Kuphwanya magazi mu ziwiya zaubongo, ziwalo zamkati ndi miyendo zimayambitsa zovuta zingapo zamitsempha, zam'mtima, zam'maso komanso zam'mimba. Pochiza ma pathologies awa, othandizira omwe amasintha ma microcirculation, mankhwala a vasodilator, anticoagulants, zotulutsa magazi, ndi mankhwala ena amagwiritsidwa ntchito.
Mankhwala odziwika kwambiri omwe amagwiritsidwa ntchito pakuchepa kwa mitsempha ndi mitsempha imaphatikizapo Trental ndi Actovegin, komanso analogues ya mankhwalawa.
Mbali Yapadera
The yogwira pophika mankhwala Trental ndi pentoxifylline. Amachepetsa kuchuluka kwa calcium mkati mwa maselo, kukhazikika ma cyclic adesin monophosphate (AMP) ndikukulitsa kuchuluka kwamamolekyu amphamvu (ATP) m'magazi ofiira. Mphamvu ya antihypoxic (kuchulukitsa kwa okosijeni kupita ku ma cell a mtima) ndi chifukwa cha kukula kwa mitsempha ya coronary. Kuwonjezeka kwa kuwala kwa ziwiya zam'mapapo ndi kuwonjezereka kwa kamvekedwe ka minofu ya kupuma kumalimbikitsa oxygenation m'magazi.
The yogwira pophika mankhwala Trental ndi pentoxifylline.
Pentoxifylline ilinso ndi zotsatirazi:
- bwino magazi, kuchepetsa magazi mamasukidwe akayendedwe;
- amachepetsa chiopsezo cha kufooka kwa maselo ofiira;
- kumawonjezera miniti ndi kukomoka voliyumu ya magazi opakidwa, osakhudza kugunda kwa mtima;
- zopindulitsa pa bioelectric ntchito ya mantha dongosolo;
- amachepetsa kukokana ndi kupweteka ndi zotumphukira mtima stenosis.
Chizindikiro chogwiritsira ntchito Trental ndi:
- ischemic stroke;
- kupewa matenda am'mimba mu ubongo ischemia ndi neuroinfections;
- encephalopathy;
- chisokonezo pakufalikira kwa magazi mu mtima matenda a mtima ndi kulowetsedwa kwa myocardial;
- matenda atherosulinosis;
- minyewa yam'maso yotupa ya m'maso, kusokonezeka kwa retinal trophism ndi ma cellcirculation ang'onoang'ono amaso kutsutsana ndi matenda a shuga;
- njira zowonongeka ndi sclerosis ya khutu lapakati motsutsana ndi maziko a zotupa za mtima mkati mwa khutu;
- kusokonezeka kwamagazi m'matumbo am'malo am'munsi (kuphatikiza ndi kutsutsana pang'ono);
- compression ya zotumphukira misempha motsutsana maziko kuwonongeka kwa msana ndi hernia ya intervertebral discs;
- matenda oletsa kupuma a m'mapapo;
- zovuta za potency wa mtima etiology.
Mankhwalawa amapezeka m'mitundu mitundu ya makomedwe a makolo ndi a makolo. Mlingo wa pentoxifylline pamapiritsi ndi 100 mg, ndipo mu kulowetsedwa - 20 mg / ml (100 mg mu 1 ampoule). Trental imatengedwa pakamwa, kudzera m'mitsempha, kudzera m'mitsempha ndi ma intraarterally (kukapumira, kawirikawiri - mu ndege).
Zoyipa zogwiritsidwa ntchito ndi mankhwalawa ndi:
- Hypersensitivity kuti kapangidwe kake kamene kamapezeka pentoxifylline ndi zina mwa kapangidwe kake;
- pachimake matenda a mtima minofu ndi chapakati mantha dongosolo (myocardial infarction, hemorrhagic stroke);
- matenda a porphyrin;
- kutaya magazi kwambiri;
- mimba
- kuyamwitsa;
- hemorrhege
- kokha kwa makolo makonzedwe: mtima arrhythmias, kwambiri atherosulinotic zotupa za chisa ndi mtima mitsempha, kulimbikira hypotension.
Ndi chizolowezi cha hypotension, zilonda zam'mimba ndi zilonda zam'mimba, kulephera kwa ziwalo, pakukonzanso pambuyo pochita opaleshoni komanso odwala omwe ali ndi zaka 18, Trental adalembedwa mosamala.
Zotsatira zoyipa zomwe zimachitika chifukwa cha mankhwala osokoneza bongo ndi monga:
- chizungulire, kupweteka mutu, kukokana;
- kuwonongeka kwamawonekedwe;
- nkhawa, chisokonezo;
- kutupa;
- kusokonekera kwa misomali;
- kuzizira kwa nkhope ndi chifuwa;
- kuchepa kwa chakudya;
- kukanika kwa ndulu, chiwindi ndi matumbo;
- kuchuluka kwa mtima, arrhythmia, angina pectoris, kutsika magazi;
- kutuluka kwamkati ndi kunja;
- thupi lawo siligwirizana;
- kuchuluka anticoagulant zotsatira za NSAIDs ndi hypoglycemic kanthu insulin.
