Ma Anticoagulants Fraksiparin ndi Kleksan: ndizosiyana kotani ndipo ndi chiyani chabwinoko panthawi yomwe muli ndi pakati?

Kupangika kwa magazi kuwundana nthawi zonse kumakhala ndi zotsatirapo zoipa ndipo sikofunika kwenikweni m'thupi la munthu.

Masiku ano, pali chiwerengero chachikulu cha mankhwala omwe amathandizira kuti asawoneke.

Mankhwalawa nthawi zambiri amagwiritsidwa ntchito ndi azimayi oyembekezera popewa, odwala omwe ali ndi thrombosis pochiza, etc. Munkhaniyi, mankhwala awiri oterewa, omwe ndi Fraxiparin ndi Kleksan, adzawunikidwa mwatsatanetsatane.

Zotsatira za pharmacological

Fraxiparin ndi mankhwala omwe ali m'gulu la anticoagulants omwe ali ndi vuto la antithrombotic.

Amasintha magazi ndipo amatulutsa cholesterol. Zomwe zimagwira mu Fraxiparin ndi calcium nadroparin. Uwu ndi heparin wotsika kwambiri womwe umapangidwa ndi depolymerizing heparin wokhazikika.

Ntchito ya antithrombotic imatheka poyambitsa fibrinolysis mwa njira yotulutsa minofu ya plasminogen activator kuchokera ku maselo a endothelial ndikulimbikitsa minofu factor pathway inhibitor.

Nadroparin alibe mphamvu kwenikweni pa heestasis yoyambira. Ili ndi kuchuluka kwamgwirizano pakati pa ntchito za anti-IIa ndi anti-Xa. Ili ndi antithrombotic mwachangu komanso nthawi yayitali.

Mankhwala Clexane 40 mg

Clexane ndi heparin wochepa kwambiri wamankhwala, komanso wothandizirana mwachindunji. Gawo lomwe limagwiritsa ntchito mankhwalawa ndi enoxaparin Na, omwe amatanthauza ma heparins ochepa.

Kuchita kwa thundu kumachitika chifukwa cha kutsegulira kwa antithrombin III, zomwe zimapangitsa kuti pakhale zoletsa komanso mapangidwe a chinthu IIa ndi X. Mankhwalawa ali ndi antithrombotic yayitali, omwe sangakhudze kumangiriza kwa fibrinogen kuphatikizira kwa mapulateleti ndi kuphatikizira kwa mapulateleti.

Zizindikiro zogwiritsidwa ntchito

Fraxiparin wovomerezeka akuvomerezeka kuti mugwiritse ntchito milandu:

• kupewa thromboembolic zovuta pambuyo ntchito;
• mankhwalawa thromboembolic zovuta;
• mankhwalawa angina pectoris, komanso myocardial infarction.

Mankhwala Clexane akulimbikitsidwa kugwiritsidwa ntchito:

• kupewa thromboembolism ndi venous thrombosis;
• Chithandizo cha mitsempha yayikulu;
• mankhwalawa angina pectoris, komanso myocardial infarction.

Njira yogwiritsira ntchito

Fraxiparin wa mankhwala amagwiritsidwa ntchito pokhapokha komanso kudzera m'mitsempha:

1. opaleshoni yayikulu. Ndikulimbikitsidwa kugwiritsa ntchito mankhwalawa kwa masiku osachepera asanu ndi awiri pa mlingo wa mamililita 0,3. Mlingo woyamba umaperekedwa kwa odwala maola awiri kapena anayi asanafike opaleshoni;
2. opaleshoni yamatsenga. Mlingo woyamba wa Fraxiparin umaperekedwa kwa odwala maola khumi ndi awiri asanachitidwe opaleshoni, komanso pambuyo pa nthawi yomweyo. Mankhwala tikulimbikitsidwa kuti mugwiritse ntchito masiku khumi.

Mankhwala Clexane amagwiritsidwa ntchito pokhapokha pochita mankhwalawa, komabe muyenera kudziwa kuti mankhwalawa saloledwa kuperekedwa kudzera mwa mankhwalawa:

• pamimba. Amagwiritsidwa ntchito pa Mlingo wa 20 mamililita kamodzi patsiku kamodzi. Mlingo woyambirira musanachitike opaleshoni imaperekedwa maola awiri;
• pa zamankhwala. Mlingo wa ma milligram 40 amagwiritsidwa ntchito kamodzi patsiku kamodzi. Poyamba, mankhwalawa amaperekedwa maola 12 asana opaleshoni. Kuphatikiza apo, pali njira ina yothandizira, ndipo ndi mamililita 30 kawiri pa tsiku, ndipo mlingo woyambirira umaperekedwa maola 12-24 atachitidwa opaleshoni.

Njira yamankhwala yothandizira ndi chida ichi kuyambira sabata limodzi mpaka masiku 10, pomwe amatha kupitilizidwa mpaka nthawi ina, pomwe pali chiopsezo cha thrombosis. Nthawi zambiri amawonjezera osaposa masabata asanu.

Contraindication

Fraxiparin wa mankhwala sayenera kugwiritsidwa ntchito pazinthu zotere:

• ngati mukusowa mbali ya mankhwala;
• ngati kale kugwiritsidwa ntchito kwa mankhwalawa kunapangitsa chitukuko cha thrombocytopenia;
• ndi chiwopsezo chowonjezeka kapena magazi;
• kuchulukitsa kwa matenda am'mimba kapena chilonda;
• ndi cerebrovascular hemorrhagic kuvulala;
• ndi matenda endocarditis mu pachimake siteji.

