Trazhenta ndi mankhwala a hypoglycemic omwe amalimbikitsidwa kuti agwiritsidwe ntchito mkati. Choguliracho chimapangidwa ngati mawonekedwe ozungulira, mapiritsi ofiira owala okhala ndi mbali zam'mphepete ndi zopindika. Kumbali ina ya piritsi ndi logo ya kampani, ndipo inayo, siginecha ya D5.
Chofunikira chachikulu cha mankhwalawa ndi 5 mg ya linagliptin, zida zothandizira za mankhwalawa ndi wowuma wa chimanga, mannitol, magnesium stearate, Copovidone, pregelatinized starch. Mutha kugula mankhwalawa m'matumba a aluminium mapiritsi 7 lililonse.
Mankhwala tikulimbikitsidwa kuti agwiritsidwe ntchito ndi mtundu wachiwiri wa matenda ashuga, chida ichi chidzakhala chimodzi chothandiza kwambiri ngati, motsutsana ndi zochitika zolimbitsa thupi zolimbitsa thupi komanso kudya, sizingatheke kuti shuga asadwale kwambiri.
Mankhwalawa amayenera kufotokozedwa ngati wodwala matenda ashuga ali ndi mbiri yolephera Impso, Metformin akupatsirana kapena munthu salola mankhwalawa. Zowoneka bwino zitha kugwiritsidwa ntchito limodzi ndi:
- zotumphukira sulfonylurea;
- Thiazolidine;
- Metformin.
Komanso, mankhwala amafunikira ngati chithandizo ndi mankhwalawa sichikulitsa thanzi la wodwalayo.
Trazenta, mtengo wa mapiritsi 30 a 5 mg uzikhala ma ruble 1,500, mutha kuwugula m'mayendedwe apamtunda ndi pa intaneti. Mankhwalawa adalowa mu radar (regista yamankhwala). Mndandanda wa mankhwalawa: Nesina, Onglisa, Yanuviya, Galvus, Komboglisa, analogues otsika mtengo pakadali pano.
Malangizo ogwiritsira ntchito mankhwalawa
Malangizowo akuwonetsa kuti mankhwalawa sayenera kuthandizidwa panthawi yoyembekezera, mtundu wa matenda ashuga 1, nthawi yoyamwitsa, ana osakwana zaka 18, ndi zomwe zimachitika chifukwa cha zinthu zina za mankhwala, ketoacidosis yoyambitsidwa ndi matenda a shuga.
Mlingo wokhazikika wodwala wamkulu ndi 5 mg, muyenera kumwa mankhwala katatu patsiku. Mankhwalawa akamwedwa ndi Metformin, mlingo wake umasinthidwa. Mankhwala kwa odwala mkhutu aimpso ntchito sikufuna kusintha.
Panthawi yophunzira za pharmacokinetics, zidapezeka kuti ndi zovuta za chiwindi ndizotheka kusintha kuchuluka kwa mankhwalawa, komabe, pakadali pano, palibe chidziwitso chokwanira ndi kugwiritsa ntchito mankhwalawa odwala matenda ashuga.
Palibe chifukwa chosinthira mlingo wa odwala okalamba, koma:
- komabe, sikulimbikitsidwa kwa odwala omwe ali ndi zaka zopitilira 80 kuti amwe mankhwalawo, popeza palibe chochitika chachipatala;
- chifukwa sichimakukhazikitsa momwe mankhwalawo aliri otetezeka kwa ana ndi achinyamata
Wodwala matenda ashuga akatenga mankhwala a Trazent pafupipafupi komanso mwangozi akumanidwa ndi mlingo, ndikofunikira kumwa piritsi lotsatira posachedwa, koma mlingo wake sungawonjezeke. Mankhwalawa amatengedwa nthawi iliyonse, mosasamala chakudya.
Chithandizo chitha kuchitika malinga ndi njira zosiyanasiyana. Mapiritsi amagwiritsidwa ntchito ngati monotherapy kwa odwala matenda ashuga omwe ali ndi vuto losakwanira la glycemic motsutsana ndi maziko olimbitsa thupi odwala matenda ashuga, zolimbitsa thupi, ngati munthu salola Metformin, mankhwala omwewo.
Mankhwalawa atenga magawo awiri a mankhwala a Metformin, thiazolidatediones, sulfonylurea kuchokera pakadalibe zotsatira za monotherapy yotchedwa mankhwala, kusakwanira kwa zochitika zolimbitsa thupi komanso kudya.
