Carbamazepine Retard imagwiritsidwa ntchito kuchepetsa mphamvu komanso kupewa kuyambika kwa zizindikiro za khunyu. Mankhwala amagwira ntchito ngati agwidwa. Kukula kwa kugwiritsa ntchito kwake ndi kwakukulu, koma pali zotsutsana zingapo, motero simungagwiritse ntchito chida chanu mwakufuna kwanu.
Dzinalo Losayenerana
Carbamazepine
Carbamazepine Retard imagwiritsidwa ntchito kuchepetsa mphamvu komanso kupewa kuyambika kwa zizindikiro za khunyu.
ATX
N03AF01
Kutulutsa mafomu ndi kapangidwe kake
Mutha kugula mankhwala pamapiritsi. Mu 1 pc 200 kapena 400 mg ya chinthu chogwira ntchito akhoza kukhala nacho, chomwe ndi pawiri wa dzina lomwelo (carbamazepine). Kuphatikizikako kumaphatikizanso zinthu zomwe sizikuwonetsa ntchito za antiepileptic, chifukwa cha iwo amapeza kusasinthika kwa mankhwala:
- ma cellcose a microcrystalline;
- magnesium wakuba;
- silicon dioxide colloidal;
- carbomer;
- sodium carboxymethyl wowuma.
Mankhwalawa amapezeka m'matumba a mapiritsi 10 ndi 50. Bokosi lamatoni lili ndi matuza (1 kapena 5 ma PC). Kuphatikiza apo, mapiritsi amatha kupezeka mumtsuko. Kusiyanitsa kwakukulu pakati pa Carbamazepine Retard ndi analogues ndikuthekera kwachinthu chogwira ntchito kuti chimasulidwe kwakutali, chomwe chimathandizidwa ndi kupezeka kwa chipolopolo chapadera.
Piritsi limodzi limatha kukhala ndi 200 kapena 400 mg ya zomwe zimagwira, zomwe ndi gulu lodziwika bwino la carbamazepine.
Zotsatira za pharmacological
Mankhwala ndi a anticonvulsants. Amagwiritsidwa ntchito antiepileptic mankhwala ndi matenda ena limodzi ndi khunyu. Kuphatikiza apo, carbamazepine amawonetsa zina:
- zolimbitsa bwino;
- antipsychotic;
- Normotymic;
- timoleptic.
Kuchepetsa mphamvu ya mankhwalawa kumachitika chifukwa cha kuthekera kwake kuletsa ntchito zamayendedwe a sodium ma cell amitsempha, omwe amadziwika ndi ntchito yowonjezereka. Kuphatikiza apo, pali kuponderezana kwa glutamate, aspartate. Ma amino acid awa ali ndi mwayi wosangalatsa. Chifukwa cha carbamazepine, kuchuluka kwa kulumikizana ndi adenosine receptors kumachepa. Izi zimathandizira kuponderezana ndi ntchito ya norepinephrine ndi dopamine, potero kumachotsa mawonekedwe a manic.
Mankhwala amagwira ntchito makamaka pothandiza ana, komanso odwala muunyamata, pakakhala njira yodziwika bwino ndi chikhalidwe chamaganizidwe: ukali, kusakwiya, kukhumudwa, ndi nkhawa zopanda pake zimathetsedwa. Carbamazepine amathandizira pakuwukira kokwanira komanso kowoneka bwino. Tithokoze iye, mkhalidwewo umafanana ndi kuphwanya kwamitsempha yamaubongo. Potere, kuchuluka kwa zowawa kumachepa.
Mankhwala amagwira ntchito makamaka mankhwalawa ana, pomwe chikhalidwe cha anthu ndi chikhalidwe chamalingaliro ndikofunikira.
Ndi chithandizo cha zizindikiro zochotsa mowa, mawonetseredwe amachepera. Kuchulukitsa kudutsa, kuchuluka kwambiri, kuyamwa kumayambiranso. Carbamazepine imagwiritsidwa ntchito ngati chothandizira pakhungu la kupuma, schizoaffective psychosis.
