Galvus Met - malangizo onse ogwiritsira ntchito, ndemanga za anthu odwala matenda ashuga komanso madokotala

Galvus Honey ndi mankhwala ophatikizika ophatikizidwa ndi hypoglycemic pharmacological. Adapangidwa kuti azichulukitsa matenda a shuga a matenda ashuga omwe ali ndi mtundu wachiwiri wa matenda. Mankhwala amawongolera mwamphamvu kagayidwe ka insulin ndi glucagon.

European Medical Association imakhulupirira kuti Galvus Honey ndiwothandiza kwambiri kuposa omwe adayambitsa, Galvus, omwe amalangizidwa kuti azigwiritsa ntchito pazomwe zimapangitsa kuti tsankho likhale ndi munthu payekha.

Kufotokozera za mtundu wa kipimo

Patsamba lamankhwala, mankhwalawa amaperekedwa mwa mapiritsi okhala ndi mphamvu; aliyense wa iwo ali ndi zosakaniza ziwiri: 50 mg ya vildagliptin ndi 500, 850 kapena 1000 mg ya metformin. Magnesium stearate, hyprolose, hypromellose, talc, titanium dioxide, macrogol 4000 ndi iron oxide amagwiritsidwa ntchito ngati ojambula.

Chithuza chilichonse chimakhala ndi mapiritsi 10. Mbalezi zimayikidwa m'mabokosi azidutswa 3, phukusi lililonse Galvus Met ili ndi malangizo.

• 50/500 mg - mapiritsi ozungulira ndi m'mphepete mwa nkhanu yachikasu. LLO imafupikitsidwa mbali imodzi ndi NVR kumbuyo.
• 50/850 mg - mawonekedwe ofanana piritsi, chipolopolo chokha ndi chachikasu ndipo chizindikirocho ndichoyenera: SEH mbali imodzi ndi NVR mbali inayo.
• 50/1000 mg - mapiritsi omwe amasiyana ndi mtundu wam'mbuyomu mumtambo wachikaso wambiri ndi kuphatikiza imvi ndi kufotokozera: NVR - kutsogolo ndi FLO - kumbuyo.

Kuthekera kwama pharmacological

Kuthekera kwa hypoglycemic kwamankhwala kumadziwika ndi mitundu iwiri yazinthu zofunika kupanga, iliyonse yomwe ili ndi njira yake yochitira. Mphamvu zawo zovuta zimakupatsani mwayi wowongolera glycemia masana.

1. Vildagliptin - choletsa wa dipeptidyl peptidase-4 (DPP-4) - imakulitsa chidwi cha maselo kuti apange insulin, imawonjezera kupanga. Zotsatira zake zimaperekedwa ndi kukondoweza ndi mitundu ya glyptin yopanga mapuloteni ofunikira kwa kapamba - mtundu wa glucagon ngati peptide 1 (GLP-1) ndi glucose-insulinotropic polypeptide (HIP).
2. Metformin, gulu la hydrochloride biguanide group, limachepetsa kukomoka kwa glycemic pochepetsa kuchepa kwa mafuta m'matumbo aang'ono, kuchepetsa kupanga glycogen mu chiwindi ndikuwonjezera kugwiritsa ntchito kwake mu zotumphukira. Phata limayambitsa hypoglycemia.

Pogwiritsa ntchito mankhwalawa pakamwa, vildagliptin ndi metformin amalowa m'magazi kudzera mu khoma lamatumbo, ndikufikira pazomwe zimachitika pakatha mphindi 25-30 ndikugawa ziwalo ndi ziwalo. Ma processor metabolism a Galvus Met amapezeka m'chiwindi. Pola impso zapamwamba ndi mkodzo. Nthawi yomwe theka la chizolowezi chogwiritsidwa ntchito chikuwonetsedwa pafupifupi maola atatu.

