Mankhwala Akkuzid: malangizo ogwiritsira ntchito

Akkuzid ndi gulu la mankhwala omwe amapangidwa kuti athetse vuto la matenda oopsa. Kukonzekera kumakhala ndi zinthu zazitali zomwe zimagwira ntchito: ndi diuretic zochita; ACE inhibitor. Chida ichi chimadziwika ndi malire. Amasiyanitsidwa ndi mitundu ingapo ya zotsatira zingapo, zoletsa kugwiritsa ntchito.

Dzinalo Losayenerana

Hydrochlorothiazide, hinapril.

Akkuzid ndi gulu la mankhwala omwe amapangidwa kuti athetse vuto la matenda oopsa.

ATX

C09BA06 Hinapril osakanikirana ndi okodzetsa

Kutulutsa mafomu ndi kapangidwe kake

Mankhwalawa amapangidwa mwanjira ya mapiritsi (phukusi limakhala ndi ma PC 30.). Itha kugulidwa m'mitundu yosiyanasiyana, yomwe imasiyana muyezo wa kuchuluka kwa zinthu:

• hydrochlorothiazide 12,5 mg, quinapril 10 mg;
• hydrochlorothiazide 12,5 mg; quinapril 20 mg;
• hydrochlorothiazide 25 mg, quinapril 20 mg.

Kapangidwe kake kamaphatikizidwanso ndi zinthu zina:

• magnesium carbonate;
• lactose monohydrate;
• crospovidone;
• povidone;
• magnesium wakuba.

Mankhwalawa amapangidwa mwanjira ya mapiritsi (phukusi limakhala ndi ma PC 30.).

Zophatikiza izi sizikuwonetsa ntchito za antihypertensive. Mapiritsiwo amakhala atakutidwa, chifukwa chomwe mankhwalawo amakwiriridwa m'matumbo, osapereka zotsatira zoyipa za m'mimba. Mulinso:

• Opadry pink OY-S-6937 (hypromellose, macrogol 400, hyprolose, titanium dioxide, utoto wa okusayidi wachikasu ndi wachikasu);
• sera wazitsamba - 0,05 mg.

Zotsatira za pharmacological

The yogwira zinthu zikuchokera wothandizira mufunsidwa amagwira ntchito zosiyanasiyana, kuwonjezera mphamvu yonse ya mankhwala. Chifukwa chake, gawo la hinapril ndi angiotensin lotembenuza enzyme inhibitor. Zikomo kwa iye, kamvekedwe ka zotengera sikakonzedwa. Mwa zina, zotsatirazi zimachitika chifukwa cha kuchuluka kwa mahomoni opangidwa ndi adrenal cortex.

Renin ali ndi vuto lolimbitsa magazi.

Kuletsa kwa angiotensin-kutembenuza enzyme chifukwa cha kuchepa kwa ntchito ya aldosterone. Ichi ndiye chimini chachikulu cha mineralocorticosteroid chopangidwa ndi adrenal cortex. Nthawi yomweyo, zotsatira zoyipa za gawo lalikulu la renin-angiotensin system (renin), lomwe limayambitsa matenda a kuthamanga kwa magazi, limachotsedwa. Zotsatira zake, ntchito ya renin yomwe ili m'madzi a m'magazi imachulukanso. Mlingo wopanikizika umakhala wokhazikika, komabe, kugunda kwa mtima kumakhalabe kosasinthika.

Zina zabwino za quinapril:

• kuyimitsa chitukuko cha myocardial hypertrophy;
• kubwezeretsa kwa magazi ku ischemic myocardium;
• kuchuluka kwa mphamvu ya magazi ndi aimpso;
• kuchepa kwa kuphatikizira kwa maselo amwazi.

Hinapril abwezeretsanso magazi ku ischemic myocardium.

Hinapril amasiya kukula kwa myocardial hypertrophy.

Hinapril amachepetsa kuphatikiza kwa mapulateleti.

Hydrochlorothiazide ndi thiazide okodzetsa. Ntchito yake yayikulu ndikuwonjezera kutulutsa kwamkodzo ndi madzi ena ochokera mthupi. Chifukwa cha izi, kuchuluka kwa zizindikiro za matenda oopsa kumacheperachepera. Kuphatikiza apo, kukula kwa nkhope ndi lilime, komanso ziwalo zina za thupi zomwe zimayambitsa kukula kwa mtima kapena kulephera kwa impso, kumachepetsedwa.

Hydrochlorothiazide amathandiza kuchepetsa kuchuluka kwa potaziyamu. Izi zimachitikanso chifukwa chakuchepa kwambiri kwa kuchuluka kwa madzi mthupi. Gawo lachiwiri logwira ntchito pakuphatikizidwa kwa Accudide (hinapril) limalipira kuchepa kwa potaziyamu.

