Alpha Lipoic Acid wa Matenda A shuga Chithandizo cha neuropathy ndi zovuta zina

Alpha lipoic acid, yomwe imadziwikanso kuti thioctic acid, idayamba kupatulidwa ku chiwindi cha bovine mu 1950. Mwa kapangidwe kake ka mankhwala, ndi asidi wamafuta okhala ndi sulufule. Imatha kupezeka mkati mwa khungu lililonse m'thupi lathu, momwe imathandizira kuti ipange mphamvu. Alpha lipoic acid ndi gawo lofunikira kwambiri mu metabolic process, omwe amasintha glucose kukhala mphamvu pazosowa zathupi. Thioctic acid ndi antioxidant - imathandizira kuti pakhale mankhwala oopsa omwe amadziwika kuti free radicals.

Pogwira ntchito yake yofunika kwambiri munjira zamankhwala amitundu mitundu, alpha-lipoic acid poyambirira idaphatikizidwa mu zovuta za mavitamini a gulu B. Komabe, pakali pano sizimaganiziridwa ngati vitamini. Amakhulupirira kuti ndi antioxidant wamphamvu kwambiri yemwe amagulitsidwa ngati chowonjezera.

Ubwino wamaukadaulo am'mthupi kuchokera mukutenga alpha-lipoic acid ndi ofanana ndi mapindu omwe mafuta am nsomba amakhala nawo. Akatswiri a mtima ku West, omwe kale adatenga vitamini E ngati antioxidant komanso pofuna kupewa matenda amtima, tsopano akusintha kwambiri ku thioctic acid.

Kodi amamwa mankhwala awa?

Poteteza ndi kuchiza matenda amtundu wa 1 kapena 2 shuga, alpha-lipoic acid nthawi zina amapatsidwa mapiritsi kapena makapisozi mu mulingo wa 100-200 mg katatu patsiku. Mlingo wa 600 mg ndiwofala kwambiri, ndipo mankhwalawa amayenera kumwa kamodzi kokha patsiku, zomwe ndizosavuta kwambiri. Ngati mumasankha zowonjezera zamakono za R-lipoic acid, ndiye kuti akuyenera kutengedwa mu yaying'ono - 100 mg 1-2 kawiri pa tsiku. Izi zikugwira ntchito makamaka kukonzekera komwe kumakhala ndi GioNova's Bio-Enhanced® R-Lipoic Acid. Werengani zambiri za iwo pansipa.

Kudya akuti adayamba kuchepa kwa bioavailability wa alpha lipoic acid. Chifukwa chake, izi zimapangidwa bwino pamimba yopanda kanthu, ola limodzi musanadye kapena maola awiri mutadya.

Ngati mankhwalawa a matenda amitsempha ya m'mimba mukufuna kulandila asidi wambiri, ndiye kuti dokotala akupatsirani mankhwalawa. Popewa kwambiri, alpha-lipoic acid nthawi zambiri amatengedwa ngati gawo limodzi la mankhwala a multivitamin, mu 20-50 mg patsiku. Mpaka pano, palibe umboni wovomerezeka kuti kumwa antioxidant mwanjira imeneyi kumapereka phindu lililonse paumoyo.

Chifukwa chiyani ma antioxidants amafunikira

Amakhulupirira kuti kudwala ndi ukalamba zimayambitsa pang'ono mwa kusintha kwa zinthu mwaulere, zomwe zimachitika ngati zinthu zokhudzana ndi oxidation ("oyaka") mthupi. Chifukwa chakuti alpha lipoic acid imasungunuka m'madzi ndi mafuta, imagwira ntchito ngati antioxidant pamagawo osiyanasiyana a metabolism ndipo itha kuteteza maselo ku zowonongeka ndi ma radicals aulere. Mosiyana ndi ma antioxidants ena, omwe amasungunuka m'madzi kapena mafuta okha, alpha lipoic acid imagwira ntchito m'madzi ndi mafuta onse. Ichi ndi chuma chake chapadera. Poyerekeza, vitamini E amangogwira ntchito m'mafuta, ndipo vitamini C amangokhala m'madzi. Thioctic acid imakhala ndi chiwonetsero chazonse chazithunzi zoteteza.

Ma antioxidants amawoneka ngati oyendetsa ndege a Kamikaze. Amadzipereka kuti athetse mitundu yaulere. Chimodzi mwazinthu zosangalatsa kwambiri za alpha lipoic acid ndikuti zimathandizira kubwezeretsa ma antioxidants ena atagwiritsidwa ntchito pazolinga zawo. Kuphatikiza apo, imatha kugwira ntchito ya ma antioxidants ena ngati thupi ndilosakwanira.

Alpha Lipoic Acid - Anti Perfect Antioxidant

Ma antioxidant othandizira achire ayenera kukwaniritsa njira zingapo. Izi ndi monga:

1. Zogulitsa ku chakudya.
2. Kusintha kwa maselo ndi minofu kukhala mawonekedwe ogwirika.
3. Ntchito zosiyanasiyana zoteteza, kuphatikizapo kuyanjana ndi ma antioxidants ena mu cell membranes ndi malo a interellular.
4. Kuopsa kochepa.

Alpha lipoic acid ndiwosiyana ndi ma antioxidants achilengedwe chifukwa amakwaniritsa zonsezi. Izi zimapangitsa kukhala othandizira othandizira kwambiri ochizira mavuto azaumoyo omwe amayamba, mwa ena, kuwonongeka kwa oxidative.

Thioctic acid imagwira ntchito zotsatirazi:

• Mwachindunji amathandizira mitundu yoopsa yogwiritsa ntchito mpweya wautali (ma free radicals).
• Imabwezeretsa antioxidants amkati, monga glutathione, mavitamini E ndi C, kuti agwiritsenso ntchito.
• Amamangirira (chelates) zitsulo zowopsa mthupi, zomwe zimapangitsa kuti kuchepa kwa kupanga ma free radicals.

