Basal, kapena monga amatchedwanso, ma insulins oyambira kumbuyo amatenga gawo lofunikira pothandizira matenda a shuga. Amathandizira kuti magazi azikhala ndi shuga pakati pa chakudya, zomwe zimalimbikitsa kuyamwa kwa glycogen omwe amasungidwa ndi maselo a chiwindi.
Mpaka pano, ma insulins amakono adapangidwa, nthawi yomwe imatha kupitilira maola 42.
Imodzi mwa mankhwalawa ndi Ryzodeg, yemwe wakhala akupanga insulin nthawi yayitali.
Kuphatikizika ndi katundu
Ryzodeg ndi m'badwo watsopano wa basal insulin womwe ungagwiritsidwe ntchito bwino pochiza matenda a shuga a mtundu woyamba wa 2. Kupadera kwa Ryzodega kuli poti nthawi imodzi imakhala ndi insuludart yodziwikiratu komanso yochepa kwambiri ya insuludec.
Ma insulini onse omwe amagwiritsidwa ntchito popanga kukonzekera kwa Ryzodeg ndi fanizo la insulin yaumunthu. Amapezeka ndi makina obwereza omwe amagwiritsa ntchito DNA pogwiritsa ntchito yisiti bowa wa genus Saccharomyces cerevisiae.
Chifukwa cha izi, zimamangirira mosavuta ku cholandilira cha insulin yawo yaumunthu ndipo, pakulumikizana nawo, zimathandizira kuyamwa kwa shuga. Chifukwa chake, Ryzodegum imagwira ntchito monga ambulensi amkati.
Ryzodeg imakhudzanso kawiri: mbali imodzi, zimathandiza ziwalo zamkati mwathupi kuti zithetse bwino shuga kuchokera m'magazi, ndipo inayo, imachepetsa kwambiri kupanga kwa glycogen kudzera m'maselo a chiwindi. Izi zimapangitsa Ryzodeg kukhala imodzi mwa insulin yofunika kwambiri.
Insulin degludec, yomwe ndi imodzi mwazomwe akukonzekera Ryzodeg, ali ndi zochita zina zazitali. Pambuyo pakuyambitsa minofu yaying'ono, imalowa pang'onopang'ono komanso mosalekeza m'magazi, zomwe zimathandiza wodwalayo kupewa magazi ochulukirapo kuposa kuchuluka kwake.
Chifukwa chake, Ryzodegum ali ndi kutchulidwa kwa hypoglycemic, ngakhale kuphatikiza kwa degludec ndi aspart. Izi ziwiri zomwe zimawoneka kuti ndizosagwirizana ndi insulin mu mankhwalawa zimapangitsa kuphatikiza kwakukulu komwe insulin siyimalimbana ndi kuyamwa kwakanthawi.
Kuchita kwa aspart kumayamba pokhapokha jakisoni wa Ryzodegum Amalowa mwachangu m'magazi a wodwalayo ndipo amathandizira kutsitsa shuga m'magazi.
Kupitilira apo, degludec imayamba kukhudza thupi la wodwalayo, lomwe limakamizidwa pang'onopang'ono ndipo limakwaniritsa kwathunthu kufunika kwa wodwala insulin ya maola 24.
Malangizo ogwiritsira ntchito mankhwalawa
Rysodeg iyenera kutumikiridwa kokha mu minofu yaying'ono yothandizira, apo ayi wodwalayo atha kukhala ndi zovuta zowopsa zomwe zimafuna chisamaliro chamankhwala mwachangu.
Kubayidwa ndi Ryzodegum ndikofunikira 1 kapena 2 pa tsiku musanadye kadzutsa, chakudya chamadzulo kapena nkhomaliro. Ngati angafune, wodwalayo amatha kusintha jakisoniyo nthawi yodziyimira, koma ngati mankhwalawo amalowa mthupi asanadye chakudya chachikulu.
Pochiza odwala omwe apezeka ndi mtundu wachiwiri wa matenda a shuga, kukonzekera kwa Ryzodeg kungagwiritsidwe ntchito ngati othandizira komanso kuphatikiza mapiritsi ochepetsa shuga kapena ofinya omwe amangokhala.
Pazochita zochizira odwala omwe ali ndi vuto la matenda a shuga 1, Ryzodeg amagwiritsidwa ntchito molumikizana ndi kukonzekera kwapafupipafupi kapena ultrashort insulin. Kwa gulu ili la odwala, ndikofunikira kupaka mankhwala musanadye, osadya.
Mlingo wa mankhwala a Ryzodeg amayenera kusankhidwa mosiyanasiyana, poganizira momwe wodwalayo alili komanso zosowa zake. Kudziwa mlingo woyenera wa insulin ingakuthandizeni kwambiri kuyeza kuchuluka kwa shuga m'magazi. Ngati ichulukitsidwa, ndiye kuti mlingo wake umafunikira kukonzedwa mwachangu.