Clexane sayenera kugwiritsidwa ntchito pazinthu ngati izi:

• ndi tsankho limodzi la magawo a mankhwala;
• ndi chiwopsezo chachikulu cha magazi;
• azimayi oyembekezera omwe ali ndi valavu yapa mtima;
• pa zaka zosakwana 18.

Ndikofunikanso kutenga Clexane mosamala ndi:

• chilonda;
• mbiri yakuwonongeka kwaposachedwa kwa ischemic;
• hemorrhagic kapena matenda ashuga retinopathy;
• owopsa ochepa matenda oopsa;
• kubadwa kwaposachedwa;
• matenda amisala;
• endocarditis;
• pericarditis;
• aimpso kuwonongeka ndi kwa chiwindi ntchito;
• kuvulala kovuta;
• kuphatikiza ndi mankhwala omwe amakhudza hemostasis;
• kugwiritsa ntchito chipangizo cha intrauterine polera.

Zotsatira zoyipa

Pa mankhwala a Fraxiparin, zotsatirazi zoyipa zimachitika:

• thupi lawo siligwirizana;
• magazi
• kuchuluka kwa chiwindi michere;
• ma hematomas ang'onoang'ono pamalo opangira jakisoni;
• zotupa zowonda zopweteka pamalo a jakisoni;
• thrombocytopenia;
• eosinophilia;
• Hyperkalemia

Pa mankhwala ndi Clexane, zotsatirazi zoyipa zimachitika:

• magazi
• hemorrhagic syndrome;
• kukula kwa hemorrhage mu kubwerera malo;
• Kukula kwa hemorrhage mu cranial patsekeke;
• zotsatira zakupha;
• Kukula kwa hematoma kwa msana;
• kukula kwa matenda amitsempha;
• ziwalo
• paresis;
• thrombocytopenia;
• thupi lawo siligwirizana malo jakisoni;
• kuchuluka kwa transaminases.

Ndi magazi, ndikofunikira kusiya kugwiritsa ntchito Clexane.

Bongo

Mu nkhani ya bongo wa Fraxiparin, makonzedwe a kuchuluka Mlingo wa jekeseni angayambitse magazi.

Potere, kugwiritsidwa ntchito kotsatira kwa mankhwalawa kuyenera kusamutsidwa, koma izi zimangothandiza pakukhetsa magazi pang'ono.

Ngati bongo umaledzera, ndiye kuti kuchuluka kwa mankhwalawo sikungayambitse zovuta, chifukwa amakhala ndi mayamwa ochepa.

Kuwonjezereka kwa Clexane mwangozi chifukwa cha jakisoni kumatha kubweretsa zovuta za hemorrhagic. Mukamamwa pakamwa, zovuta zilizonse sizingatheke chifukwa mankhwalawa samamwetsa.

Ndemanga

Komabe, odwala otere amasokonezeka chifukwa chakuti jakisoni imachitika m'mimba.

Ubwino umadziwikanso kuti mankhwalawa amalepheretsa kuwonekera kwa magazi, kuwongolera kayendedwe ka magazi, kuchitapo kanthu mokwanira komanso kosavuta kugwiritsa ntchito.

Mwa minus, mtengo wokwera kwambiri umadziwika, hematomas pambuyo pa jakisoni, kupezeka kwa zovuta zoyipa, koma nthawi yomweyo ndizosowa. M'mawunikidwe a Clexane, zikuwonetsedwa kuti ndizovomerezeka panthawi yoyembekezera, ndipo kwa ambiri izi ndi kuphatikiza. Kuchita bwino, kugwiritsa ntchito bwino komanso kugwiritsa ntchito mosavuta kumadziwika.

Mwa maminiti, chinthu chofala kwambiri ndikuti jakisoni amayenera kuchitidwa m'mimba, ndipo pazambiri ndizosasangalatsa. Kugula kwambiri kumadziwikanso, komanso kukhalapo kwa zovuta zambiri zoyipa ndi zotsutsana.

Zabwino ndi ziti?

Kuwona zomwe zili bwino, Fraxiparin kapena Clexane ndizovuta. Wodwala aliyense amafunikira chithandizo chamanokha komanso kusankha mankhwala oyenera kwambiri.

Mankhwala Fraksiparin 0,3 ml

Fraxiparin imakhala ndi zoyipa zochepa komanso contraindication, ndipo Clexane, nayenso ali ndi zotsatira zambiri zomwe zimakhala ndi zotsatira zoyipa, kuphatikizapo imfa.

Ngati tilingalira gawo la mtengo, ndiye kuti Fraxiparin ndiotsika mtengo pang'ono. Pankhani yokhudza bwino mankhwalawa, mankhwalawa atsimikizanso chimodzimodzi pakati pa odwala.

Pomaliza

Obstetrician-gynecologist za thrombophilia pa nthawi yapakati:

Mukamasankha mankhwala oti mupereke kwa wodwala, Fraxiparin kapena Clexane, dokotala ayenera kuyang'ana kwambiri pa zotsutsana zomwe ali nazo. Ndikulimbikitsidwa, ngakhale pali zisonyezo zomwe zimapangitsa kugwiritsa ntchito mankhwalawa poyang'aniridwa komanso mosamala kwambiri, sankhani mankhwala omwe alibe.