Katunduyu amagwira ntchito yofunika kwambiri pakusunga mgwirizano wama antioxidants - machitidwe omwe amatchedwa antioxidant defense network. Thioctic acid imabwezeretsa vitamini C mwachindunji, glutathione ndi coenzyme Q10, ndikuwapatsa mwayi wotenga nawo gawo la metabolism yayitali. Imabweretsanso mosavomerezeka vitamini E. Kuphatikiza apo, akuti imawonjezera kaphatikizidwe ka glutathione m'thupi mwa nyama zokalamba. Izi zili choncho chifukwa kuchuluka kwa ma cell a cysteine, amino acid yofunikira pakapangidwe ka glutathione, kumawonjezeka. Komabe, sizinadziwikebe ngati alpha lipoic acid imathandizadi pakuwongolera njira za redox m'maselo.

Ntchito mu thupi la munthu

Mu thupi laumunthu, alpha-lipoic acid (kwenikweni, mawonekedwe ake a R okha, amawerengedwa kwambiri pansipa) amapangidwa m'chiwindi ndi minofu ina, komanso zakudya zam'chinyama ndi chomera. R-lipoic acid muzakudya imapezeka mu mawonekedwe omwe amalumikizidwa ndi amino acid lysine m'mapuloteni. Zozama za antioxidant izi zimapezeka m'matupi aminyama, omwe ali ndi zochita zapamwamba kwambiri. Uwu ndi mtima, chiwindi ndi impso. Zomera zazikuluzikulu ndi sipinachi, broccoli, phwetekere, nandolo zam'munda, mphukira za Brussels, ndi chinangwa cha mpunga.

Mosiyana ndi R-lipoic acid, yemwe amapezeka muzakudya, mankhwala alpha-lipoic acid omwe amapezeka m'mankhwala amapezeka mwaulere, i.e. samamangidwa kumapuloteni. Kuphatikiza apo, Mlingo womwe umapezeka m'mapiritsi ndi jakisoni wa intravenous (200-600 mg) ndiwokwera kwambiri kuchulukirapo kawiri kuposa womwe anthu amapeza kuchokera kuzakudya zawo. Ku Germany, thioctic acid ndi mankhwala ovomerezeka a matenda amitsempha, ndipo amapezeka ngati akupereka mankhwala. Ku United States ndi mayiko olankhula Chirasha, mutha kugula ku malo ogulitsira mankhwala monga adokotala adauzira kapena monga zakudya zowonjezera.

Zachizolowezi Alpha Lipoic Acid motsutsana ndi R-ALA

Alfa-lipoic acid amapezeka m'mitundu iwiri ya maselo - kumanja (R) ndi kumanzere (imatchedwa L, nthawi zina imalembedwanso S). Kuyambira zaka za 1980s, mankhwala osokoneza bongo komanso zakudya zopatsa thanzi akhala osakaniza a mitundu iwiriyi pa mulingo wa 50/50. Kenako asayansi adazindikira kuti mawonekedwe omwe amagwirawo ndi ufulu (R) wokha. Mu thupi laumunthu ndi nyama zina mu vivo mawonekedwe awa ndi omwe amapangidwa ndikugwiritsidwa ntchito. Amasankhidwa kuti R-lipoic acid, mu Chingerezi R-ALA.

Pali Mbale zambiri za alpha lipoic acid, zomwe ndi zosakaniza ndi "kumanja" ndi "kumanzere," chilichonse. Koma pang'onopang'ono imatsitsidwa pamsika ndi zowonjezera zomwe zimakhala ndi "yoyenera" yokha. Dr. Bernstein iyemwini amatenga R-ALA ndikungopereka odwala ake kwa odwala ake. Ndemanga za makasitomala ogulitsira achingelezi opezeka pachingerezi zimatsimikizira kuti R-lipoic acid ndiwothandiza kwambiri. Kutsatira Dr. Bernstein, tikulimbikitsa kusankha R-ALA m'malo mwa alpha lipoic acid.

R-lipoic acid (R-ALA) ndi mtundu wina wa molekyu ya alpha-lipoic acid yomwe zomera ndi nyama zimapangira ndikugwiritsa ntchito pansi pazachilengedwe. L-lipoic acid - yokumba, yopanga. Zowonjezera za alpha-lipoic acid ndizosakanikirana ndi mitundu ya L- ndi R-R, mu chiyerekezo cha 50/50. Zowonjezera zatsopano zimakhala ndi R-lipoic acid, R-ALA kapena R-LA zokha zolembedwa.

Tsoka ilo, kufananizira kwachindunji kwakukhudzana kwa mitundu yosakanikirana ndi R-ALA sikunapangidwepo komanso kusindikizidwa. Mutatenga mapiritsi "osakanikirana", kuchuluka kwa plasma ya R-lipoic acid ndiwokwera 40-50% kuposa mawonekedwe a L-form. Izi zikusonyeza kuti R-lipoic acid imagwira bwino ntchito kuposa L. Komabe, mitundu yonseyi ya thioctic acid imakonzedwa mwachangu kwambiri. Pafupifupi maphunziro onse osindikizidwa okhudzana ndi alpha-lipoic acid m'thupi la munthu adachitika mpaka 2008 ndipo zowonjezera zokha ndizomwe zidagwiritsidwa ntchito.

Ndemanga za makasitomala, kuphatikizapo odwala matenda ashuga, amatsimikizira kuti R-lipoic acid (R-ALA) ndiwothandiza kwambiri kuposa mankhwala osakanikirana a alpha-lipoic acid. Koma mwalamulo izi sizinatsimikizidwebe. R-lipoic acid ndi mawonekedwe achilengedwe - ndi thupi lake lomwe limatulutsa ndikugwiritsa ntchito. R-lipoic acid ndi wamphamvu kwambiri kuposa thioctic acid wamba, chifukwa thupi "limazindikira" ndipo limadziwa nthawi yomweyo kugwiritsa ntchito. Opanga amati thupi la munthu silingatengere mtundu wa L-mtundu, ndipo lingatilepheretse kugwira ntchito mwachilengedwe kwa R-lipoic acid.

