KODI LACTIC ACIDOSIS NDI CHIYANI NDIPO IMAGWIRIZANA BWANJI NDI MATENDA ASHUGA?

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Kuchulukitsa kwa kapangidwe kake kapena kuchepetsedwa kogwiritsa ntchito lactic acid kumabweretsa kuchepa kwakukulu muyezo wokhala ndi asidi m'thupi. "Acidization" imeneyi imayambitsa matenda akulu - lactic acidosis.

Kodi lactate owonjezera amachokera kuti?

Glucose metabolism ndi njira yovuta, ntchito yomwe sikuti ndikungokhala kwa thupi ndi "mphamvu", komanso kutenga nawo gawo la "kupuma kwamaselo."

Mothandizidwa ndi michere yamankhwala am'magazi, mamolekyulu a shuga amawola ndipo amapanga mamolekyulu awiri a pyruvic acid (pyruvate). Ndi okosijeni wokwanira, pyruvate imakhala choyambira pazinthu zazikulu kwambiri za metabolic mu cell. Pakachitika njala ya oxygen, imasanduka lactate. Pang'ono pokha ndikofunikira kwa thupi, lactate imabwezedwa ku chiwindi ndikusinthidwa kukhala glucose. Izi ndimomwe zimapangidwira glycogen.

Nthawi zambiri, mulingo wa pyruvate ndi lactate ndi 10: 1, mothandizidwa ndi zinthu zakunja, muyezo ungasunthe. Pali chiopsezo cha moyo - lactic acidosis.

Zinthu zomwe zimapangitsa kuchuluka kwa lactic acid ndi:

minofu hypoxia (kuwopsa kwa mankhwalawa, poyizoni wa kaboni dayoksayidi, kuchepa magazi kwambiri, khunyu);
njala yopanda minofu ya okosijeni (poyizoni ndi methanol, cyanides, biguanides, kulephera kwaimpso / chiwindi, oncology, matenda oopsa, matenda a shuga).

Kuwonjezeka kwakukulu kwa mulingo wa lactic m'thupi ndi chinthu chomwe chofunikira kuchipatala mwachangu. Mpaka 50% ya milandu yomwe yadziwika ndiyopha!

Zomwe zimayambitsa matenda ashuga Lactic Acidosis

Lactic acidosis ndimachitika kawirikawiri, ndipo oposa theka la milandu yotchulidwa yomwe imachitika mwa odwala matenda ashuga.

Hyperglycemia imatsogolera ku chakuti shuga owonjezera m'magazi amasinthidwa kwambiri kukhala lactic acid. Kuperewera kwa insulin kumakhudza kutembenuka kwa pyruvate - kusowa kwa chothandizira chazachilengedwe kumabweretsa kuwonjezereka kwa kaphatikizidwe ka lactate. Kubowoleza kosalekeza kumapangitsa kuti maselo azikhala ndi matenda oopsa a m'maselo, kumabweretsa zovuta zambiri (impso, chiwindi, dongosolo la mtima) zomwe zimachulukitsa kufa ndi mpweya wa okosijeni.

Gawo lalikulu la mawonekedwe a lactic acidosis amapezeka mwa anthu omwe amamwa mankhwala a hypoglycemic. Ma biguanides amakono (metformin) samayambitsa kuchuluka kwa lactic acid mthupi, komabe, ngati zinthu zingapo zoyambitsa (matenda opatsirana, zoopsa, poyizoni, kumwa mowa kwambiri, kuchita zolimbitsa thupi kwambiri) zitha kuchititsa kuti pakhale matenda.

Zizindikiro za lactic acidosis mu shuga

Chithunzithunzi chazomwe chimawonetsedwa ndizofanana ndi shuga wambiri

Kugona, kufooka, kutopa, kulemera miyendo kumayang'aniridwa, nseru, kusanza kawirikawiri kumachitika. Lactic acidosis ndiyowopsa chifukwa imakula mofulumira m'maola ochepa chabe. Pambuyo pa matenda am'mbuyomu, matenda am'mimba, kusanza, ndi chisokonezo zimayamba mwadzidzidzi. Nthawi yomweyo, kulibe matupi a ketone mu mkodzo, palibe fungo la acetone.

