Ngakhale chitukuko cha matekinoloje azachipatala, kupezeka kwa mankhwala atsopano, matenda ashuga sangathe kuchiritsidwabe ndipo vutoli likufunika kwambiri kwa anthu.
Ziwerengero zikuwonetsa kuti anthu opitilira 2 biliyoni ali ndi matendawa, 90% ya iwo amadwala matenda a shuga a mtundu wachiwiri.
Vuto lotere la endocrine limawonjezera ngozi ya mikwingwirima, mtima, komanso kufupikitsa moyo. Kuti azimva bwino, odwala amayenera kumwa mapiritsi a antihypertensive kapena kubayidwa insulin.
Actovegin yatsimikizira bwino matenda ashuga. Kodi chida ichi ndi chiyani komanso momwe chimagwirira ntchito, malamulo oyambira kugwiritsa ntchito - zonsezi zifotokozedwa munkhaniyi.
Kodi Actovegin ndi chiyani?
Actovegin ndi kuchotsera komwe kumapezeka m'magazi a ng'ombe ndikuyeretsedwa kuchokera ku mapuloteni. Zimathandizira kukonza minofu: mwachangu amachiritsa mabala pakhungu ndi kuwonongeka kwa mucosal.
Amakhudzanso ma cell metabolism. Zimathandizira kukonza kayendedwe ka okosijeni ndi glucose kumaselo.
Mitundu ya mankhwala Actovegin
Chifukwa cha izi, mphamvu zama cell zimachuluka, kuopsa kwa hypoxia kumachepa. Njira zoterezi ndizofunikira pakugwira ntchito kwamanjenje. Mankhwala amathandizanso poteteza magazi. Nthawi zambiri amalembera odwala matenda a shuga.
Mankhwalawa ali ndi ma nucleosides, amino acid, zinthu za phosphorous, magnesium, sodium, calcium, zopangidwa ndi lipid ndi carbohydrate metabolism. Izi zimathandizira pantchito ya mtima, ubongo. Muzochita zachipatala Actovegin wagwiritsidwa ntchito kwa zaka zoposa 50 ndipo nthawi zonse amapereka zotsatira zabwino.
Kutulutsa Fomu
Pali mitundu yosiyanasiyana yotulutsira Actovegin:
- 5% mafuta;
- mapiritsi
- 20% gel osakaniza akunja;
- yankho la jakisoni;
- 20% khungu lamaso;
- 5% kirimu;
- 0.9% yankho la kulowetsedwa.
Njira zothetsera mavuto ndi mapiritsi zimagwiritsidwa ntchito pochiza matenda ashuga. Yogwira pophika imatha hemoderivative.
Mapiritsi, imakhalapo pakukumana kwa 200 mg. Makapisozi amaikidwa m'matumba ndikuwakhazikitsa m'mabokosi amakadi 10, 30 kapena 50 mapiritsi. Zokomera ndi povidone K90, mapadi, magnesium yanthaka komanso talc.
Ampoules a jakisoni yankho la voliyumu ya 2, 5 kapena 10 ml ali ndi 40, 100 kapena 200 mg ya yogwira, motero. Zina mwa zinthu ndi sodium chloride, madzi osungunuka. Ampoules amagulitsidwa m'matumba a 5 kapena 25 zidutswa.
Mafuta onunkhira komanso mafuta ali ndi 2 mg ya hemoderivative, ndipo mu gel - 8 mg. Ma keloni, mafuta opangira mafuta ndi miyala yamtengo wapatali amadzaza mu chubu cha aluminiyumu ndi voliyumu ya 20.30, 50 kapena 100 g.
Zokhudza matenda a shuga
Actovegin amachita ngati insulin pa munthu amene wapezeka ndi matenda a shuga a 2.
Izi zimatheka chifukwa cha kukhalapo kwa oligosaccharides. Zinthu izi zimayambiranso ntchito ya omwe amayendetsa glucose, omwe alipo mitundu 5. Mtundu uliwonse umafunikira njira inayake, yomwe mankhwalawa amapereka.
Actovegin imathandizira kayendedwe ka mamolekyu a glucose, imakhutitsa maselo amthupi ndi mpweya, imakhala ndi phindu pa kugwira ntchito kwa ubongo komanso mtima wamagazi.
