Kodi pali kusiyana kotani pakati pa Lorista ndi Losartan?

Chomwe chimayambitsa matenda a mtima ndi matenda oopsa, omwe amawonekera pakuthamanga kwa magazi. Izi zimachepetsa moyo wamunthu. Akatswiri amalimbikitsa kuti azigwiritsa ntchito mankhwala osiyanasiyana a antihypertensive omwe amatseketsa ma oligopeptide mahomoni (angiotensins) omwe amachititsa vasoconstriction. Mankhwalawa akuphatikizapo Lorista kapena Losartan.

Kodi mankhwalawa amagwira ntchito bwanji?

Kuthamanga kwa magazi kungayambitse kusintha kwa pathological m'mitsempha yamagazi m'magazi onse. Izi ndizowopsa pamtima, bongo, retina komanso impso. Chomwe chimagwira ntchito m'magulu awiriwa (losartan potaziyamu) chimalepheretsa angiotensins, ndikupanga vasoconstriction komanso kukakamizidwa, zomwe zimapangitsa kuti ma cell ena azitulutsa ma cell (ma aldosterones) kuchokera m'magazi a adrenal kupita m'magazi.

Lorista kapena Losartan ndi mankhwala a antihypertensive omwe amatseketsa ma oligopeptide mahomoni (angiotensins) omwe amachititsa vasoconstriction.

Mothandizidwa ndi aldosterone:

• reabsorption (mayamwidwe) wa sodium amathandizidwa ndi kuchepa kwake mthupi (Na amalimbikitsa hydration, akukhudzidwa ndi zofunikira za mankhwala a metabolism a impso, amapereka malo amchere a m'magazi);
• N-ions zochulukirapo ndi amoni zimathetsedwa;
• m'thupi, ma chloride amayendetsedwa mkati mwa cell ndikuthandizira kupewa kuchepa kwa madzi m'thupi;
• kuchuluka kwa magazi kumayenda;
• mulingo wa asidi-woyambira umakhala wofanana.

Lorista

Mankhwala a antihypertensive amapangidwa ngati mapiritsi okhala ndi mphamvu zambiri, amaphatikizanso potaziyamu wolartan, komanso zosakaniza zina:

• cellactose;
• silicon dioxide (sorbent);
• magnesium stearate (binder);
• wowuma chimanga wa galatinized;
• hydrochlorothiazide (okodzetsa amene amawonjezeredwa kuti ateteze ntchito ya impso yomwe imapezeka mumayendedwe a Lorista, monga Lorista H ndi ND).

Monga gawo la chigamba chakunja:

• zoteteza mankhwala a hypromellose (mawonekedwe ofewa);
• propylene glycol plasticizer;
• utoto - quinoline (chikasu E104) ndi titanium dioxide (yoyera E171);
• talcum ufa.

Kodi ndimaphikidwe otani a keke omwe angagwiritsidwe ntchito kwa odwala matenda ashuga?

Cardioactive Taurine: zikuonetsa ndi contraindication kwa mankhwala.

Werengani za zomwe zimayambitsa matenda a shuga m'nkhaniyi.

Zomwe zimagwiritsidwa ntchito, zoletsa angiotensin, zimapangitsa kuti kukanika kwa mtima kukhale kosatheka. Izi zimathandizira kuyendetsa bwino. Losartan adatumizidwa:

• ndi zizindikiro zoyambirira matenda oopsa mu monotherapy;
• mkulu matenda oopsa mu kuphatikiza mankhwala;
• matenda ashuga.

Lorista imapangidwa pa 12.5, 25, 50 ndi 100 mg pazinthu zazikulu piritsi limodzi. Mmatumba 30, 60 ndi 90 ma PC. m'matumba a makatoni. M'magawo oyamba a matenda oopsa, 12,5 kapena 25 mg pa tsiku ndi omwe amapatsidwa. Ndi kuchuluka kwa matenda oopsa, kuchuluka kwake kwa magazi kumakulanso. Kutalika kwa maphunzirowa ndi kuchuluka kwake kuyenera kuvomerezana ndi dokotala.

