Cocarnit ndimakonzedwe ovuta okhala ndi mavitamini a B ndi triphosadenine. Ntchito zochizira matenda ashuga polyneuropathy, neuralgia, kupweteka kwa minofu. Amagwiritsidwanso ntchito kukonza kagayidwe ka matenda a mtima.
ATX
A11DA (Vitamini B1).
Cocarnit ndimakonzedwe ovuta okhala ndi mavitamini a B ndi triphosadenine.
Kutulutsa mafomu ndi kapangidwe kake
Lyophilisate pokonza yankho la pinkish, ma ampoules atatu a 3 ml mu phukusi la khungu. Mbale 1 ili ndi:
- Trifosadenin 10 mg.
- Nicotinamide - 20 mg.
- Cyanocobalamin - 0,5 mg.
- Cocarboxylase - 50 mg.
Omwe amathandizira: glycine 105.8 mg, zosungirako (methyl parahydroxybenzoate - 0,6 mg, propyl parahydroxybenzoate - 0,15 mg). Zosungunulira: lidocaine hydrochloride - 10 mg, madzi a jakisoni - 2 ml.
Zotsatira za pharmacological
Mankhwalawa ndi mavitamini awiri, coenzyme imodzi ndi metabolic chinthu.
Trifosadenin ndi chida chomwe chili ndi ma macroergic ambiri omwe amapereka mphamvu zamagetsi ndi minofu ya mtima. Imakhala ndi zotsutsana ndi antiarrhythmic. Amakulitsa mitsempha ya m'magazi ndi coronary. Amasintha kagayidwe ka minyewa ya mitsempha.
Trifosadenin ndi chida chomwe chili ndi macroergic bond omwe amapatsa mphamvu minofu ya mtima.
Nicotinamide - Vitamini PP, amagwira nawo ntchito zamagetsi, zochita za kayendedwe ka Krebs. Amasintha kagayidwe kazakudya ndi mapuloteni, kupuma kwam ma cell. Amachepetsa cholesterol.
Cyanocobalamin - vitamini B12. Kuperewera kwamtunduwu kumabweretsa tambala wosakhazikika, kuwonongeka kwa ntchito ya msana ndi zotumphukira zamitsempha. Ndiwopereka magulu a methyl kuti achepetse kuchuluka kwa homocysteine, komwe kumavulaza mtima. Chimalimbikitsa kusinthika kwa maselo.
Cocarboxylase ndi coenzyme wa enboxme wa carboxylase yemwe amawongolera kaphatikizidwe ndi mawonekedwe a magulu a carboxyl kuti alpha-keto acid. Kutanthauza antihypoxants, kumawonjezera kukana kwa myocardial pakuchepa kwa mpweya. Amachepetsa ndende ya lactate ndi pyruvate mu cardiomyocyte ndi thupi. Zomwe zimaphatikizidwa ndi kaphatikizidwe kazinthu zama acid, mapuloteni, mafuta.
Pharmacokinetics
Trifosadenin imasweka m'maselo mu ma phosphates ndi adenosine, omwe amaphatikizidwa pakupanga molekyulu ya ATP pazofunikira zamthupi, kuphatikizapo minyewa yamitsempha ndi mtima.
Cocarboxylase amalowa m'matipi, amaphatikizidwa ndi michere, kenako amawola. Zinthu zonyansa zimapakidwa mkodzo.
Cyanocobalamin imayendetsedwa ndi mapuloteni a transcobalamin mu minofu, yomwe imasungidwa makamaka ndi chiwindi, komwe imadulidwa pang'ono ndi bile. Kusintha kukhala 5-deoxyadenosylcobalamin. Kumanga mapuloteni ndi 0.9%. Anachotsa mofulumira pambuyo pa utsogoleri wa makolo. Kuzindikira kwakukulu kumatheka ola limodzi pambuyo pakubaya. Kuchotsa theka moyo ndi 500 masiku. Amayikidwira pamatumbo ambiri - pafupifupi 70-100%, 7-10% amasiya thupi kudzera mu impso. Imalowa mkati mwa placenta, komanso mkaka wa m'mawere.