Mankhwalawa amagwiritsidwa ntchito ngati mankhwala ophatikiza atatu ndi zina zomwe zimachokera ku Metformin. Dokotala amafotokozeranso mankhwala limodzi:
- jakisoni wa insulin;
- Pioglitazone;
- zochokera sulfonylurea.
Mukatha kugwiritsa ntchito 5 mg ya mankhwala mkati, zinthu zomwe zimayamba kugwira ntchito zimayamba kuyamwa, mpaka zimafika pozama pambuyo pa maola 1.5. Ndendeyi idzachepa malinga ndi gawo la magawo atatu, nthawi yotsika ndi theka imakhala yoposa maola 100, omwe amayamba chifukwa cha linagliptin, yokhazikika.
Kuthandiza kwa theka la moyo kuchokera ku thupi pambuyo pakupereka mankhwala mobwerezabwereza kumakhala maola 12.
Pakangogwiritsidwa ntchito kamodzi pa mankhwalawa, kukhazikika kwa thunthu kumawonedwa pambuyo pa gawo lachitatu.
Milandu yama bongo osokoneza bongo, kusintha kosiyana kwa thupi
Zambiri zakufufuza zamankhwala zikuwonetsa kuti kugwiritsa ntchito kamodzi kwa 600 mg ya mankhwalawa sikuyambitsa zizindikiro zowonjezera ndipo sikuvulaza thanzi la odwala matenda ashuga. Palibe chidziwitso cha milandu ya bongo. Komabe, pofuna kuteteza, mukamagwiritsa ntchito mankhwala ochulukirapo, ndikofunikira kuchotsa m'mimba pang'onopang'ono kapena kusanza.
Onetsetsani kuti mukumane ndi dokotala kapena kuyimbira gulu la ambulansi. Mwina pali kuphwanya kulikonse kwa thanzi, ndikofunikira kupereka mankhwala okwanira.
China chake ndikusintha koyipa kwa thupi, kuchuluka kwa izi zimachitika ndikofanana ndi kuchuluka kwa zotsatira zoyipa chifukwa chotenga placebo. Chifukwa chake, wodwalayo angayambe: njira yotupa mu kapamba, kutsokomola, nasopharyngitis, chidwi cha zinthu zina, hypertriglyceridemia.
Muyenera kudziwa kuti yogwira mankhwala ingayambitse chizungulire, chifukwa chake:
- ndibwino kukana kuyendetsa poyendetsa zinthu ndi zina;
- Pewani kuchita masewera olimbitsa thupi mopitirira malire.
Zotsatira zoyipa zomwe zimatchulidwazi zimachitika nthawi ya mankhwala a Trazent komanso zotumphukira za sulfonylurea ndi Metformin.
Mankhwalawa akaphatikizidwa ndi mankhwala a linagliptin kapena pioglitazone, odwala matenda ashuga nthawi zambiri amawonjezera kulemera, kapamba, hypersensitivity ya chitetezo chathupi.
Malangizo apadera
Mankhwalawa sanatchulidwe kwa amayi apakati, momwe zimayambira m'thupi la munthu wamkazi pakadabereka mwana sizinaphunzire mpaka pano. Komabe, mayesero azachipatala mwa nyama sizinawonetse vuto lililonse pakubereka. Kuyesa pa kuthekera kwa kubereka kwa amayi sikunachitike, kuyesa kwa nyama sikunawonetse zotsatira zoyipa.
Zambiri zomwe zidapezedwa pa maphunziro a pharmacodynamic pazinyama zimawonetsa kulowetsedwa kwa mankhwalawa mkaka wa m'mawere. Pazifukwa izi, momwe mankhwalawo amathandizira mwana sikuchotsedwa. Nthawi zina, madokotala amaumiriza kukomoka kwa mkaka mwa mayi, ngati pakufunika kuti amuwonetsere Trazhenta weniweni.
Malangizo a Trazenta ogwiritsira ntchito akuwonetsa kuti ndikofunikira kusunga mankhwalawo pa kutentha kosaposa 25 digiri pamalo amdima, kutali ndi ana. Moyo wa alumali ndi zaka 2,5.
Endocrinologists samapereka mankhwala kwa odwala:
- ndi matenda a shuga 1
- ndi matenda ashuga ketoacidosis.
Anthu omwe ali ndi matenda ashuga amatha kukhala ndi hypoglycemia, chifukwa chake chimatha kuphatikizidwa ndi chithandizo chogwirizana ndi sulfonylureas.