Kuphatikiza apo, kusintha kungafunike pakusintha kudya kwa wodwala kapena zolimbitsa thupi. Komanso, kudya mankhwala enaake kumakhudzanso shuga ya magazi, yomwe ingafune kuwonjezeka kwa Rysodeg.
Momwe mungasankhire mlingo wa basal insulin Ryzodeg:
- Mtundu woyamba wa shuga. Ndi matendawa, mlingo wa Ryzodeg uyenera kukhala pafupifupi 65% ya zomwe wodwala amafunikira tsiku lililonse. Ndikofunikira kuperekera mankhwalawa kamodzi patsiku musanadye osakaniza ndi insulin yochepa. Ngati ndi kotheka, mlingo wa basal insulin uyenera kusintha;
- Type 2 shuga. Kwa odwala omwe ali ndi mtundu uwu wa matendawa, ngati gawo loyambirira la mankhwalawa, tikulimbikitsidwa kulowa magawo 10 a Ryzodeg tsiku lililonse. Mlingo uwu amathanso kusinthidwa malinga ndi zosowa za wodwala payekha.
Momwe mungagwiritsire ntchito Ryzodeg:
- Ralg ya basal insulin imapangidwira ma subcutaneous makonzedwe. Mankhwalawa sioyenera kubayira jekeseni wam'mimba, chifukwa amatha kuyambitsa matenda a hypoglycemia;
- Mankhwala Ryzodeg sayeneranso kupatsidwa mankhwala a intramuscularly, chifukwa pamenepa kuyamwa kwa insulini m'mwazi kumathandizira kwambiri;
- Ryzodeg sanapangidwe kuti azigwiritsa ntchito pampu ya insulin;
- Jekeseni wa insulin Rizodeg uyenera kuchitidwa matako kapena m'mimba, nthawi zina amaloledwa kuyika jakisoni m'manja;
- Jekeseni aliyense akapezeka, tsamba la jekeseni liyenera kusinthidwa kuti lipodystrophy isachitike mu shuga.
Mankhwala Ryzodeg angagwiritsidwe ntchito pochiza odwala mu gulu lapadera, omwe ali ndi zaka zopitilira 65 kapena akuvutika ndi vuto la impso kapena chiwindi. Komabe, pankhaniyi, muyenera kuwunika bwino kuchuluka kwa shuga m'magazi ndipo ngati kuli koyenera, musinthe kuchuluka kwa insulin.
Insulin yoyambira iyi ingagwiritsidwe ntchito mankhwalawa matenda a shuga kwa ana ndi achinyamata osakwana zaka 18.
Koma palibe maphunziro omwe atsimikizira chitetezo cha Ryzodegum kwa odwala a ana.
Mtengo wa mankhwalawo
Mtengo wa basal insulin Ryzodeg zimatengera mtundu wa mankhwalawa. Chifukwa chake ma cartridge agalasi a 3 ml (300 PIECES) akhoza kugula pamtengo wa 8150 mpaka 9050 rubles. Komabe, m'mafamu ena mankhwalawa amaperekedwa pamtengo wokwera kwambiri, ma ruble oposa 13,000.
Mtengo wa cholembera ndi syringe ndi wokhazikika ndipo, monga lamulo, umachokera ku 6150 mpaka 6400 rubles. Nthawi zina, amatha kufikira ma ruble 7000.
Mtengo wa mankhwala Ryzodega ndi wofanana m'madera onse a Russia. Komabe, ndi mankhwala osowa kwambiri m'dziko lathu, chifukwa chake sangagulidwe kuzipatala zonse zaku Russia.
Nthawi zambiri, iwo amene akufuna kugula Ryzodeg amayenera kuyika mankhwala awa pasitolo, chifukwa ngakhale mtengo wake umagulitsidwa mwachangu ndi odwala omwe ali ndi matenda ashuga. Izi ndichifukwa choti ndemanga zakugwiritsa ntchito mankhwalawa zili zabwino kwambiri.
Analogi
Mitundu ina ya insulin ya basal ndi fanizo la Ryzodeg. Izi zimaphatikizapo mankhwala monga insulin Glargin ndi Tujeo, opangidwa chifukwa cha insulin glargine ndi Levemir, yomwe imaphatikizapo Detemir insulin.
Mankhwalawa ndi ofanana kwambiri mu mphamvu yawo, yomwe amakhala nayo pa thupi la wodwalayo. Chifukwa chake, posintha kuchokera ku Lantus, Tujeo kapena Levemir kupita ku Raizodeg, wodwalayo safunikira kusintha mulingo, chifukwa umamasuliridwa pamlingo wa 1: 1.
Kanemayo m'nkhaniyi akuwonetsa momwe angabayire insulin bwino.
