Anthu ambiri ali ndi matenda ashuga. Komanso, chaka chilichonse chiwerengero cha anthu omwe akudwala matendawa chikukula.
Ndikosatheka kuchiritsa matendawa, komabe, ndizotheka kuzilamulira ndikusunga mawonekedwe abwinobwino a thupi.
Kuti muchite izi, pangani mankhwala osiyanasiyana, amodzi mwa awa ndi Amaryl. Ndemanga za kumwa mankhwala nthawi zambiri zimakhala zabwino. Chachikulu ndikuwonetsetsa kuti mulingo ndi nthawi yokwanira. Werengani zambiri za mankhwalawa munkhaniyi.
Zotsatira za pharmacological
Kukonzekera kwa gulu la sulfonylurea kumatanthauza othandizira pakamwa. Mwa kutseka njira za cytoplasmic potaziyamu zotengera za cell ya beta yomwe ilipo mu kapamba, kukondoweza kwa kubisala kumachitika.
Zotsatira zake, insulin imamasulidwa m'maselo a beta, omwe amawonetsa pancreatic athari. Mphamvu ya extrapancreatic imawonekeranso, chifukwa chomwe zochita za insulin zimapangidwira.
Amaril
Chithandizo chogwira mankhwalawa chimatha kuphatikiza mwachangu mokwanira ndi mapuloteni a beta-cell. Kulemera kwake kwa maselo ndi 65 kD / SURX. Pali exocytosis ya insulin. Ndikofunikira kuti zomwe zimapangidwira mahomoni ndi mawonekedwe ake osafunikira ndizomwe zingathandize kuti muchepetse vuto la hypoglycemia.
Amaryl alinso ndi antioxidant, antiplatelet, anti-atherogenic effect. Zotsatira zake zimafikira mu mtima, zimachepetsa kukana insulini. Kugwiritsidwa ntchito kwa glucose ndi minofu ndi adipose minofu kumawonjezeka chifukwa cha kupezeka kwa mapuloteni enieni onyamula.
Powonjezera zochita zawo, chida chimathandizira kuti kupezeka kwa shuga. Lipogenesis ndi glycogeneis adalumikizananso.
Kupanga kwa hepatic glucose kumatsekedwa, chifukwa chomwe kuchuluka kwa fructose-2,6-bisphosphate mu hepatocytes kumachulukanso.
Kubisala kwa COX pa nthawi ya utsi wamankhwala kumatsekedwa, asidi wa arachidonic amachepetsa kusintha. Izi zimathandizira kuchepetsa kuphatikiza kwa maselo, mwachitsanzo, pali mphamvu ya antithrombotic.
Alpha-tocopherol imawonjezeka ikamadziwika ndi mankhwalawa. Kuphatikiza apo, ntchito ya superoxide dismutase, catalase, glutathione peroxidase imalimbikitsidwa, ndipo mawonekedwe a oxidative omwe amapezeka mu shuga mellitus amachepa.
Zizindikiro zogwiritsidwa ntchito
Amaryl adapangidwa kuti azigwiritsanso ntchito matenda a shuga a 2. Gwiritsani ntchito ngati monotherapy, komanso mankhwala osakanikirana. Amaril wa mankhwala a matenda a shuga a mtundu 2 amakhala ndi malingaliro abwino mukamamwa ndi metformin kapena insulin.
The zikuchokera mankhwala, kumasulidwa mawonekedwe
Amaryl imapangidwa ngati mapiritsi, omwe amatha kukhala ndi mlingo wosiyana, womwe ndi 1, 2, 3, 4 mg.
Zomwe zimagwira pano ndi glimepiride, ndipo zinthu zothandizira zimaphatikizapo lactose monohydrate, magnesium stearate, microcrystalline cellulose, utoto wa E132 ndi E172, povidone.
Piritsi lirilonse limakhala ndi mzere wogawaniza, komanso lolemba. Phukusili lili ndi matuza awiri momwe muli mapiritsi 15.
Contraindication
Amaril sayenera kumwedwa pazotsatirazi:
- mkaka wa m`mawere ndi pakati;
- mtundu 1 matenda a shuga;
- tsankho limodzi pazigawo;
- zaka za ana;
- matenda ashuga ketoacidosis;
- matenda a chiwindi ndi impso;
- lactose akusowa, shuga-galactose malabsorption.
Zotsatira zoyipa
Ndi kugwiritsa ntchito molakwika mankhwalawa, zotsatira zoyipa zambiri zitha kupezeka:
- kusokoneza kwamanjenje: kugona, kusowa mgwirizano, kukhumudwa, kutopa, kusokonezeka, chizungulire, paresis, kunjenjemera, aphasia, kuda nkhawa, kupenyerera, kumva, kugona, kusokonezeka tulo, kupweteka mutu, kulephera kudziletsa, kupsinjika;
- mtima - tachycardia, angina pectoris, ochepa matenda oopsa, bradycardia, mtima mungoli chisokonezo;
- kagayidwe kachakudya - chizindikiritso cha hypoglycemic zimachitika;
- m'mimba - kupweteka kwam'mimba, kusanza, jaundice, kutsegula m'mimba, kulephera kwa chiwindi, hepatitis, cholestasis;
- dongosolo lamagazi - thrombocytopenia, granulocytopenia, agranulocytosis, erythrocytopenia, hemolytic kapena aplastic anemia;
- zochita zina kuwonongeka kwa mawonekedwe ndi kupuma kosakhazikika, kuchepa kwa magazi mu mawonekedwe a kuyabwa, zotupa pakhungu, urticaria, matupi a vasculitis.
Malangizo ogwiritsira ntchito
Muyenera kumwa mapiritsi oterowo mkati osafuna kutafuna. Imwani ayenera kukhala osachepera theka la kapu ya madzi.
