Kuthamanga kwa magazi, zovuta zopsetsa mtima, komwe ubongo, mitsempha yamagazi ndi mtima zimavutikira, amapezeka mwa 30% ya achinyamata ndi 70% azaka zadziko lathu. Mankhwala osokoneza bongo omwe ali ndi antihypertensive kwambiri a Lozap ndi Lozartan cholinga chake ndikuchepetsa kuchuluka kwa mtima ndi zomwe zimachitika pambuyo pake, monga ischemic stroke kapena vuto la mtima.
Khalidwe Lozap
Chofunikira chachikulu pa mankhwalawa ndi losartan potaziyamu. Njira yotulutsira - mapiritsi a mavoliyumu osiyanasiyana (12.5 mg, 50 mg, 100 mg). Kuphatikiza pazomwe zimagwira, mawonekedwewo akuphatikizapo:
- zakudya zamkati zamkati;
- silicon dioxide sorbent;
- magnesium stearate emulsifier;
- hypromellose plasticizer;
- enterosorbent povidone;
- mankhwala ofewetsa tuvi tinthu tambiri;
- talc;
- utoto woyera titanium dioxide;
- diuretic mannitol.
Zochita za Lozap ndi Lozartan cholinga chake ndikuchepetsa kuchuluka kwa zamitsempha yama mtima ndi zovuta zawo.
Lozap adalembedwa:
- kuchokera pamavuto;
- monga prophylaxis yamitsempha yamagazi;
- pamodzi mankhwalawa mtima kulephera;
- ndi matenda ashuga nephropathy;
- ndi hypertrophy ya kumanzere kwamitsempha;
- ndi hyperkalemia (monga okodzetsa).
Zoyipa:
- aimpso mtsempha wamagazi stenosis (kuchepetsa);
- hypotension;
- kuphatikiza matenda okhudzana ndi minofu;
- tsankho;
- nthawi ya pakati ndi mkaka wa m`mawere;
- ana ndi achinyamata ochepera zaka 18.
Ngati matenda aimpso ndi chiwindi, kuwonongeka kwa mankhwalawa ndikotheka, koma kuyang'aniridwa ndi adokotala, kuyambira muyezo ndi mawonekedwe ochepa.
Khalidwe la losartan
Mankhwala amapezeka pamapiritsi a 25 mg, 50 mg, 100 mg. Ntchito zake zazikulu ndizopatsa chidwi. Ntchito ya mankhwala mbali imeneyi imapanganso yogwira pophika - potaziyamu losartan. Zowonjezera ndizophatikiza:
- CHIKWANGWANI (chakudya cha fiber cellulose);
- silicon dioxide sorbent;
- magnesium stearate emulsifier;
- hypromellose plasticizer;
- enterosorbent povidone;
- macrogol othandizira;
- talc;
- utoto woyera titanium dioxide;
- shuga la mkaka (lactose monohydrate);
- croscarmellose sodium chakudya zosungunulira;
- mowa wa polyvinyl (E1203 monga othandizira glazing).
Losartan imayang'anira kuthamanga kwa magazi ndipo imalepheretsa ziwiya kuti zisamachepetse.
Losartan amathandizira kubwezeretsa magwiridwe antchito a thupi lonse:
- amayang'anira kukakamiza;
- amalepheretsa ziwiya kuti zisamachepetse;
- imathandizira kamvekedwe ka mitsempha yam'mapapo;
- amachepetsa matenda oopsa am'manja.
Zoyipa:
- aimpso mtsempha wamagazi stenosis;
- shuga mellitus (chifukwa cha kupezeka kwa lactose mu kapangidwe kake);
- ochepa hypotension;
- matenda a minofu;
- Hypersensitivity;
- mimba ndi mkaka wa m`mawere;
- ana ndi achinyamata ochepera zaka 18.
Mwa kuperewera kwaimpso ndi kwa chiwindi, mankhwalawa amachitika moyang'aniridwa ndi dokotala, kuyambira ndi Mlingo wochepa.
