maninil kulipira matenda a shuga, ndemanga zambiri zabwino komanso zoyipa zomwe madokotala ndi odwala matenda ashuga akhala nazo.
Odwala ambiri amazindikira kufunika kwa zakudya zapamwamba za Manilin komanso moyo wawo. Kudumpha chakudya, kusowa kwa chakudya chamagulu, kugawa kwawo kosasinthika masana, katundu wotalikirapo - zinthu zonsezi zimayambitsa hypoglycemia. M'madera ena a shuga, shuga amawonjezerera tsiku lonse: kugwa pambuyo p kumwa mapiritsi ndikuwuka pambuyo podyera. Komanso, odwala amazindikira kuchuluka kwakufuna kudya komanso kunenepa. Monga lamulo, mankhwalawa ndi Maninil amaloledwa bwino, milandu ya mseru komanso kusanza komwe amafotokozedwa mu malangizo ndi sporadic. Gawo lalikulu la anthu odwala matenda ashuga, m'malo mwa Maninil, adayamba kukhala otetezeka a matenda ashuga ndi Amaryl.
Akatswiri a Endocrin amati Maninil ndi "chikwapu" chothandiza chomwe chimatulutsa kapamba. Amayesa kupereka mankhwalawa ngati njira zina zowalipirira matenda osokoneza bongo sizokwanira kapena zoletsedwa pazowonetsa.