Posachedwa, kampani ya GeroNova, yomwe imapanga "kukhazikika" R-lipoic acid, yatsogolera dziko lolankhula Chingerezi. Amatchedwa Bio-Enhanced ® R-Lipoic Acid, i.e. atukuka kuposa wamba R-ALA. Zakudya zowonjezera zomwe mutha kuyitanitsa kuti muchize odwala matenda ashuga a m'magazi ntchito mchere wake wa sodium wotchedwa BioEnhanced® Na-RALA. Anadutsa njira yokhazikika, yomwe GeroNova idachita. Chifukwa cha izi, digestibility ya Bio-Enhanced® R-lipoic acid yachulukanso ka 40.

Pakukhazikika, zitsulo zapoizoni ndi zosungunulira zotsalira zimachotsedweratu ndi chakudya. GeroNova's Bio-Enhanced® R-Lipoic Acid ndiye alpha lipoic acid wapamwamba kwambiri. Amaganiziridwa kuti kutenga izi m'mapilogalamu osavomerezeka sikunapweteke kuposa kuperekera kwa thioctic acid ndi ma dontho.

GeroNova amapanga yaiwisi ya alpha lipoic acid. Ndipo makampani ena: Best Best Doctor, Life Extension, Jarrow Formulas ndi ena, akunyamula ndikugulitsa kwa ogula kumapeto. Pa tsamba la GeroNova kwalembedwa kuti anthu ambiri patatha milungu iwiri atazindikira kuti ali ndi mphamvu zambiri komanso akuganiza bwino. Komabe, tikulimbikitsidwa kuti mutenge R-lipoic acid kwa miyezi iwiri, kenako ndikumaliza.

• Dr's Best Biotin R-Lipoic Acid;
• R-lipoic acid - Mlingo wowonjezera wa Life Extension;
• Jarrow Formulas Sustched kumasulidwa Masamba.

Monga lamulo, anthu amatha kuphatikiza zokwanira za alpha lipoic acid kuti akwaniritse zosowa za thupi lawo. Komabe, kapangidwe kazinthu kameneka kamachepa ndi zaka, komanso mwa anthu omwe ali ndi mavuto azaumoyo, kuphatikizapo matenda a shuga komanso zovuta zake, monga neuropathy. Muzochitika izi, thioctic acid yowonjezereka, ikhoza kukhala yofunikira kupeza kuchokera kumagulu akunja - kuchokera pazowonjezera za chakudya m'mabotolo kapena jekeseni wamkati.

Kuwongolera Matenda a shuga: Zambiri

Alpha lipoic acid imakhala ndi phindu m'malo ambiri opweteka - matenda ashuga, kufooka kwamtundu wambiri, kuchepa kwa kuzindikira komanso kuchepa kwa chidwi. Popeza tili ndi tsamba pofotokoza za matenda ashuga, pansipa tikambirana momwe asidi wa thioctic alili mu mtundu woyamba wa 1 ndi mtundu wa 2 wa matenda a shuga pofuna kupewa komanso kuchiza matenda. Ingodziwa kuti antioxidant iyi imatha kuchiza mavuto ambiri azaumoyo omwe matenda ashuga amayambitsa. Kumbukirani kuti ndi matenda amtundu 1 shuga, insulin secretion imachepetsedwa kwambiri chifukwa cha kuwonongeka kwa maselo a beta. Mtundu wachiwiri wa matenda ashuga, vuto lalikulu si kusowa kwa insulini, koma kufooka kwa minofu.

Zatsimikiziridwa kuti zovuta za shuga zimachitika makamaka chifukwa cha kuwonongeka kwa minofu chifukwa cha kupsinjika kwa oxidative. Izi zitha kukhala chifukwa chowonjezeka pakupanga ma free radicals kapena kuchepa kwa chitetezo cha antioxidant. Pali umboni wamphamvu kuti kupsinjika kwa oxidative kumathandizira pakukula kwa zovuta za matenda ashuga. Shuga wokwera amatsogolera kukuwonjezeka kwa mitundu yamagetsi yotupa. Kupanikizika kwa Oxidative sikumangoyambitsa zovuta za shuga, komanso kumatha kugwirizanitsidwa ndi insulin. Alpha lipoic acid imatha kukhala ndi prophylactic komanso achire pamavuto osiyanasiyana amtundu wa 2 komanso matenda a shuga.

Matenda a shuga a Mtundu woyamba adawagwirira mu mbewa zasayansi pogwiritsa ntchito cyclophosphamide. Nthawi yomweyo, adaba jekeseni wa alpha-lipoic acid pa 10 mg pa 1 kg ya kulemera kwa thupi kwa masiku 10. Zinapezeka kuti kuchuluka kwa mbewa zomwe zimayambitsa matenda a shuga zatsika ndi 50%. Asayansi adawonanso kuti chida ichi chimawonjezera kugwiritsidwa ntchito kwa glucose mu minofu ya makoswe - diaphragm, mtima ndi minofu.

Mavuto ambiri omwe amayamba chifukwa cha matenda ashuga, kuphatikiza mitsempha ya m'mimba komanso amphaka, amawoneka kuti ndi chifukwa chachulukidwe chopanga mitundu ya okosijeni yogwira mthupi. Kuphatikiza apo, zimaganiziridwa kuti kupsinjika kwa oxidative kumatha kukhala chochitika cham'mbuyo mu matenda a shuga, ndipo pambuyo pake kumakhudza zochitika komanso kuwonjezereka kwa zovuta. Kafukufuku wa odwala 107 omwe ali ndi matenda amtundu woyamba wa 2 ndi mtundu wa 2 adawonetsa kuti iwo omwe amamwa alpha-lipoic acid pa 600 mg patsiku kwa miyezi itatu adachepetsa kupsinjika kwa oxidative poyerekeza ndi omwe amadwala matenda ashuga omwe sanakhazikitsidwe antioxidant. Izi zimawonetsedwa ngakhale mphamvu ya shuga m'magazi ingakhale yopanda ntchito komanso kuchuluka kwa mapuloteni mumkodzo kunali kwakukulu.