Pharmacokinetics
Mankhwala amadziwika ndi kuchepa kochepa, motero zotsatira zabwino sizikupezeka mwachangu. Carbamazepine imalowa kwathunthu. Zakudya zomwe zimadyedwa sizikhudzana ndi kuchuluka kwa zoperewera.
Mlingo wambiri wa zomwe zimagwiritsidwa ntchito m'magazi am'magazi umafikiridwa pakati pa maola 12 mpaka 24 mutatha kumwa koyamba kwa mankhwala.
Mgwirizano wa zinthu zokhala mu plasma umakhala pambuyo pa masiku 7-14. Kuthamanga kwa njirayi kumadalira zinthu zingapo zamkati, makamaka chiwindi ndi kufunika kwa mankhwala ena. Kuthekera kwa mankhwalawa kumangiriza m'mapuloteni a magazi ndizosiyana. Mthupi la ana, chizindikiro ichi sichidutsa 59%, mwa achikulire chimafika 80%.
Carbamazepine amasinthika m'chiwindi. Pankhaniyi, ma metabolites angapo amasulidwa. Ndondomekozi zimapitilira ndi kutenga nawo ma cytochrome P450 enzyme, komanso UGT2B7 isoenzymes. Kutalika kwa nthawi yomwe kuchepa kwa ntchito yogwira ntchito kumadalira kuchuluka kwa mankhwalawa, kuchuluka kwa kayendetsedwe kake ndipo ndi maola 16-36. Amadziwika kuti kugwiritsa ntchito mankhwalawa pafupipafupi, kuchuluka kwa kuchotsedwa kwa carbamazepine ndi metabolites kumawonjezeka.
Kodi chimathandiza ndi chiyani?
Mankhwala tikulimbikitsidwa kuti ntchito zotumphukira zinthu:
- chachikulu cha chithandizo - khunyu, khunyu, limodzi ndi kupweteka: ambiri, kwanuko, osakaniza mawonekedwe;
- neuralgia ya glossopharyngeal, mphamvu ya nkhope yamafupa atatu, kuphatikizapo momwezi zotupa, koma kukulira motsutsana ndi maziko a chifuwa chachikulu;
- matenda a hangover;
- neuropathy (yemwe ali ndi matenda a shuga);
- kusokonezeka kwamalingaliro osiyanasiyana, zizindikiro zomwe zimachitika pafupipafupi zomwe ndizisonyezo zakugwiritsa ntchito mankhwalawa motere: nkhawa, kupsa mtima, kuvutika maganizo, kusokonezeka kwa tulo;
- neuralgia ya magawo osiyanasiyana, kuphatikiza matenda omwe adakumana ndi maziko ovulala.
Contraindication
Chipangizocho choletsedwa kutenga milandu ingapo:
- zoipa za munthu pazinthu zilizonse zomwe zimapangidwa ndi mankhwala omwe amafunsidwa ndi antidepressants a gulu lachitatu;
- kusokonezeka kwa hematopoietic dongosolo, mwachitsanzo, leukopenia, kuchepa kwa hemoglobin;
- atrioventricular block;
- kuphwanya pigment metabolism (hepatic porphyria), yomwe imayendera limodzi ndi khungu;
- mowa.
Zofooka zingapo zimadziwika mukamagwiritsa ntchito Carbamazepine retard:
- kusakwanira kwa mtima ntchito (gawo lophatikizika);
- kuphwanya adrenal kotekisi;
- matenda a m'magazi oyambitsidwa ndi kuchepa kwa chiwindi ndi impso;
- kuchuluka kwa ziwalo zamasomphenya;
- kukula kwambiri kwa minofu ya prostate;
- kuchepa kwa kuchuluka kwa sodium mthupi, chifukwa cha zotsatira zoyipa zomwe zimachitika munthawi ya njira za sodium.
