Glurenorm ndi mankhwala omwe ali ndi vuto la hypoglycemic. Matenda a shuga a Type 2 ndi vuto lofunika kwambiri lakuchipatala chifukwa chofala kwambiri komanso zovuta zake. Ngakhale ndi kulumpha kwakung'ono m'magazi a glucose, mwayi wa retinopathy, kugunda kwa mtima kapena sitiroko umakulitsidwa kwambiri.
Glurenorm ndi amodzi mwa oopsa kwambiri poyerekeza ndi zotsatira zoyipa za antiglycemic, koma sizotsika mtengo pogwira mankhwala ena omwe ali mgululi.
Pharmacology
Glurenorm ndi othandizira a hypoglycemic omwe amatengedwa pakamwa. Mankhwalawa ndi sulfonylurea. Ili ndi pancreatic komanso extrapancreatic kanthu. Zimawonjezera kupanga kwa insulin pokhudza kuphatikiza kwa glucose -edi
Mphamvu ya hypoglycemic imachitika pambuyo pa maola 1.5 kuchokera pakukonzekera kwamkati mankhwala, nsonga ya izi imachitika pakatha maola awiri kapena atatu, kumatenga maola 10.
Pharmacokinetics
Mutatenga gawo limodzi mkati, Glyurenorm imatengeka mwachangu komanso pafupifupi kwathunthu (80-95%) kuchokera kumimba yotsekemera ndikumamwa.
The yogwira mankhwala - glycidone, ali ndi kuyanjana kwakukulu kwa mapuloteni m'madzi a m'magazi (99%). Palibe chidziwitso pakuyenda kapena kusapezeka kwa chinthuchi kapena zinthu zake za metabolic pa BBB kapena placenta, komanso kutulutsidwa kwa glycvidone mumkaka wa mayi woyamwitsa panthawi yoyamwitsa.
Zinthu zambiri za kagayidwe ka glycidone zimasiya thupi, kukhala zotulutsidwa m'matumbo. Kachigawo kakang'ono ka zinthu zopasuka zomwe zimatuluka kudzera impso.
Kafukufuku wapeza kuti pambuyo pa kayendetsedwe ka mkati, pafupifupi 85% ya mankhwala osokoneza bongo a isotope amatulutsidwa m'matumbo. Mosasamala kukula kwa mlingo ndi njira yoyendetsera kudzera mu impso, pafupifupi 5% (mu mawonekedwe a mankhwala a metabolic) a kuchuluka kovomerezeka kwa mankhwalawa amamasulidwa. Mlingo wa kutulutsidwa kwa mankhwalawa kudzera mu impso umakhalabe wocheperako, ngakhale utakhala wambiri.
Zizindikiro za pharmacokinetics zimagwirizana ndi odwala okalamba komanso azaka zapakati.
Kuposa 50% ya glycidone imatulutsidwa m'matumbo. Malinga ndi chidziwitso china, kagayidwe ka mankhwala sikusintha mwanjira iliyonse ngati wodwala walephera. Popeza glycidone imachoka m'thupi kudzera mu impso yaying'ono, odwala omwe ali ndi vuto la impso, mankhwalawa saunjikira m'thupi.
Zizindikiro
Type 2 matenda ashuga okalamba komanso okalamba.
Contraindication
- Mtundu woyamba wa shuga
- Shuga yokhudzana ndi matenda a shuga;
- Matenda a shuga
- Kuchepa kwa chiwindi ntchito kwambiri;
- Matenda opatsirana aliwonse;
- Zaka zosakwana 18 (popeza palibe chidziwitso chokhudza chitetezo cha Glyurenorm cha gulu ili la odwala);
- Munthu payekha hypersensitivity kuti sulfonamide.
Kusamala kowonjezereka kumafunikira mukamamwa Glyurenorm pamaso pa ma pathologies otsatirawa:
- Thupi
- Matenda a chithokomiro;
- Uchidakwa wambiri
Mlingo
Glurenorm imapangidwa kuti igwiritsidwe ntchito mkati. Kutsatira mosamalitsa zofunikira za chipatala zokhudzana ndi kuchuluka ndi zakudya ndizofunikira. Simungaletse kugwiritsa ntchito Glyurenorm osakambirana kaye ndi dokotala.
Mlingo woyambirira ndi theka la mapiritsi omwe amwedwa ndi kadzutsa.
Glurenorm iyenera kudyedwa koyambirira kwa chakudya.