Kuchuluka kwa insulin

Kumangidwa kwa insulini ku ma receptor ake, omwe amakhala pamwamba pa ziwalo zam'mimba, kumayendetsa kayendedwe ka glucose transmitter (GLUT-4) kuchokera mkati mpaka membrane wa cell ndikuwonjezera kukweza kwa maselo kuchokera m'magazi. Alpha-lipoic acid adapezeka kuti ayambitsa GLUT-4 ndikuwonjezera kutulutsa kwa shuga ndi adipose ndi minofu ya minofu. Zimapezeka kuti zimakhudzanso insulin, ngakhale nthawi zambiri imakhala yofooka. Minofu yachigoba ndiye gawo lalikulu la glucose scavenger. Thioctic acid kumawonjezera minofu minofu glucose. Ndiwothandiza kwambiri pakanthawi yayitali matenda a shuga.

Komabe, kafukufuku adawonetsa kuti, mosiyana ndi kasamalidwe ka intravenous, mutamwa mapiritsiwo pakamwa, pali kusintha kochepa kwambiri pakumverera kwa minofu kumapangitsa insulin (<20%). Sizinali zotheka kuti pakhale chiwopsezo chachikulu cha insulin sensitivity ngakhale ndi milingo yayikulu, mpaka 1800 mg patsiku, komanso nthawi yayitali yodwala, masiku 30 a kumwa mapiritsi motsutsana ndi masiku 10 othandizira. Kumbukirani kuti zonsezi ndi kuchuluka kwa kafukufuku wakale wa 1990s, pomwe kunalibe zowonjezera za R-lipoic acid ndipo, kuwonjezera apo, GeroNova Bio-Enhanced® R-Lipoic Acid. Mitundu yatsopano ya alpha-lipoic acid mumapiritsi ndi mapiritsi imapereka mphamvu yofanana ndi yomwe imapezeka ndi jakisoni wambiri.

Matenda a shuga

Mtundu woyamba wa 2 komanso wa matenda ashuga a 2, ma neuropathy amachitika chifukwa magazi amatuluka ndipo kusokonezedwa kwa mitsempha kumawonekera. Kafukufuku wofufuza zinyama adawona kuti chithandizo cha alpha lipoic acid chimasintha kayendedwe ka magazi ndi msempha wamitsempha.Zotsatira zabwinozi zalimbikitsa asayansi kuchititsa mayesero azachipatala mwa anthu omwe ali ndi matenda ashuga. Thioctic acid adagwiritsidwa ntchito koyamba kuchiza matenda ashuga ku Germany zaka zopitilira 30 zapitazo. Adavomerezedwa ngati mankhwala, ngakhale kuti panthawiyo padalibe zambiri zokwanira pazomwe zimayambitsa zovuta za matenda ashuga. Amakhulupirira kuti chida ichi chimawonjezera kugwiritsa ntchito glucose m'mitsempha yamafungo.

Mu matenda a shuga a shuga, wodwalayo amakumana ndi dzanzi, kupweteka komanso ndi zina zosasangalatsa. Amayesedwa kuti oxidative nkhawa ndi ma free radicals amatenga gawo lalikulu pakukula kwa zovuta. Ngati ndi choncho, chitani matendawa ndi antioxidants. Monga tafotokozera pamwambapa, alpha lipoic acid ndi antioxidant wamphamvu. Komabe, umboni wotsimikizika wa kugwira kwake ntchito wake udapezeka kokha mu maphunziro momwe mankhwalawa adathandizira odwala matenda ashuga m'mitsempha, osati m'mapiritsi ndi pakamwa.

Maphunziro akulu adachitidwa mpaka 2007. Pambuyo pake, zowonjezera zam'tsogolo zomwe zimakhala ndi R-lipoic acid zokha zimayamba kuwonekera pamsika, iyi ndiye isomer yogwira ya alpha-lipoic acid. Zowonjezera zotere zilibe L-lipoic acid yopanda ntchito, pomwe kukonzekera kwachikhalidwe kumakhala ndi R- ndi L-mawonekedwe a 50% aliyense. Amaganiziridwa kuti mapiritsi amakono ndi makapisozi a alpha-lipoic acid ndi othandiza kwambiri, kufananizidwa ndi otsitsa okhazikika, popewa jakisoni. Komabe, lingaliro ili limangotengera zomwe opanga, Dr. Bernstein, komanso ndemanga zambiri zamakasitomala ogulitsa pa intaneti a Chingerezi. Kafukufuku wapadera wa mankhwala atsopano a R-lipoic acid sanachitikebe.

Ndi matenda ashuga, mitsempha ina m'thupi la munthu imawonongekanso, yomwe ndimitsempha ya autonomic yomwe imayang'anira ziwalo zamkati. Izi zikachitika mumtima, ndiye kuti ma neuronomic amayamba, omwe amatsogolera ku mtima. Autonomic neuropathy ndimavuto owopsa a matenda ashuga, omwe ali ndi chiopsezo chachikulu cha kufa mwadzidzidzi. Pali umboni kuti alpha lipoic acid imathandizira pang'onopang'ono kukula ndi chithandizo cha matenda.