Hydrochlorothiazide imasokoneza kupukusira kwa calcium kuchokera mthupi, imathandizira kuchotsedwa kwa sodium.

Izi zimakhudza kwambiri impso ndikuwonetsa katundu wofanana ndi ACE inhibitor: zimawonjezera kuchuluka kwa kupanga kwa aldosterone ndikulimbikitsa kuwonjezeka kwa ntchito ya plinma renin.

Pharmacokinetics

Zizindikiro za matenda oopsa zimatha pang'ono pang'ono (kapena mphamvu zawo zimachepa) ola limodzi mutatha kumwa piritsi loyamba. Komabe, mankhwala pakadali pano sagwira ntchito mwamphamvu. Chiwopsezo cha ntchitoyi chimafikira maola 1-2. Chifukwa chake, mphamvu yayikulu ingathe kuyembekezeredwa maola 4 mutangotenga Accuzide.

Zotsatira zomwe zimapezeka zimasungidwa maola 24 otsatira ndipo kwakanthawi. Mphamvu ya hydrochlorothiazide ndiyotsika, chifukwa zotsatira zimasungidwa kwa maola 6-12. Zinthu zoterezi sizikhudzana wina ndi mzake pakachulukidwe. Pakusintha kwa quinapril, gawo lochita kwambiri la quinaprilat limamasulidwa. Chipangizochi sichingatengeke kwathunthu (60% ya kuchuluka kwathunthu).

Zizindikiro za matenda oopsa zimatha pang'ono pang'ono (kapena mphamvu zawo zimachepa) ola limodzi mutatha kumwa piritsi loyamba.

Quinapril amachotsedwa magazi mwachangu - 1 ola limodzi. Kutuluka kwake kumachoka m'thupi pang'onopang'ono, mkati mwa maola atatu. Impso zimagwira nawo ntchito yotulutsa mankhwala awa. Hydrochlorothiazide imachotsedwanso osasinthika, popeza siupanga.

Zizindikiro zogwiritsidwa ntchito

Njira yayikulu komanso yokhayo yomwe kumakhala kofunika kugwiritsa ntchito wothandizirayo ndi matenda oopsa. Komabe, ziyenera kukumbukiridwa kuti mankhwalawa sanafotokozedwe nthawi zonse, pokhapokha ngati mankhwala a quinapril afunikira limodzi ndi okodzetsa.

Contraindication

Chiwerengero chambiri choletsa kusankha Akkuzid amati:

• ochepa hypotension;
• Hypersensitivity zotsatira za chinthu chachikulu mankhwala mankhwala zikuchokera, sulfanilamide zotumphukira;
• angioedema a etiologies osiyanasiyana, kuphatikizapo mbiri yakale (chifukwa cha mankhwala aposachedwa omwe ali ndi angiotensin-converting enzyme inhibitors);
• angapo a pathological zochitika chifukwa cha kusintha kagayidwe: hypokalemia, hyponatremia, etc;
• Matenda a Addison, omwe amaphatikizidwa ndi vuto la adrenal cortex;
• matenda a shuga monga matenda a impso amawonongeka;
• cholowa cham'thupi chokhudzana ndi lactase tsankho, kuperewera kwa lactose ndi shuga-galactose malabsorption.

Pali chiwerengero chachikulu choletsa kusankhidwa kwa Accuid kwa ochepa hypotension.

Pali zoletsa zambiri pakuika Akkuzid ndi hypersensitivity pazotsatira za chinthu chachikulu.

Pali chiwerengero chachikulu choletsa kusankhidwa kwa Accuzide mu shuga.

Ndi chisamaliro

Mikhalidwe zingapo za pathological momwe ndizololedwa kugwiritsa ntchito mankhwalawa, komabe, chithunzi chachipatala chiyenera kuyang'aniridwa:

• hemodialysis waposachedwa kapena okodzetsa;
• kulephera kwa mtima limodzi ndi kuwonongeka kwambiri kwa impso;
• kuchepa kwa mphamvu ya hematopoietic system;
• kuchepa kwa lumen ya mitsempha;
• kuchira nthawi pambuyo opaleshoni impso;
• autoimmune connective minofu matenda;
• opaleshoni kuchitapo kanthu;
• Hyperkalemia

Mosamala, Accuzide imagwiritsidwa ntchito kulephera kwa mtima.

Zomera zogwira ntchito zimakhazikitsa ma membala am'mimba.

Mosamala, Accuzide imagwiritsidwa ntchito kufupikitsa kuwala kwa mitsempha.