Musadumphe zakudya mutamwa mankhwalawa.
Kutenga theka la mapiritsi sikothandiza, muyenera kufunsa dokotala yemwe, mwina, adzakulitsa mlingo.
Potumiza mankhwala opitirira malire omwe ali pamwambawa, kuthekera kwakukulu kotheka kumatha kugwiritsidwa ntchito ngati mukugawa mlingo umodzi wa tsiku ndi tsiku mumagawo awiri kapena atatu. Mlingo waukulu kwambiri pamenepa uyenera kumamwa nthawi ya chakudya cham'mawa. Kuchulukitsa kwa mankhwalawa kwa mapiritsi anayi kapena kupitilira patsiku, monga lamulo, sikuti kumayambitsa kuchuluka.
Mlingo wapamwamba kwambiri patsiku ndi mapiritsi anayi.
Kwa odwala mkhutu aimpso ntchito
Pafupifupi 5 peresenti ya zinthu zopangidwa ndi metabolism za Glurenorm zimachoka m'thupi kudzera mu impso. Ngati wodwala wasokoneza ntchito yaimpso, kusintha kwa mankhwala sikofunikira.
Kwa odwala omwe ali ndi chiwindi
Mukamagwiritsa ntchito mankhwala oposa 75 mg kwa odwala omwe ali ndi vuto la chiwindi, kuyang'anira dokotala ndikofunikira. Glurenorm sayenera kumwedwa chifukwa cha kuwonongeka kwambiri kwa chiwindi, popeza 95% ya mankhwalawa imakonzedwa m'chiwindi ndi kunja kwa matumbo.
Kuphatikiza mankhwala
Pankhani yosakwanira kugwiritsidwa ntchito kwa Glyurenorm popanda kuphatikiza ndi mankhwala ena, kuphatikiza kwa metmorphine monga wothandizira wina kumasonyezedwera.
Zotsatira zoyipa
- Metabolism: hypoglycemia;
- CNS: kugona kwambiri, kupweteka mutu, kufooka kwa matenda, paresthesia;
- Mtima: hypotension;
- Matumbo am'mimba: Kutha kwa chilakolako chofuna kudya, kusanza, kutsegula m'mimba, kusapeza bwino pamimba, cholestasis.
Bongo
Mawonekedwe: kutuluka thukuta kwambiri, njala, kupweteka mutu, kusachedwa, kugona, kukomoka.
Chithandizo: ngati pali zizindikiro za hypoglycemia, kudya glucose wamkati kapena zinthu zomwe zili ndi chakudya chambiri zimafunikira. Woopsa hypoglycemia (limodzi ndi kukomoka kapena chikomokere), kuyikiridwa kwamkati kwa dextrose ndikofunikira.
Kukhudzana kwa mankhwala
Glurenorm imatha kukulitsa zotsatira za hypoglycemic ngati itengedwa chimodzimodzi ndi zoletsa za ACE, allopurinol, painkillers, chloramphenicol, clofibrate, clarithromycin, sulfanilamides, sulfinpyrazone, tetracyclines, cyclophosphamides omwe atengedwa pakamwa ndi mankhwala a hypoglycemic.
Pangakhale kufooka kwa zotsatira za hypoglycemic pankhani yothandizirana ndi glycidone mogwirizana ndi aminoglutethimide, sympathomimetics, glucagon, thiazide diuretics, phenothiazine, diazoxide, komanso mankhwala omwe amakhala ndi nicotinic acid.
Malangizo apadera
Odwala omwe ali ndi matenda ashuga ayenera kutsatira mosamalitsa malangizo a dokotala. Ndikofunikira kwambiri kuwunikira momwe akusankhira mlingo kapena kusintha kwa Glyrenorm kuchokera kwa wothandizira wina yemwe ali ndi vuto la hypoglycemic.
Mankhwala osokoneza bongo omwe ali ndi hypoglycemic effect, omwe amatengedwa pakamwa, sangathe kugwira ntchito monga chakudya chokwanira chomwe chimakupatsani mwayi wambiri wodwala. Chifukwa chodumpha zakudya kapena kuphwanya malangizo a dokotala, kutsika kwakukulu kwa shuga m'magazi ndikotheka, zomwe zimapangitsa kukomoka. Ngati mumwa mapiritsi musanadye, m'malo momwera chakudyacho, zotsatira za Glyrenorm pamagazi a magazi ndizolimba, motero, mwayi wa hypoglycemia ukuwonjezeka.