Umboni woyambirira komanso wotsutsa ukusonyeza kuti kumwa alpha-lipoic acid kumatha kusintha osati maphunziro a neuropathy, komanso mbali zina za matenda ashuga. Thioctic acid imasintha pang'ono magazi a shuga ndikuthandizira kuletsa kwamitsempha yamavuto yayitali - matenda a mtima, impso ndi mitsempha yaying'ono ya magazi. Tikukumbutsani kuti njira yayikulu yoletsera komanso kuchiza matenda amtundu wa 2 komanso mtundu wachiwiri wa shuga ndi chakudya chamagulu ochepa. Gwiritsani ntchito zowonjezera kuwonjezera pa izo.

Mu 1995-2006, mayesero angapo azachipatala adachitidwa kuti athe kuwunika momwe alpha lipoic acid amathandizira odwala matenda ashuga.

Onse awa anali akhungu m'maso, owongoleredwa ndi placebo, i.e., ophunzitsidwa kwambiri. Tsoka ilo, asayansi sanapeze umboni uliwonse wosonyeza kuti kumwa mapiritsi osachepera pang'ono kumathandizanso kuyendetsa bwino shuga mu shuga. Komabe, zatsimikiziridwa kuti kugwiritsa ntchito shuga m'magazi kumachulukirachulukira. Chifukwa chake, ngakhale pali kusiyana pakati pa malingaliro pakati pa asayansi, pali umboni wamphamvu wazachipatala kuti alpha lipoic acid imasintha bwino njira ya matenda ashuga a mtima. Makamaka zabwino, ngati mungalowe mu intravenly, komanso ngakhale muyezo waukulu komanso kwa nthawi yayitali.

Zowonjezera zamakono za R-lipoic acid, kuphatikizapo GeroNova's Bio-Enhanced® R-Lipoic Acid, zidayamba kuwonekera pambuyo pa 2008. M'maphunziro omwe tanena pamwambapa, sanatenge nawo mbali. Amakhulupirira kuti amachita bwino kwambiri kuposa kukonzekera kwa alpha-lipoic acid, omwe ndi osakanikirana ndi ma R- ndi L- (S-) isomers. Ndikothekanso kuti kumwa mankhwalawa kumatha kukhala ndi zotsatira zofanana ndi zoperekedwa ndi jakisoni wamkati. Tsoka ilo, panthawi yolemba (Julayi 2014), mayeso azachipatala aposachedwa kwambiri anali asanapezeke.

Ngati mukufuna kutenga jakisoni wa alpha lipoic acid, ndiye m'malo mwake yesani kutenga makapisozi a Bio-Enhanced® R-Lipoic Acid kuchokera ku GeroNova, omwe amakanikidwa ndi Doctor's Best, Life Extension, kapena mapiritsi a Jarrow Formulas.

• Dr's Best Biotin R-Lipoic Acid;
• R-lipoic acid - Mlingo wowonjezera wa Life Extension;
• Jarrow Formulas Sustched kumasulidwa Masamba.

Mwina zitha kugwira bwino ntchito kotero kuti omwe akutsikira safunika. Nthawi yomweyo, timakumbukira kuti chithandizo chachikulu cha matenda ashuga ndichakudya chamafuta ochepa. Matenda a shuga ndi matenda osokoneza bongo omwe amatha kusintha. Ngati musinthasintha shuga m'magazi anu ndimakudya ochepa wamafuta, ndiye kuti zonse zomwe zimachitika zimatha miyezi ingapo mpaka zaka zitatu. Mwina kumwa alpha lipoic acid kungathandize kuti izi zitheke. Koma palibe mapiritsi ndi majekeseni omwe amagwira ntchito mpaka chakudya chanu chimadzaza ndi mafuta owopsa.

Zotsatira zoyipa

Chithandizo cha alpha lipoic acid nthawi zambiri chimavomerezedwa, ndipo zovuta zoyipa ndizochepa. Mwachizolowezi, kugaya nseru kapena kukhumudwa m'mimba, komanso kuonjezera nkhawa, kutopa, kapena kusowa tulo kumachitika. Mlingo waukulu wa mankhwalawa ungathe kuchepetsa shuga. Izi nthawi zambiri zimakhala zothandiza kwa odwala matenda ashuga, koma zimafunikira kuwunika mosamala kuchuluka kwa shuga. Chiwopsezo cha hypoglycemia chimawonjezeka ngati wodwala matenda ashuga ayamba kale kumwa mankhwala a sulfonylurea kapena kumwa jakisoni wa insulin, ndipo tsopano akuwonjezera alpha-lipoic acid pamenepa.

600 mg patsiku ndi gawo labwino komanso labwino la matenda ashuga. Pa Mlingo wapamwamba, odwala samakhala ndi zizindikiro zam'mimba: kupweteka kwam'mimba, nseru, kusanza, komanso kutsegula m'mimba ndi anaphylactic, kuphatikizapo laryngospasm. Kuphatikiza apo, thupi limatulutsa, kuphatikizapo zotupa, urticaria, komanso kuyabwa kwa khungu. Anthu omwe amamwa mapiritsi a thioctic acid pa mlingo wa 1200 mg patsiku amakhala ndi fungo losasangalatsa la mkodzo.

Kutenga alpha-lipoic acid m'mapiritsi kapena ma donolo kumatsitsa biotin m'thupi. Biotin ndi amodzi mwa mavitamini osungunuka am'magazi a gulu B. Ndi gawo la ma enzymes omwe amawongolera kagayidwe ka mapuloteni ndi mafuta. Pamodzi ndi alpha lipoic acid, timalimbikitsidwanso kutenga biotin mu 1%. Chonde dziwani kuti zowonjezera zamakono za R-lipoic acid zomwe timalimbikitsa ndizophatikizanso biotin.

• Dr's Best Biotin R-Lipoic Acid;
• R-lipoic acid - Mlingo wowonjezera wa Life Extension;
• Jarrow Formulas Sustched kumasulidwa Masamba.