Lactic acid coma ndi imodzi yoopsa, momwe matulukidwe ake sanakhalire abwino!

Ngati zingwe za mayeso a ketoacidosis ndi glucose zikuwonetsa shuga wambiri, pomwe pali ululu wamisempha, muyenera kuyimbira ambulansi mwachangu! Ngati simukuyesetsa kuchitapo kanthu kuti muthane ndi vutolo, ndiye kuti kuchepa kwamphamvu kwa magazi, kupuma kosaneneka komanso kaphokoso, kuphwanya malungo a mtima, kumatsatiridwa ndi chikomokere.

Kusiyana kwakukulu pakati pa lactic acidosis ndi ketoacidosis kapena hyperglycemia yayikulu ndi kupezeka kwa zowawa m'misempha, zomwe nthawi zambiri zimayerekezedwa ndi minofu yolumikizidwa ya othamanga.

Hyperlactatacidemia Chithandizo

Kuzindikira kwa lactic acidosis kumatha kuchitika kokha ndi mayeso a labotale. Choyamba, amayesa kusiyanitsa acidosis. Magulu a Serum lactate kuchokera ku 5.0 mmol / L ndi ph yochepera 7.25 amakulolani kuti muzindikire poyizoni wa lactic acid m'thupi. Mulingo wokhala ndi asidi pansipa 6.8 ndizofunikira.

Kuchiza kumakhala ndi kubwezeretsa moyenera acid-based, kuthetsa zomwe zimayambitsa hyperglycemia

Ngati ph ndi yotsika kuposa 7.0, njira yokhayo yopulumutsira wodwalayo ndi hemodialysis - kuyeretsa magazi.
Kuti muthane ndi CO2 owonjezera, mapangidwe oopsa am'mapapo adzafunika.
M'malo ocheperako, kupezeka kwa akatswiri pa nthawi yake, dontho la alkaline (sodium bicarbonate, trisamine) ndilokwanira. Mlingo wa makonzedwe amatengera kupanikizika kwapakati kwapakati. Ma metabolism anu akangotukuka, mutha kuyamba kutsika magazi anu. Chifukwa cha izi, njira zosiyanasiyana zoperekera njira yothetsera shuga ndi insulin zitha kugwiritsidwa ntchito. Monga lamulo, awa ndi magawo 2-8. ndi liwiro la 100-250 ml / h.
Ngati wodwala ali ndi zinthu zina zomwe zimakhudzana ndi lactic acidosis (poyizoni, kuchepa kwa magazi m'thupi), chithandizo chawo chimachitika molingana ndi mfundo yakale.

Palibe chovuta kupereka thandizo kwa zizindikiro za lactic acidosis. Kuchepetsa acidity yamagazi kunja kwa chipatala sikugwira ntchito. Mafuta amchere a alkaline ndi koloko sangagwiritse zotsatira zomwe mukufuna. Ndi kuthamanga kwa magazi kapena kugwedezeka, kugwiritsa ntchito dopamine kumakhala koyenera. Ndikofunikira kuti zitsimikizire kutuluka kokwanira kwa mpweya, pakapanda pilo la okosijeni kapena inhaler, mutha kuyatsa chinyezi ndikutsegula mawindo onse.

Momwe matendawo amachira kuchokera ku lactic acidosis ndi osauka. Ngakhale chithandizo chokwanira komanso kufikira madokotala moyenera sikutsimikizira kupulumutsa moyo. Chifukwa chake, odwala matenda ashuga, makamaka iwo omwe akutenga metformin, ayenera kumvetsera matupi awo mosamala ndikuwonetsetsa kuti shuga yawo yayandikira.

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