Malangizo ogwiritsira ntchito Glidiab MV

Chithandizo cha matenda ashuga sichingosintha m'zakudya zokha, komanso pakugwiritsa ntchito mankhwala apadera.

Ndi nthenda yachiwiri, anthu nthawi zambiri amakhala mankhwala kuti akwaniritse kuchuluka kwa glycemia. Njira imodzi yothanirana ndi Glidiab MV.

Zambiri, kapangidwe ndi mawonekedwe ake amasulidwe

Mankhwala Glidiab MV ndi amodzi mwa zotumphukira za sulfonylurea (2 mibadwo), chifukwa chake adapangidwa kuti alimbikitse maselo a beta omwe amapezeka mu kapamba.

Mankhwalawa amapangidwa m'chigawo cha Moscow ndi kampani yamankhwala Akrikhin ndipo amadziwika kuti ndi mapiritsi a hypoglycemic Diabeteson MV, opangidwa ku France. Wothandizirayo ali ndi fomu yodziwika ndi kumasulidwa kosinthidwa.

Mankhwalawa amapezeka mu mawonekedwe a mapiritsi okhala ndi kuyera kwake. Amakhala ngati ma cylinders athyathyathya. Mankhwalawa amapezeka m'matumba a 30 kapena 60 mapiritsi.

Poyerekeza ndi Diabeteson MV, yomwe ili ndi mulingo wa 0,06 g, Glidiab MV ili ndi theka logwira ntchito (0.03 g).

Zopangidwa:

• Gliclazide ndiye chinthu chachikulu;
• cellulose (microcrystalline);
• hydroxypropyl methylcellulose;
• magnesium wakuba;
• Aerosil;

Odwala ambiri amalembedwa Glidiab 80, yomwe ili ndi yogwira, osati 30 mg, koma 80 mg piritsi lililonse.

Zotsatira za pharmacological

Zigawo za Glidiab MV zimakhudza thupi motere:

• imathandizira katulutsidwe ka insulin yomwe imapangidwa mu kapamba;
• kuwonjezera kukhudzika kwa minofu ku mahomoni opangidwa;
• muchepetse nthawi kuchokera pa nthawi yomwe chakudya chizikhala chakumapeto kwa insulini;
• Mothandizidwa ndi mankhwalawa, insulin katulutsidwe amabwezeretsedwa mu gawo loyambirira poyerekeza ena sulfonylureas;
• Sinthani kukoka kwa microscircular chifukwa cha kupindika maselo a kupatsidwa zinthu zam'magazi, kubwezeretsanso kwamitsempha yama khoma ndi chiwopsezo chochepa cha micothrombosis;
• kuchepetsa glycemia;
• amathandizira kuthetsa protenuria;
• chepetsani kukula kwa retinopathy;
• zimathandizira kuchepetsa thupi, malinga ndi zakudya zoyenera.

Pharmacokinetics

Njira ya mayamwidwe, kugawa thupi, kagayidwe kachakudya ndi kupukusira kwa zinthu zimachitika motere:

1. Zogulitsa. Mankhwalawa ali pafupifupi odziwikiratu kudzera m'mimba, (m'mimba). Kuchuluka kwake kumachulukanso plasma pang'onopang'ono, mpaka kufika pazomwe zimayambira pambuyo pa maola 6 kapena 12. Zakudya zazing'ono sizimakhudza kuchuluka kwa mayamwidwe. Mankhwalawa ndi othandizira kwa maola 24.
2. Kugawa. Kuyankhulana ndi mapuloteni a plasma ndi zigawo za mankhwala amakhazikitsidwa pa 95%.
3. Kupenda. Izi zimachitika m'chiwindi, zomwe zimadziwika ndi mapangidwe ofananira metabolites.
4. Kuswana. Excretion imachitika kudzera mu impso mu mawonekedwe a metabolites, ndi 1% yokha ya mankhwala omwe amatuluka ndi mkodzo. Kutha kwa theka la moyo wa mankhwalawa kumachitika maola 16.

Mapulogalamu a pharmacokinetic a mankhwala mwa odwala okalamba sasintha.

Zizindikiro ndi contraindication

Mapiritsi a Glidiab MV ndi mankhwala a hypoglycemic, chifukwa chake amagwiritsidwa ntchito pochiza matenda amtundu wa 2, pamene njira zina zochepetsera glucose sizinabwezeretse chizindikirocho.

Zotsatira zoyenera kumwa mankhwalawa ndi:

• ketoacidosis;
• kuphwanya impso ntchito;
• Mtundu woyamba wa shuga;
• chikomokere (diabetes kapena hyperosmolar);
• magwiridwe;
• kuvulala
• matumbo kutsekereza;
• mimba
• zinthu zoyambitsa hypoglycemia (mwachitsanzo, matenda opatsirana);
• leukopenia;
• kuwotcha kwakukulu;
• Hypersensitivity kwa zinthu mu mankhwala;
• yoyamwitsa.

Malangizo ogwiritsira ntchito ndi malangizo apadera

Mlingo wa mankhwalawa umatengera mawonekedwe a shuga komanso mawonekedwe ake, chifukwa chake amasankhidwa ndi dokotala aliyense payekha kwa wodwala aliyense.