Vuto lalikulu ndilokwera mtengo kwa mankhwalawa. Mlingo wa tsiku ndi tsiku umakulandirani $ 0.3. Ndipo palibe amene angatsimikizire pasadakhale kuti mudzapeza phindu lenileni la ndalama iyi. Apanso, njira yayikulu yothanirana ndi matenda a shuga a mtundu woyamba ndi zovuta zina zamtundu woyamba wa 2 ndi chakudya chaulere, chokhutiritsa komanso chokoma cha carbohydrate. Alpha lipoic acid amangomaliza. Amanenanso kuti imathandizira kupumula kwanu kuchokera kuzizindikiro za neuropathy. Ngati zakudya za munthu wodwala matenda ashuga azikhalanso ndi chakudya, ndiye kuti kudya zina zowonjezera ndikungowononga ndalama.

Mapiritsi kapena ogwetserako - ndibwino?

Kodi ndi chifukwa chiyani alfa lipoic acid yachikhalidwe "yosakanikirana" imakhala yopanda phindu ngati itengedwa pamapiritsi kapena mapiritsi? Zimawonjezera chidwi cha maselo ku insulin ndipo kwenikweni sizimakhudza kuchuluka kwa shuga m'magazi. Chifukwa chiyani izi zikuchitika? Kulongosola komwe kungakhalepo ndikuti kuphatikiza kwakukulu kwa mankhwala omwe ali m'magazi kumakhalabe kwakanthawi kochepa kwambiri. Thioctic acid imakhala ndi theka lalifupi m'moyo, pafupifupi mphindi 30. Kuzindikira kwake kwakukulu m'magazi kumawonedwa pambuyo pa mphindi 30-60 pambuyo pakulowetsedwa. Imalowa mwachangu m'magazi, koma kenako imakonzedwa mwachangu ndikuchotsa m'thupi.

Pambuyo pa limodzi mlingo wa 200 mg, ndi bioavailability wa mankhwala pafupifupi 30%. Ngakhale atatha kudya mapiritsi mosalekeza, mapangidwe ake achilengedwe m'magazi samachitika. Kuchuluka kwake kwa plasma kumatheka mosavuta, koma pambuyo pake kumatsika mwachangu, mpaka pamlingo wosakwanira kukhudza chidwi cha maselo kutsata insulin kapena glucose control. Kodi ndi chifukwa chiyani mapangidwe a thioctic acid amagwira bwino kuposa mapiritsi? Mwina chifukwa mlingo wa mankhwalawa suulowa mthupi nthawi yomweyo, koma pang'onopang'ono, mkati mwa mphindi 30 mpaka 40, pomwe munthu wagona pansi pa dontho.

Nkhani ya mu Chingerezi ya 2008 imati asayansi adakhazikitsa muyeso wa alpha lipoic acid piritsi lotulutsa. Izi zimakuthandizani kuti muzikhala ndi kuchuluka kwa mankhwalawa m'magazi kwa maola 12. Tsoka ilo, nkhani zaposachedwa kwambiri za momwe njirayi idathandizira sizinapezeke. Mutha kuyesa Jarrow Fomula yokhazikika yotulutsa alpha lipoic acid. Ndemanga zamakasitomala zimatsimikizira kuyendetsa bwino kwake, koma palibe zidziwitso zovomerezeka. Ngati vuto lanu la matenda ashuga limawonetsedwa ndi gastroparesis, i.e., kumasulidwa pang'onopang'ono m'mimba, ndiye kuti mankhwalawa adzakhala opanda ntchito. Werengani zambiri pa nkhani ya "Diabetesic gastroparesis".

Kodi ndizoyenera kugula alpha lipoic acid mu mankhwala?

M'mayiko olankhula Chirasha mumakhala anthu masauzande ambiri omwe ali ndi matenda a shuga. Onsewa amafunitsitsa kuti athetse mavuto awo, ndipo ndikofunikira kuti achire kwathunthu. Alpha-lipoic acid (aka thioctic acid) ndiye mankhwala okhawo omwe angagwiritsidwe ntchito ku neuropathy kuwonjezera pa njira zambiri zodziwirira matenda ashuga. Ndizosadabwitsa kuti kukonzekera kwake kukufunika kwambiri pakati pa odwala, ngakhale akukwera mtengo.

Mankhwala wamba a alpha-lipoic acid omwe amagulitsidwa ku malo ogulitsa mankhwala:

• Kuphatikizana;
• Lipamide;
• Lipothioxone;
• Neuroleipone;
• Oktolipen;
• Thiogamm;
• Thioctacid;
• Tiolepta;
• Thiolipone;
• Espa Lipon.

Opanga amalengeza mwachidwi mapiritsi ndi njira zothetsera kukhazikitsa magazi pakati pa odwala matenda a shuga komanso madokotala. Komabe, tikukulimbikitsani kuti musagule alpha lipoic acid ku pharmacy, koma muyiitanitse pa intaneti kuchokera ku USA (werengani momwe mungachitire izi). Mwanjira imeneyi, mudzapeza phindu lenileni la ndalama zanu. Anthu odwala matenda ashuga omwe nthawi zambiri amathandizidwa ndi alpha-lipoic acid dropers amatha kusintha mapiritsi ndi mapiritsi amakono. Mwachidziwikire, izi ndizosavuta, komanso zotsika mtengo.

Ochepa ochepa olankhula Chirasha ndi odwala matenda a shuga amadziwa kuti alpha-lipoic acid amapezeka m'mitundu iwiri ya ma cell (isomers) - kumanja (R) ndi kumanzere, komwe kumasonyezedwa ndi L- kapena S-. Kukonzekera kwa Thioctic acid kwakhala kukugwiritsidwa ntchito pochiza matenda ashuga a m'mimba kuyambira m'ma 1970. Awa amatha kukhala mankhwala omwe mumalandira kapena zowonjezera zomwe zimapezeka mosavuta pa kampaniyi. Mpaka posachedwa, onse anali ndi mitundu yosakanikirana ya R- ndi L-isomers pamlingo wa 1: 1. Kenako asayansi adazindikira kuti mtundu wokhawo wa R-alpha lipoic acid ndi wothandiza pazachipatala. Kuti mumve zambiri pa izi, werengani nkhani ya Wikipedia mu Chingerezi.