Palibe deta pakukhudzana ndi mankhwalawa ndi insulin; odwala omwe amalephera kupweteka aimpso amathandizidwa kulandira chithandizo pamodzi ndi mankhwala ena kuti achulukitse matenda a glycemia. Ndemanga za Trazenta nthawi zonse zimakhala zabwino.
Mukagwiritsidwa ntchito molumikizana ndi mankhwalawa, Ritonavir imakulitsa linagliptin pafupi ndi katatu, kutsanulira kosasunthika (nthawi zambiri 1% ya mankhwala othandizira), ndipo ichulukitsa ka 5 pambuyo pakuphatikizidwa kwa mankhwalawa. Kusintha kotereku mu pharmacokinetics sikuti kumawoneka kuti ndi kwamankhwala kwakukulu, chifukwa cha ichi, kulumikizana kwakukulu ndi zoletsa zina sikuyembekezeredwa, mulingo woyeserera sawunikiranso.
Pochiza ndi Rifampicin, pali kuchepa kwama pharmacokinetics a mankhwalawa onse kuchokera pa 39 mpaka 43%, kuchepa kwa ntchito zoyipa zapakati pa 30%. Mphamvu ya chithandizo imasungidwa, koma sizichitika mokwanira.
Pogwiritsa ntchito Trazhenty ndi Digoxin, kukhudzana sizimachitika, ngakhale kuphatikiza kumene kumagwiritsidwa ntchito:
- mobwerezabwereza;
- Mlingo wosiyanasiyana.
Mobwerezabwereza kugwiritsa ntchito mankhwalawa mlingo wa 5 mg / tsiku sangathe kusintha pharmacokinetics ya Warfarin. Ngati Simvastatin ndi kuchuluka kwa linagliptin kumagwiritsidwa ntchito mobwerezabwereza, zotsatira za pharmacokinetics za mankhwala oyamba zimachitika. Izi ndizabwinobwino; kusintha masinthidwe ofunikira sikofunikira. Pambuyo mankhwala okhazikika ndi Trazenta kuchuluka ndi Simvastatin 40 mg, ntchito yotsiriza inakula ndi 34%, m'magazi ndi 10%.
Munthu wodwala matenda ashuga amtundu wachiwiri atenga njira zakulera pakamwa pa maziko a chithandizo cha Trezhenta, palibe kusintha kosasunthika komanso kwakukulu mu pharmacokinetics yamankhwala otere.
Ndemanga zowoneka
Ma Dhib-4 inhibitors (mankhwalawa ndi a gulu lino) samadziwika ndi mphamvu yochepetsera shuga, komanso chiwopsezo chowonjezeka, popeza sizingayambitse kukwera kwa thupi la odwala matenda ashuga komanso a hypoglycemic. Mankhwala a gululi amawonedwa kuti ndi othandiza komanso odalirika kwambiri pa chithandizo cha matenda amtundu wa 2 ana ndi akulu.
Kuchita bwino kwa mankhwalawa kumatsimikiziridwa ndi maphunziro ambiri asayansi, ndikofunikira kuyambitsa maphunziro othandizira kuphatikiza ndi mankhwala ena. Pamaso pa chiwopsezo cha kusiyana kwa shuga ndende ndikuchepa kwake, m'malo mwa sulfonylureas akuwonetsedwa.
Nthawi zina zimakhala zomveka kugwiritsa ntchito mankhwalawa ngati njira yoperekera monotherapy ndi kukana kwa thupi ku insulini ya mahomoni komanso kunenepa kwambiri. Patatha miyezi itatu yakuthandizira, kuchepa kwakukulu kwa zolemetsa kumadziwika.
Chiwerengero chachikulu cha ndemanga chinalandiridwa kuchokera kwa odwala matenda ashuga omwe amagwiritsa ntchito 5 mg ya mankhwalawa ngati gawo la zovuta mankhwala. Poganizira izi, ndikovuta kuti kumuwunika moyenera Trazhent ndi iye:
- kugwira ntchito;
- chitetezo.
Komabe, pafupifupi odwala onse akutsimikiza kuti ndi mankhwalawa omwe adawathandiza kuti achepetse thupi.
Ngakhale zoletsa zina pa Trazent zimagwiritsidwa ntchito, zimaperekedwa kwa odwala matenda ashuga amtundu wachiwiri uliwonse, kuphatikiza okalamba, omwe akuvutika ndi matenda a impso, chiwindi, mtima. Zotsatira zoyipa kwambiri za mankhwalawa ndi nasopharyngitis.
Zambiri pazomwe DPP-4 inhibitors yaperekedwa kanema munkhaniyi.
