Chiwerengero cha mankhwala omwe amachepetsa kuthamanga kwa magazi ndikuwakhalitsa pamlingo woyenera kwambiri akuphatikiza Telsartan 40 mg. Ubwino wa mankhwalawa: kumwa piritsi 1 patsiku, nthawi yayitali ya antihypertensive kwenikweni, osakhudza kugunda kwa mtima. Zizindikiro za systolic ndi diastolic kuthamanga kwa magazi momwe angathere pambuyo pa mwezi wokhazikika wogwiritsa ntchito mankhwalawa.
Dzinalo Losayenerana
Telmisartan
Chiwerengero cha mankhwala omwe amachepetsa kuthamanga kwa magazi ndikuwakhalitsa pamlingo woyenera kwambiri akuphatikiza Telsartan 40 mg.
ATX
Code: C09DA07.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa ndi piritsi yoyera yoyera yopanda chipolopolo, convex mbali zonse ziwiri. Pamwamba pa aliyense wa iwo pamakhala zoopsa chifukwa chophweka ndi zilembo "T", "L", pansi - chiwerengero "40". Mkati, mutha kuwona zigawo ziwiri: chimodzi ndichipi cha mitundu yosiyanasiyana, china chimakhala choyera, nthawi zina chimakhala ndi timalingaliro tating'ono.
Mu piritsi 1 la mankhwala osakanikirana - 40 mg ya kaphatikizidwe kamene kamapezeka mu telmisartan ndi 12,5 mg wa hydrochlorothiazide diuretic.
Zinthu zothandiza zimagwiritsidwanso ntchito:
- mannitol;
- lactose (shuga mkaka);
- povidone;
- meglumine;
- magnesium wakuba;
- sodium hydroxide;
- polysorbate 80;
- utoto E172.
Mu piritsi 1 la mankhwala osakanikirana - 40 mg ya kaphatikizidwe kamene kamapezeka mu telmisartan ndi 12,5 mg wa hydrochlorothiazide diuretic.
Mapiritsi a 6, 7 kapena 10 ma PC. kuyikidwa mu matuza okhala ndi zojambula za aluminium zojambulazo ndi filimu ya polima. Atadzaza matakatoni 2, 3 kapena 4 matuza.
Zotsatira za pharmacological
Mankhwala amatulutsa wapawiri zochizira: hypotensive ndi okodzetsa. Popeza kapangidwe kazinthu kamene kamapanga kantchito kameneka kamafanana ndi kapangidwe ka mtundu wa 2 angiotensin, telmisartan imachotsa timadzi tomwe timalumikizana ndi zotengera zamagazi ndikutseka ntchito yake kwakanthawi.
Nthawi yomweyo, kupanga aldosterone yaulere imalephereka, yomwe imachotsa potaziyamu m'thupi ndikusunga sodium, zomwe zimapangitsa kuti mawu azikhala ndi mtima. Nthawi yomweyo, ntchito ya renin, enzyme yomwe imayendetsa kuthamanga kwa magazi, siyikakamizidwa. Zotsatira zake, kukwera kwa kuthamanga kwa magazi kumayima, kuchepa kwake kwakukulu kumachitika pang'onopang'ono.
Pambuyo maola 1.5-2 mutamwa mankhwalawa, hydrochlorothiazide imayamba kupereka mphamvu zake. Kutalika kwa nthawi ya diuretic kumasiyana kwa maola 6 mpaka 12. Nthawi yomweyo, kuchuluka kwa magazi ozungulira kumachepa, kupanga aldosterone kumawonjezeka, ntchito ya renin imachulukanso.
Kuphatikizika kwa telmisartan ndi diuretic kumatulutsa mphamvu yotchedwa antihypertensive kwambiri kuposa momwe zimagwirira aliyense wa iwo payekhapayekha. Pa mankhwala ndi mankhwalawa, mawonetseredwe a myocardial hypertrophy amachepetsa, kufa kumachepetsedwa, makamaka kwa odwala okalamba omwe ali ndi chiwopsezo chachikulu cha mtima.
Pa mankhwala ndi mankhwalawa, mawonekedwe a myocardial hypertrophy amachepetsedwa.
Pharmacokinetics
Kuphatikiza kwa telmisartan ndi hydrochlorothiazide sikumasintha ma pharmacokinetics a zinthu. Awo wonse bioavailability ndi 40-60%. Zigawo zogwira ntchito za mankhwalawa zimatengedwa mwachangu kuchokera kugaya chakudya. Kuchuluka kwa telmisartan kudzikundikira m'madzi am'magazi pambuyo pa maola 1-1,5 ndi kutsika kwa 2-3 kwa amuna kuposa akazi. Kutenga pang'ono kwa mthupi kumachitika m'chiwindi, umatulutsidwa m'zimbudzi. Hydrochlorothiazide imachotsedwa m'thupi pafupifupi osasinthika ndi mkodzo.