Zomwe zimagwiritsidwa ntchito ndi Lorista poletsa angiotensin zimapangitsa kupangika kwa mtima kukhala kosatheka. Izi zimathandizira kuyendetsa bwino.

Losartan

Mafomu amatengedwa pakamwa ndipo ali ndi 25, 50 kapena 100 mg wa chinthu chachikulu komanso zinthu zina piritsi limodzi:

• lactose (polysaccharide);
• cellulose (fiber);
• silicon dioxide (emulsifier ndi chakudya chowonjezera E551);
• magnesium stearate (emulsifier E572);
• croscarmellose sodium (chakudya chamagulu osakaniza);
• povidone (enterosorbent);
• hydrochlorothiazide (pokonzekera Lozartan N Richter ndi Lozortan Teva).

Kupanga mafilimu kumakhala ndi:

• emollient hypromellose;
• utoto (titaniyamu yoyera, mchere wachikasu);
• macrogol 4000 (amachulukitsa kuchuluka kwa madzi mthupi);
• talcum ufa.

Losartan, kupondereza angiotensin, kumathandizira kubwezeretsa magwiridwe antchito a thupi lonse:

• sizimakhudzanso michere;
• sizimayambitsa vasoconstriction (vasoconstriction);
• amachepetsa kukana kwawo;
• imayang'anira kupanikizika mu msempha ndi mabwalo amtsempha wamagazi ochepa;
• amachepetsa hypyo;
• imathandizira mamvekedwe amitsempha;
• amagwira ntchito ngati okodzetsa;
• zimasiyanasiyana nthawi yayitali (kuposa tsiku).

Mankhwalawa amatengeka mosavuta kuchokera kum'mimba, kupukusidwa m'maselo a chiwindi, kuchuluka kwambiri m'magazi kumachitika pambuyo pa ola limodzi, ndikupanga mapuloteni a plasma 95% ya metabolite yogwira. Losartan amatuluka osasinthika ndi mkodzo (35%) ndi bile (60%). Mlingo wovomerezeka ndi mpaka 200 mg patsiku (logawidwa mu 2 waukulu).

Losartan, kupondereza angiotensin, kumathandizira kubwezeretsa kayendedwe kazinthu zonse.

Kuyerekezera kwa Lorista ndi Losartan

Zochita zamankhwala onse awiri ndizolinga zochepetsera kupanikizika. Odwala oopsa nthawi zambiri amawalembera, popeza kuti njira yothandiza yazindikirika popewa matenda amtima komanso a mtima, komanso monga njira yayikulu yothandizira matenda aakulu. Mankhwala samayambitsa zotsatira zoyipa, amakhala ndi zidziwitso zofananira komanso kusiyana pang'ono.

Kufanana

Kuchita bwino kwa mankhwalawa kwatsimikiziridwa kwa odwala omwe ali ndi kuthamanga kwa magazi, limodzi ndi zinthu zoopsa monga:

• ukalamba;
• bradycardia;
• kusintha kwa pathological kumanzere kwamitseko yamitsempha yama cell chifukwa cha tachycardia;
• kulephera kwa mtima;
• patadutsa vuto la mtima.

Mankhwala ozikidwa pa potaziyamu wa losartan ndi osavuta chifukwa:

• lembani 1 nthawi patsiku (kapena pafupipafupi, koma monga mwalembera katswiri);
• phwando sizimadalira chakudya;
• ntchito yogwira imakhala ndi zotsatirapo;
• mulingo woyenera kwambiri ndi kuyambira sabata mpaka mwezi.

Kuchita bwino kwa mankhwalawa kumatsimikiziridwa kwa odwala okalamba.

Kulephera kwa hepatatic ndi chimodzi mwazinthu zotsutsana ndi mankhwalawa.

Ukalamba mpaka zaka 18 ndi chimodzi mwazinthu zotsutsana ndi mankhwalawa.

Ziwengo ndi chimodzi mwazinthu zotsutsana ndi mankhwalawa.