Kukonzekera kwa Thioctic acid, komwe kumapangidwa theka la mitundu ya R ndi L, kudakali kofalikira. M'mafakitala a mayiko olankhula Chirasha, amangogulitsidwa. Komabe, Kumadzulo pang'onopang'ono akusinthidwa ndi zina zowonjezera zomwe zimakhala ndi R-lipoic acid yokha. Ndemanga za odwala omwe amalankhula ku Russia omwe ali ndi matenda ashuga amawonetsa kuti kumwa mapiritsi a alpha-lipoic acid kulibe ntchito, koma makina okhazikika omwe amawathandiza ndi omwe amathandizadi. Nthawi yomweyo, m'maiko otukuka, odwala matenda ashuga amatenga zowonjezera zamakono za R-lipoic acid ndikutsimikizira mapindu awo abwino. Kutulutsa pang'onopang'ono mapiritsi a alpha-lipoic acid amathandizanso, omwe amathandiza kuti pakhale nthawi yayitali pakumwa mankhwala ambiri.

• Dr's Best Biotin R-Lipoic Acid;
• R-lipoic acid - Mlingo wowonjezera wa Life Extension;
• Jarrow Formulas Sustched kumasulidwa Masamba.

Othandizira a American-alpha-lipoic acid a m'badwo wotsiriza ndi njira yeniyeni kwa othandizira omwe odwala Russian omwe akudwala matenda a shuga akuwachiza. Komabe, kumbukirani kuti kudya zakudya zamagulu ochepa ndizothandiza kwambiri kwa anthu odwala matenda ashuga komanso mavuto ena. Mapiritsi aliwonse amakhala ndi gawo lachiwiri poyerekeza ndi zakudya zoyenera. Sinthani shuga lanu ndi chakudya chamafuta ochepa - ndipo zizindikiro zonse za neuropathy zimatha pang'onopang'ono. Amanena kuti alpha lipoic acid imathandizira pang'onopang'ono njirayi, koma sichilowetsa chakudya.

Momwe mungayitanitsire alpha lipoic acid kuchokera ku USA pa iHerb - tsitsani malangizo mwatsatanetsatane mu Mawu kapena mawonekedwe a PDF. Malangizo mu Chirasha.

Chifukwa chake, tidazindikira chifukwa chake zowonjezera za alpha-lipoic acid zaku America ndizothandiza komanso zosavuta kuposa mankhwala omwe mungagule ku pharmacy. Tsopano tiyeni tiyerekeze mitengo.

Kuchiza ndi mankhwala apamwamba kwambiri a ku America a alpha-lipoic acid kumafuna ndalama $ 0,3- $ 0,6 patsiku, kutengera mlingo. Mwachiwonekere, izi ndizotsika mtengo kuposa kugula mapiritsi a thioctic acid ku pharmacy, ndipo ndi omwe akuponya kusiyana pamtengo nthawi zambiri kumakhala cosmic. Kuitanitsa zowonjezera kuchokera ku US pa intaneti kungakhale kovutirapo kuposa kupita ku pharmacy, makamaka kwa achikulire. Koma zidzabweza, chifukwa mudzalandira zabwino zenizeni pamtengo wotsika.

Umboni wochokera kwa madokotala ndi odwala matenda ashuga

Gome ili pansipa lili ndi zolemba zokhudzana ndi matenda a shuga a neuropathy omwe ali ndi alpha lipoic acid. Zida pamutuwu zimapezeka pafupipafupi m'magazini azachipatala. Mutha kudziwana nawo mwatsatanetsatane, chifukwa zofalitsa zaluso nthawi zambiri zimatumiza zolemba zawo pa intaneti kwaulere.

Komabe, ndemanga za madokotala olankhula ku Russia zokhudzana ndi kukonzekera kwa alpha-lipoic acid ndi zitsanzo zomveka bwino zachikondi chabodza. Zolemba zonse zomwe zimafalitsidwa zimathandizidwa ndi omwe amapanga mankhwala amodzi kapena ena. Nthawi zambiri, Berilition, Thioctacid ndi Thiogamm amalengezedwa motere, koma opanga ena amayesetsanso kupititsa patsogolo mankhwala awo komanso zowonjezera.

Mwachiwonekere, madokotala ali ndi chidwi chachuma polemba eulogies okha pazokhudza mankhwala. Kudalira kwa iwo omwe ali ndi odwala omwe ali ndi matenda ashuga sikuyenera kukhala kokha kwa ansembe achikondi, akamawatsimikizira kuti sakadwala ndi matenda opatsirana pogonana. M'mawunikidwe awo, madotolo amawonetseratu kuchuluka kwa mankhwala omwe amagulitsidwa ku malo ogulitsa mankhwala. Koma ngati muwerenga ndemanga za wodwalayo, mudzazindikira kuti chithunzicho sichabwino kwambiri.

Ndemanga ya omwe amalankhula odwala matenda ashuga olankhula Chirasha za alpha lipoic acid, yomwe imapezeka pa intaneti, imatsimikizira izi:

1. Mapiritsi kwenikweni samathandiza.
2. Madontho okhala ndi thioctic acid amathandizadi kukhala ndi thanzi la matenda ashuga, koma osakhalitsa.
3. Kulingalira kwakuthengo, zabodza zokhudzana ndi kuwopsa kwa mankhwalawa ndizofala pakati pa odwala.

Hypoglycemic coma imatha kupezeka pokhapokha ngati wodwala matenda ashuga amathandizidwa kale ndi insulin kapena mapiritsi okhala ndi sulfonylurea. Kuphatikizika kwa thioctic acid ndi othandizira amatha kutsika magazi ochulukirapo kwambiri, mpaka kufika pakutha kwa chikumbumtima. Ngati mwaphunzira nkhani yathu yokhudza mankhwala omwe ali ndi matenda ashuga a mtundu wa 2 ndikusiya mapiritsi owopsa, ndiye kuti palibe chodandaula.

