Pentilin ndi antispasmodic yokhala ndi zochitika zingapo, zomwe zili m'gulu la purines. Mitundu iwiri yomasulidwa, kuphatikizapo mapiritsi, imafunika kulandira mankhwala. Mankhwalawa akagwiritsidwa ntchito ngati prophylactic komanso achire, zotupa za m'mimba zimawonjezeka, makoma amakhala odabwitsa. Zothandiza pamitsempha yopuma. Mu kapangidwe ka fomu iliyonse pali zinthu zofunika komanso zothandiza zomwe zimathandizana. Kugwiritsa ntchito kumachitika molingana ndi malangizo. Zotsatira zoyipa zimatha kuchitika, makamaka ngati pali contraindication.
Dzinalo Losayenerana
INN ya mankhwala ndi pentoxifylline.
Pentilin ndi antispasmodic yokhala ndi zochitika zingapo, zomwe zili m'gulu la purines.
ATX
Mankhwalawa adapatsidwa nambala ya ATX yapadera - C04AD03 ndi nambala yolembetsa - Ayi RK-LS-5№004325 kuchokera pa 16.10.2101.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwala amagulitsidwa mwanjira ya mapiritsi ndi yankho la mtsempha wa magazi kapena wamkati. Kuphatikizidwa kwa mitundu yonse ya mlingo uli ndi zinthu zofunikira, zikafika m'thupi la wodwalayo, izi kapena kuti achire zimatheka. Zinthu zothandiza sizikhudzanso kukhudzana kwa mankhwalawa ndikuchita ngati okhazikika.
Mapiritsi
Fomu ya mlingo uli ndi 400 mg ya pentoxifylline. Mapiritsiwa amaphatikizidwa ndi filimu-film, yomwe ili ndi:
- titanium dioxide;
- macrogol;
- hypromellose;
- talcum ufa.
Mlingo wa Pentilin uli ndi 400 mg ya pentoxifylline.
Zinthu zothandizazi ndi monga:
- magnesium wakuba;
- anhydrous silica colloidal;
- macrogol.
White, biconvex, mapiritsi oblong amagulitsidwa m'matumba 10.
Chiwerengero cha matuza mu bokosi la makatoni - zosaposa 2 ma PC.
Kumbuyo kwa bokosi kuli chizindikiritso chofunikira. Malangizo ogwiritsira ntchito adatsekedwa mkatimu.
Njira Zothetsera
Madzimadzi amkati ndi ma infusions a intraarterial ali ndi 100 mg ya yogwira pophika.
Mafuta a Pentilin amapitilira kugulitsa ma ampoules a 5 ml.
Ndi madzi owoneka bwino, opanda utoto kapena wachikasu opanda ma tinthu akunja. Zowonjezera zina za mawonekedwe a mlingo:
- sodium dihydrogen phosphate dihydrate;
- sodium hydrogen phosphate dihydrate;
- madzi a jakisoni;
- sodium kolorayidi;
- edetate disodium.
Madziwo amamugulitsa mu ampoules 5 ml. M'katoni 5 ma ampoules ambiri omwe amayikidwa mchimake. Malangizo ogwiritsidwira ntchito ngati pepala komanso zolemba kumbuyo kwa bokosi amapezeka.
Zotsatira za pharmacological
The yogwira pophika mtundu uliwonse Mlingo amakhudza bwino mtima dongosolo, kupuma dongosolo, kubereka ndi kwamikodzo dongosolo. Kugwiritsa ntchito otolaryngology, gynecology ndi urology. Ndi kugwiritsa ntchito pafupipafupi, kufalikira kwa magazi kumathandizanso kuti magazi azisinthasintha.
The yogwira pophika mtundu uliwonse wa Pentilin amakhudza bwino mtima dongosolo.
