Mu 1 ml. Insulin Humulin ili ndi 100 IU ya insombinant insulin ya anthu. Zomwe zimagwiritsidwa ntchito ndi 30% sungunulira wa insulin komanso 70% insulin isofan.
Monga momwe othandizira amagwiritsidwa ntchito:
- metacresol
- phenol
- sodium hydrogen phosphate heptahydrate,
- hydrochloric acid,
- glycerol
- zinc oxide
- protamine sulfate,
- sodium hydroxide
- madzi.
Kutulutsa Fomu
Kukonzekera kwa insulin Humulin M3 insulin imapezeka mu mawonekedwe a kuyimitsidwa kwa ma transcutaneous makonzedwe mu 10 ml mabotolo, komanso ma 1.5 ndi 3 ml makatoni, oikidwa m'mabokosi a 5 zidutswa. Cartridges adapangidwa kuti azigwiritsa ntchito syringes ya Humapen ndi BD-pen.
Mankhwala ali ndi hypoglycemic.
Humulin M3 amatanthauza mankhwala obwerezabwereza a DNA, insulin ndi kuyimitsidwa kwa jekeseni kawiri ndi nthawi yayitali.
Pambuyo kumayambiriro kwa mankhwalawa, kuphatikiza kwa zamankhwala kumachitika pambuyo pa mphindi 30-60. Kuchuluka kwake kumatenga maola awiri mpaka 12, kutalika kwa zotsatirazi ndi maola 18-24.
Ntchito za humulin insulin zimatha kusiyanasiyana malinga ndi malo omwe mankhwalawo amaperekera, kulondola kwa mlingo wosankhidwa, zochita za thupi, wodwala, zina ndi zina.
Zotsatira zazikulu za Humulin M3 zimagwirizana ndi kayendedwe ka kusintha kwa shuga. Insulin ilinso ndi anabolic. Pafupifupi minofu yonse (kupatula ubongo) ndi minofu, insulin imayendetsa kayendedwe ka glucose ndi amino acid, komanso imayambitsa kuthamanga kwa protein anabolism.
Insulin imathandizira kusintha shuga kukhala glycogen, komanso imathandizira kusintha shuga yambiri kukhala mafuta ndikuletsa gluconeogeneis.
Zizindikiro zogwiritsidwa ntchito ndi zoyipa
- Shuga mellitus, momwe insulin tikulimbikitsidwa.
- Matenda a gestational (shuga ya amayi apakati).
Zotsatira zoyipa
- Kukhazikika hypoglycemia.
- Hypersensitivity.
Nthawi zambiri pa mankhwala akukonzekera insulin, kuphatikiza Humulin M3, kukula kwa hypoglycemia kumawonedwa. Ngati ili ndi mawonekedwe owopsa, imatha kupangitsa kuti mukhale ndi vuto la hypoglycemic (kukhumudwa komanso kusala chikumbumtima) komanso kungapangitse wodwalayo kuti afe.
Mwa odwala ena, thupi lawo siligwirizana, kuwoneka pakuluma pakhungu, kutupa ndi kufupika kwa malo a jakisoni. Nthawi zambiri, matendawa amadzidzidzikira okha patatha masiku kapena milungu yochepa atayamba chithandizo.
Nthawi zina izi sizimakhudzana ndikugwiritsa ntchito mankhwalawo pawokha, koma ndi chifukwa cha mphamvu ya zinthu zakunja kapena jakisoni wolakwika.
Pali ziwonetsero zomwe sizigwirizana ndi zachilengedwe. Amachitika kawirikawiri, koma zowopsa. Ndi izi, izi zimachitika:
- kuvutika kupuma
- kuyabwa kofananira;
- kukoka kwamtima;
- dontho la kuthamanga kwa magazi;
- kupuma movutikira
- thukuta kwambiri.
M'mavuto ovuta kwambiri, matalala amatha kuwopsa m'moyo wa wodwalayo ndikupempha chithandizo chamankhwala mwadzidzidzi. Nthawi zina insulin m'malo kapena desensitization chofunika.
Mukamagwiritsa ntchito insulin ya nyama, kukana, hypersensitivity mankhwala, kapena lipodystrophy imayamba. Ndi poika insulin Humulin M3, kuthekera kwa zoterezi ndi pafupifupi zero.
Malangizo ogwiritsira ntchito
Insulin ya Humulin M3 saloledwa kuti iperekedwe kudzera m'mitsempha.
Popereka mankhwala a insulin, ndi adokotala okha omwe angasankhe mwanjira ndi makonzedwe ake. Izi zimachitika payekhapayekha kwa wodwala aliyense payekhapayekha, kutengera mtundu wa glycemia m'thupi lake. Humulin M3 idapangidwa kuti ikwaniritse kayendetsedwe ka subcutaneous, koma imathanso kuperekedwa kudzera mwa intramuscularly, insulin ilola izi. Mulimonsemo, wodwala matenda ashuga ayenera kudziwa momwe angabayire insulin.