Cyanocobalamin amasungidwa makamaka ndi chiwindi, komwe chimasungidwa pang'ono ndi bile.
Nicotinamide imagawidwa mwachangu mthupi lonse. Zimapangidwa ndi chiwindi - nicotinamide-N-methylnicotinamide imapangidwa. Kuthetsa theka-moyo ndi maola 1.3. Imafufutidwa kudzera mu impso, chilolezo cha 0.6l / min.
Zizindikiro zogwiritsidwa ntchito
Amasonyezedwa matenda ashuga a m'mimba (goosebumps, neurogenic ululu), matenda a mtima, a neurocirculatory dystonia, munthawi yomwe akuchira matenda a mtima, munthawi yovuta ya ischemic, kukomoka. Malangizo ogwiritsira ntchito akuwonetsa sciatica, radiculitis.
Contraindication
Contraindicated vuto la hypersensitivity mankhwala, kuchuluka magazi, mimba, mkaka wa m`mawere, osakwana zaka 18, pachimake mtima kulephera, thromboembolism, hemorrhagic sitiroko, kupweteka kwa chiwindi, mphumu, chiwindi, chiwindi kapena thovu.
Simungagwiritse ntchito mankhwalawa chifukwa chosagwirizana, hypotension, kuchuluka kwa nthawi ya QT, cardiogenic shock, bradyarrhythmias.
Simungagwiritse ntchito mankhwalawa kwa matenda oopsa osagwirizana.
Momwe mungatenge Cocarnit
Mukamagwiritsa ntchito mankhwalawa, muyenera kudziwa momwe mungamwere.
Zomwe muyenera kuswana
Dilute 2 ml ya 0,5% (10 mg) kapena 1 ml ya 1% ya lidocaine wa 1 ml ya madzi a jekeseni.
Kumwa mankhwala a shuga
Jekeseni amayikidwa pansi kwambiri. Maphunzirowa ndi masiku 9 a 1 okwanira. Pambuyo pochotsa ululu wammbuyo, mankhwala amapitilizidwa - jakisoni amatha masiku onse atatu. Maphunzirowa ndi milungu itatu.
Zotsatira zoyipa
Mankhwala amatha kuyambitsa mavuto.
Matumbo
Kusanza, kusanza, kutsekula m'mimba - kawirikawiri.
Hematopoietic ziwalo
Kuwonjezeka kwa maselo ofiira am'magazi, maselo oyera oyera, mapulateleti.
Pakati mantha dongosolo
Chisangalalo, kupweteka mutu, vertigo.
Kuchokera kumbali ya dongosolo lamanjenje lamkati, zovuta zoyambira m'mutu zimatheka.
Kuchokera pakhungu ndi minofu yapamtunda
Kuchokera pakhungu ndi zotsekeka zimakhala - totupa, kuyabwa, khungu rede, ziphuphu zakumaso, thukuta.
Kuchokera ku chitetezo chamthupi
Edema ya Quincke, kuyabwa, zotupa.
Kuchokera kumbali ya mtima
Arrhythmia, tachy ndi bradycardia, kupweteka pachifuwa, kuchepa kwa mavuto.
Matupi omaliza
Kugwedezeka kwa anaphylactic, zotupa pakhungu.
Wodwala amatha kuwonetseredwa mawonekedwe a khungu lotupa.
Malangizo apadera
Kuchiza ndi mankhwalawa kuyenera limodzi ndi matenda a shuga komanso mothandizidwa ndi mankhwala a hypoglycemic. Ngati zizindikiro zikukula kapena ngati palibe kusintha, malangizowo asinthidwa.
Njira yothetsera vutoli imagwiritsidwa ntchito mukangokonzekera. Iyenera kukhala ndi utoto wapinki. Zikasintha, mankhwalawa sangathe kugwiritsidwa ntchito.
