Amitriptyline 25 imathandizira kuthetsa zizindikiro za kupsinjika ndi zina zokhudzana ndi pathological zomwe zinabuka motsutsana ndi maziko a zovuta zamaganizidwe ndi zovuta. Ubwino wake umaphatikizapo mtengo wotsika komanso chiwerengero chochepa chotsutsana, chifukwa chomwe kuchuluka kwa wothandiziraku kukukulira. Kuchokera pamawuwo, mutha kudziwa kuchuluka kwa mankhwalawa (25 mg).
Dzinalo Losayenerana
Amitriptyline.
ATX
N06AA09.
Kutulutsa mafomu ndi kapangidwe kake
Mutha kugula mankhwala mu mawonekedwe a yankho ndi mapiritsi. Amitriptyline hydrochloride imagwira ntchito. Kutulutsa kwake kumasiyana, kutengera kapangidwe kazinthu. Piritsi 1 ili ndi 25 mg ya amitriptyline. Mu phukusi 50 ma PC.
The kuchuluka kwa yogwira pophika 1 ml ya madzi ndi 10 mg. Kuchuluka kwa ampoules ndi yankho ndi 2 ml. Chifukwa chake, kuchuluka kwa amitriptyline ndi 20 mg. Mankhwala amapangidwa mwanjira iyi m'matumba a 5 ndi 10 ampoules.
Amitriptyline 25 imathandizira kuthetsa zizindikiro za kupsinjika ndi zina zokhudzana ndi pathological zomwe zinabuka motsutsana ndi maziko a zovuta zamaganizidwe ndi zovuta.
Zotsatira za pharmacological
Chipangizochi chikuimira antidepressants. Cholinga chake chachikulu ndikuchotsera chizindikiro cha zovuta zakukhumudwa. Zina:
- nkhawai;
- sedative;
- timoleptic.
Amitriptyline amatha kukhala ndi mpumulo wamthupi pang'onopang'ono, nkhawa, nkhawa. Kusokonezeka kwa mitsempha kumachepetsedwa chifukwa choletsa kubwezeretsanso kwa ma neurotransmitters, omwe amaphatikizapo serotonin, norepinephrine. Njirayi imayamba ndi kutenga gawo la mitsempha yotsiriza ya mitsempha. Mothandizidwa ndi amitriptyline, kudzikundikira kwa monoamines mu synaptic cleft kumathandizira. Kuphatikiza apo, chinthu ichi chimalimbikitsa mayankho a postynaptic.
Sedation imachitika chifukwa chakuchepa kwa chidwi cha chidwi chakunja. Komabe, zochita za wodwala tsiku ndi tsiku zimachepa. Kutsika kwa chisangalalo cha mitsempha kumadziwika. Mphamvu yoletsa kuponderezedwa imawonetsedwa chifukwa cha kuchepa kwa ntchito ya zolandilira ubongo wina.
Nthawi yomweyo, njira ya kutumiza kwa beta-adrenergic ndi serotonin imabwezeretseka. Kutsika kwamphamvu kwa chiwonetsero cha kukhumudwa kumakhalanso chifukwa chobwezeretsanso mkhalidwe wofananira wa machitidwe awa. Kuphatikiza apo, ntchito ya M-choline ndi histamine receptors imalepheretsa.
A mawonekedwe a mankhwalawa ndi kuthekera kowonetsa zinthu zosiyanasiyana chifukwa cha kuyang'anira mitundu yambiri. Mwachitsanzo, pazinthu zina, zotsatira zovomerezeka zimaperekedwa. Mukasintha mlingo, malo osangalatsa amawonekera. Pankhaniyi, zotsatira zake ndi zosiyana ndi kupandukira.
Mosiyana,, pakatha kusintha kwa kuchuluka kwa amitriptyline mu plasma, zinthu zolimbikitsazo zimafooka.
Ndikosavuta kudziwa kuchuluka kwa Mlingo womwe mphamvu yakuchepa mphamvu imachepa ndipo mphamvu yokhazikika imakhala yolimba, chifukwa kuchuluka kwa mankhwalawa kumatsimikiziridwa payekhapayekha.
Kuphatikiza apo, katundu wina amawonetsedwa pamankhwala. Amakhala osatchulidwa, koma chifukwa cha izi, Amitriptyline amathandizira kuwonjezera zochita za mankhwala ena, limodzi ndi omwe amagwiritsidwa ntchito. Chifukwa chake, mankhwalawa amathandizira kukonza kukodza, kuwonetsa katundu wofooka wa analgesic, komanso kuletsa chilakolako chofuna kudya.