Mankhwalawa amabwezeretsa shuga. Ngati mankhwalawa akuperewera, ndiye kuti mankhwalawo amathandizira kuti munthu akhale ndi thanzi labwino, amathandizanso thupi.
Kuphatikiza pa zochita za insulin, pali umboni wazomwe zotsatira za Actovegin pakukana insulini.
Mu 1991, kuyesaku kunachitika komwe mitundu 10 ya matenda ashuga II adatenga nawo gawo. Actovegin pa mlingo wa 2000 mg amaperekedwa kwa anthu kwa masiku 10.
Pamapeto pa kafukufukuyu, zidapezeka kuti odwala amawona akukweza glucose ndi 85%, komanso kuchuluka kwa shuga. Kusintha uku kunapitilira maola 44 atatha kulowetsedwa.
The achire zotsatira za Actovegin zimatheka mwa njira:
- kuchuluka kwa ma phosphates okhala ndi mphamvu yayikulu;
- kapangidwe ka mapuloteni ndi zakudya zimapangidwira;
- Ma enzyme omwe amaphatikizidwa ndi oxidative phosphorylation adayambitsa;
- kusokonezeka kwa glucose kumathandizira;
- kupanga ma enzyme omwe amatulutsa sucrose ndi glucose;
- zochitika zama cell zimayenda bwino.
Phindu lopindulitsa la Actovegin pa shuga limadziwika ndi pafupifupi odwala onse omwe amagwiritsa ntchito mankhwalawa mankhwalawa. Mfundo zoyipa zimachitika chifukwa chogwiritsa ntchito molakwika, hypersensitivity, komanso bongo.
Mlingo ndi bongo
Mlingo wa Actovegin zimatengera mtundu wa kumasulidwa, mtundu wa matenda ndi kuuma kwa njira yake.
M'masiku oyambilira, tikulimbikitsidwa kuperekedwa kwa 10-20 ml ya mankhwalawa kudzera m'mitsempha. Ndiye kuchepetsa mlingo mpaka 5 ml patsiku.
Ngati infusions imagwiritsidwa ntchito, ndiye kuti 10-50 ml imayendetsedwa. Kwa jakisoni wa mu mnofu, muyezo waukulu ndi 5 ml.
Mu pachimake ischemic sitiroko, 2000 mg tsiku limasonyezedwa kudzera m`mitsempha. Kenako wodwalayo amasamutsidwa ku fomu ya piritsi ndikupatsidwa katatu makapisozi katatu patsiku.
Mlingo watsiku ndi tsiku wokhala ndi dementia ndi 2000 mg. Ngati kufalikira kwazungulira kumalephera, ndikulimbikitsidwa kugwiritsa ntchito 800-2000 mg patsiku. Anthu odwala matenda ashuga polyneuropathy amathandizidwa ndi mankhwala osokoneza bongo a 2000 mg patsiku kapena mapiritsi (3 zidutswa katatu patsiku).
Ndikofunika kuti musapitirire mlingo womwe umawonetsedwa mu malangizo ndi adokotala. Kupanda kutero, pamakhala chiwopsezo chachikulu chotenga zochita zoipa. Kuti muchepetse zovuta zosasangalatsa zomwe zimachitika chifukwa cha bongo, mankhwala othandizira amasonyezedwa. Kwa ziwengo, corticosteroids kapena antihistamines amagwiritsidwa ntchito.
Malangizo ogwiritsira ntchito mankhwalawa
Kuphatikiza pa kuchiza matenda ashuga, Actovegin amagwiritsidwa ntchito ngati ischemic stroke, ngozi ya cerebrovascular, mitsempha ya varicose, kuvulala pamutu, zipsinjo zam'mimba komanso kuwotcha, komanso kuvulala kwa corneal.
Mankhwalawa amatha kuperekedwa pakamwa, mwaubwino komanso makamaka.
Actovegin mu mawonekedwe a piritsi ayenera kumwedwa theka la ola musanadye kapena maola angapo mutatha. Chifukwa chake, kuyamwa kwakukulu kwa kachipangizoka kumakwaniritsidwa ndipo chithandizo chamankhwala chimayamba msanga.