Zotsatira zoyipa za Trental chithandizo zimaphatikizira kuwonongeka kwa mawonekedwe.
Makhalidwe Actovegin
Mankhwala amakhudzidwa ndi Actovegin amatengera mphamvu ya antihypoxic ndi kagayidwe kachakudya ka zinthu zomwe zimagwira - zotulutsa (zochokera) kuchokera m'magazi a ng'ombe.
Hemoderivative amapangidwa ndi dialysis ndi kusefera kwa tinthu tokhala ndi kulemera molemera kuposa 5000 dalton.
Mankhwalawa ali ndi zotsatirazi mthupi:
- kumapangitsa kuti mpweya ubwereke kupita ku maselo amanjenje, mtima komanso zotumphukira;
- amalimbikitsa mayendedwe ndi kugwiritsa ntchito chakudya mochuluka, kuchepetsa kuchuluka kwa zinthu zopanda shuga zowonjezera shuga (lactates);
- imakhazikika michere ya cytoplasmic pamikhalidwe ya hypoxia;
- kumawonjezera kuchuluka kwa macroergs ndi zotumphukira za glutamic, aspartic ndi gamma-aminobutyric acid.
Actovegin adalembedwa zotsatirazi:
- kuzungulira kwa matenda amkati mwa mitsempha ya m'mimba pambuyo pakuvulala kwa ubongo kapena kulowetsedwa kwa ubongo;
- thrombosis yamitsempha yamagazi ndi zotumphukira, zotsatira za kuphatikizika kwa mitsempha ndi mitsempha (kuphatikizapo zilonda zam'mimba);
- kuphwanya magazi kwa mitsempha ululu matenda a msana;
- kuchiritsa kwa nthawi yayitali mabala, zilonda zam'mimba, zilonda za kupsinjika, kuwotcha ndi kuvulala kwina mu matenda a mtima, metabolic ndi endocrine;
- radiation kuvulala kwamkati ziwalo, mucous nembanemba.
Nthawi zina, hemoderivative infusions amagwiritsidwa ntchito pathupi pathupi (kukhudzika kwa magazi kwa mwana wosabadwayo ndi placenta).
Actovegin imapezeka m'mitundu ingapo:
- mafuta (50 mg / g);
- gel (200 mg / g);
- yankho la kulowetsedwa (4 mg kapena 8 mg mu 1 ml);
- yankho la jakisoni (4 mg, 8 mg, 20 mg kapena 40 mg mu 1 ml);
- mapiritsi (200 mg).
Mankhwalawa amadziwika ndi kuyanjana bwino ndi mankhwala ena a antihypoxic ndi metabolites, koma ndikosayenera kusakaniza mu dontho limodzi.
Zoyipa zogwiritsidwa ntchito ndi mankhwalawa ndi:
- Hypersensitivity ku zotumphukira zamagazi;
- kulephera mtima;
- pulmonary edema;
- madzimadzi zotupa zotulutsa.
Actovegin iyenera kugwiritsidwa ntchito mosamala mu shuga.
Mochenjera, mankhwalawa amayenera kugwiritsidwa ntchito ngati matenda a shuga (chifukwa cha zomwe zili mu dextrose pazomwe zimachokera), owonjezera wa chlorine ndi sodium.
Mankhwalawa amatha kutsatiridwa ndi zotupa (zotupa pakhungu, kutentha thupi, khungu, ndi zina zotere) komanso kusungidwa kwa madzi mthupi.
Kuyerekeza kwa Trental ndi Actovegin
Actovegin ndi Trental amagwiritsidwa ntchito pazomwe zikuwonetsa. Zofanana za antihypoxic zimaperekedwa m'njira zosiyanasiyana za pharmacodynamic.
Kufanana
Kufanana kwa mitundu iwiriyi kumawonedwa m'mbali zotsatirazi:
- Kufunikira kwa matenda amkati komanso kufalikira kwazinthu za m'magazi;
- zopindulitsa mu kagayidwe kachakudya ka maselo, kayendedwe ka okosijeni ndi kudzikundikira kwa ATP;
- chiopsezo chachikulu cha edema pa mankhwala;
- kukhalapo kwa mafomu otulutsa pakamwa ndi makolo.
Actovegin ndi Trental ndizothandiza pamachitidwe a metabolic m'maselo.
Kodi pali kusiyana kotani?
Kusiyanitsa pakati pa Actovegin ndi Trental kumaonekera pazinthu monga:
- chiyambi cha ntchito yogwira;
- mphamvu ya mankhwala;
- kuchuluka kwa contraindication ndi mavuto;
- chitetezo kwa oyembekezera ndi kuyamwitsa odwala.
Chotsika mtengo ndi chiyani?