Mosamala, Carbamazepine Retard imagwiritsidwa ntchito ndikuwonjezeka kwa ziwalo zamasomphenya.
Momwe mungatengere Carbamazepine Retard?
Njira zochizira zimasiyanasiyana kutengera mtundu wamatenda, zaka za wodwalayo, kupezeka kwa zovuta zina mthupi. Zomwe Mungasankhe:
- khunyu: akulu akulimbikitsidwa kuti ayambe maphunzirowa, kutenga 100-200 mg ya thunthu 1 kapena 2 pa tsiku, mlingo umakulirakulira, simuyenera kupitirira malire a kuchuluka kwa tsiku lililonse - 1200 mg (wogawidwa mu 2 waukulu);
- trigeminal neuralgia: mankhwalawa amayamba ndi 200-400 mg patsiku, pang'onopang'ono, mankhwalawa amawonjezeka kawiri, mankhwalawa amayenera kutengedwa mpaka zizindikiro za matenda atathetsedwa;
- kupweteka komwe kumachitika chifukwa cha kusagwira ntchito kwamanjenje: 100 mg kawiri pa tsiku, mlingo uwu umakulanso ndi mankhwala, kusunga kuchuluka kwa carbamazepine patsiku - osaposa 1200 mg (wogawidwa mu 2 waukulu);
- pathological chifukwa chakumwa poizoni: 200 mg katatu patsiku, ngati mavuto akayamba, tikulimbikitsidwa kumwa pawiri - 400 mg katatu patsiku;
- popewa kukhudzika kwamalingaliro okhudzana: 600 mg osapitirira kanayi pa tsiku, pafupipafupi kumwa mankhwalawa amatsimikiza payekhapayekha;
- Chithandizo cha kupuma ndi kusokonezeka kwamankhwala chimachitika ndi njira ya mankhwala pazomwe zimayambira 400 mpaka 1600 mg patsiku, kuchuluka kwake ndikulimbikitsidwa kuti mugawidwe ma Mlingo angapo.
Chithandizo cha ana omwe ali ndi khunyu:
- wazaka 4 mpaka 10: Njira ya mankhwala imayamba ndi 200 mg patsiku, pang'onopang'ono kuchuluka kwake, Mlingo wokonza umakhala wokulirapo (400-600 mg 2 kawiri pa tsiku);
- zaka kuyambira zaka 11 mpaka 15: 200 mg patsiku (makamaka madzulo), ndiye m'mawa ndikulimbikitsidwa kutenga 200-400 mg, madzulo - 400-600 mg;
- Odwala kuyambira azaka 15 akuwonetsedwa kuti ndi wamkulu mankhwala.
Zaka za mwana kuyambira zaka 4 mpaka 10: njira ya mankhwala omwe amakhalanso ndi carbamazepine Retard imayamba ndi 200 mg patsiku.
Asanadye kapena pambuyo chakudya?
Kudya sikumakhudza mphamvu za mankhwalawa, kotero mapiritsi amatha kumwedwa ndi chakudya.
Kutenga nthawi yayitali bwanji?
Kutalika kwa nthawi ya maphunzirowa kumatsimikiziridwa munjira iliyonse payokha, chifukwa njira zochiritsira zimasinthidwa molingana ndi momwe thupi liliri.
Kumwa mankhwala a shuga
Kwa odwala a gululi, mankhwalawa amadziwitsidwa muyezo wa 200 mg kangapo patsiku.
Pafupipafupi makonzedwe zimatengera mtundu wa matenda.
Chifukwa chake, ngati mankhwala a polyneuropathy amafunikira motsutsana ndi matenda a shuga, mankhwalawa amatengedwa 2-4 patsiku. Chithandizo cha matenda a pathological omwe adayamba chifukwa cha matenda a shuga a insipidus amachitika malinga ndi zomwe zimaphatikizapo kumwa mapiritsi osapitilira katatu patsiku.
