Lantus ndi insulin yotsitsa shuga. Glargine imagwira ntchito ngati chinthu chogwira ntchito, ndi analogue ya insulin ya anthu, yomwe singasungunuke bwino m'malo osagwirizana nawo. Kamodzi popanga mankhwala, glargine imasungunuka kwathunthu chifukwa cha kukhalapo kwa chilengedwe chapadera cha acid.
Pa subcutaneous makonzedwe, asidi samasinthidwa ndipo microprecipitates imapangidwa, pomwe pamakhala kutulutsa pang'onopang'ono kwa insulin Lantus pang'ono. Chifukwa cha dongosolo lotere, wodwala matenda ashuga sasintha kwambiri m'thupi, timadzi tating'onoting'ono timakhudza thupi, ndipo shuga amayamba kuchepa. Chifukwa chake, zochita za insulin zimapitilira.
The yogwira mankhwala glargine ali ndi mphamvu yomweyo mogwirizana ndi insulin zolandilira monga anthu insulin. Mankhwalawa amathandizira kuthamangitsa kuyamwa kwa glucose ndi minofu yamafuta ndi minofu, chifukwa chomwe minofu ya plasma imachepetsedwa. Kuphatikiza apo, mankhwalawa amalepheretsa kugwira ntchito kwa shuga mu chiwindi.
Zolemba za mankhwala
Choyamba, insulin Lantus yomwe imagwira ntchito kwa nthawi yayitali imayendetsa kagayidwe kazakudya ndipo imasintha kagayidwe kazakudwala. Mukamagwiritsa ntchito mankhwalawa, kumwa shuga kumathandizira ndi mafuta ndi minofu minofu, chifukwa, zotsatira za shuga zimachepetsedwa. Wothandizira mahomoni amalimbikitsa ntchito yogwira mapuloteni m'thupi ndipo nthawi yomweyo amalepheretsa lipolysis, proteinolysis mu adipocytes.
Mphamvu ya mankhwala a insulin Lantus zimatengera kupezeka kwa zinthu monga zolimbitsa thupi, kudya komanso kukhalabe ndi moyo wabwino. Ngati mankhwalawa akaperekedwa kudzera m'mitsempha, glargine imachita chimodzimodzi ndi insulin ya anthu.
Panthawi yokonza Lantus, kumizidwa pang'ono pang'onopang'ono, chifukwa chake umagwiritsidwa ntchito kuchepetsa shuga kamodzi patsiku. Kafukufuku wasonyeza kuti kugwiritsa ntchito timadzi timeneti usiku kumathandizira kuchepetsa chiopsezo cha hypoglycemia mwa ana ndi achinyamata, pomwe shuga amawonjezeka.
- Ubwino wabwino ndi chakuti Lantus insulin imatengedwa, ndiye chifukwa chake odwala matenda ashuga alibe chiwonetsero chazomwe zimayendera. Ngati mukugwiritsa ntchito mankhwalawa kamodzi tsiku lililonse, patsiku lachiwiri kapena lachinayi mutha kukwaniritsa kuchuluka kwa mankhwalawa. Ndi jakisoni wamkati, timadzi timatulutsa m'thupi chimodzimodzi ndi insulin ya munthu.
- Panthawi ya glargine metabolism, mapangidwe awiri othandizira a M1 ndi M2 amapangidwa, chifukwa chomwe jekeseni wa subcutaneous amakhala ndi zotsatira zomwe akufuna. Mankhwalawa amathandizanso odwala matenda ashuga, mosatengera zaka za odwala. Ana ndi achinyamata sanatengepo kafukufuku wa mankhwala a pharmacokinetic a mankhwalawo.
Mankhwala amamasulidwa mu mawonekedwe a yankho la jekeseni, lomwe limayikidwa m'makalata atatu a 3 ml. Muli makatoni asanu mu chithuza chimodzi; chithuza chimodzi chikuphatikizidwa ndi katoni imodzi. Mtengo wa mankhwalawa m'masitolo amakankhira ndi 3500 mpaka 4000 rubles, m'malo osungirako intaneti mankhwala ndi otsika mtengo.
Mwambiri, insulin ili ndi ndemanga zabwino kuchokera kwa odwala ndi madokotala ambiri.
Malangizo ogwiritsira ntchito mankhwalawa
Kugwiritsa ntchito insulin Lantus kumawonetsedwa kwa akulu ndi ana opitirira zaka zisanu ndi chimodzi omwe amapezeka ndi matenda a shuga a mtundu woyamba. Jakisoni wothandizila ndi insulin amachitika mosakakamiza, osamwetsa jakisoni mankhwala, apo ayi pamakhala chiwopsezo cha hypoglycemia.