Kuyerekeza kwa Lozap ndi Lozartan
Mankhwalawa ndi mawonekedwe ofanana omwe amafananako pakuchita. Amakhala ndi zinthu zomwe zimagwira - potaziyamu losartan, omwe ntchito zake zimayang'ana kuti atseke angiotensins, omwe amachititsa vasoconstriction komanso kuwonjezeka kwa kuthamanga kwa magazi (BP). Kusiyana kwakukulu komwe kumaganiziridwa nthawi yoikidwiratu ndizinthu zomwe zimaphatikizidwa pazomwe zimapangidwa, zomwe zotsutsana ndi chiwopsezo cha mavuto zimadalira.
Kufanana
Cholinga chachikulu cha mankhwalawa ndikuchepetsa magazi. Ntchito ya losartan potaziyamu ndikusokoneza njira yomwe imabwezeretsa ma electrolyte a impso, omwe amachititsa kuti chithokomiro cha chlorine ndi sodium chizioneka. Chifukwa cha hydrochlorothiazide yopangidwa ndi thupi, kuchuluka kwa aldosterone kumawonjezera, renin imayambitsidwa m'magazi am'magazi, ndipo kuwonjezeka kwa potaziyamu kumachitika mu seramu. Njira zonse zomwe zimapitilira zimatsogolera, chomaliza, mpaka kuzowonetsa izi:
- kuthamanga kwa magazi kufanana;
- katundu pa mtima amachepetsa;
- kukula kwakukuru kwa mtima kumabwerera kwawamba.
Pharmacological zochita za Lozap ndi Lozartan:
- zigawo zikuluzikulu za mankhwala zimatengedwa mosavuta ndi maselo am'mimba;
- kagayidwe amapezeka chiwindi;
- kuchuluka kwambiri m'magazi kumawonedwa pambuyo pa ola limodzi;
- mankhwalawa amachotsedwa mu mawonekedwe osasintha ndi mkodzo (35%) ndi bile (60%).
Zina zofananira:
- yogwira ya losartan potaziyamu sangathe kulowa kudzera mu GEF (magazi muubongo wamagazi) m'chigawo chachikulu chamanjenje, kuteteza maselo abongo a ubongo ku poizoni;
- Zotsatira zake kuchokera munthawi ya chithandizo zimawonekera pakatha mwezi umodzi;
- zotsatira zimapitirira kwa nthawi yayitali;
- Mlingo woyenera wambiri ndi 200 mg tsiku lililonse (muyezo zingapo).
Zotsatira zoyipa zomwe zimapezeka ndi mankhwala osokoneza bongo ndi monga:
- kukula kwa matenda otsegula m'mimba (mu 2% ya odwala);
- myopathy - matenda a connective minofu (1%);
- yafupika libido.
Zotsatira zoyipa zomwe zimachitika mukamatenga Losartan ndi Lozap zimaphatikizanso kukulira kwa m'mimba.
Kodi pali kusiyana kotani?
Kusiyana pakati pa mankhwala ndizochepa kwambiri kuposa kufanana, koma kuyenera kuganiziridwa posankha mankhwala.
Popeza Lozap imaphatikizapo mannitol diuretic, mawonekedwe otsatirawa ogwiritsira ntchito akuyenera kuwonedwa:
- sayenera kumwedwa molumikizana ndi othandizira ena okodzetsa;
- Maphunziro asanachitike, kuwunika kwa Laborator kwa zizindikiro za VEB (madzi osakanikirana ndi ma electrolyte) kuyenera kuchitika;
- Pa chithandizo pachokha, tikulimbikitsidwa kupenda pafupipafupi mchere wa potaziyamu m'thupi.
Losartan ili ndi mitundu yambiri yowonjezera. Pachifukwa ichi, pali mwayi wambiri wowonetsera thupi lawo komanso:
- Mosiyana ndi Lozap, kusankhidwa ndikuwonetsa chithandizo chovuta momwe ma diuretic amagwiritsidwa ntchito;
- Losartan ali ndi ma analogi ambiri, pogwiritsa ntchito omwe, ndikofunikira kuphunzira zowonjezera mwatsatanetsatane;
- Losartan ndi yotsika mtengo.
Kusiyanitsa mankhwala ndi wopanga. Lozap imapangidwa ndi Slovak Republic (kampani ya Zentiva), Lozartan ndi mankhwala a Vertex opanga opangira opanga (analogues omwe amaperekedwa ndi Belarus, Poland, Hungary, India).