Mfundo zoyenera kuchitira mtundu wina uliwonse wa mankhwalawa zimakhazikika pakuletsa kwa phosphodiesterase. Nthawi yomweyo, pali kuwonjezeka kwa kuchuluka kwa cyclic AMP m'mapulateleti ndi ATP m'maselo ofiira amwazi. Vasodilation imayamba chifukwa cha kuchuluka kwa mphamvu zamagetsi, zotumphukira mtima zimatsika. Ndi voliyumu yowonjezereka, kugunda kwamphamvu kumakhalabe kosasinthika.
Mphamvu ya antianginal imatheka chifukwa chakutha kwa mankhwalawa kukulitsa ziwiya zamkati, zomwe zimatsimikizira kutuluka kwa magazi omwe amadzaza ndi oksijeni kupita ku myocardium. Oxygenation yamagazi imatheka chifukwa chochulukitsa kuunika kwa mitsempha ya m'mapapo.
Ndi kugwiritsa ntchito pafupipafupi, kamvekedwe ka diaphragm ndi minofu ya dera lachiberekero limakula.
Kuchekacheka kwa magazi kumayenda bwino, ma cellular elasticity a zimimba za m'magazi ofiira amawonjezeka. Magazi amayamba kuchepa. Kuwonongeka kwa zotumphukira zam'mitsempha kungapangitse kukulira kwa kulankhulirana kwapang'onopang'ono. Mwanjira imeneyi, kugwiritsa ntchito mankhwalawa kumachotsa kupweteka komanso kukokana m'matumbo a ng'ombe, makamaka usiku.
Pharmacokinetics
Mtundu uliwonse wamasulidwa umatengedwa mwachangu mosasamala kanthu ndi njira yomwe angagwiritsire ntchito. Fomu lamapiritsi silimakwiyitsa mucous membrane wam'mimba, matumbo. The pazipita kuchuluka kwa pentoxifylline mu madzi am`magazi zitha kutsimikiza pambuyo 3-4 mawola koyamba. Kumangiriza kwa mapuloteni amwazi sikuchitika.
Piritsi la Pentilin silimakwiyitsa matumbo.
Kuchitapo kotalika kwa mawonekedwe a piritsi kumadalira pang'onopang'ono kumasulidwa kwazinthu zomwe zikugwira ndikuyamwa kwake mwachangu. Sizimachepetsa ntchito za ma enzymes a chiwindi, ngakhale kuti metabolism imachitika ndi thupi. Ma metabolabolites (carboxypropyl ndi hydroxyhexyl dimethylxanthine) amawonedwa akugwira ntchito.
Mothandizidwa ndi mtsempha wa magazi, mankhwalawa amakhala ndi gawo lochulukirapo komanso magawo ambiri. Hafu ya moyo ndi maola 1.5. Ma metabolite amasiya thupi ndi mkodzo (mpaka 95%). Gawo laling'ono (3-4%) limatulutsidwa ndi matumbo. Imatha kulowa mkaka wa m'mawere.
Zizindikiro zogwiritsidwa ntchito
Zizindikiro zazikuluzomwe zimagwiritsidwa ntchito ndi ma pathologies omwe amagwirizana ndi zovuta zamagazi. Izi zikuphatikiza:
- zovuta zamitsempha yama mtima
- pachimake, subacute komanso aakulu kufalikira kwazovuta ndi zina zowonongeka;
- ngozi yamitsempha;
- kusokoneza endarteritis;
- zotumphukira zozungulira zotumphukira zomwe zimayambitsidwa ndi matenda a shuga ndi atherosclerosis;
- angiopathy;
- Matenda a Raynaud;
- paresthesia;
- kusokonezeka kwa venous ndi ochepa magazi chifukwa cha frostbite, gangrene, trophic zilonda;
- atherosulinotic ndi dyscirculatory encephalopathy.
An antispasmodic amaloledwa kugwiritsidwa ntchito mu gynecology pa premenstrual syndrome.
