Glidiab ndi mankhwala omwe anthu amafunafuna kwambiri omwe amathandiza kukonza mkhalidwe wa odwala omwe ali ndi matenda a shuga a mtundu wachiwiri. Zinthu zokhudzana ndi kapangidwe zimathandizira kuchepetsa kuchuluka kwa shuga ndikuyambitsa kuwongolera kwa glycemic.
Dzinalo Losayenerana
INN Gliclazide (gliclazide).
Mu Chilatini - Glidiab.
Ath
Mu gulu la atomiki-achire, mankhwala amapatsidwa nambala A10BB09.
Glidiab ndi mankhwala omwe anthu amafunafuna kwambiri omwe amathandiza kukonza mkhalidwe wa odwala omwe ali ndi matenda a shuga a mtundu wachiwiri.
Kutulutsa mafomu ndi kapangidwe kake
Glidiab imapezeka mu mapiritsi omwe ali ndi mawonekedwe ozungulira komanso otsekemera (kapena wachikasu pang'ono). Phukusili lili ndi miyala 60.
Chofunikira chachikulu pakuphatikizika ndi gliclazide. Kuchuluka kwake piritsi lililonse kumafika 80 mg.
Glidiab MV ili ndi 30 mg yogwira ntchito.
Kuphatikizidwa kwazinthu kumaphatikizapo: magnesium stearate, shuga mkaka, talc, hypromellose, sodium starch glycolate, MCC.
Glidiab amapezeka mu mawonekedwe am'mapiritsi omwe amakhala ozungulira.
Zotsatira za pharmacological
Mapiritsi ndi mankhwala am'mgulu la opanga hypoglycemic othandizira. Mphamvu ya mankhwalawa cholinga chake ndikuwongolera njira zingapo:
- Maselo a Pancreatic B amayamba kupanga insulin mwachangu;
- zotumphukira zimakhala ndi chidwi chambiri cha insulin;
- Kuchita kwa glucose amapeza insulin secretory katundu;
- nthawi kuyambira pakudya mpaka pakuyamba kupanga insulin yafupika;
- kuchuluka kwa gluprose kuchulukitsidwa;
- nsonga zoyambirira zopanga insulin zimabwezeretseka.
Mankhwalawa ali ndi zotsatira zabwino pakuchulukitsa kwam'mimba:
- mtima kukhathamiritsa kubwezeretsedwa;
- kuphatikiza kwa mapulateleti ndi zomatira zimachepa;
- physiological parietal fibrinolysis ndi yachibadwa;
- chiopsezo chokhala ndi atherosulinosis ndi microthrombosis yafupika;
- amachepetsa mphamvu ya mtima receptors kwa adrenaline.
Chachilendo cha mankhwalawa ndikuti zimakhudza mwachindunji gawo loyambirira la insulin. Khalidwe limasiyanitsa ndi njira zina, popeza odwala samachulukitsa thupi. Malinga ndi zakudya zomwe dokotala amalimbikitsa, odwala omwe onenepa kwambiri angabwezeretsenso thupi.
Pharmacokinetics
Mutatha kumwa mankhwalawo, gawo lalikulu la gawo logwira ntchito m'magazi a magazi limafikiridwa pambuyo pa maola 4. Mu chiwindi, biotransfform ya metabolites imachitika: amachepetsa, pali glucuronidation wogwira ndi hydroxylation. Zotsatira zake, ndalamazo 8 zimapangidwa zomwe sizimagwirizana ndi glucose.
Thupi limachotsedwa mthupi kudzera mu impso (pafupifupi 70%) komanso kudzera m'matumbo (pafupifupi 12%). Kutha kwa theka la moyo kumapangitsa maola 8-11.
Zizindikiro zogwiritsidwa ntchito
Mankhwalawa amathandizidwa ndi odwala omwe ali ndi vuto lachiwiri la matenda a shuga. Ndibwino pakakhala zovuta (microangiopathy). Muzochitika izi, mankhwalawa amatha kugwiritsidwa ntchito ngati monotherapy kapena ngati chithandizo chovuta pamodzi ndi mankhwala a hypoglycemic.
Mankhwalawa amathandizidwa ndi odwala omwe ali ndi vuto lachiwiri la matenda a shuga.
Monga prophylactic, mapiritsi akulimbikitsidwa kuti aletse kukula kwa zovuta za hemorheological mu shuga.
Contraindication
Mndandanda wa contraindication ku mankhwalawa umaphatikizapo zotsatirazi zamatenda ndi matenda:
- mtundu 1 shuga;
- kukula kwa mtundu wa matenda ashuga a 2;
- kukhalapo kwa insuloma wodwala;
- ketoacidosis;
- aimpso ndi chiwindi kulephera;
- microangiopathy yayikulu;
- Hypersensitivity kuti sulfonylurea;
- mimba ndi mkaka wa m`mawere;
- matenda opatsirana;
- nthawi yamankhwala ochita opaleshoni isanachitike komanso itatha (maola 48);
- ana ochepera zaka 18.