Pharmacokinetics
Mankhwalawa amamwetsa msanga. Mapiritsi alibe vuto pazakudya zam'mimba, zomwe zimachitika chifukwa cha katundu wa antiulcer (kutengera makina a M-anticholinergic ndi sedative zotsatira). The bioavailability wa amitriptyline ndi pafupifupi: 30-60%. Metabolite yogwira ya zinthu iyi imadziwika ndi kukweza bioavailability: 40-70%.
Chidachi chimayamba kugwira ntchito mwachangu: patatha maola awiri, njira zomwe zimapangidwa ndi Amitriptyline zimayendetsedwa. Ngakhale kuthamanga kwambiri kwa kufikira kwa plasma ndende ya chinthu chachikulu, mankhwalawa amachotsa zofooka zamtundu wina wamavuto ena ndi nkhawa zina pambuyo pa masabata awiri.
Mankhwalawa amachotsa zisonyezo za kukhumudwa ndi mavuto ena amisempha pambuyo pa masabata awiri.
Amitriptyline pafupifupi imafanana kwathunthu ndi mapuloteni amwazi (mpaka 96%). Vutoli limalowa m'malo osiyanasiyana achilengedwe, chifukwa chake magwiritsidwe ake ndi ochepa. Kusintha kwa gawo lochitika kumachitika ndi kutenga chiwindi. Zotsatira zake, metabolites yogwira komanso yolimba imamasulidwa. Zina mwazomwe zimawonetsa malo okhala, antidepressant katundu ndi amitriptyline, pomwe ena ndiapamwamba pamtunduwu malinga ndi kugwiririra (mwachitsanzo, nortriptyline).
Hafu ya moyo wa mankhwalawa kuchokera ku plasma imasiyanasiyana malinga ndi momwe impso ikuyendera, chifukwa chiwalo ichi chimayendetsa gawo lothandiza m'thupi. Zinthu izi zimapukusidwa mkati mwa maola 10-44. Komanso, theka-moyo wa nortriptyline ndi wautali. Wothandizirayo amachotsedwa kwathunthu kuchokera mthupi pokhapokha masabata awiri.
Ndi chiyani?
Cholinga chachikulu ndikuchiza nkhawa. Komanso, Amitriptyline imagwira ntchito pochiza matenda amisempha yosiyanasiyana: oyambitsidwa ndi vuto laubongo, kugwiritsa ntchito mankhwala osokoneza bongo omwe ali ndi mawonekedwe (tranquilizer, sedatives ndi zina zofunikira), zomwe zimayambitsa mkati, neurosis, etc. zina zokhudzana ndi matenda. Imafotokozedwa ngati gawo la zovuta mankhwala angapo milandu:
- psychosis pa maziko a schizophrenia;
- kuvutika mtima;
- mowa wotsekemera;
- kuchepa chidwi, kuchuluka kwa zochitika tsiku ndi tsiku;
- envesis oyambitsidwa ndi mavuto amisala;
- mutu
- migraine prophylaxis;
- bulimia (wokwiyitsidwa ndi kusokonezeka kwa thupi);
- minyewa ya neuropathy yomwe imachitika pakhungu;
- neuralgia wokwiyitsidwa ndi herpes zoster atadwala herpes;
- matenda am'mimba ndi duodenum, kuphatikizapo chironda chachikulu.
Popeza kuti mankhwalawa amadziwika ndi zolimbitsa zotsatira za analgesic, amatha kugwiritsidwa ntchito kupweteka, mwachitsanzo, pakukula kwa osteochondrosis kapena khansa. Komabe, muzochitika izi, amitriptyline amangoikidwa ngati gawo la zovuta mankhwala.
Contraindication
Zoletsa zingapo mwamtheradi mukamagwiritsa ntchito chida ichi:
- tsankho la zigawo zikuluzikulu zake: hypersensitivity kuti amitriptyline ndi lactose zimayamba;
- poyizoni wa ethanol;
- subacute, pachimake nthawi ya myocardial infaration;
- ma pathologies ena a ziwalo zamasomphenya (makamaka, angle-kutsekeka glaucoma);
- kuphwanya mtima;
- ana ochepera zaka 6;
- Zotsatira zoyipa za galactose, shuga-galactose malabsorption, kuperewera kwa lactase.