Chonde dziwani kuti chida chachikulu chothandizira matenda a neuropathy ndi zovuta zina za matenda ashuga ndi chakudya chamagulu ochepa. Alpha lipoic acid imatha kuthandizira, ndikufulumizitsa kubwezeretsa kwachilengedwe. Koma bola zakudya za anthu odwala matenda ashuga azikhala ndi chakudya chamagulu ambiri, sipadzakhala kanthu kena kotenga zakudya zowonjezera, ngakhale mu mawonekedwe a kubaya.

Tsoka ilo, ndi odwala ochepa olankhula Chirasha omwe amadziwa bwino za zakudya zamagulu otsika pang'ono a mtundu 1 ndi matenda ashuga a 2. Uku ndikusintha kochiritsika kwenikweni, koma kumadutsa pang'onopang'ono kuchuluka kwa odwala ndi madokotala. Anthu odwala matenda ashuga omwe samadziwa za zakudya zamagulu ochepa ndipo osatsatira, amataya mwayi wokhala ndi ukalamba wopanda zovuta, ngati anthu athanzi. Kuphatikiza apo, madokotala akukana zosintha, chifukwa ngati odwala onse omwe ali ndi matenda a shuga a mtundu wachiwiri amathandizidwa palokha, ndiye kuti endocrinologists adzasiyidwa osagwira ntchito.

Kuyambira 2008, zakudya zatsopano za alpha-lipoic acid zatulukira ku mayiko olankhula Chingerezi, zomwe zili ndi "patsogolo" - R-lipoic acid. Makapisozi awa amakhulupirira kuti amagwira ntchito kwambiri mu matenda ashuga a m'mimba, ofanana ndi mtsempha wamitsempha. Mutha kuwerenga ndemanga zokhudzana ndi mankhwala atsopano pamasamba achilendo ngati mukudziwa Chingerezi. Palibe ndemanga mu Russia pano, chifukwa tangoyamba kuuza odwala matenda ashuga okhudza mankhwalawa. Ma supplements a R-lipoic acid, komanso mapiritsi olimbitsa a alpha-lipoic acid, ndi malo abwino olowa m'malo otsika mtengo komanso osasangalatsa.

• Dr's Best Biotin R-Lipoic Acid;
• R-lipoic acid - Mlingo wowonjezera wa Life Extension;
• Jarrow Formulas Sustched kumasulidwa Masamba.

Tikugogomezeranso kuti kudya zakudya zamagulu ochepa ndizomwe zimathandiza kwambiri odwala matenda ashuga komanso mavuto ena, ndipo alpha lipoic acid ndi zina zowonjezera zimathandizanso. Timapereka zidziwitso zonse zamagulu ochepa a chakudya chamagulu 1 ndi mtundu wa 2 waulere.

Mapeto

Alpha lipoic acid imatha kukhala yothandiza kwambiri popewa komanso kuchiza matenda ashuga. Imakhala ndi zochizira munthawi zingapo munjira zingapo:

1. Imateteza khungu la ma pancreatic beta, limalepheretsa kuwonongeka kwawo, ndiye kuti, limachotsa zomwe zimayambitsa matenda a shuga 1.
2. Zimalimbikitsa kukoka minofu glucose mu mtundu 2 shuga, kumawonjezera insulin.
3. Imagwira ngati antioxidant, yomwe ndiyofunikira kwambiri kuti muchepetse kukula kwa matenda ashuga, komanso osakhalitsa vitamini C.

Kukhazikitsidwa kwa alpha-lipoic acid ogwiritsa ntchito mafupa amkati mochulukitsa kumawonjezera chidwi cha insulin kwa odwala omwe ali ndi matenda a shuga a 2. Nthawi yomweyo, maphunziro azachipatala omwe adachitika 2007 zisanachitike akuwonetsa kuti kumwa mapiritsi a antioxidant kulibe kanthu. Izi zili choncho chifukwa mapiritsi sangakhalebe othandizira pama cell a magazi nthawi yayitali. Vutoli limathetsedwa makamaka pofika zakudya zatsopano za R-lipoic acid, kuphatikiza Bio-Enhanced® R-Lipoic Acid, yomwe imapangidwa ndi GeroNova ndikuwayika ndikuigulitsa ndikugulitsa ndi Doctor Best and Life Extension. Mutha kuyesanso alpha lipoic acid mu mapiritsi a Jarrow Formulas opulumutsidwa.

• Dr's Best Biotin R-Lipoic Acid;
• R-lipoic acid - Mlingo wowonjezera wa Life Extension;
• Jarrow Formulas Sustched kumasulidwa Masamba.

Apanso, tikukukumbutsani kuti chithandizo chachikulu cha matenda a shuga si mapiritsi, zitsamba, mapemphero, ndi zina zambiri, koma makamaka zakudya zamafuta ochepa. Phunzirani mosamala ndikutsatira mwakhama pulogalamu yathu yothandizira odwala matenda ashuga kapena mtundu wa 2 mtundu wa chithandizo cha matenda ashuga. Ngati muli ndi nkhawa ndi matenda a shuga, ndiye kuti mungasangalale kudziwa kuti ndi zovuta kusintha. Mukasinthasintha shuga m'magazi anu ndikamadya ochepera pang'ono, zizindikiro zonse za neuropathy zimatha kuchoka miyezi ingapo mpaka zaka zitatu. Mwina kumwa alpha lipoic acid kungathandize kuti izi zitheke. Komabe, 80-90% ya mankhwalawa ndi zakudya zoyenera, ndipo zithandizo zina zonse zimangomaliza. Mapiritsi ndi zochitika zina zitha kuthandizika mukachotsa chakudya chamafuta kwambiri m'zakudya zanu.