Kukula kwakutali kwa timadzi timene kumatheka pokhapokha ngati insulin itabayidwa usiku uliwonse m'mankhwala othamanga. Chithandizo chofunikira chifukwa cha mankhwala osokoneza bongo chitha kuchitika pokhapokha ngati muli ndi moyo komanso njira yoyenera yoyendetsera mankhwalawo.
Ndikofunikira kudziwa kuchuluka kwa mankhwalawa komanso kuchuluka kwa jakisoni. Jakisoni amapangidwa m'dera lam'mimba, ntchafu kapena minofu yolimba. Nthawi yomweyo, palibe kusiyana kowoneka bwino makamaka pakubayidwa. Kubayira kulikonse kumachitika bwino m'malo osiyanasiyana kuti muchepetse kukhazikika pakhungu.
- Kwa kubereka, insulin Lantus sioyenera, kugwiritsidwa ntchito kwa mahomoni limodzi ndi mankhwala ena kumaletsedwanso. Chifukwa cha nthawi yayitali, mankhwalawa amaperekedwa kamodzi patsiku, jakisoni amaperekedwa nthawi yomweyo - m'mawa, masana kapena usiku. Mlingo ndi nthawi ya jakisoni imasankhidwa ndi adotolo, kuwunikira zomwe zimachitika m'thupi la wodwalayo.
- Anthu odwala matenda ashuga omwe ali ndi mtundu wachiwiri wa shuga amaloledwa kugwiritsa ntchito mankhwala a insulin pomwe amagwiritsa ntchito mankhwala othana ndi shuga, mwachitsanzo, mapiritsi a Trazent. Mukamagwiritsa ntchito timadzi tambiri, tiyenera kukumbukira kuti gawo la Lantus ndi losiyana ndi gawo la mankhwala omwe ali ndi insulin.
- Pochiza anthu achikulire ndi Lantus, mlingo uyenera kusinthidwa payekhapayekha, chifukwa ntchito ya impso imasokonekera ndi ukalamba ndipo kufunika kwa mahomoni nthawi zambiri kumachepa. Kuphatikiza pa kufunika kwa mankhwalawa kumachepetsedwa mwa anthu omwe ali ndi vuto la chiwindi. Chowonadi ndi chakuti pali kuchepa kwa insulin metabolism ndi kuchepa kwa gluconeogeneis.
Momwe mungasinthire ku glargine ndi mtundu wina wa insulin
Ngati munthu wodwala matenda ashuga agwiritsa ntchito mankhwala osokoneza bongo a ultrashort insulin kapena mankhwala okhala ndi nthawi yayitali komanso yayitali kuchitira chithandizo, panthawi yosintha kupita ku Lantus, kusintha kwa mankhwalawa ndikuwunikanso njira yayikulu yochiritsira ndiyofunikira.
Kuchepetsa chiopsezo cha hypoglycemia m'mawa kapena usiku pakusintha kuchokera jakisoni wachiwiri wa insulin kulowa jakisoni imodzi, m'masiku makumi awiri oyamba, mankhwalawa amachepetsa ndi 20-30 peresenti. Nthawi yomweyo, Mlingo wa mahomoni womwe umayambitsidwa panthawi yakudya umangokulira. Pambuyo masiku 14-20, kusintha kwa mlingo kumachitika aliyense payekhapayekha.
Ngati wodwala matenda ashuga ali ndi mankhwala a insulin yaumunthu, ndikofunikira kuwerenganso kuchuluka kwa mankhwalawa.
Kuphatikiza kusintha kwa mlingo, ngati munthu asintha moyo wake, achepetsa thupi, amayamba kuchita zolimbitsa thupi.
Momwe mungachepetse shuga wa insulin
Mankhwala Lantus amalowetsedwa mthupi kokha mothandizidwa ndi chida chapadera - cholembera cholembera KlikSTAR kapena OptiPen Pro1. Musanapange jekeseni, muyenera kudziwa malangizo omwe angagwiritse ntchito cholembera ndikutsatira malangizo onse.
Pakasweka, chigwacho chimayenera kutayidwa. Kapenanso, amaloledwa kupereka mankhwalawo kuchokera ku cartridge pogwiritsa ntchito syringe ya insulin, yomwe kukula kwake ndi 100 mayunitsi 1 ml.