Panthawi yovuta yochiritsira yokhala ndi mankhwala awiri tsiku lililonse la metformin 1500-3000 mg ndi vildagliptin 50 mg, yogawa zokhudzana ndi 2 ntchito, kuchepa kwakukulu kwa shuga m'magazi kunalembedwa zoposa chaka chimodzi. Nthawi yomweyo, mafakitala a glycosylated hemoglobin adatsika ndi 0,7%, poyerekeza ndi gulu lolamulira, lomwe limalandira metformin yokha.

Kwa odwala matenda ashuga omwe anali pa zovuta za Galvus Metom, kuwongolera kwakukulu kwa thupi sikunalembedwe. Kupitilira masabata 24 ogwiritsa ntchito mankhwalawa, kuchepa kwakukulu kwa kuthamanga kwa magazi kunawululidwa kwa odwala oopsa omwe ali ndi matenda a shuga a 2. Milandu ya Hypoglycemic inalemba zochuluka.

Pamene Galvus Meta adalembedwa panthawi ya chithandizo ndi insulin (pa mlingo wa mayunitsi 41) odzipereka odwala matenda ashuga omwe akuchita nawo kafukufukuyu, kuchuluka kwa hemoglobin ya glycosylated kudatsika ndi 0,72%. Hypoglycemia m'magulu oyesera komanso mu gulu la placebo sizinali zosiyana pakamodzi kawirikawiri.

Pogwiritsa ntchito kufanana kwa glimepiride (kuyambira 4 mg / tsiku) ndi Galvus Met, kuchepa kwakukulu kwa hemoglobin ya glycosylated kunalembedwanso - ndi 0,76%.

Zambiri za pharmacokinetics

Vildagliptin

Ngati mumwa mapiritsi musanadye, zosakaniza mwachangu zimatenga msanga, mpaka zimatha pambuyo pa mphindi 105 mutayamba kumwa. Mukamagwiritsa ntchito mankhwalawa ndi chakudya, kuchuluka kwa mayamwidwe kumachepa pang'ono.

Mtheradi bioavailability wa mankhwalawa ndiwokwera kwambiri - 85%. Kugawa kwa metabolite pakati pa plasma ndi erythrocyte ndi yunifolomu, kumangokhala mwamphamvu kumapuloteni amwazi - 9,3% yokha.

Njira yayikulu yothetsera kuthetsa mankhwalawa ndi biotransfform, 69% ya mlingo mu thupi umasandulika kukhala wa cellacologically wosagwira metabolite ais151. Kutupa kwa vildagliptin kumachitika kudzera mu impso (85%) komanso matumbo (23%).

Oimira amitundu yosiyanasiyana, amuna kapena akazi, azinthu zosiyananso thupi amaonetsa pafupifupi pharmacokinetics omwewo a mankhwalawo.

Ndi hepatic osakwanira ofatsa kapena olimbitsa, bioavailability wa vildagliptin akutsikira ku 20%, mwa mawonekedwe owonjezereka amakula ndi 22%.

Ndi matenda a impso, mitundu yofatsa, yochepa komanso yolimba ya AUC, vildagliptin imakula 1.4 mpaka 2 nthawi.

Zotsatira za vildagliptin pa pharmacokinetics za ana sizinaphunzire.

Metformin

Pa mlingo wa 500 mg, bioavailability wa metformin ndi 50-60% ngati atadyetsedwa musanadye. Ndi kuchuluka Mlingo, chizindikirocho chikuwonjezeka. Ngati mumwa mankhwalawo limodzi ndi chakudya, bioavailability amachepetsa.

Ndi gawo limodzi, metabolite sikugwirizana kwenikweni ndi mapuloteni a plasma (kuyerekezera, kukonzekera kwa sulfonylurea kumangiriza 90%). Pogwiritsa ntchito nthawi yayitali, mankhwalawa amalowerera m'magazi ofiira.

Jekeseni imodzi yokha ya mankhwalawa kwa odzipereka athanzi anasonyezanso kuperewera kwa impso chimodzimodzi. Palibe ma metabolites omwe amapezeka m'chiwindi. Pa anthu odwala matenda ashuga, mpaka 90% ya mankhwalawa amatsitsidwa ndi impso mkati mwa maola 24.