Ndi chisamaliro
Malinga ndi malangizo, pali matenda angapo ndi momwe mungagwiritsire ntchito mankhwalawa kuti muthandizidwe kusintha ndi kuchuluka kwa makonzedwe. Izi ndi:
- matenda a chithokomiro;
- malungo
- uchidakwa (uchidakwa);
- gululi yogwira inshuwaransi;
- kukhalapo kwa matenda ashuga nephroangiopathy.
Pamaso pa chimodzi kapena zingapo mwazomwe zili pamwambapa, adokotala ayenera kusankha njira yochiritsira payekhapayekha. Kuthekera kwa kupereka mankhwala Glidiab kumaganiziridwa.
Momwe mungatenge Glidiab
Kuti zitheke, ndichizolowezi kusiyanitsa Mlingo watsiku ndi tsiku wa mankhwala:
- muyezo - 80 mg / tsiku.;
- pafupifupi - 160 mg / tsiku.;
- okwera ndi 320 mg / tsiku.
Kuchuluka kwa tsiku ndi tsiku mgawo umagawidwa m'magawo awiri ofanana ndipo umatengedwa m'mawa ndi madzulo 30 mphindi musanadye. Imwani mankhwalawo ndi madzi ambiri.
Kumwa mankhwala a shuga
Sitikulimbikitsidwa kuti muzidzipangira nokha, chifukwa mankhwalawo saloledwa mtundu woyamba wa matenda a shuga ndi mtundu 2 kuti akule bwino. Asanapange mankhwala, dokotala amayang'ana zaka za wodwalayo, matenda ake, zizindikiro za glycemia, komanso kugwiritsa ntchito mankhwala ena.
Asanapange mankhwala, dokotala amayang'ana zaka za wodwalayo, matenda ake, zizindikiro za glycemia, komanso kugwiritsa ntchito mankhwala ena.
Zotsatira zoyipa za Glidaba
Zotsatira zoyipa za kumwa mankhwalawa ndizochepa. Mwambiri, mapiritsiwo amalekeredwa bwino.
Odwala angadandaule za:
- Chizungulire
- mutu
- kutopa;
- thupi lawo siligwirizana (kuyabwa ndi urticaria);
- kukulira kwa discriram-like syndrome (nseru, kutsegula m'mimba, kapena kudzimbidwa);
- asthenia;
- zithunzi.
Zodziwika pang'ono:
- paresis;
- hypoglycemia;
- thrombocytopenia;
- agranclocytosis;
- leukopenia;
- kuchepa magazi
Zokhudza mphamvu pakuwongolera njira
Mukamamwa mankhwalawa, odwala ayenera kusamala kuyendetsa, kugwiritsa ntchito makina, komanso kuchita nawo masewera oopsa.
Malangizo apadera
Kuchepetsa chiopsezo cha mavuto, mankhwalawa amayenera kuikidwa pakudya. Zofunikira ndikusowa kwa kufa ndi njala komanso kupatula mowa.
Njira ya mankhwalawa imachitika molumikizana ndi chakudya chokhala ndi chakudya chamagulu ochepa. Nthawi yomweyo, muyenera kuyang'anira kuchuluka kwa shuga m'magazi pamimba yopanda kanthu ndikatha kudya.
Kuchepetsa chiopsezo cha mavuto, mankhwalawa amayenera kuikidwa pakudya.
Zikakhala kuti wodwalayo amakhala ndi nkhawa kwambiri kapena akakhala ndi nkhawa zambiri, muyezo wa mankhwalawa umayenera kusintha.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwala sanatchulidwe.
Kupangira Glidiab kwa Ana
Chifukwa chakuti palibe chidziwitso pa zoopsa ndi mapindu a mankhwalawa kwa ana, sichikuperekedwa kwa odwala omwe ali ndi zaka zosakwana 18.
Gwiritsani ntchito mu ukalamba
Odwala okalamba safuna kusintha kwa mlingo. Kupatula ndiye anthu omwe ali ndi ma pathologies omwe amafunikira chidwi chochulukirapo.
Odwala okalamba safuna kusintha kwa mlingo.
Mankhwala ochulukirapo a Glidab
Kupitilira Mlingo wa Mankhwalawa kumapangitsa kuchepa kwamphamvu kwa shuga m'magazi. Kusintha kotereku kumatha kuyambitsa hypoglycemic chikomokere, matenda a shuga.
Kukhazikika kumachepetsa kukhazikitsa shuga, sucrose kapena dextrose kulowa mthupi. Pali njira zingapo zochitira izi:
- pakamwa (ngati munthu angathe kumeza);
- kudzera m'mitsempha (ngati wodwalayo sakudziwa) - 40% dextrose solution imayendetsedwa.