Zokhudza mphamvu pakuwongolera njira
Zotsatira zoyipa zimatheka - chizungulire, kusokonezeka kwa chikumbumtima. Zikafika, simungayendetse magalimoto komanso magwiridwe antchito.
Zotsatira zoyipa zimatheka - chizungulire, kusokonezeka kwa chikumbumtima.
Gwiritsani ntchito panthawi yoyembekezera komanso mkaka wa m`mawere
Zotsimikizika. Mukamamwa mankhwalawa, amakana kudyetsa.
Mlingo wa Cockarnit wa ana
Mankhwalawa ali otsutsana mpaka wazaka 18 zakubadwa.
Gwiritsani ntchito mu ukalamba
Kusintha kwa Mlingo sikofunikira.
Bongo
Chifukwa cha zomwe zili ndi vitamini PP ndikugwiritsa ntchito nthawi yayitali, mankhwalawa amatha kuyambitsa matenda a chiwindi chamafuta chifukwa cha kuchepa kwa magulu a methyl. Ndi bongo wa cyanocobalamin, kuchuluka kwa folic acid kumachepa.
Kuchita ndi mankhwala ena
Cyanocobalamin imagwirizana ndi mavitamini B1, B2, B6, folic, ascorbic acid, zitsulo zolemera (De-nol, Cisplatin), mowa.
Cyanocobalamin imagwirizana ndi mowa.
Pogwiritsa ntchito munthawi yomweyo mankhwala a biguanides (Metformin) omwe ali ndi vuto la shuga wosaloledwa, mankhwala aminoglycoside, salicylates, potaziyamu, colchicine, anticonvulsants, kuyamwa kwa vitamini B12 kumachepetsedwa.
Pofuna kupewa kuthana ndi magazi, simungagwiritsidwe ntchito ndi mankhwala omwe amachititsa kuti magazi aziwoneka bwino.
Cyanocobalamin sigwirizana ndi chloramphenicol.
Imawonjezera vasodilating mphamvu ya dipyridamole.
Otsuka - Caffeine, Theophylline - okonda mankhwala.
Mukamagwiritsidwa ntchito ndi mtima glycosides, chiopsezo cha mavuto amabwera.
Nicotinamide imawonjezera zotsatira za anti-nkhawa, sedative ndi kuchepetsa-kukakamiza mankhwala
Xanthinol nikotini amachepetsa mphamvu ya mankhwalawa.
Wopanga
World Medical Limited.
Analogi
Palibe ndalama zokhala ndi mawonekedwe ofanana. Komabe, pali mankhwala a metabolic - sodium adenosine triphosphate, cocarboxylase, mapiritsi a nicotinic acid, cyanocobalamin.
Kupita kwina mankhwala
Yoperekedwa ndi mankhwala. Mndandanda B.
Mtengo wa Cocarnith
Mtengo wa ma ampoules atatu ndi ma ruble 636.
Kusungidwa kwa mankhwala Kokarnit
Sungani pamalo ouma pa kutentha kwa + 15 ... + 25 ° ะก.
Tsiku lotha ntchito
Zaka zitatu Zosungunulira ndi zaka 4.
Ndemanga za Kokarnit
Nastya
Mankhwala siotsika mtengo, koma ululu ndi radiculitis amachotsedwa bwino. Anaponya majekeseni 12.
Katherine V.
Matenda a 2 a shuga ndi matenda oopsa. Imadziwonekera yokha mu mkono ndi miyendo. Anadutsa milungu itatu. Zizindikiro za polyneuropathy zinachepa kwambiri. Kwakhala kosavuta kuyenda.
Peter
Ndikudwala matenda ashuga a 2 komanso angina pectoris. Dokotalayo adamuwuza kuti aphatikize mankhwalawa tsiku lililonse ndimankhwala amodzi kuti ululuwo uchoke. Ndakhala ndikuluma kwa masiku 5, thanzi langa layamba kuyenda, zopweteka zanga m'manja mwanga zachepa. Ngakhale zopsinjika zidachepa pang'ono ndipo kupweteka kwa mtima kudachepera.