Kusiyana kwa kugonana sikumakhudza ma pharmacokinetics a mankhwalawa. Anthu odwala matenda ashuga amitundu yosiyanasiyana adalemba zomwe zimachitika mu metformin.

Zolemba za mayamwidwe, kufalitsa ndi kuthetsa mankhwalawa kwa odwala omwe ali ndi matenda a chiwindi sizinaphunzire. Ndi a impso matenda, theka moyo limachulukana. Chifukwa cha kuchepa kwa kuchuluka kwa impso mwa odwala okhwima, zotsatira zofananira zimawonedwa. Palibe chidziwitso cha mankhwalawa pamankhwala omwe amachitika mu ana.

Yemwe amawonetsedwa ngati mankhwalawo

Kuphatikiza kwake kumapangidwira kuchitira odwala matenda ashuga a mtundu 2. Kutengera Galvus Meta, pali mitundu yochiritsira yosiyanasiyana.

1. Monotherapy - kusintha shuga, amagwiritsa ntchito mankhwala amodzi - Galvus Met.
2. Kugwiritsa ntchito mosiyanasiyana kwa magawo a Metformin ndi Vildagliptin ngati mankhwala odziimira pawokha.
3. Kuphatikiza mankhwala limodzi ndi zotumphukira za sulfanylurea.
4. Njira yapatatu komanso kuphatikizira kwa insulin kwa Galvus Meta.
5. Monga mankhwala mzere woyamba womwe umagwiritsidwa ntchito kumayambiriro kwa mankhwala osokoneza bongo, pamene chakudya chochepa kwambiri cha carb komanso minofu ya doses sichimatsogolera ku zotsatira zomwe mukufuna.

Galvus chithandizo chokomera amayi apakati komanso oyembekezera

Kafukufuku wazinyama zapakati, zomwe zimaperekedwa Mlingo wa vildagliptin 200m kuposa momwe zimakhalira, zimawonetsa kuti mankhwalawa saphwanya mapangidwe a mazira ndipo alibe mphamvu. Kugwiritsa ntchito kwa Galvus Meta mu gawo la 1/10 kunawonetsa zofanana.

Mphamvu ya mankhwalawa pa mwana wosabadwa sanaphunzire bwino, motero, amayi apakati sanakhazikitsidwe. Metformin imadutsa mkaka wa m'mawere; palibe chidziwitso pakulowerera kwa vildagliptin.

Mwambiri, Galvus Met sigwiritsidwa ntchito poyamwitsa.

Kwa yemwe hypoglycemic wothandizirana wapatsidwa

Pathologies momwe metabolite sichinatchulidwe:

• Kusatetezeka kwa munthu aliyense, hypersensitivity ku zilizonse za mankhwala;
• Matenda a shuga 1 amtundu - ndi matenda omwe amadalira insulin a mawonekedwe awa, insulin ndiyofunikira;
• Masiku angapo asanachite opareshoni, kuyezetsa kwa X-ray ndi radioisotropic, kuzindikira kwazowopsa;
• Acetonemia ndimatenda a metabolic omwe amadziwika ndi mawonekedwe a matupi a ketone mu madzi achilengedwe, makamaka izi zimachitika ndi hyperglycemia;
• Psal pathologies (mu mawonekedwe owopsa kapena osakhazikika), njira zomwe zimayambitsa kuperewera kwa madzi m'thupi - thupi lakuthwa chifukwa cha m'mimba kapena kusanza pafupipafupi, kutentha thupi, matenda (sepsis, matenda opuma);
• Kuchepa kwa chiwindi komwe kumalumikizidwa ndi zochitika zomwe zimachepetsa kugwira kwake (cirrhosis, hepatitis);
• Matenda a mtima, kugunda kwa mtima, kufupika;
• Mowa monga matenda kapena uchidakwa kamodzi;
• Zakudya za Hypocaloric, zimakwana 1000 kcal / tsiku zikulowa m'thupi .;
• Nthawi iliyonse ya bere;
• Ana - chitetezo ndi mphamvu ya mankhwalawa sizinakhazikitsidwe.