Pang'onopang'ono, mankhwalawa amalowetsedwa pamimba, ntchafu, phewa kapena matako. Mu malo omwewo jakisoni sangaperekedwe mopitilira kamodzi pamwezi. Panthawi ya njirayi, ndikofunikira kugwiritsa ntchito jakisoni moyenera, kuti singano isalowe m'mitsempha yamagazi, kuti musamayesere malo a jakisoni pambuyo pobayira.
Humulin M3 ndi osakaniza wopangidwa ndi Humulin NPH ndi Humulin Regular. Izi zimapangitsa kuti asakonzekere yankho lisanayambike kwa wodwalayo.
Kukonzekera insulin ya jakisoni, cartridge ya Humulin M3 kapena NPH iyenera kukukhidwira maulendo 10 mmanja mwanu, ndikutembenuka madigiri a 180, gwedezani pang'onopang'ono kuchokera mbali ndi mbali. Izi zikuyenera kuchitika mpaka kuyimitsidwa kumakhala ngati mkaka kapena kukhala ngati mitambo, yunifolomu.
Kugwedeza mwachangu insulin NPH sikulimbikitsidwa, chifukwa izi zimatha kuyambitsa mawonekedwe a thovu ndikusokoneza mlingo wofanana. Osagwiritsa ntchito mankhwalawa pogwiritsa ntchito matope kapena mapepala opangidwa mutasakaniza.
Makulidwe a insulin
Kuti mupeze jakisoni moyenera mankhwalawo, muyenera kuchita njira zina zoyambirira. Choyamba muyenera kudziwa malo omwe jakisoniyo, sambani manja anu ndikupukuta malowa ndi nsalu yothinidwa ndimowa.
Kenako, chotsani kapu yoteteza ku singano ya syringe, kukonza khungu (kukoka kapena kutsina), ikani singano ndikupanga jakisoni. Kenako singano iyenera kuchotsedwa ndipo masekondi angapo, osafunikira, kanikizani tsamba la jekeseni ndi chopukutira. Pambuyo pake, mothandizidwa ndi kapu yakunja yoteteza, muyenera kumasula singano, kuichotsa ndikubwezeranso chipewacho.
Simungagwiritse ntchito cholembera chofanana chimodzi. Vial kapena cartridge imagwiritsidwa ntchito mpaka itapanda kanthu, ndiye kuti imatayidwa. Ma cholembera a syringe amapangidwira kuti azigwiritsa ntchito payekha.
Bongo
Humulin M3 NPH, monga mankhwala ena omwe ali mgululi. Komabe, bongo wa insulin yambiri imatha kukhala ndi zotsatirapo zoyipa kwambiri.
Hypoglycemia imayamba chifukwa cha kusamvana pakati pa zinthu za insulin m'madzi am'madzi komanso kuwononga mphamvu ndi chakudya.
Zizindikiro zotsatirazi ndizodziwika za hypoglycemia:
- ulesi;
- tachycardia;
- kusanza
- thukuta kwambiri;
- kutsekeka kwa khungu;
- kunjenjemera
- mutu
- chisokonezo.
Nthawi zina, mwachitsanzo, ndi mbiri yayitali ya matenda a shuga kapena kuyang'anitsitsa kwake, Zizindikiro za kutha kwa hypoglycemia zimatha kusintha. Hypoglycemia yofatsa imatha kupewedwa pakutenga shuga kapena shuga. Nthawi zina mungafunikire kusintha kuchuluka kwa insulini, kuunikanso zakudya kapena kusintha zolimbitsa thupi.
Hypoglycemia yolimbitsa thupi nthawi zambiri imachitidwa ndi subcutaneous kapena intramuscular dongosolo la glucagon, kenako ndikuyamba kugaya chakudya. Woopsa milandu, pamaso pa vuto la minyewa, kukomoka kapena chikomokere, kuwonjezera pa jakisoni wa glucagon, kugwiritsidwa ntchito kwa shuga kuyenera kuthandizidwa.
M'tsogolomo, popewa kuyambiranso kwa hypoglycemia, wodwalayo ayenera kudya zakudya zopatsa thanzi. Mlingo woopsa kwambiri wa hypoglycemic umafuna kuchipatala mwadzidzidzi.
Zochita Zamankhwala NPH
Kugwiritsa ntchito kwa Humulin M3 kumatheka chifukwa chogwiritsa ntchito mankhwala amkamwa a hypoglycemic, ethanol, zotuluka za salicylic acid, monoamine oxidase inhibitors, sulfonamides, ACE inhibitors, angiotensin II receptor blockers, osasankha beta-blockers.
Mankhwala a Glucocorticoid, mahomoni akukula, njira zakulera zam'mlomo, danazole, mahomoni a chithokomiro, thiazide diuretics, beta2-sympathomimetics amatsogolera kuchepa kwa zotsatira za hypoglycemic insulin.
Limbitsani kapena, mutafooketsa kudalira insulin yomwe imatha lancreotide ndi ma analogu ena a somatostatin.