Onetsetsani kuti mankhwalawa amayenera kumangirizidwa ku chakudya, apo ayi amawopseza ndi kuchepa kwambiri kwa shuga m'magazi.
Izi zikutanthauza kuti muyenera kumwa piritsi nthawi yomweyo musanadye kapena panthawiyi. Izi zimachitika bwino m'mawa, ngati ntchito ndi imodzi tsiku lililonse, kuti athe kuyendetsa shuga.
Mlingo woyambirira wa mankhwalawa ndi 1 mg ya thunthu patsiku. Kupitilira apo, ngati pakufunika kutero, mutha kuwonjezera kuchuluka kwa masabata awiri ndi awiri. Pankhaniyi, mlingo wotsatira ndi 2 mg, kenako 3 mg, kenako 4 mg, kenako 6 mg utha kugwiritsidwa ntchito. Mlingo ndiwotheka kwambiri, ndipo osavomerezeka kuti upitirire.
Kuwonjezeka kwa mlingo kuyenera kuchitidwa ndi dokotala, kutengera zomwe munthu ali nawo, moyo wa wodwalayo, njira ya matendawa.
Amaril akhoza kumwedwa limodzi ndi insulin kapena metformin. Milandu pomwe Metformin sikubweretsa kuchepa kokwanira kwa misinkhu ya shuga, ndiye Amaril adayikidwa.
Panthawi imeneyi, Metformin imapitilirabe kumwa panthawi yomweyo, ndipo Amaryl amayamba kumwa ndi mlingo wochepa wa 1 mg, womwe umatha kupitilizidwa mpaka 6 mg. Ngati kuphatikiza uku sikothandiza, ndiye kuti Metformin imasinthidwa ndi insulin. Pankhaniyi, mlingo wa Amaril umasiyidwa osasinthika, ndipo insulin imatengedwa pazomwe ndizovomerezeka, pang'onopang'ono kuwonjezera kuchuluka.
Bongo
Ngati mulingo wa mankhwalawa ukadutsa, ndiye kuti wodwalayo akuwopsezedwa ndi hypoglycemia, wokhala maola 12-72.
Zizindikiro zake ndi zofanana ndi zovuta zomwe zimapezeka m'mankhwala. Mu milandu yayikulu, mwayi wokhala ndi vuto lakukalamba ndi wapamwamba.
Ngati zoterezi zikuchitika, chinthu choyamba muyenera kudya chidutswa cha shuga, kumwa madzi kapena tiyi wokoma. Ndikofunika nthawi zonse kunyamula glucose osachepera 20 g mwachitsanzo, amatha kukhala magawo 4 a shuga. Okometsera mchere pamenepa sangadzetse ntchito kwenikweni.
Ngati milanduyo ndi yayikulu, ndiye kuti kuchipatala kukafunika. Kuchipatala, kukonza kwa m'mimba kumachitika, ndipo ma adsorbents amafunikanso. Kuwongolera glucose ndikofunikira kwambiri. Zizindikiro zina zosasangalatsa zimachotsedwa ndi chithandizo chamankhwala.
Kuyanjana kwa mankhwala osokoneza bongo
Ndi mankhwala ena, kugwiritsa ntchito Amaril kumatha kubweretsa kuwonjezeka kapena kuchepa kwa zotsatira za hypoglycemic.
Mlandu woyamba, zotsatira zake zidzachepa ndikumamwa mankhwalawa: mahomoni a chithokomiro, adrenaline, chlorpromazine, sympathomimetics, glucocorticosteroids, diazoxide, barbiturates, mankhwala opatsirana, saluretics, thiazide diuretics, glucagon, phenytoin, phenothiazine, aceticolide acid, aceticolide acid , progestogens ndi estrogens, mchere wa lithiamu.
Kuwonjezeka kwa zotsatira za hypoglycemic kumawonedwa mukamamwa mankhwalawa ndi Amaril: mankhwala ena othandizira hypoglycemia, angiotensin-converting factor inhibitors, allopurinol, anabolic steroids, coumarin, zotumphukira, tritokvalin, mankhwala okhala ndi mahomoni ogonana amuna, oxyphenbutazone, pentoxifylline , fibrate, pheniramidol, MAO zoletsa, azapropazone, fenfluramine, phenenecid, salicylates, sulfinpyrazone, tetracyclines, Tro-, cyclo-, isophosphamide, sulfonyls yaitali zochita.
Ndemanga zamankhwala Amaryl
Zokhudza mankhwala Amaril, ndemanga za anthu odwala matenda ashuga ndi zabwino. Odwala omwe Amaryl amakhulupirira kuti mankhwalawa amalimbana ndi shuga wamkulu wambiri matenda a shuga.Chachikulu ndikusankha kuchuluka kwa mankhwalawa. Mbali yabwino ndilinso yosiyanasiyana ya mapiritsi, omwe amagwiritsidwa ntchito mosiyanasiyana. Izi zimakuthandizani kuti musasokoneze yoyenera.
Komabe, pali malingaliro ambiri olakwika, makamaka omwe amaphatikizidwa ndi kupezeka pafupipafupi kwa zotsatira zoyipa, monga kunjenjemera, kufooka, chizungulire, kunjenjemera m'thupi, kuchuluka kwa chilakolako cha thupi. Pali zochitika za hypoglycemia, motero ndikofunikira kunyamula maswiti kapena zinthu zina zomwe zimakhala ndi shuga wambiri.
Makanema okhudzana nawo
Ndemanga kanema wa mankhwala Amaryl:
Chifukwa chake, matenda ashuga nthawi zonse samayambitsa zovuta zambiri komanso kusasangalala. Mankhwala amtundu wa Amaril amatha kukhala ndi shuga wamba.