Mtengo wa Actovegin umachokera ku ma ruble 361. kwa ma ampoules asanu a yankho, kuchokera ku ma ruble 1374. mapiritsi 50 ndi ma ruble 190. 20 g yamafuta. Mtengo wa Trental umayamba kuchokera ku ma ruble 146. kwa ma ampoules 5 komanso kuchokera ku ma ruble 450. mapiritsi 60.
Zomwe zili bwino: Trental kapena Actovegin?
Ubwino wa Trental ndikuwonetsetsa kwake. Ma pharmacodynamics ndi pharmacokinetics a mankhwalawa adawerengera bwino, zomwe zimakupatsani mwayi wosankha mankhwalawa molondola malinga ndi kupezeka kwa matendawa ndi zina.
Actovegin mankhwala sakuphatikizidwa mu mapuloteni othandizira m'maiko ena otukuka, koma akatswiri ambiri amitsempha amawona phindu la mankhwalawa pa microcirculation ndikuchepetsa kwa zotupa za hypoxic. Malangizo ndi mapiritsi a hemoderivative ndi otetezeka ndipo angagwiritsidwe ntchito ngati ali ndi pakati, mkaka wa m'mawere, matenda a hematopoietic system, matenda oopsa a magazi, ndi zina zambiri.
Ngati pali contraindication kutenga Trental, Mexicoidol, Mildronate ndi mankhwala ena omwe amalimbikitsa magazi mu ziwiya zaubongo, mtima ndi zotumphukira zimakhala zitha kuperekedwa munthawi yomweyo ndi Actovegin.
Ndemanga za Odwala
Elena, wazaka 49, ku Moscow
Kuyambira nditakhala pamaso pa kompyuta nthawi yayitali kudawoneka chizungulire, kupweteka m'mutu ndi m'khosi. Dokotala wamitsempha anapeza khomo lachiberekero la osteochondrosis ndipo adapereka mankhwala angapo, omwe anali a Trental. Maphunziro oyamba atatha, zizindikirizo zidazimiririka, koma kuchuluka kwake kumachitika nthawi ndi nthawi. Zaka zitatu zapitazi, ndikuwoneka ngati zizindikiro zoyambirira za kukokomeza (migraines, pressure surges), ndakhala ndikutenga maphunziro a otsitsa 10 ndi Trental, ndiye kuti ndakhala ndikumwa mapiritsi kwa miyezi iwiri. Maphunzirowa atatha, Zizindikiro zimatha miyezi isanu ndi umodzi.
Kuperewera kwa mankhwalawa - ndikulowetsa mwachangu (ngakhale kukhuthala), kupsinjika kumatsika kwambiri ndikuyamba kumva kuti ndikuziziritsa.
Svetlana, wazaka 34, Kerch
Pambuyo pakuvulala koopsa kwaubongo, adotolo adalemba Actovegin. Ndimatenga jakisoni wambiri miyezi isanu ndi umodzi (2 kawiri pachaka kapena pakufunika). Kale pa 2 - tsiku la 3 la chithandizo, kupindika komanso chizungulire zimatha, ntchito ikuwonjezeka, ndipo kutopa kumatha. Kuphatikiza kowonjezerapo - nthawi ya jakisoni, kuchiritsa kwa mabala atsopano kumathandizira. Pofuna kupewa kuwonongeka, ndibwino kugwiritsa ntchito mafuta. Njira yokhayo yomwe mankhwalawa amachepetsa ndi kupweteka kwa jakisoni, ndikovuta kulekerera ngakhale 5 ml ya yankho.
Ndemanga za madotolo za Trental ndi Actovegin
Tikushin EA, neurosurgeon, Volgograd
Trental ndi chida chothandiza chomwe chimagwiritsidwa ntchito kwambiri mu neurology, mtima, neurosurgery, angiology ndi magawo ena. Neurosurgeons imapereka mankhwala kwa odwala omwe ali ndi zotupa zamkati mwa mitsempha, craniocerebral traum ndi compression radiculopathy motsutsana ndi kuwonongeka kwa ma discs a intervertebral disc.
Mankhwalawa amapezeka m'mitundu ingapo, yomwe ndi yoyenera kwa wodwala, chifukwa njira yochepa yotsalira ikhoza kupitilira pakumwa mapiritsi.
Birin M.S., katswiri wa zamitsempha, Ulyanovsk
Actovegin ndi mankhwala okwera mtengo komanso otchuka pamitundu yosiyanasiyana ya mtima. Ubwino wake pamankhwala opangidwa ndi chitetezo chake komanso chitetezo chambiri chambiri. Kuchita bwino komanso kusowa kwa zotsatira zaukazi ndizokayikitsa, chifukwa wopanga sanatsimikizire kutha kwa mankhwalawo m'maphunziro azachipatala. Kuphatikiza apo, kuchuluka kwa kuyeretsa komwe kumachokera pazomwe mukupanganso ndikofunikira.