Zizindikiro za hypoglycemia zimatsitsidwa ndikutenga clonidine, reserpine ndi beta-blockers.
Malonda ogulitsa, osungira
Humulin M3 NPH imapezeka pa pharmacy pokhapokha ngati mwalandira mankhwala.
Mankhwalawa amayenera kusungidwa pamtunda wa madigiri 2 mpaka 8, sangathe kuwundana ndikuwonetsa kuwala kwa dzuwa ndi kutentha.
Vala yotseguka ya insulin NPH imatha kusungidwa pa kutentha kwa madigiri 15 mpaka 25 kwa masiku 28.
Malinga ndi boma lotentha, kukonzekera kwa NPH kumasungidwa zaka 3.
Malangizo apadera
Kuchepetsa kwa chithandizo kapena kusankhidwa kwa mankhwala olakwika (zomwe zimachitika makamaka kwa odwala omwe amadalira insulin) zimatha kuyambitsa matenda a diabetesic ketoacidosis kapena hyperglycemia, yomwe ikhoza kuwononga moyo wa wodwalayo.
Mwa anthu ena, mukamagwiritsa ntchito insulin yaumunthu, Zizindikiro zakuyamba kwa hypoglycemia zimatha kusiyana ndi zomwe zimadziwika ndi insulin ya nyama, kapena zimatha kuwonetsa modekha.
Wodwala ayenera kudziwa kuti ngati kuchuluka kwa shuga m'magazi ndikwabwinobwino (mwachitsanzo, ndi insulin Therapy), ndiye kuti zizindikiro zomwe zikusonyeza kuti hypoglycemia ikhoza kutha.
Mawonetsedwe awa amatha kuchepera mphamvu kapena kuwoneka mosiyanasiyana ngati munthu atenga mankhwala a beta-blockers kapena ali ndi matenda osokoneza bongo a nthawi yayitali, komanso pamaso pa matenda a shuga.
Ngati hyperglycemia, monga hypoglycemia, siinakonzedwenso munthawi yake, izi zitha kuchititsa kuti ataye chidwi, chikomokere, komanso ngakhale kufa kwa wodwalayo.
Wodwalayo amasinthira kukonzekera kwina kwa insulin NPH kapena mitundu yawo kokha moyang'aniridwa ndi dokotala. Kusintha kwa insulin kukhala mankhwala okhala ndi zochitika zina, njira yopangira (DNA recombinant, nyama), mitundu (nkhumba, analog) ingafune mwadzidzidzi kapena, mmalo mwake, kukonza kosavuta kwa Mlingo wokhazikitsidwa.
Ndi matenda a impso kapena chiwindi, kusakwanira kwa ntchito ya pituitary, kugwira ntchito kwa minyewa ya adrenal ndi chithokomiro cha chithokomiro, kufunikira kwa insulini kumatha kuchepa, komanso kupsinjika kwamphamvu ndi zina zina, m'malo mwake, kumawonjezeka.
Wodwala nthawi zonse ayenera kukumbukira mwayi wokhala ndi hypoglycemia ndikuwunika bwino momwe thupi lake limayendetsa galimoto kapena kufunika kwa ntchito yoyipa.
Analogi
- Monodar (K15; K30; K50);
- Novomix 30 Flekspen;
- Ryzodeg Flextach;
- Kusakaniza kwa Humalog (25; 50).
- Gensulin M (10; 20; 30; 40; 50);
- Gensulin N;
- Rinsulin NPH;
- Farmasulin H 30/70;
- Humodar B;
- Vosulin 30/70;
- Vosulin N;
- Mikstard 30 NM;
- Protafan NM;
- Humulin.
Mimba komanso kuyamwa
Ngati mayi woyembekezera ali ndi matenda ashuga, ndiye kuti ndikofunikira kwambiri kuti azilamulira glycemia. Pakadali pano, zofuna za insulin nthawi zambiri zimasintha nthawi zosiyanasiyana. Mu trimester yoyamba, imagwera, ndipo chachiwiri ndi chachitatu chikuwonjezeka, kotero kusintha kwa mankhwalawa kungakhale kofunikira.
Komanso, kusintha kwa muyezo, kudya ndi kuchita masewera olimbitsa thupi zitha kufunikira pakukonzekera msambo.
Ngati kukonzekera kwa insulin kumeneku kuli koyenera kwa wodwala yemwe ali ndi matenda osokoneza bongo, ndiye kuwunika za Humulin M3, monga lamulo, ndizabwino. Malinga ndi odwala, mankhwalawa ndi othandiza kwambiri ndipo mothandizidwa alibe zotsatira zoyipa.
Ndikofunika kukumbukira kuti ndizoletsedwa kupatsa insulin nokha, komanso kusintha kwina.
Botolo imodzi ya Humulin M3 yokhala ndi voliyumu ya 10 ml imayambira ku 500 mpaka 600 ma ruble, phukusi la ma cartridge atatu a 3 ml okhala ndi ma ruble a 1000-1200.