Zizindikiro zogwiritsidwa ntchito
Telsartan adalembedwa:
- mankhwalawa pulayimale ndi yachiwiri yamankhwala oopsa, pamene chithandizo cha mankhwala a telmisartan kapena hydrochlorothiazide chokha sichikupereka zotsatira zofunika;
- pofuna kupewa zovuta za mtima matenda a mtima wazaka zoposa 55-60;
- popewa zovuta za odwala omwe ali ndi matenda a shuga II amtundu wa (osagwirizana ndi insulin) omwe amawonongeka chifukwa cha matenda oyambitsidwa ndi matendawa.
Contraindication
Zifukwa zoletsa kulandira chithandizo ndi Telsartan:
- Hypersensitivity kwa yogwira mankhwala;
- matenda oopsa a impso;
- kutenga Aliskiren mwa odwala ndi aimpso Kulephera;
- chiwindi kulephera;
- bile duct kutsekeka;
- lactase akusowa, lactose tsankho;
- hypercalcemia;
- hypokalemia;
- mimba ndi mkaka wa m`mawere;
- ana ochepera zaka 18.
Ndi chisamaliro
Chenjezo liyenera kuchitika ngati matenda otsatirawa kapena matenda atapezeka mwa odwala:
- kutsika kwa magazi;
- stenosis ya mitsempha ya impso, mavavu amtima;
- kulephera kwamtima kwambiri;
- kulephera kwa chiwindi kofinya;
- matenda ashuga
- gout
- adrenal cortical adenoma;
- kutsekeka kotsekera glaucoma;
- lupus erythematosus.
Momwe mungatenge Telsartan 40
Mlingo wambiri: kuyamwa tsiku lililonse musanadye kapena piritsi limodzi, lomwe liyenera kutsukidwa ndi madzi ochepa. Mulingo wambiri watsiku ndi tsiku wa mitundu yayikulu ya matenda oopsa mpaka 160 mg. Kuyenera kukumbukiridwa: njira zoyenera zochiritsira sizimachitika mwachangu, koma pambuyo pa miyezi 1-2 yogwiritsa ntchito mankhwalawa.
Mlingo wambiri: kuyamwa tsiku lililonse musanadye kapena piritsi limodzi, lomwe liyenera kutsukidwa ndi madzi ochepa.
Ndi matenda ashuga
Odwala omwe ali ndi matendawa nthawi zambiri amawalembera kuti asachotse zovuta pamtima, impso, maso. Kwa odwala matenda ashuga ambiri omwe ali ndi matenda oopsa, kuphatikiza kwa Telsartan ndi Amlodipine kukuwonetsedwa. Nthawi zina, kuchuluka kwa uric acid m'magazi kumakwera, gout ikukula. Pangakhale kofunikira kusintha mlingo wa mankhwala a hypoglycemic.
Zotsatira zoyipa za Telsartan 40
Ziwerengero zosagwirizana ndi mankhwalawa komanso telmisartan zotengedwa popanda hydrochlorothiazide ali ofanana. Pafupipafupi pamavuto ambiri, mwachitsanzo, kusokonezeka kwa minofu trophism, metabolism (hypokalemia, hyponatremia, hyperuricemia), sikugwirizana ndi kuchuluka, jenda komanso zaka za odwala.
Matumbo
Mankhwala osowa nthawi zina angayambitse:
- kamwa yowuma
- dyspepsia;
- chisangalalo;
- kupweteka kwam'mimba
- kudzimbidwa
- kutsegula m'mimba
- kusanza
- gastritis.
Hematopoietic ziwalo
Zokhudzana ndi mankhwalawa zingaphatikizeponso:
- kutsika kwa hemoglobin;
- kuchepa magazi
- eosinophilia;
- thrombocytopenia.
Pakati mantha dongosolo
A pafupipafupi zotsatira chizungulire. Sizichitika kawirikawiri:
- paresthesia (zotupa za tsekwe, kumva kugunda kwa mtima, ululu woyaka);
- kusowa tulo, kapena, kuwodzera;
- mawonekedwe osasangalatsa;
- nkhawa;
- Kukhumudwa
- syncope (kufooka mwadzidzidzi), kukomoka.