Momwe mungatengere Accuide

Asanaperekane, zimafotokozeredwa ngati wodwalayo alandira zodumphitsa. Ngati mankhwala omwe mukufunsidwa amagwiritsidwa ntchito ndi monotherapy, mankhwala ayenera kuyamba piritsi limodzi. Kukumana kwa zinthu zogwira ntchito kuyenera kukhala kochepa. Pambuyo kanthawi, mlingo umakulitsidwa mpaka wokwera (25 mg ya hydrochlorothiazide ndi 20 mg ya quinapril). Kutalika kwa mankhwalawa kumatsimikiziridwa ndi adokotala ndipo zimatengera momwe wodwalayo alili.

Ndi matenda ashuga

Mlingo uyenera kukhala wochepa. Ngati vuto la wodwalayo silikukulirakulira, mankhwalawo akhoza kuchuluka. Mankhwalawa amachitika moyang'aniridwa ndi dokotala.

Asanaperekane, zimafotokozeredwa ngati wodwalayo alandira zodumphitsa.

Zotsatira zoyipa Akkuzida

Zotsatira zoyipa zimawonedwa mu ochepa odwala. Ngati mulingo wa mankhwalawa suphwanyidwa, chiwopsezo cha mavuto amachepetsa.

Pa mbali ya gawo la masomphenyawo

Acuity owoneka amachepa.

Kuchokera minofu ndi mafupa

Ululu m'malimba.

Matumbo

Pakamwa pakamwa, kusintha kwa chopondapo kapangidwe kake, cholecystitis, magazi m'mimba kapena matumbo, kuchuluka kwa mapangidwe a gasi, kutupa kwamatumbo, matumbo a anorexia, sialadenitis.

Zotsatira zoyipa za Akkuzid kuchokera kumimba;

Hematopoietic ziwalo

Angapo a zikhalidwe za pathological limodzi ndi kusintha kapangidwe magazi: thrombocytopenia, leukopenia, kuchepa magazi, etc.

Pakati mantha dongosolo

Hyper chisangalalo,, kapena, kugona, mayiko achisoni.

Kuchokera kwamikodzo

Matenda otupa a kutupa ndi kutukukira kwa chikhodzodzo ndi urethra, kukanika kwa impso, kuphwanya mkodzo wam'mimbamo, mwachitsanzo oliguria, pyuria, ndi zina zambiri.

Kuchokera ku kupuma

Kutupa kwa mucous nembanemba amkamwa, kupuma movutikira.

Zotsatira zoyipa za Akkuzid kuchokera pakupuma:

Pa khungu

Urticaria, limodzi ndi kuzizira kwa chilengedwe.

Kuchokera ku genitourinary system

Kuwonongeka kwa potency.

Kuchokera pamtima

Mitsempha yamagazi yotupa, kusintha kwa kugunda kwa mtima (arrhythmia, bradycardia), ochepa hypotension.

Matupi omaliza

Vasculitis ya necrotic chikhalidwe, photosensitivity, kupuma ntchito chifukwa cha angioedema, anaphylactic mantha.

Kumwa mankhwalawa sikuti kumatiletsa kuchita zinthu zofunika kwambiri.

Zokhudza mphamvu pakuwongolera njira

Kumwa mankhwalawa sikuti kuphwanya zochita kuti tichite chidwi, koma tiyenera kusamala.

Malangizo apadera

Ngati pali zizindikiro za edema ya laryngeal, chithandizo chimasokonekera. Pali mwayi wokhala ndi matumbo otupa. Chizindikiro chachikulu ndi kupweteka.

Malinga ndi ziwerengero, mwayi wokhala ndi angioedema ndiwokwera kwambiri pankhani yothandizira odwala a liwiro la Negroid.

Ngati munthu alandira mankhwala omwe akufuna kuti achepetse kuchuluka kwa poyizoni ndi kuluma kwa Hymenoptera, chiwopsezo cha kupuma mthupi chifukwa cha chotupa chikukula.

Nthawi zina, ntchito ya m'mafupa imaponderezedwa pamankhwala akumwa ACE zoletsa.

Kukhosomola kumatha kuchitika. Chizindikiro ichi chimazimiririka kumapeto kwa maphunziro.

Pa chithandizo, kuchuluka kwa ma electrolyte omwe amapezeka m'madzi a m'magazi kumayendetsedwa.

Kukhosomola kumatha kuchitika. Chizindikiro ichi chimazimiririka kumapeto kwa maphunziro.

Gwiritsani ntchito mu ukalamba

Hafu ya moyo wa mankhwala kuchokera ku thupi imachulukanso, zomwe zikutanthauza kuti kusintha kwa mlingo kungafunike.