Pamaso jakisoni, katemera wa insulin ayenera kukhala kutentha kwambiri kwa maola angapo. Ndikofunikira kuyang'anitsitsa botolo lirilonse kuti mutsimikizire kuti kulibe, mawonekedwe, mawonekedwe ndi mawonekedwe a yankho sayenera kusintha.
Mbale zotumphukira zimachotsedwa mu katiriji malinga ndi buku lothandizidwa. Kudzaziratu ma cartridge ndi mahomoni ndizoletsedwa. Kuti mupewe mwangozi mankhwala ena, muyenera kuwonetsetsa kuti ndi katangale uti amene amagwiritsidwa ntchito, pamenepa, botolo lililonse limayendera nthawi yomweyo jekeseni lisanachitike.
Kupezeka kwa zoyipa ndi contraindication
Nthawi zambiri, odwala matenda ashuga, mukamagwiritsa ntchito mahomoni Lantus osatsatira malamulo oyambira, zotsatira zosayenerera mu mawonekedwe a hypoglycemia zimawonedwa. Zofananazo zimachitika pambuyo pakupereka mankhwala ochuluka.
Kuphatikiza apo, mawonekedwe a wodwala amatha kuwonongeka, zizindikiro za retinopathy, dysgeusia, lipohypertrophy, lipoatrophy. Zomwe zimachitika chifukwa cha insulin mu mawonekedwe a edema, redness pakhungu pakhungu, urticaria, anaphylactic, bronchospasm, ndi Quincke edema ndizotheka. Chifukwa cha kuchedwa kwa ayodini m'thupi, munthu amatha kumva kupweteka kwamisempha.
Ndi pafupipafupi hypoglycemia wodwala matenda ashuga, kugwira ntchito kwamanjenje kungadodometse. Ndi kukula kwa nthawi yayitali komanso kwamphamvu kwa chizindikiro ichi, pamakhala chiopsezo chachikulu cha kufa msanga kwa wodwala.
- Pa mankhwala ndi insulin, kupanga ma antibodies ku mankhwalawa kumaonedwa. Mu ana ndi achinyamata, kupweteka kwa minofu, thupi lawo siligwirizana, komanso kupweteka m'malo a jekeseni kumawonekeranso. Pankhaniyi, kusankha molakwika mulingo wowopsa kwa akulu ndi ana.
- Hormoni imaletsedwa kutenga pamaso pa tsankho la munthu pazinthu zomwe zili mbali ya mankhwalawa. Simungagwiritsenso ntchito Lantus ya hypoglycemia. Ana amatha kumwa mankhwalawa pokhapokha atakwanitsa zaka zisanu ndi chimodzi.
- Mu diabetesic ketoacidosis, mtundu wa insulin suti. Kusamalidwa kwapadera kuyenera kuthandizidwa pochiza anthu omwe ali ndi prinifosic retinopathy komanso kuchepetsedwa kwa ziwiya zamafuta ndi mtima. Ndikofunikanso kuwunika mosamala zaumoyo wa achikulire omwe amasinthira ku insulin ya anthu omwe ali ndi mankhwala ochokera ku nyama.
Mitu ya mankhwalawa
Analogue yayikulu yamankhwala omwe amachepetsa shuga yayikulu, ndipo wopikisana momveka bwino ndi insulin Levemir ku kampani Novo Nordisk. Pafupifupi pafupifupi inshuwaransi zonse za Novo Nordisk zili ndi mitengo yambiri yothandiza.
Ndi insulin iti yomwe mungasankhe - Funso ili limayanjanitsidwa bwino ndi dokotala.
Hormon iyi, yokhala ndi ndemanga zabwino, imatha kuyamwa pang'onopang'ono kuchokera pamalo opangira jakisoni ndipo imakhala ndi zotsatira zazitali. Izi zimatheka chifukwa chakuti mankhwalawo amalowa m'magazi ndi minyewa ya cell pang'onopang'ono.
Popeza insulin iyi ilibe chiopsezo chochita, chiopsezo chokhala ndi hypoglycemia usiku chimachepetsedwa kwambiri. Jakisoni amaperekedwa katatu kapena kanayi patsiku, jakisoni m'modzi amayenera kuchitidwa pakatikati pa 1 mpaka 3 koloko m'mawa kuti athe kuwongolera zochitika zam'mawa.
Kanemayo munkhaniyi apereka zambiri za Lantus insulin.