Kwa odwala matenda a shuga, mankhwalawa amadziwitsidwa muyezo wa 200 mg kangapo patsiku.
Zotsatira zoyipa za carbamazepine
Pa mankhwala, pamakhala kuthekera kwakukulu kovutikira komwe kumachitika chifukwa cha mankhwalawa. Komanso, zoyipa zimawonekera ndi ziwalo zosiyanasiyana.
Matumbo
Kumverera kwa nseru, kuyanika kuchokera mucous nembanemba, kusintha kapangidwe ka ndowe, stomatitis, matenda a m'matumbo otupa kuchokera kumimba (pancreatitis, etc.).
Hematopoietic ziwalo
Matenda angapo omwe amaphatikizidwa ndikusintha kwa kapangidwe kake ndi magazi, mwachitsanzo, leukopenia, thrombocytopenia, leukocytosis ndi zovuta zina ndizochepa.
Pakati mantha dongosolo
Chizungulire, kupweteka mutu, kufooka thupi, kugona, kusowa kudya, kukhumudwa, nkhawa, kuthamanga kwa chidwi, luso la magalimoto, kugwira ntchito kwa ziwalo zamasomphenya, kuyankhula, kusokoneza malo okhala.
Chimodzi mwazotsatira zoyipa za Carbamazepine Retard ndi kukhumudwa.
Kuchokera kwamikodzo
Osakwanira aimpso ntchito, yotupa njira mu zimakhala za chiwalo, kwamikodzo posungira kapena mbali ya izi - pafupipafupi pokodza. Mwa odwala amuna, kuchepa kwa potency kumadziwika.
Kuchokera ku kupuma
Thupi, kuwonetsa kwa hypersensitivity reaction, kuphwanya ntchito kupuma chifukwa cha chibayo.
Dongosolo la Endocrine
Kuchepa kwa mchere wa sodium m'thupi, edema, kunenepa kwambiri, mafupa, kuchuluka kwa mafuta a cholesterol, triglycerides, kusalingalira kwa mahomoni.
Matupi omaliza
Matenda osiyanasiyana oyambitsidwa ndi ziwengo: dermatitis, urticaria, vasculitis, edema ya edi ya Quincke, kusintha kwa anaphylactoid.
Mankhwala omwe amafunsidwa angayambitse ziwengo.
Zokhudza mphamvu pakuwongolera njira
Palibe cholakwika chilichonse kuchita zochitika zofunikira kwambiri. Komabe, ndikofunikira kusamala mukamayendetsa.
Malangizo apadera
Pa mankhwala, tikulimbikitsidwa kuti nthawi zonse muziyang'ana kuchuluka kwa yogwira magazi m'magazi a magazi.
Musanagwiritse ntchito mankhwalawa, kuyezetsa kumachitika, choyambirira, ndikofunikira kuyang'ana momwe ziwalo zamasomphenya zimachitikira.
Gwiritsani ntchito mu ukalamba
Mankhwala tikulimbikitsidwa kuti kumwedwa mosamala. Zadziwika kuti pharmacokinetics mu odwala a gululi sasiyana ndi zomwe zimachitika mwa achinyamata.
Kupatsa ana
Zochizira odwala ochepera zaka 4, kuphatikizapo akhanda, mankhwalawa sagwiritsidwa ntchito.
Zochizira zatsopano, Carbamazepine Retard sagwiritsidwa ntchito.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwala angagwiritsidwe ntchito mwa mkazi. Komabe, ndikofunikira kusamala panthawi yamankhwala. Chithandizo chikuyenera kuyang'aniridwa ndi dokotala, kuyesedwa kwa Laborator kumafunikira pafupipafupi: kapangidwe ka magazi, chiwindi ndi impso zimayesedwa. Onani zomwe zimachitika mwana wosabadwayo ali ndi pakati.