Contraindication
Kugwiritsa ntchito mankhwalawa ndikosavomerezeka ngati wodwala ali ndi contraindication mogwirizana ndi malangizo. Izi zikuphatikiza:
- matenda am'mimba;
- zotupa m'mimba;
- kutaya magazi kwambiri, kuphatikizapo magazi a m'mimba;
- hemorrhagic stroke (pachimake ndi subacute);
- kwambiri arrhythmias;
- ochepa hypotension;
- myocardial infarction;
- porphyria;
- kuwonongeka kwambiri kwa mitsempha ndi mitsempha;
- nthawi yobereka mwana;
- kuyamwitsa;
- ana ndi achinyamata (mpaka zaka 18);
- Hypersensitivity.
Mankhwalawa ali ndi zotsutsana zingapo, momwe mumaloledwa kugwiritsa ntchito mosamala.
Kugwiritsa ntchito mankhwalawa ndikosavomerezeka kuti magazi azitha kutuluka m'mimba.
Ndi chisamaliro
Contraindication zokhudzana zimaphatikizapo chironda chachikulu cha m'mimba ndi duodenum. Kulephera kwa mtima, matenda a impso ndi chiwindi zimafunikanso kugwiritsidwa ntchito mosamala. Ngati wodwala ali ndi mbiri yakutuluka kwa magazi ndi matumbo a m'matumbo, makonzedwe amachitika motsogozedwa ndi katswiri.
Momwe mungatenge Pentilin
Fomu yokhala ndi mulingo woyenera kutsata pakamwa imatha kuthandizidwa pang'onopang'ono ngati mulingo wofunikira umafuna. Ndikulimbikitsidwa kuti mumwera ndi kapu ya madzi owiritsa pamoto kutentha. Achire tsiku lililonse - osapitilira 3 mapiritsi patsiku, piritsi limodzi kamodzi pakudya.
Nthawi ya ntchito imatsimikiziridwa payekhapayekha, nthawi zambiri zimakhala masabata 7-8.
Njira yothetsera vutoli imalowetsedwa mu mtsempha kapena mtsempha pogwiritsa ntchito dontho. Njira yamankhwala imatsimikiziridwa kutengera thanzi la odwala. Asanapereke kulowetsedwa, wodwalayo ayenera kugona. Palibe oposa 300 mg (3 ampoules) omwe amaperekedwa kamodzi. Kutalika kwa kulowetsedwa ndi ola limodzi, patsiku - zosaposa 2 njira.
Pentilin solution imalowetsedwa mu mtsempha kapena mtsempha pogwiritsa ntchito dontho.
Kuti mukwaniritse bwino, mutha kusintha mitundu yonseyo. Masana, wodwalayo amapatsidwa yankho, asanagone, mungatenge piritsi limodzi.
Ma antispasmodic amatha kusakanikirana ndi mayankho ena kulowetsedwa pokhapokha poyesa.
Mlingo wa kulowetsedwa (Ringer, 0,9% sodium kolorayidi) amadziwikanso aliyense payekhapayekha.
Ndi matenda ashuga
Odwala omwe ali ndi mtundu wa 2 ndi mtundu wa 3 wodwala matenda a shuga amafunika kumwa mankhwala moyang'aniridwa ndi katswiri. Kusintha kwa magazi kungafunike.
Zotsatira zoyipa za Pentilin
Odwala omwe ali ndi hypersensitive komanso ndi mankhwala osankhidwa bwino, chiwopsezo chokana kukakamizidwa ndi mankhwala chikuwonjezeka ndi thupi. Zizindikiro zoyipa zimawonedwa mbali ya ziwalo zamkati, dongosolo lamanjenje lamkati ndi khungu.
Mutatha Pentilin, kutsegula m'mimba kumatha kuchitika.
Pa mbali ya gawo la masomphenyawo
Zowonongeka, ng'ombe zimadziwika chifukwa chotsatira zoyipa.