Momwe mungagwiritsire ntchito mankhwalawa

Piritsi liyenera kumezedwa lonse, osafuna kutafuna kapena kusungunuka, kutsukidwa ndi madzi okwanira pamtunda wabwino. Ngati mumamwa mapiritsi ndi chakudya, chiopsezo cha mavuto amachepetsa.

Mlingo wa Galvus Meta zimatengera kuchuluka kwa chiphuphu cha shuga, zotsatira za chithandizo cham'mbuyomu ndi analogues, komanso kutalika kwa matendawa. Mulimonsemo, dongosolo la chithandizo ndi dokotala.

Ngati mankhwalawa adalembedwa koyamba, monga kuwonjezera pakudya chamagulu osakwanira komanso zolimbitsa thupi, chizolowezi chake chimakhala 50/500 mg (chizindikiro choyamba ndi vildagliptin, chachiwiri ndi metformin). M'tsogolomu, osakwanira achire, omwe amatsimikiziridwa ndi njira zantchito, mankhwalawa amatha kusintha.

Wodwala akakhala kuti amadziwa kale mankhwalawa (adawatenga mosiyana kapena kuphatikiza kwina), amalimbikitsa imodzi mwazosankha - 50/850 mg kapena 50/1000 mg.

Mu zaka zakukhwima kapena kukula kwa matenda a impso, muyezo wocheperako nthawi zambiri umalimbikitsa.

Kuti muwone zotsatira za chithandizo cha Galvus Metom, ndikofunikira kuyang'ana kuchuluka kwa shuga (onse kunyumba, ndi glucometer, ndi labotale) pafupipafupi.

Zotsatira zoyipa

Zotsatira zosafunika sizinalembedwe nthawi zambiri, koma ndikofunikira kuphunzira mndandanda musanayambe kugwiritsa ntchito odwala matenda ashuga.

1. Matumbo am'mimba - vuto la dyspeptic, kutentha kwa mtima, kapamba, kulawa kwazitsulo pakamwa, kusamwa bwino kwa vitamini B12.
2. CNS - kutayika kwa mgwirizano, mutu, manja akunjenjemera.
3. Chiwindi ndi bile ducts - chiwindi ndi chiwindi kukanika.
4. Musculoskeletal system - kuphatikizika ndi kupweteka kwa minofu.
5. Khungu - matuza, kutupa, khungu lowuma.
6. Metabolism - lactic acidosis (kuchuluka kwa kuchuluka kwa uric acid, acidic reaction ya chilengedwe).
7. Ziwengo - zotupa pakhungu, kuyabwa, urticaria; mukumva kwambiri - edio ya angioedema Quincke (kutupa kwa nkhope ndi maliseche) ndi kugwedezeka kwa anaphylactic (dontho lakuthwa mu kuthamanga kwa magazi, komwe kumathandizidwa ndi ziwalo zingapo).

   
   

Nthawi zina hypoglycemia imayamba ndi thukuta lakuthwa, manja akunjenjemera. Pazizindikiro zoyambirira, muyenera kumwa theka kapu ya tiyi wokoma kapena msuzi, idyani maswiti.

Malangizo apadera

Popereka mankhwala, wodwala matenda ashuga ayenera kuphunziranso yekha malangizowo. Malangizo apadera amathandiza kupewa mavuto.