Kuchokera kwamikodzo
Nthawi zina amati:
- kuchuluka kwa kuchuluka kwa uric acid, creatinine m'madzi am'magazi;
- kuchuluka kwa enzyme CPK (creatine phosphokinase);
- pachimake aimpso kulephera;
- matenda amkodzo thirakiti, kuphatikizapo cystitis.
Kuchokera ku kupuma
Zotsatira zoyipa:
- kupweteka pachifuwa;
- kupuma movutikira
- matenda ngati chimfine, sinusitis, pharyngitis, bronchitis;
- chibayo, edema yamapapu.
Pa khungu
Zitha kuwonekera:
- erythema (kufiira pakhungu);
- kutupa
- zotupa
- kuyabwa
- thukuta;
- urticaria;
- dermatitis;
- chikanga
- angioedema (osowa kwambiri).
Kuchokera ku genitourinary system
Telsartan sikuti imawononga ntchito ya maliseche.
Kuchokera pamtima
Zitha kukhala:
- ochepa kapena orthostatic hypotension;
- brady, tachycardia.
Kuchokera musculoskeletal system ndi minofu yolumikizana
Zotsatira zotsatirazi za musculoskeletal system ndizotheka:
- cramping, kupweteka kwa minofu, tendons, mafupa;
- kukokana, nthawi zambiri m'miyendo;
- lumbalgia (kupweteka kwapweteka kumbuyo.
Pa mbali ya chiwindi ndi biliary thirakiti
Mothandizidwa ndi mankhwalawa nthawi zina, zotsatirazi zingaoneke:
- kupatuka mu chiwindi;
- kuchuluka kwa michere yopangidwa ndi thupi.
Matupi omaliza
Kugwedezeka kwa anaphylactic ndikosowa kwambiri.
Zokhudza mphamvu pakuwongolera njira
Popeza ndizosatheka kupatula chiopsezo cha kugona, chizungulire, tikulimbikitsidwa kusamala poyendetsa, kuchita ntchito yomwe imafuna chisamaliro chachikulu.
Malangizo apadera
Ndi kuchepa kwa sodium mu plasma kapena kuchuluka kosakwanira kozungulira magazi, kuyambitsidwa kwa mankhwala osokoneza bongo kumatha kutsagana ndi kuchepa kwa kuthamanga kwa magazi. Odwala aimpso mtima stenosis, mtima matenda, ndi kulephera mtima, owopsa ochepa hypotension amakhala. Kugwa kovuta kwa kupsinjika kumatha kubweretsa stroko kapena myocardial infaration.
Gwiritsani ntchito mankhwalawa mosamala komanso ndi mitral kapena aortic valve stenosis.
Mu odwala matenda ashuga, matenda a hypoglycemia amatha. Ndikofunikira kuyang'ana kuchuluka kwa shuga m'magazi, kusintha magawo a othandizira a hypoglycemic.
Mu odwala matenda ashuga, matenda a hypoglycemia amatha.
Hydrochlorothiazide monga gawo la Telsartan imatha kuwonjezera kuchuluka kwa nayitrogeni mankhwala osakanikirana aimpso, komanso imayambitsa kukula kwa pachimake myopia, khungu-kutsekeka kwa glaucoma.
Kugwiritsa ntchito mankhwalawa kwa nthawi yayitali nthawi zambiri kumayambitsa hyperkalemia. Pangakhale kofunikira kuti muwunikire zomwe zili ma elekitirodi mu madzi am'magazi.
Kuchotsa mwadzidzidzi kwa mankhwalawa sikuti kukuyambitsa kuchoka.
Ndi chachikulu hyperaldosteronism, achire zotsatira za Telsartan kulibe.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwala osokoneza bongo amatsutsana panthawi ya gestation ndi yoyamwitsa.
Kulemba Telsartan kwa ana 40
Mankhwalawa sanapangidwe kuti azigwiritsidwa ntchito ndi odwala ochepera zaka 18.
Gwiritsani ntchito mu ukalamba
Palibe matenda ophatikizika kwambiri, palibe chifukwa chosinthira mlingo.
The ntchito aimpso kuwonongeka
Kusintha kwa Mlingo sikofunikira kwa odwala omwe ali ndi vuto laimpso mosiyanasiyana, kuphatikiza zikuchitika hemodialysis njira.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Malinga ndi zotsatira za maphunziro ambiri mwa odwala omwe ali ndi vuto la chiwindi chochepa, mlingo wa mankhwalawa sikuyenera kupitirira 40 mg.
Malinga ndi zotsatira za maphunziro ambiri mwa odwala omwe ali ndi vuto la chiwindi chochepa, mlingo wa mankhwalawa sikuyenera kupitirira 40 mg.