Ngati pali chiwonetsero cha hypoglycemia, kudya zakudya zomwe zili ndi shuga wambiri ndizofunikira. Ngati hypoglycemia ikupitirirabe, ngakhale zitatha izi muyenera kufunsa kuchipatala msanga.
Chifukwa cha kupsinjika kwakuthupi, zotsatira za hypoglycemic zitha kukulira.
Chifukwa cha mowa, kuwonjezeka kapena kuchepa kwa vuto la hypoglycemic kumatha kuchitika.
Glyurenorm piritsi ili ndi lactose mu 134.6 mg. Mankhwalawa amatsutsana ndi anthu omwe ali ndi matenda amtundu wa makolo.
Glycvidone ndi sulfonylurea yotumphukira, yodziwika ndi yochepa, chifukwa imagwiritsidwa ntchito ndi odwala omwe ali ndi matenda a 2 komanso amakhala ndi vuto la hypoglycemia.
Kulandilidwa kwa Glyurenorm kwa odwala omwe ali ndi matenda a shuga a 2 komanso matenda amchiwindi chodalirika. Chokhacho ndikuchotsa pang'onopang'ono zinthu zomwe sizigwira ntchito glycidone metabolism mu odwala a gululi. Koma mwa odwala omwe ali ndi vuto la chiwindi, mankhwalawa ndi osayenera kumwa.
Mayeso awonetsa kuti kutenga Glyurenorm kwa chaka chimodzi ndi theka ndi zaka zisanu sikubweretsa kuchuluka kwa thupi, ngakhale kuchepa pang'ono thupi kumatheka. Kafukufuku woyerekeza wa Glurenorm ndi mankhwala ena, omwe ndi mankhwala a sulfonylureas, adawululira kusowa kwa kusintha kwa odwala omwe akugwiritsa ntchito mankhwalawa kwa nthawi yoposa chaka chimodzi.
Palibe chidziwitso cha mphamvu ya Glurenorm pa kuthekera koyendetsa magalimoto. Koma wodwalayo ayenera kuchenjezedwa za zomwe zingachitike ndi hypoglycemia. Mawonetsedwe onsewa amatha kuchitika panthawi ya mankhwala ndi mankhwalawa. Kusamala kumafunikira poyendetsa.
Mimba, yoyamwitsa
Palibe chidziwitso pakugwiritsa ntchito Glenrenorm ndi amayi panthawi yomwe ali ndi pakati komanso mkaka wa m'mawere.
Sizikudziwika ngati glycidone ndi zinthu zake za metabolic zimalowa mkaka wa m'mawere. Amayi oyembekezera omwe ali ndi matenda ashuga amayenera kuyang'anitsitsa shuga wawo wamagazi.
Kugwiritsa ntchito mankhwala am'mimba a shuga kwa amayi apakati sikumapangitsa kuti pakhale kagayidwe kazakudya. Pachifukwa ichi, kumwa mankhwalawa panthawi yapakati komanso mkaka wa m`mawere ndi contraindicated.
Mimba ikachitika kapena ngati mukukonzekera nthawi yothandizidwa ndi wothandizirayi, muyenera kusiya Glyurenorm ndikusintha kupita ku insulin.
Ngati aimpso kuwonongeka
Popeza kuchuluka kwakukulu kwa Glyurenorm kumachotsedwa m'matumbo, mwa odwala omwe impso zawo zimalephera, kudzikundikira kwa mankhwalawa sikuchitika. Chifukwa chake, imatha kuperekedwa popanda zoletsa kwa anthu omwe ali ndi vuto la nephropathy.
Pafupifupi 5 peresenti ya zomwe zimapezeka mu mankhwala amtunduwu zimaperekedwa kudzera mu impso.
Kafukufuku yemwe anachitidwa kuyerekeza odwala omwe ali ndi matenda a shuga komanso kuwonongeka kwa impso kwamisinkhu yosiyanasiyana, odwala omwe akudwala matenda ashuga, koma osavulala ndi vuto laimpso, adawonetsa kuti kugwiritsa ntchito 50 mg ya mankhwalawa kumathandizanso ndi shuga.
Palibe kuwonetsa kwa hypoglycemia komwe kudadziwika. Izi zikutanthauza kuti kwa odwala omwe alembetsa impso, kusintha kwakofunikira sikofunikira.