Kumayambiriro kwa kumwa mankhwalawa, mufunika 30% kapena piritsi limodzi. Kutengera mtundu wa wodwala panthawi ya mankhwala, kuchuluka kwa zinthu zogwira ntchito patsiku kungathe kuwonjezeka mpaka 120 mg (mlingo waukulu).

Mapiritsi amatengedwa pakamwa pa kadzutsa (kamodzi patsiku). Kuchepa kwambiri kwa impso (ndi creatinine kuyambira 15 mpaka 80 ml / mphindi) sikutanthauza kusintha kwa mlingo.

Kumayambiriro kwa mankhwala osokoneza bongo mpaka mlingo woyenera utasankhidwa, odwala omwe ali ndi vuto la hypoglycemia sayenera kugwira ntchito yofunika kuyankha mwachangu kapena chidwi chochulukirapo.

Azimayi sangathe kugwiritsa ntchito mankhwalawa panthawi yakubala, komanso poyamwitsa.

Kuwonongeka kwakukulu kwa impso kapena chiwindi kumaletsa kugwiritsa ntchito mankhwalawo ngakhale muyezo waukulu.

Malamulo Akugwiritsa:

1. Chofunikira kuti mukwaniritse zotsatira za ntchito ndikutsatira zakudya komanso masewera olimbitsa thupi. Pazakudya za tsiku ndi tsiku, chakudya chopatsa mphamvu chimayenera kupezeka mokwanira.
2. Ndikofunikira kuti glycemia imayang'aniridwa isanachitike komanso itatha chakudya, kuti mankhwalawa asinthidwe kutengera zotsatira za muyeso.
3. Pochita opaleshoni kapena matenda a shuga, mankhwalawo amayenera kulowedwa ndi jakisoni wa insulin.
4. Pofuna kupewa kuwonongeka kwa hypoglycemia, komanso kusachita monga disulfiram, musamwe mowa.
5. Sizoletsedwa kudumphira chakudya, osayang'anira zokhwasula-khwasula panthawi yachinyamata.
6. Pamaso ntchito zolimbitsa thupi, mlingo uyenera kuchepetsedwa.

Mankhwala omwe amadziwika kwambiri ndi mankhwala a hypoglycemic ndi awa:

• anthu okalamba;
• odwala omwe sangathe kudya mokwanira;
• anthu okhala ndi thupi lofooka;
• odwala omwe ali ndi matenda monga pituitary-adrenal insufficiency.

Zotsatira zoyipa ndi bongo

Kumwa mapiritsi kumatha kuyambitsa zotsatirazi mwa munthu:

• mokhudzana ndi endocrine dongosolo - hypoglycemia yokhala ndi mawonekedwe am'mutu, thukuta, kufooka, kukhumudwa, kunjenjemera, kugontha kwa chikumbumtima, kusawona bwino ndi kugwirizanitsa;
• kuchokera kugawo lakudya - dyspepsia, anorexia, kusokonezeka kwa chiwindi;
• leukopenia, thrombocytopenia, kuchepa magazi;
• mawonetseredwe a thupi lawo lonse (kuyabwa, zidzolo, kapena urticaria).

Ndi mankhwala osokoneza bongo ambiri, hypoglycemia imachitika. Kuti muchepetse chizindikiro chake, ndikokwanira kudya chakudya chamagulu angapo, ngati munthuyo akudziwa. Nthawi yomwe wodwalayo sangathenso kudya yekha, amayenera kupatsidwa shuga wambiri (40%) ndi jakisoni wambiri wa glucagon. Pambuyo pobwerera kwa munthu wodwala matenda ashuga, mumafunikira chakudya china kuti musatseguke pafupipafupi shuga.

Kuchita ndi mankhwala ena ndi analogi

Kugwiritsa ntchito mankhwala ena molumikizana ndi Glidiab MV kungalimbikitse kapena kuchepetsa mphamvu ya hypoglycemic.

Mankhwala osakanikirana ndi mankhwala monga:

• ACE zoletsa;
• othandizira antifungal (fluconazole);
• NSAIDs;
• antihistamines;
• Fizates;
• anti-tuberculosis mankhwala;
• Salicylates;
• Pentoxifylline;
• Ethanoli;
• mankhwala omwe amatchinga katulutsidwe ka tubular.

Mphamvu ya hypoglycemic imaphatikizidwa akaphatikizidwa ndi mankhwala otsatirawa:

• barbiturates;
• thiazide okodzetsa;
• Furosemide;
• mahomoni kuti azisamalira ntchito ya chithokomiro;
• kukonzekera kwa lithiamu;
• estrogens;
• njira zakulera pakamwa.

Mwa mankhwala omwe ali ndi vuto lofanana ndi mapiritsi a Glidiab MV, zotsatirazi nthawi zambiri zimalembedwa:

• Meglimide;
• Guwa
• Glibetic;
• Clay;
• Glimepiride;
• Eglim;
• Glairie
• Glibenclamide;
• Ziphuphu.