Lipase ndi chinthu chopangidwa ndi thupi la munthu chomwe chimalimbikitsa kupatsirana, kugaya, komanso kuwonongeka kwa lipids zosaloledwa. Pamodzi ndi bile, puloteni yamadzimadzi yosungunuka imayambira kugaya mafuta acids, mafuta, mavitamini A, D, K, E, amawasinthira kutentha ndi mphamvu.
Katunduyu akuphatikizidwa ndi kuwonongeka kwa triglycerides m'magazi, chifukwa cha njirayi, kayendedwe ka mafuta acid kupita ku maselo kumatsimikiziridwa. Zikondamoyo, matumbo, mapapu, ndi chiwindi ndizomwe zimapangitsa kuti pakhale pancreatic lipase.
Mu ana aang'ono, kupanga enzyme kumapangidwanso ndi timadzi tambiri tambiri, kutulutsa kwawo pakamwa. Chilichonse mwazinthu zokhudzana ndi pancreatic zimapangidwira kudzimbidwa kwamagulu ena amafuta. Pancreatic lipase m'magazi ndi chidziwitso cholondola cha kuyambika kwa chitukuko cha kupweteka kwa mthupi.
Ntchito ya Lipase
Ntchito yayikulu ya lipase ndikupanga mafuta, kuphwanya ndi kupatula. Kuphatikiza apo, mankhwalawo amatenga nawo gawo pakukonzekera mavitamini angapo, mafuta achilengedwe a polyunsaturated, komanso mphamvu ya metabolism.
Pancreatic lipase yopangidwa ndi kapamba imakhala chinthu chamtengo wapatali kwambiri chomwe chimapangitsa kuti mafuta azikhala ndi nthawi komanso nthawi. Imalowa m'mimba mwa njira yogwiritsira ntchito prolipase, enzyme ina; pancreatic enzyme ina, colipase ndi bile acid, imadzakhala chinthu choyambitsa ntchito.
Pancreatic lipase imaphwanyidwa ndi lipids emulsified ya hepatic bile, yomwe imathandizira kuchepa kwa mafuta osaloledwa omwe amapezeka muzinthu zamagulu azakudya mu glycerol, acid acids apamwamba. Chifukwa cha hepatic lipase, mayamwidwe a lipoproteins otsika, chylomicrons, komanso kuchuluka kwa mafuta m'madzi a m'magazi amathandizidwa.
Gastric lipase imalimbikitsa chidwi cha tributyrin, zinthu zosiyanasiyana zomwe zimagwiritsidwa ntchito zimaphwanya lipids zopezeka mkaka wa m'mawere.
Pali njira zina zomwe zimakhala ndi lipase mthupi, kwa abambo ndi amayi akuluakulu, chiwerengero 0-190 IU / ml chizikhala chizindikiro, kwa ana osakwana zaka 17 - 0-130 IU / ml.
Pancreatic lipase iyenera kukhala ndi 13-60 U / ml.
Kuchuluka kwa lipase
Ngati pancreatic lipase ikwera, ichi ndi chidziwitso chofunikira mukamapanga matenda, chimakhala chidziwitso cha kukula kwa zovuta zina mu kapamba.
Matenda akulu amatha kuonjezera kuchuluka kwa zinthu, kuphatikiza khansa yapakhungu, colic, zilonda zapakhosi, chikhodzodzo, kupweteka kwa matenda a chikhodzodzo.
Nthawi zambiri, kuchuluka kwa lipase kumawonetsa cysts ndi pseudocysts mu kapamba, kutsekeka kwamkati mwamiyala ndi miyala, chilonda, intracranial cholestasis. Zomwe zimayambitsa matenda a pathological azikhala pachimake m'matumbo, peritonitis, kulephera komanso kupweteka kwa aimpso, kukonzanso kwa zilonda zam'mimba.
Kuphatikiza apo, kuchuluka kwa lipase kumakhala chiwonetsero cha:
- kukonzanso kwa chiwalo;
- kagayidwe kachakudya matenda;
- kunenepa
- mtundu uliwonse wa matenda ashuga;
- mumps ndi kuwonongeka kwa kapamba;
- nyamakazi ya gouty;
- kupatsidwa ziwalo zamkati.
Vutoli nthawi zina limayamba ndi kugwiritsidwa ntchito kwa nthawi yayitali kwa mankhwala ena: barbiturates, narcotic-mtundu analgesics, Heparin, Indomethacin.