Kuphatikiza apo, 1-2 mg ya glucagon imayendetsedwa intramuscularly. Munthu akazindikira, amawonetsedwa kudya zakudya zopatsa mphamvu za m'mimba.
Kupitilira Mlingo wa Mankhwalawa kumapangitsa kuchepa kwamphamvu kwa shuga m'magazi.
Kuchita ndi mankhwala ena
Kuti musankhe Mlingo, kuyanjana kwa mankhwalawa ndi mankhwala ena omwe amagwiritsidwa ntchito pochiritsira kuyenera kuganiziridwa.
Mankhwalawa sagwirizana ndi kukonzekera kwa miconazole.
Zochita za yogwira gliclazide zimatheka ndi mankhwala otsatirawa:
- mafupa;
- ACE zoletsa;
- beta-blockers;
- biguanides (metformin);
- anabolic steroids;
- salicylates;
- Mao zoletsa;
- tetracyclines;
- maantibayotiki
- phosphamides;
- mabwinja.
Mphamvu ya mankhwalawa imafooka ndi mankhwala otsatirawa pamndandanda:
- glucocorticoids;
- barbiturates;
- sympathomimetics;
- mahomoni a chithokomiro;
- saluretics;
- mchere wa lithiamu;
- Rifampicin;
- Chlorpromazine;
- Glucagon.
Mlingo waukulu wa estrogen, njira zakulera zamkamwa, asidi a nikotini amatha kufooketsa mphamvu.
Kuyenderana ndi mowa
Pa mankhwala ndi Glidiab, mowa uyenera kusiyidwa kwathunthu. Akaphatikizidwa, mphamvu ya mankhwalawo imakhala yotsika. Kuphatikiza apo, kupezeka kwa ethanol kumawonjezera chiopsezo cha mavuto.
Analogi
Mankhwala oyamba a gululi ndi Gliclazide (ili ndi zomwe zili ndi dzina lomweli). Mankhwala ena onse omwe ali ndi mawonekedwe awa amawonedwa ngati ma genetic. Mankhwala otsatirawa amatchulidwa kwa othandizira odwala matenda am'mimba omwe ali ndi gliclazide:
- Zolemba;
- Dziwani;
- Diabefarm;
- Diabinax;
- Predian;
- Diabresid;
- Gliklada;
- Diabetesalong;
- Glucose;
- Predian;
- Glioral;
- Diabresid;
- Glucostabil;
- Medoclazide.
Pali mitundu ingapo ya mankhwala omwe amagwirizana mu cholinga (mtundu 2 matenda a shuga). Pakati pawo pali ena mwa omwe amafunidwa kwambiri:
- Januvius;
- Glucobay;
- Bagomet;
- Baeta;
- Lymphomyozot;
- Avandia
- Methamine;
- Multisorb;
- Fomu.
Kupita kwina mankhwala
Mutha kugula mankhwalawa mu mankhwala okha ndi mankhwala.
Mtengo wa Glidiab
Mtengo wa mankhwalawa umasiyanasiyana pang'onopang'ono malinga ndi ndondomeko yamitengo yamapiritsi. Ku Moscow, mtengo wake umachokera ku ruble 120 mpaka 160.
Mutha kugula mankhwalawa mu mankhwala okha ndi mankhwala.
Zosungidwa zamankhwala
Mankhwalawa amalembedwa ngati B. Ayenera kusungidwa m'malo amdima kutali ndi ana pa kutentha osaposa + 25 ° C.
Tsiku lotha ntchito
Nthawi yosungirako ndi zaka 4. Pambuyo pa nthawi imeneyi, mankhwalawo amaletsedwa kumwa.
Wopanga
Wopanga ndi kampani yaku Russia Akhirin Chemical Farm OJSC. Ofesi ya kampaniyo ndikupanga zinthuzi ili mdera la Moscow, mudzi wa Staraya Kupavna.
Ndemanga za Glidiab
Irina, wazaka 49, Tyumen
Ndakhala ndikumwa Glidiab kwa chaka chimodzi tsopano, mkhalidwe wanga wakhazikika. Zabwino: mumamwa piritsi m'mawa ndipo mumatha kupita kuntchito osadandaula ndi shuga. Chokhacho chomwe sichiyenera kuyiwalika ndizakudya zochiritsa. Kupanda kutero, mankhwalawo amayamba kukhala osathandiza.
Natalia, wazaka 35, Izhevsk
Kwa kanthawi ndimamwa mankhwala ena omwe ali ndi vuto lofananalo. Miyezi ingapo yapitayo, adotolo adasamukira ku Glidiab. Poyamba, zinkabweretsa chisangalalo pang'ono m'mimba. Pambuyo pa masabata angapo, mavuto ake adatha. Ndikupitilirabe kumwa mapiritsiwa. Pakadali pano, zonse zili bwino.