Ndi chisamaliro
Zotsutsana:
- kupuma kwambiri kulephera;
- uchidakwa wokhazikika;
- schizophrenia
- khunyu, limodzi ndi zovuta;
- kuphwanya kwa hematopoietic dongosolo;
- kupsinjika kwa m'maganizo;
- minyewa yamitsempha yamagazi;
- kulephera kwa mtima;
- kupweteka pachifuwa;
- stroke, myocardial infarction (mbiri);
- matenda oopsa
- kuchuluka kwa kukakamizidwa mu ziwalo zamasomphenya;
- kuphwanya contractile ntchito m'mimba, matumbo;
- kwambiri ntchito ya Prostate minofu kukula;
- chithokomiro;
- matenda a chikhodzodzo, zomwe zimapangitsa kuti mkodzo usokonekere.
Momwe mungatenge Amitriptyline 25?
Mapiritsi sayenera kutafunidwa. Amadyedwa pambuyo chakudya.
Mlingo wa Amitriptyline wa ana 25
Mankhwalawa amagwiritsidwa ntchito pochiza matenda osiyanasiyana, njira zochiritsira mosiyanasiyana. Malangizo ogwiritsira ntchito:
- nocturnal enursis motsutsana ndi maziko a zovuta zamaganizidwe: 10-20 mg patsiku pogona kwa ana azaka 6 mpaka 10, 50 mg patsiku kwa odwala azaka 10 mpaka 16;
- Chithandizo cha matenda osiyanasiyana amisala m'matenda amisala: ana kuyambira zaka 6 mpaka 12 amaikidwa 10-30 mg patsiku kapena 1-5 mg / kg, odwala omwe ali ndi zaka 12 - 100 mg patsiku.
Dosing dongosolo la akulu
Mlingo woyamba: 25-75 mg patsiku. Mulingo wovomerezeka wa mankhwala patsiku: 150-200 mg. Ndi mitundu yambiri ya pathological, dongosolo la mankhwalawa limasinthidwa:
- Kukhumudwa: koyamba tsiku lililonse ndi 300 mg, ndiye kuti pang'onopang'ono masabata anayi, njira ya chithandizo ndi miyezi itatu;
- kufooka kwamisala, chithandizo cha okalamba: 25-100 mg patsiku;
- kupweteka kwamatenda osiyanasiyana: 100 mg patsiku.
Mapiritsi amatengedwa popanda kutafuna.
Kumwa mankhwala a shuga
Chipangizocho chikuvomerezedwa kuti chigwiritsidwe ntchito, koma chisamaliro chiyenera kumwedwa nthawi ya mankhwala. Ngati ndi kotheka, Mlingo wa amitriptyline umasinthidwa (payekhapayekha).
Kutalika kwake?
Kusintha kumawonedwa maola angapo mutatha kumwa koyamba. Pamwamba kwambiri limakwaniritsidwa masabata awiri ndi atatu. Zotsatira zake zimasungidwa kwa masiku 14 atachotsedwa ndalamazo.
Momwe mungalembetse Amitriptyline 25?
Ndikofunikira pang'onopang'ono kuchepetsa mlingo wa mankhwalawa. Izi zitha kutenga masabata angapo. Njira yakuchiritsira sikuyenera kusokonezedwa mwadzidzidzi. Pankhaniyi, chiwopsezo cha zizindikiritso zochoka chikuwonjezeka.
Zotsatira zoyipa
Arrhythmia, tachycardia imayamba, yomwe imayamba chifukwa chophwanya ntchito ya minofu ya mtima. Vuto lokomoka limawonekera, zizindikiro za kuperewera kwa ntchito ya mtima, kupuma movutikira kumachitika.
Matumbo
Kutentha pa chifuwa, matenda a m'mimba chifukwa cha kuperewera kwa chakudya, kuchepa kwa kukoma, kupweteka m'mimba, chimbudzi, kapena, kudzimbidwa kwambiri.
Hematopoietic ziwalo
Sinthani kapangidwe ka magazi.
Pakati mantha dongosolo
Mutu, kufooka, kuwonjezereka kwa malingaliro amisala (kusokonekera, kulota maliseche, kusokonezeka, kuyerekezera zinthu zina, kuwonjezereka komanso kusokonezeka), kunjenjemera, kutaya mphamvu, komanso kusokonezeka kwamaganizidwe (hypomania, mania).
Kuchokera kumbali ya kagayidwe
Hypo-, hyperglycemia.
Matupi omaliza
Kuthamanga, kuyabwa - zizindikiro zotsatana ndi urticaria. Angioedema ndi zizindikiritso zakuthambo dzuwa zimawonekeranso.
Zokhudza mphamvu pakuwongolera njira
Pa chithandizo ndi Amitriptyline, munthu ayenera kupewa kuyendetsa galimoto.
Pa chithandizo ndi Amitriptyline, munthu ayenera kupewa kuyendetsa galimoto.