Ndikotheka kuti kutsegula kwa pancreatic lipase kumachitika chifukwa cha kuvulala, mafupa a mafupa a tubular. Komabe, kusinthasintha kosiyanasiyana kwa zinthu zamagetsi m'magazi sikungaganizire kuti kungowunikira.
Chifukwa chake, kusanthula kwa lipase sikufanana konse ndi njira yodziwira kuvulala kwamatenda osiyanasiyana.
Kodi matenda a lipase amakula ndi matenda ati?
Kafukufuku wokhudzana ndi ma lipase amadzimadzi amadzimadzi akuyamba kufunika pazilonda zingapo zam'mimbazi. Kenako kusanthula kwa enzymeyi ndikulimbikitsidwa kuti kuchitika pamodzi ndi kutsimikiza kuchuluka kwa amylase, enzyme yomwe imalimbikitsa kuthyoloka kwa zinthu zosakhazikika mu oligosaccharides. Ngati zikuwonetsa kuti zonsezi zikuwonjezeka kwambiri, izi zikuwonetsa kukula kwa njira yayikulu ya pathological mu kapamba.
Munthawi yamankhwala odwala komanso omwe amakhala nawo nthawi yayitali, amylase ndi lipase sakhala okwanira nthawi imodzi, lipase imakhala yokwezeka kwambiri kuposa amylase.
Kafukufuku wa Laborator awonetsa kuti ndi njira yotupa mu kapamba:
- kuchuluka kwa lipase kumangowonjezera kuchuluka kokha;
- Zizindikiro sizimafika pamlingo wina pomwe dokotala mosakayikira angadziwe zowona zake;
- matendawa amatha kukhazikitsidwa patsiku lachitatu.
Ndikofunikira kuzindikira kuti ndi puffness kwambiri, kuchuluka kwa chinthucho kumakhalabe kwabwinobwino, kuchuluka kwa enzyme kumawonedwa pamaso pa mafuta pancreatic necrosis. Mlingo wa ntchito ya lipase imachulukitsa pafupifupi katatu ndi hemorrhagic mawonekedwe a pancreatic necrosis.
High lipase imatha masiku 3-7 kuyambira kumayambiriro kwa kutukusira pachimake, chizolowezi chodziwika bwino cha zinthu chimawonedwa pokhapokha pa tsiku la 7-14th la matenda. Pamene encyme ya pancreatic idalumphira pamlingo wa 10 ndi kupitilira, kudalirika kwa matendawa kumawoneka kuti sikwabwino, makamaka ngati umboni wamwazi wawonetsa kuti ntchitoyi ikupitilira masiku angapo, sikuchepera katatu.
Kuwonjezeka kwachangu kwa ma pancreatic lipase indices ndizodziwikiratu, zogwirizana kwambiri ndi zomwe zimayambitsa kusokonezeka. Acute pancreatitis amadziwika ndi kukula kwa enzyme 2-6 patatha maola ochulukirapo, patatha maola 12-30, lipase imafika pamtunda wambiri ndipo pang'onopang'ono imayamba kutsika. Pambuyo patatha masiku 2-4, ntchito ya thupilo imayamba bwino.
Mu matenda omwe kale amadwala, poyamba pamakhala kuwonjezeka pang'ono kwa lipase, pomwe matendawa amakula, kusintha kwa gawo lakukhululukidwa, kumachitika modabwitsa.
Zoyambitsa Low Lipase
Kukhazikika kwa ma neoplasms owopsa a gawo lililonse la thupi, osati matenda a kapamba okha, amatha kutsitsa kuchuluka kwa lipase. Komanso, zifukwa zake ziyenera kufunafuna kuchepa kwa ntchito ya pancreatic, vuto la majini lomwe limakhala ndi choopsa chambiri chomwe chimachitika chifukwa cha kuwonongeka kwa endocrine glands (matenda a cystic fibrosis).
Pambuyo pochita opaleshoni yochotsa mankhwalawa kuti muchotse kapamba, ndimagayidwe ochulukitsa am'magazi, omwe adayambitsa kudya kosayenera ndi mafuta ambiri, cholowa cham'thupi chimachepetsa mulingo wa pancreatic enzyme. Nthawi zambiri, kuchepa kwa milingo ya lipase kumawonedwa ndikusintha kwa kapamba kuyambira pachimake kupita pamakhala osachiritsika.
Kusakhalapo kwathunthu kwa pancreatic lipase kumachitika ndi kuperewera kwa kupangidwa kwake.
Zomwe michere imasungidwa ndi kapamba zimafotokozedwa mu kanema munkhaniyi.