Mankhwalawa ali ndi zotsutsana zomwezo:

• ziwengo zosiyanasiyana;
• hypotension;
• kutenga pakati (kungayambitse kufa kwa fetal);
• nthawi ya mkaka wa m`mawere;
• zaka mpaka zaka 18 (chifukwa chakuti zotsatira za ana sizimamveka bwino);
• kukanika kwa hepatic.

Kwa odwala omwe ali ndi vuto la impso, mankhwalawa sanapatsidwe ndipo akhoza kuikidwa ngati pali hydrochlorothiazide pakapangidwe, komwe:

• Iyamba Kuthamanga magazi aimpso;
• amachititsa nephroprotective zotsatira;
• bwino urea chimbudzi;
• Zimathandizira kuchepa kwa gout.

Kodi pali kusiyana kotani?

Kusiyana komwe kulipo pakati pa zida izi kumatsimikiziridwa makamaka ndi mtengo ndi wopanga. Lorista ndi chipangizo cha kampani ya Slovenia KRKA (Lorista N ndi Lorista ND imapangidwa ndi Slovenia pamodzi ndi Russia). Chifukwa cha kafukufuku waluso, kampani yayikulu yopanga mankhwala yomwe ili ndi dzina pamsika wapadziko lonse imatsimikizira mtundu wa mankhwalawo.

Losartan imapangidwa ku Ukraine ndi Vertex (Losartan Richter - Hungary, Losartan Teva - Israel). Iyi ndi analogue yotsika mtengo ya Lorista, zomwe sizitanthauza mikhalidwe yoipa kapena kugwirako ntchito kochepa. Akatswiri omwe amapereka mankhwala awa kapena mankhwalawa, adazindikira zosiyana, zomwe zimakhala ndi zotsatirapo zoyipa.

Mukamagwiritsa ntchito Lorista:

• mu 1% ya milandu, arrhythmia imachitika;
• mawonetseredwe amawonetsedwa, amakwiya ndi diuretic hydrochlorothiazide (kutayika kwa potaziyamu ndi mchere wa sodium, anuria, gout, proteinuria).

Amakhulupirira kuti losartan ndiyosavuta kunyamula, koma sizowonjezera izi:

• 2% ya odwala - kukulitsa kutsegula m'mimba (gawo la macrogol ndi provocateur);
• 1% - kwa myopathy (kupweteka kumbuyo ndi minyewa ndi kukula kwa minofu kukokana).

Nthawi zina, losartan angakhudze kutsegula m'mimba.

Chotsika mtengo ndi chiyani?

Mtengo umayendetsedwa ndi zinthu monga dera la dzikolo, kukwezedwa ndi kuchotsera, kuchuluka ndi kuchuluka kwa mawonekedwe omwe akukhudzidwayo.

Mtengo wa Lorista:

• 30 ma PC 12,5 mg uliwonse - ma ruble a 113-152. (Lorista N - ma ruble 220.);
• 30 ma PC 25 mg iliyonse - 158-211 rubles. (Lorista N - 302 ma ruble, Lorista ND - 372 ma ruble);
• Ma PC 60. 25 mg iliyonse - ma ruble 160-245. (Lorista ND - ma ruble 570);
• 30 ma PC 50 mg iliyonse - 161-280 rubles. (Lorista N - 330 ma ruble);
• Ma PC 60. 50 mg iliyonse - 284-353 rubles;
• Ma PC 90 50 mg iliyonse - ma ruble 386-491;
• 30 ma PC 100 mg iliyonse - ma ruble 270-330;
• 60 tabu. 100 mg - 450-540 rubles;
• Ma PC 90 100 mg iliyonse - ma ruble 593-667.

Mtengo wa osowa:

• 30 ma PC 25 mg aliyense - 74-80 ma ruble. (Losartan N Richter) - ma ruble 310 .;
• 30 ma PC 50 mg iliyonse - ma ruble 87-102;
• Ma PC 60. 50 mg iliyonse - ma ruble 110-157;
• 30 ma PC 100 mg - ma ruble a 120 -138;
• Ma PC 90 100 mg iliyonse - mpaka ma ruble 400.