Malangizo apadera
Pa mankhwala ndi mankhwala, kuwunika pafupipafupi za zikuluzikulu za magazi kumachitika.
Mlingo waukulu wa mankhwalawa umachepetsa chitseko chogwira ntchito. Izi ziyenera kuganiziridwa pa nthawi yochotsa anticonvulsants.
Kuti muchepetse malingaliro ofuna kudzipha, poyambira, amitriptyline amaphatikizidwa ndi antipsychotic kapena gulu la benzodiazepine.
Ngati pali opareshoni, muyenera kumuuza wodabwitsayo za vuto la kumwa mankhwalawo.
The ntchito aimpso kuwonongeka
Mankhwala amatchulidwa mosamala pokonza matenda a chiwalo. Izi ndichifukwa choti impso zimachita nawo kagayidwe ka amitriptyline.
Gwiritsani ntchito mu ukalamba
Kusamala kumalangizidwa pochiza odwala azaka zapakati pa 50 ndi akulu.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mukamayamwa, mankhwalawa sagwiritsidwa ntchito, chifukwa amitriptyline imadutsa mkaka wa m'mawere ndipo imatha kulowa mthupi la wakhanda.
Pa nthawi yoyembekezera, mankhwalawa amaloledwa kumwa, koma kuwunika pafupipafupi mu trimester yoyamba kumafunika.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Mankhwala amatchulidwa mosamala matenda a chiwalo.
Bongo
Kuwonjezeka kwa kuchuluka kwa mankhwalawa mankhwalawa kwa ana kumapha. Mankhwala amathandizira kukula kwa mawonekedwe owoneka bwino mwa akulu. Kuti muchepetse mavuto, m'mimba mumatsukidwa, chithandizo chiyenera kusokonezedwa. Madziwo amalowetsedwa m'thupi.
Kuchita ndi mankhwala ena
Mankhwala a Amitriptyline amatsirizidwa milungu iwiri isanayambe chithandizo ndi Mao inhibitors. Kugwiritsa ntchito ndalamazi nthawi imodzi kumatsutsana.
Ngati mankhwala ena omwe ali ndi katundu wofanana adayikidwa pamodzi ndi Amitriptyline, mphamvu ya mankhwalawa imalimbikitsidwa.
Wothandizirayo amafunsira kuwonjezeka kwa ntchito ya anticholinergics.
Kuyenderana ndi mowa
Mankhwalawa saphatikizidwa ndi zakumwa zoledzeretsa.
Analogi
Zoyimira wothandizirazo zomwe zikufunsidwa:
- Saroten
- Doxepin;
- Amitriptyline Nycomed.
Kupita kwina mankhwala
Mankhwala omwe mumalandira.
Kodi ndingagule popanda kulandira mankhwala?
Ayi.
Mtengo wa amitriptyline 25
Mtengo wake ndi ma ruble 20-60.
Zosungidwa zamankhwala
Kutentha kotsimikizika - osapitirira + 25 ° ะก. Ana sayenera kulandira mankhwala.
Tsiku lotha ntchito
Mphamvu za mankhwalawa zimakhalabe zaka zitatu kuyambira tsiku lotulutsidwa.
Wopanga
ALSI Pharma, Russia.
Ndemanga pa amitriptyline 25
Akatswiri azamisala
Pedak A.A., wazaka 35, Pskov
Ndimaona kuti mankhwalawa ndi othandiza kwambiri pakati pa antidepressant. Nthawi zambiri zimaphatikizidwa ndi njira zina, ndipo nthawi zambiri, zotsatira zoyipa sizimachitika. Ubwino wake ndi mtengo wotsika.
Izyumov S.V., wazaka 46, Saratov
Mankhwala ali ponseponse, ogwira mtima. Choyipa ndichofunikira kugwiritsa ntchito ngati gawo la zovuta mankhwala ambiri a pathologies. Kuphatikiza apo, chidachi chimakwiyitsa kukhazikitsa zovuta zingapo.
Odwala
Veronika, wazaka 33, Saransk
Mankhwala amapereka osakhalitsa. Pokhala ndi nkhawa yayikulu, adathandizira mwachangu, koma atachotsa, zizindikirazo zidabweranso ndi mphamvu zambiri.
Olga, wazaka 39, Bryansk
Mankhwala othandiza. Pomwe ndidayamba kuzilandira motsutsana ndi maziko osakhazikika mtima, ndidamva kuti ndilibe chidwi ndi zomwe zimachitika pafupi ndi ine, kunali kugona, kufooka. Sindinakonde zotsatira za mankhwalawa, ndinena zambiri - ndinkaopa kupitiliza maphunziro.