• Galvus Met simalo analogue a insulin, ndikofunikira, choyambirira, kwa odwala matenda ashuga omwe amadalira matenda a shuga.
• Mankhwalawa ndi mankhwalawa, kuyang'anira shuga wa magazi pafupipafupi (ma labotale komanso anthu ena, pogwiritsa ntchito glucometer) kumafunika.
• Mwezi uliwonse, njira zasayansi zimayendera momwe impso, chiwindi, ndi kuchuluka kwa lactic acid.
• Pa chithandizo, Galvus Metom ndi yosavomerezeka kumwa mowa - izi zimathandizira kukulitsa lactic acidosis.
• Kulowetsedwa bwino kwa vitamini B12, chifukwa chogwiritsa ntchito mankhwalawa, kumatha kupangitsa kuti muchepetse magazi m'thupi.
• Ana, amayi apakati komanso oyamwitsa Galvus Met savomereza.
• Magawo omwe amagwira ntchito a metabolite amalumikizana ndi mankhwala ambiri, popanga dongosolo la mankhwala, adokotala ayenera kudziwa zamankhwala onse omwe amamwa.
• Zotsatira za Galvus Meta pa zochitika zama psychomotor komanso kuchuluka kwa chidwi sizinaphunzire. Pogwira ntchito ndi makina ndi makina pakumwa mankhwalawa, munthu ayenera kusamala kwambiri.

Bongo

Ngati mulingo woyenera wapitirira nthawi zambiri, myalgia, hypoglycemia, matenda a dyspeptic, edema ya malekezero, lactic acidosis (kuchokera ku kuchuluka kwa metformin) amakula. Zizindikiro za bongo zimatha atasiya kulandira chithandizo.

Ndi zizindikiro zotere, mankhwalawa amachotsedwa, kutsukidwa ndimatumbo ndipo chithandizocho chimachitidwa. Kugwiritsa ntchito hemodialysis, ndi metformin yokha yomwe ikhoza kufufutidwa kwathunthu, vildagliptin ndiyotulutsa pang'ono.

Galvus Met - analogi

Ngati tingayerekeze kapangidwe ndi zotsatira za chithandizo, ndiye malinga ndi zomwe zikuchitika komanso kuthandizira kwachidziwitso, ma analogu akhoza kukhala:

• Nova Met;
• Sofamet;
• Trazenta;
• Methadiene;
• Forin Pliva.

Malangizo osungira ndi mtengo wamankhwala

Malinga ndi malangizo, Galvus Met ndiyoyenera kugwiritsidwa ntchito mkati mwa miyezi 18 kuyambira tsiku lotulutsidwa, malinga ndi kusungidwa koyenera. Mankhwala omalizira ayenera kutayidwa. Malo amdima ndi owuma osayang'aniridwa ndi ana ndi oyenera kusungidwa, kutentha kwake mpaka 30 ° C.

Mankhwala omwe mumalandira amamasulidwa. Kwa Galvus Met, mlingo umatsimikiziridwa ndi Mlingo:

1. 50/500 mg - avareji a ma ruble a 1457;
2. 50/850 mg - avareji ma ruble 1469;
3. 50/1000 mg - pafupifupi 1465 rubles.

Ngakhale atagwiritsidwa ntchito kamodzi, sikuti anthu onse omwe amadwala matenda ashuga amakhutira ndi mtengo wake, ambiri amadandaula kwa omwe amapuma pantchito ndi ndalama zochepa. Komabe, zopangidwa ndi kampani yaku Swiss Novartis Pharma nthawi zonse zimasiyanitsidwa ndi mtundu wawo wabwino, ndipo sakhala gawo la bajeti la othandizira anzawo.

Galvus Met - ndemanga za odwala matenda ashuga ndi madokotala

Pamabwalo azodzisankhira, endocrinologists amayankha bwino pazotsatira za chithandizo cha Galvus Metom. Sitikulimbikitsidwa kuti mupeze zovuta zamavuto a oncological, popeza DPP-4, enzyme yomwe imalepheretsa kukula kwa neoplasms, imalepheretsedwa ndi Galvus Metom. Mu khansa ya kapamba, insulin nthawi zambiri imayikidwa. Ndemanga za odwala za Galvus Mete ndizosakanikirana, nkhani yayikulu pamikangano ndi mtengo.

Zambiri zokhudzana ndi mankhwala a Galvus Met ophatikizira zotsatira za hypoglycemic pa insulin ndi glycogen m'thupi zimakhazikitsidwa potsatira malangizo a boma, koma zimaperekedwa pazidziwitso zokhazokha ndipo sizingakhale chitsogozo chodziwunikira kapena kudzidziwitsa nokha.