Kuchokera pazomwe tatchulazi zikuwonekeratu kuti ndizopindulitsa kwambiri kugula losartan kapena mankhwala aliwonse, koma ndimapiritsi ambiri phukusi limodzi.

Kodi pali lorista kapena losata?

Ndi mankhwala ati omwe ali bwino, ndizosatheka kunena mosalinganika, popeza amachokera pazinthu zomwezo. Izi ziyenera kuthandizidwa ndi adokotala, potengera momwe wodwalayo alili. Koma zikagwiritsidwa ntchito, mphamvu ya zinthu zina zomwe zimaphatikizidwa pokonzekera ziyenera kukumbukiridwa.

Chifukwa chakuti Lorista imachitika ndi Mlingo wochepa (12.5 mg), amathandizira kupewa matenda oopsa, kupezeka kwa kugunda kwa mtima kosagwirizana, pazosintha za spasmodic pamlingo wopanikizika. Inde, ndi osagwiritsidwa ntchito mopitirira muyeso wama hypotension osaneneka, ndizowopsa kwa wodwalayo, chifukwa zizindikiro zake sizimawoneka nthawi yomweyo. Hypertension yozindikirika ndi kukwera pafupipafupi komanso kuchepa kwapang'onopang'ono kwa magazi kumatha kuwongoleredwa ndi mlingo wochepa wa mankhwalawa omwe amaperekedwa kawiri.

Ndemanga za Odwala

Olga, wazaka 56, Podolsk

Sindingathe kumwa mankhwalawa opangidwa ndi akatswiri. Choyamba ndimamwa mlingo wa tsiku lililonse wa 50 mg wa losartan. Patatha mwezi umodzi, magazi amawoneka m'manja (akukhathamira ndi kuphulika m'manja). Askorutin anasiya kumwa ndikuyamba kumwa, ngati kuti zotengera zake zatha. Koma zitsenderezo zimakhalabe. Anasamukira ku Lorista yodula kwambiri. Pakapita kanthawi, zonse zidabwerezedwa. Ndinawerenga malangizo - pamakhala mavuto ena. Samalani!

Margarita, wazaka 65, mzinda wa Tambov

Wolemba Lorista, koma adasinthira yekha ku Losartan. Chifukwa chiyani amalipira mankhwala omwe ali ndi zomwezi?

Nina, wazaka 40, Murmansk

Matenda oopsa ndi matenda a zaka zana lino. Kupanikizika kuntchito komanso kunyumba zaka zilizonse kumabweretsa zovuta. Adalangiza Lorista ngati njira yotetezedwa, koma muzowonjezera zamankhwala pamakhala zotsutsana zambiri. Nditawerenga malangizowo, ndidaganiza zofunsanso kwa dokotala.

Mimba ndi kuphwanya kumwa mankhwala onse awiri.

Ndemanga za akatswiri amtima pa Lorista ndi Losartan

M.S. Kolganov, katswiri wa zamtima, Moscow

Ndalamazi zili ndi zovuta zachilengedwe za gulu lonse la angiotensin blockers. Amakhala m'lingaliro loti vutoli limachitika pang'onopang'ono, choncho palibe njira yochizira matenda oopsa oopsa.

S.K. Sapunov, katswiri wamtima, Kimry

Mu kapangidwe ka ma angiotensin onse omwe amapezeka amtundu wachiwiri, ndi a Losartan okha omwe amakumana ndi zisonyezo 4 zovomerezeka kuti agwiritse ntchito: ochepa matenda oopsa; kuthamanga kwa magazi chifukwa chakumanzere kwamitsempha yamagazi; mtundu wachiwiri wa shuga-wochititsa nephropathy; kulephera kwa mtima kosatha.

T.V. Mironova, katswiri wamtima, Irkutsk

Mapiritsi oponderezawo amayendetsa bwino vutolo ngati atengedwa mosalekeza. Ndi chithandizo chamankhwala, mwayi wamavuto umachepetsedwa kwambiri. Koma ali pachimake sathandizira. Kugulitsa ndi mankhwala.