Zomwe zimakhala zotsika mtengo
Mtengo Wotayika:
- 30 ma PC 12,5 mg - 128 ma ruble;
- 30 ma PC 50 mg - 273 ma ruble;
- Ma PC 60. 50 mg - ma ruble 470;
- 30 ma PC 100 mg - 356 rub .;
- Ma PC 60. 100 mg - ma ruble 580;
- Ma PC 90 100 mg - 742 rub.
Mtengo wa osowa:
- 30 ma PC 25 mg - 78 ma ruble;
- 30 ma PC 50 mg - ma ruble 92;
- Ma PC 60. 50 mg - 137 ma ruble;
- 30 ma PC 100 mg - 129 ma ruble;
- Ma PC 90 100 mg - 384 rub.
Chingakhale bwino ndi lzap kapena losartan
Malinga ndi akatswiri, awa ndi mankhwalawa ofanana mu lingaliro la kuchitapo kanthu, osiyana mu mayina, mtengo ndi wopanga okha. Koma ayenera kumwedwa monga adanenera ndi adotolo, kuti asakuze mphamvu ya kufananirana ndi zinthu zina zothandizira. Zovuta zazikulu zimakhudzana ndi zowonjezera zowonjezera mphamvu. Pa upangiri wa Myasnikov A.L. (cardiologist), posankha antihypertensive mankhwala, ndikofunikira kuti akuwongoleredwe ndi mulingo wa uric acid m'magazi. Ndi zochulukirapo zake komanso kugwiritsa ntchito mankhwala popanda diuretics, pamakhala chiopsezo cha arthrosis.
Ndemanga za Odwala
Katerina, wazaka 51, Kursk
Dotolo adayambitsa Lozap, koma adagula Lozartan (mtengo wake unali wabwino). Sindinakonde zotsatirapo, kukakamizidwa kwa kulumikizana, tachycardia kunapezeka. Patatha mwezi umodzi, zotsatira zoyipa ngati thrombosis (zimapezeka motere mu malangizo a mankhwalawo). Chifukwa chake khalani osamala.
Maria, wazaka 45, St. Petersburg
Ndikofunikira kuti muchepetse kukakamizidwa, koma izi sizichiritsa matendawa. Ndidamva kuti amuna omwe amamwa mankhwala osokoneza bongo a antihypertgency amawopseza kuti alibe mphamvu. M'pofunika kufufuza zomwe zimayambitsa. Mwambiri, awa ndi mitsempha, kuperewera kwa chakudya, kusowa tulo, kusuntha pang'ono. Kupatula apo, zonse zimapita patchuthi ndipo kukakamizidwa kumatha.
Alexandra, wazaka 42, Penza
Lozap sayenera kumwedwa usiku. Ma analogi a Lozartan (Tevo, Richter) amathandizidwanso ndi ma diuretics, izi ziyenera kukumbukiridwa. Ndikupangira kulandira m'mawa, kukonzekera usiku kumayambitsa zovuta.
Cholinga chachikulu cha mankhwalawa Lozap ndi Lozartan ndikuchepetsa kuthamanga kwa magazi.
Ndemanga za madotolo za Lozap ndi Lozartan
M.N. Petrova, wothandizira, Omsk
Mankhwalawa ali ndi zovuta zina - amagwira ntchito pokhapokha ngati atenga nthawi yayitali, ndipo ngati palibe mavuto. Sathanso kuchiritsa matenda oopsa; sangapulumutsidwekonso.
S.T. Smirnov, cardiologist, Apatity
Izi angiotensin 2 blockers amakumana ndi zomwe zimavomerezeka zomwe zimagwiritsidwa ntchito: ochepa matenda oopsa, kuthinitsidwa kwamphamvu chifukwa chakuwonjezeka kwa voliyumu yamanzere, nephropathy ya mtundu 2 odwala matenda ashuga, mtima. Mankhwala omwe mumalandira sangaperekedwe okha.
T.D. Makarova, katswiri wamtima, Ivanovo
Mankhwalawa ndi ofanana. Amasankhidwa kukhala ndi mbiri yayitali ya mbiri yakale (kulekerera bwino komanso kusapezeka kwa contraindication, mutha kuyitenga kuti ikhale ndi moyo). Chifukwa, kuchuluka kwa mlingo, analogi - amasankhidwa kokha ndi katswiri. Kudzichitira wekha matenda amtima sikuloledwa.