Matumbo
Pa gawo la ziwalo zogaya chakudya, kutsegula m'mimba, xerostomia, kusowa chilakolako cha chakudya, nseru ndi kusanza zimawonedwa. Cholecystitis imatha kukulira komanso matenda a anorexia.
Hematopoietic ziwalo
Zotsatira zoyipa zochokera kuzungulira kwa dongosolo zimafotokozedwera mu mawonekedwe a pancytopenia, thrombocytopenia, leukopenia ndi magazi m'matumbo.
Pakati mantha dongosolo
Kuchokera kumbali ya chapakati mantha kumakhala chizungulire, kukhumudwa, kumva kuda nkhawa, kusowa tulo komanso migraine.
Kuchokera ku kupuma
Zotsatira zoyipa m'gululi zimaphatikizapo kupuma movutikira.
Kutenga Pentilin kungayambitse kufupika.
Pa khungu
Zotsatira zoyipa pakhungu zimawonekera mu mawonekedwe a hyperemia. Misomali yamanja ili m'manja kwambiri.
Kuchokera pamtima
Kuchokera kumbali ya mtima, wodwalayo amakhala ndi tachycardia, cardialgia ndi arrhasmia. Hypotension imayamba.
Matupi omaliza
Thupi lawo siligwirizana amawoneka mu urticaria, khungu hyperemia, kuyabwa ndi kuyaka. Nthawi zina, manenedwe a anaphylactic angayambe.
Zokhudza mphamvu pakuwongolera njira
Antispasmodic siyimakhudzanso kuthamanga kwa ma psychomotor, chifukwa kuyendetsa galimoto mukamalandira mankhwala ndikotheka.
Malangizo apadera
Pogwiritsa ntchito, ndikofunikira kuyang'anira kuthamanga kwa magazi. Odwala omwe ali ndi matenda oopsa angafunike kuchepetsa njira.
Pogwiritsa ntchito Pentilin, ndikofunikira kuyang'anira kuthamanga kwa magazi.
Kuthana ndi ukhondo paumoyo wamunthu pakukonzekera ndikofunikira, koma madzi ayenera kupewedwa pamalo operekera jakisoni.
Gwiritsani ntchito mu ukalamba
Okalamba odwala amafunikira chithandizo chamankhwala mosamala ndi kusintha kwa mankhwalawa.
Kupatsa ana
Zaka za ana zimawerengedwa kuti ndi zotsutsana kwathunthu.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Panthawi yoyamwitsa ndi kubereka mwana, ndizoletsedwa kutenga antispasmodic.
The ntchito aimpso kuwonongeka
Matenda a impso amaonedwa kuti ndi achibwenzi, kugwiritsa ntchito panthawiyi kuyenera kusamala.
Ndi pathologies a impso, mankhwalawa ayenera kugwiritsidwa ntchito mosamala.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Kuwonongeka kwa chiwindi kumafuna kasamalidwe mosamala.
Pentilin bongo
Mobwerezabwereza owonjezera achirewo kumapangitsa kukula kwa bongo. Zizindikiro zake zimaphatikizapo:
- kukomoka
- magazi m'mimba;
- kuchepa kwakukulu kwa kuthamanga kwa magazi;
- kufooka kwathunthu;
- chisokonezo cha kugona (kugona, kugona tulo);
- kutengeka mtima.
Kudandaula kuchipatala ndizovomerezeka, chithandizo chamankhwala chimayikidwa. Thandizo loyamba limakhala ndi kutsuka m'mimba mwa wodwalayo. Komanso, ayenera kupatsidwa enterosorbent iliyonse.
Kuchita ndi mankhwala ena
Ndi munthawi yomweyo makonzedwe antispasmodic ndi mankhwala amachepetsa kuthamanga kwa magazi, chiopsezo chotumphukira m'mitsempha yamagazi chimawonjezeka.
Pentilin amatha kuwonjezera ntchito ya mankhwala opha tizilombo.