Mukamayamwitsa, kuwunika mayendedwe ofunikira a mwana amafunikira.
Mankhwala tikulimbikitsidwa kuti atenge pa nthawi yoyembekezera komanso mkaka wa m`mawere, koma pokhapokha ngati zabwino zomwe zachitika chifukwa cha mankhwala zipitilira kuvulaza. The yogwira pophika mankhwala amafunsira kuchepa kuchuluka kwa folic acid, ndipo amadziwikanso mu chiwindi ndi impso za mwana wosabadwayo. Kuphatikiza apo, carbamazepine yambiri imalowerera mkaka wa amayi. Potere, zimapangitsa kuti zinthu zosiyanasiyana zomwe zimachitika mwa mwana zisamachitike.
Mankhwala ochulukirapo a Carbamazepine retard
Ngati njira ya chithandizo ikuphwanyidwa, mavuto obwera chifukwa cha mtima, kupuma komanso mantha am'mimba amayamba.
Popeza kuti palibe mankhwala, mankhwala othandizira amachitika kuti athetse vuto la bongo, pomwe ntchito za ziwalo zofunika zimayendetsedwa.
Kuchita ndi mankhwala ena
Osavomerezeka kuphatikiza
Kukhazikitsidwa munthawi yomweyo kwa carbamazepine Retard ndi mankhwala omwe amalepheretsa CYP ZA4, komanso ma inhibitors a MAO, amathandizira kukulitsa zotsatira zoyipa zingapo.
Pali kuwonjezeka kwa kuchuluka kwa mankhwalawo pamafunso pamene mukumwa Felodipine, Dextropropoxyphene, Viloxazine, Fluoxetine, Nefazodon, ndi ena onse.
Pali kuwonjezeka kwa kuchuluka kwa mankhwalawo mukufunsira pamene mukumwa Felodipine.
Kuphatikiza komwe kumafunikira kusamala
Mankhwala angapo, ndikumatenga omwe carbamazepine amathandizira kuchepetsa ndende: Clobazam, Clonazepam, Digoxin, Ethosuximide, Primidone, Alprazolam, glucocorticosteroids, etc.
Kuyenderana ndi mowa
Sichikulimbikitsidwa kumwa zakumwa zoledzeretsa zam'kati pamankhwala omwe mukufunsidwa.
Analogi
Malonda a Carbamazepine retard:
- Finlepsin;
- Carbamazepine-Akrikhin.
Kupita kwina mankhwala
Mankhwala ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Ayi.
Kodi Carbamazepine Retard ndi ndalama zingati?
Mtengo wapakati ndi ma ruble 50.
Zosungidwa zamankhwala
Kutentha kolimbikitsidwa - osati kupitirira + 25 ° ะก.
Tsiku lotha ntchito
Mankhwalawa amasungabe katundu kwa zaka zitatu kuyambira tsiku lomwe amatulutsa.
Wopanga
CJSC Alsi Pharma, AO Akrikhin (Russia), etc.
Analogue ya Carbamazepine Retard - mankhwala Finlepsin akhoza kugulidwa kokha ndi mankhwala.
Ndemanga Carbamazepine Retard
Valentina, wazaka 38, Samara.
Mankhwalawa sagwira ntchito mwachangu monga tikufuna. Koma chifukwa cha chithandizo pamakhala kusintha kosasintha. Matendawa amawonongeka nthawi zambiri ndikayerekeza ndi nthawi yomwe ndimamwa mankhwala ena kapena sindinalandiridwe nkomwe.
Svetlana, wazaka 44, Bryansk.
Anamulembera mwanayo mankhwala. Pamene mlingo unakulirakulira, mavuto adayamba kuoneka: ziwopsezo, kutupa, kutulutsa kwamkodzo. Ndinkayenera kuthandizidwa malinga ndi zomwe zimakhudza kumwa kosalekeza kwa mankhwalawa tsiku lililonse.