Ndikofunikira kutsatira mlingo. Kwa munthu wamkulu, malangizowo amalimbikitsa kugwiritsa ntchito mapiritsi a 1-2 patsiku. Ngati ndi kotheka, dokotala amatha kusintha mlingo wake. Kutalika kwa chithandizo kuchokera pa 1 mpaka 1.5 miyezi.
Ngati njira yothetsera jakisoni kapena kulowetsedwa yagwiritsidwa ntchito, iyenera kuperekedwa mosadukiza, popeza mankhwalawo ali ndi vuto lothetsa chidwi. Ndikofunikira kuti kukakamizidwa kusapondereze kwambiri. Kutalika kwa maphunzirowa kumatsimikiziridwa payekha kwa wodwala aliyense.
Chithandizo cha kupsa, mabala ndi zilonda zam'mimba zimachitika pogwiritsa ntchito 20% Actovegin gel. Chilondacho chimatsukidwa ndi antiseptic. Gelalo limayikidwa mu wochepa thupi.
Pomwe amachiritsa, chilonda nthawi zambiri chimayamba kupanga. Kuti zitheke, gwiritsani ntchito kirimu 5% kapena mafuta. Ikani katatu patsiku mpaka kuchira kwathunthu. Gwiritsani ntchito mankhwala okhala ndi alumali.
Simungagwiritse ntchito yankho lomwe mumakhala timalingaliro tating'ono, mitambo. Izi zikusonyeza kuti mankhwalawa adachepa chifukwa chosasungidwa mosayenera. Ndi chithandizo chotenga nthawi yayitali, odwala matenda ashuga amalangizidwa kuti azitha kuyendetsa bwino madzi. Mukatsegula vial kapena ampoule sikuloledwa.
Kuyanjana kwa mankhwala kwa Actovegin ndi mankhwala ena sikunakhazikitsidwe. Koma kuti mupewe kusagwirizana, simuyenera kuwonjezera mankhwala ena kulowetsedwa kapena jakisoni.
Zotsatira zoyipa
Actovegin amalekeredwa bwino. Nthawi zina, odwala amawona mawonekedwe oyipa:
- thupi lawo siligwirizana (mu mawonekedwe a anaphylactic mantha, malungo);
- myalgia;
- redness yadzidzidzi pakhungu;
- mapangidwe a edema pakhungu;
- lacrimation, redness ya ziwiya za sclera (a khungu gel osakaniza);
- kuchuluka kwa kutentha kwa thupi;
- kuyabwa, kuyaka m'dera la ntchito (mafuta odzola, miyala);
- hyperthermia;
- urticaria.
Madokotala amazindikira kuti nthawi zina Actovegin ali ndi vuto logwira ntchito mu mtima. Pankhaniyi, wodwalayo akuwonjezera kuthamanga kwa magazi, kupumira msanga, kukomoka, kupweteka mutu, kufooka komanso kutha. Kuphwanya Mlingo wa mapiritsi, nseru, kumalimbikitsa kusanza, kukhumudwa m'mimba, kupweteka pamimba nthawi zina.
Contraindication
Pali gulu lina la anthu omwe saloledwa kugwiritsa ntchito Actovegin.
Zotsutsana ndi:
- Hypersensitivity kwa yogwira komanso lothandiza zinthu za mankhwala;
- kulephera kwamtima mu gawo la kubweza;
- anuria
- zosokoneza pantchito ya mapapu;
- nthawi ya pakati ndi mkaka wa m`mawere;
- kusungunuka kwa madzi mthupi;
- zaka mpaka zaka zitatu;
- oliguria.
Mochenjera, ndikofunikira kumwa mankhwalawa kwa odwala omwe amadziwika kuti ali ndi hyperchloremia (plasma chlorine ndende ndi yodziwika bwino) kapena hypernatremia (sodium owonjezera m'magazi).
Makanema okhudzana nawo
About limagwirira a ntchito mankhwala Actovegin mu kanema:
Chifukwa chake, Actovegin ndi mankhwala othandiza kuchiza matenda a shuga a mitundu yoyamba ndi yachiwiri, komanso zovuta za matendawa. Ngati mugwiritsa ntchito mankhwalawa molondola, kutsatira malangizo a dokotala-endocrinologist, kuganizira mawonekedwe a thupi, ndiye kuti Actovegin idzakhala bwino ndipo sichidzayambitsa mavuto.