Overdose wa Telsartan 40
Kutsika kwakuthwa kwa kuthamanga kwa magazi ndi brady kapena tachycardia ndikotheka. Kukhazikitsidwa kwa hemodialysis ndikosatheka, chithandizocho chikuchitika. Ndikofunikira kuwongolera milingo ya creatinine ndi ma electrolyte m'mwazi.
Kuchita ndi mankhwala ena
Kugwiritsa ntchito pamodzi ndi mankhwala ena omwe amachepetsa kuthamanga kwa magazi, mankhwalawa amawonjezera mphamvu zawo zochizira.
Mukatenga Telsartan ndi Digoxin, kuchuluka kwa mtima glycoside kumawonjezeka kwambiri, chifukwa chake kuyang'anira kuchuluka kwake kwa seramu ndikofunikira.
Popewa hyperkalemia, mankhwalawa sayenera kuphatikizidwa ndi othandizira omwe ali ndi potaziyamu.
Mphamvu zoyendetsera ndende ya lithiamu m'magazi pogwiritsa ntchito mankhwala okhala ndi zitsulo zamchere zamtunduwu, chifukwa Telmisartan imawonjezera kawopsedwe awo.
Glucocorticosteroids, Aspirin ndi mankhwala ena omwe si a antiidal anti-yotupa amachepetsa mphamvu ya antihypertensive.
Ma NSAID osakanikirana ndi telmisartan amatha kusokoneza ntchito yaimpso.
Kuyenderana ndi mowa
Mukamamwa mankhwala, simuyenera kumwa mowa wamtundu uliwonse.
Analogi
Telsartan ikhoza m'malo mwa mankhwalawa ndi zotsatira zomwezi:
- Mikardis;
- Wotsogolera;
- Tanidol;
- Izi;
- Telzap;
- Telmisartan;
- Telmista;
- Telpres
- Tsitsi
- Hipotel.
Kupita kwina mankhwala
Kugulitsidwa kuwonetsedwa kwa Chinsinsi.
Mtengo wa Telsartan 40
Mtengo wa 1 phukusi ndi ma 30 ma PC. - kuchokera 246-255 rub.
Zosungidwa zamankhwala
Kutentha kokwanira kwa mapiritsi kulibe kutentha kuposa + 25 ° C. Malo awo osungira sayenera kupezeka ndi ana.
Tsiku lotha ntchito
Zaka 2
Wopanga
Kampani yopanga mankhwala ku India "Dr. Reddy's Laboratories Ltd." (Dr. Reddy's Laboratories Ltd.).
Mukamatenga Telsartan ndi Digoxin, kuchuluka kwa mtima glycoside kumawonjezeka kwambiri.
Ndemanga pa Telsartan 40
Maria, wazaka 47, Vologda
Mapiritsi akulu ndipo akuwoneka kuti ndiye otetezeka kwambiri pazithandizo zambiri zamatenda a mtima. Ndizodabwitsa kuti mankhwalawa amapangidwa ku India, osati ku Germany kapena Switzerland. Zotsatira zoyipa ndizochepa. Nthawi zina chiwindi chimangondivuta, koma zandipweteka kwa nthawi yayitali pomwe sindinatengepo Telsartan.
Vyachedlav, wazaka 58, Smolensk
Ndili ndi matenda oopsa kwa nthawi yayitali. Kuphatikiza kulephera kwambiri kwaimpso. Kukonzekera kokha komwe sikunatengedwe kwa zaka zambiri! Koma nthawi zina zimayenera kusinthidwa, chifukwa thupi limazolowera, kenako zimasiya kuchita ngati kale. Ndakhala ndikutenga Telsartan posachedwapa. Malangizo ake amapereka mndandanda wazotsatira zoyipa, koma palibe amene adakumana nawo. Mankhwala abwino omwe amakhala ndi mavuto. Choonadi ndichokwera mtengo.
Irina, wazaka 52, Yekaterinburg
Kwa nthawi yoyamba, katswiriyu adati Amlodipine ayenera kumwedwa, koma patatha sabata limodzi miyendo yake idayamba kutupa. Adotolo adalowa m'malo mwake ndi Enap - posakhalitsa chifuwa chidayamba kundisokoneza. Kenako ndinasinthira ku Telsartan, koma zinafika poti ndinali ndi vuto lililonse ndi iye. Panali mseru, kenako zotupa pakhungu linatuluka. Apanso ndinapita kuchipatala. Ndipo pokhapokha akatswiri odziwa Concor atachita zonse zidachitika. Ndilibe vuto ndi mapiritsi awa. Chifukwa chake ndikofunikira kwambiri kuti adokotala asankhe molondola mankhwalawo omwe akukuyenererani.