Mankhwalawa amatha kuwonjezera ntchito ya maantibayotiki. Insulin ndi mankhwala ena a hypoglycemic, limodzi ndi mankhwalawa, amalimbikitsa kukula kwa hypoglycemia. Zowonjezera ndi mavitamini osiyanasiyana nthawi yomweyo monga antispasmodic zimapangitsa zotsatira zoyipa kuchokera kugaya chakudya.
Kuyenderana ndi mowa
Mankhwalawa sagwirizana ndi zakumwa zilizonse zoledzeretsa.
Analogi
Mankhwalawa ali ndi mapangidwe angapo ofanana ndi mawonekedwe ena ofanana ndi omwe amathandizanso chimodzimodzi. Ma antispasmodic omwe ali ndi dzina lofanana ndi oyambirirawo, ali ndi choyambirira "Retard" ndipo akupezeka piritsi.
Amagwiritsidwa ntchito pamavuto am'magazi, omwe ali ndi contraindication ofanana ndi chithandizo choyambirira.
Agapurin amatchulidwa kuti ndi zamagetsi. Angioprotector ndi kutchulidwa vasodilating kwenikweni. Kupezeka mu mawonekedwe a mapiritsi ndi kulowetsedwa njira. Pentoxifylline (400 kapena 600 mg) alipo. Mtengo wa analogues mu pharmacy umasiyana ndi 280-400 rubles.
Kupita kwina mankhwala
Kutulutsa kwamtundu uliwonse wa antispasmodic kumafuna mankhwala kuchokera ku pharmacies.
Kodi ndingagule popanda kulandira mankhwala?
Mankhwala sangathe kugula popanda kulandira mankhwala achi Latin.
Mtengo wa Pentilin
Mtengo wamapiritsi ndi yankho la antispasmodic muma pharmacies amasiyanasiyana kutengera ndi magawo omwe agulitsa. Mankhwalawa sanalembetsedwe m'gawo la Russian Federation.
Zosungidwa zamankhwala
Mankhwalawa amayenera kusungidwa m'makokati apamwamba a nduna kutali ndi nyama ndi ana. Malowa akhale owuma komanso ozizira.
Tsiku lotha ntchito
Kusunga kwa mtundu uliwonse wamasulidwe kuyambira nthawi yotsegula phukusi - osapitilira miyezi 60.
Analog ya Pentilin - Agapurin ikhoza kugulidwa popanda mankhwala.
Wopanga
Mankhwala oyamba amapangidwa ku Slovenia. Ma analogu apafupi kwambiri amapangidwa ku Russia.
Ndemanga za Pentilin
Ndemanga za madotolo ndi odwala za antispasmodics ndi zabwino.
Daniil Sviridov, dokotala wa opaleshoni ya mtima, Ekaterinburg
Ndimagwiritsa ntchito mankhwalawa kwa zaka zitatu. Sizovuta kupeza m'masitolo; mankhwalawo amangogulitsidwa pamisika yayikulu. Mankhwalawa ndi othandizika, kusintha kumachitika pambuyo pa milungu 3-4 ya kudya pafupipafupi. Magazi amayamba kuchepa kwambiri, makoma a ziwiya zazikulu amakhala otanuka kwambiri. Zimathandizirana ndimankhwala ambiri, pomwe sindimalimbikitsa kumwa maantibayotiki nthawi imodzi ...
Valentina, wazaka 47, Novorossiysk
Anayamba kumwa mankhwalawa miyezi isanu ndi umodzi yapitayo. Anamuchita opaleshoni yamaso, mu chipatala, njira yokhazikika idatayidwa. Nditataya ndikanafunika kumwa mapiritsi, koma mtengo wake udawoneka wokwera, kotero ndidagula analogue yotsika mtengo. Zomwe zidanong'oneza bondo nthawi yomweyo.
Mankhwala oyambawo ali bwino. Kusintha kunabwera mwachangu, ngakhale panali zovuta zina zomwe zidachoka pazokha pakatha masiku anayi.