Kupatsa ana

Zikugwira ntchito. Izi ndichifukwa chosowa chidziwitso pazokhudza zinthu zazikuluzikulu mthupi la odwala omwe ali ndi zaka 18.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Mankhwala sagwiritsidwa ntchito ngati mkazi. Pa nthawi ya pakati, mwayi wokhala ndi vuto logona mkati mwa mwana wosabadwa, makamaka mtima, umachulukana.

Mankhwalawa sagwiritsidwa ntchito pa nthawi yapakati.

The ntchito aimpso kuwonongeka

Kuchuluka kwa ziphuphu za creatinine kumachepa, nthawi yayitali magawo ake amachotsedwa m'thupi. Pachifukwa ichi, kuwerengetsa kuchuluka kwa mankhwalawa kungafunike. Ndi kuchepa kwa creatinine chilolezo cha 30 ml pa mphindi, kumwa mankhwala oletsedwa, chifukwa mu nkhani iyi aimpso kulephera.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Mankhwala amagwiritsidwa ntchito mosamala.

Overdose Akkuzida

Milandu yokhudzana ndi zovuta zomwe zimachitika pakumwa mankhwala ndi wothandizirawa sizinalembedwe. Komabe, poganiza kuti izi zitha kukhalako. Zizindikiro zomwe zingatheke: kuchepa kwakukulu kwa kupanikizika, kuphwanya kwamadzi yamagetsi yamagetsi. Njira zochizira zochizira matenda:

• lekani kumwa mankhwalawa;
• chapamimba;
• kudya kwa odzipereka;
• mtsempha wamitsempha njira zothetsera zomwe zimathandizira kubwezeretsanso kwa zamagetsi zamagetsi.

Pankhani ya mankhwala osokoneza bongo, kupweteka kwam'mimba kumachitika.

Kuchita ndi mankhwala ena

Mukamapereka mankhwala a Consuid, kuchuluka kwa zotsatira zoyipa m'thupi la wodwala m'njira zina zingapo kumachitika. Mankhwalawa samayenderana ndi antiseptics.

Kuphatikiza kophatikizidwa

Kukonzekera kwa Lithium kumathandizira kuti pakhale kuledzera kwa lithiamu.

Ma diuretics motsutsana ndi kumbuyo kwa kutenga Accudide kumayambitsa kuchepa kwamphamvu kwa zovuta. Zomwezi zimapangidwanso ndi barbiturates, ethanol, mankhwala a analgesic a gulu la narcotic.

Ma diuretics motsutsana ndi kumbuyo kwa kutenga Accudide kumayambitsa kuchepa kwamphamvu kwa zovuta.

Osavomerezeka kuphatikiza

Kuchiza ndi GCS kumabweretsa kuphwanya kwamanja-electrolyte, kuchepa kwa kuchuluka kwa potaziyamu.

Kuwonjezeka kwa zotsatira za gulu lopuma minofu kungachitike.

Pali chiopsezo cha hypersensitivity ku gawo lalikulu lamankhwala lomwe likuthandizira kuthetsa zizindikiro za gout.

Kuphatikiza komwe kumafunikira kusamala

Tetracycline imadzigwira mwachangu pomwe imagwiritsidwa ntchito ndi Accuzide.

Mankhwala a Hypoglycemic. Potere, kusintha kwa wothandizirayo pamfunso nthawi zambiri kumafunikira.

Mphamvu ya norepinephrine imachepa. Kukonzekera kwa gulu la NSAID kumayambitsa kuchepa kwamphamvu kwa zochita za Akkuzid.

Mosamala, othandizira omwe ali ndi potaziyamu amagwiritsidwa ntchito, chifukwa pamenepa chiopsezo chokhala ndi hyperkalemia chikuwonjezeka.

Tetracycline imadzigwira mwachangu pomwe imagwiritsidwa ntchito ndi Accuzide.

Kuyenderana ndi mowa

Kuthamanga kwa magazi kupita ku ubongo kungasokonezeke ndi kusintha kwa thupi.

Analogi

Mankhwala othandizira omwe amagwiritsidwa ntchito m'malo mwa Accuzide:

• Quinard
• Quinapril.

Othandizira osiyanasiyana omwe ali ndi mawonekedwe osiyana amatha kukhazikitsidwa ... Komabe, kukonzekera kokhala ngati mapiritsi ndikosavuta chifukwa sikutanthauza kutsatira malamulo aukhondo, monga makandulo, kapena kukonzekera kwa zinthu zapadera (mukamagwiritsa ntchito njira ya lyophilisate pokonzekera yankho).

Mankhwalawa ndi mankhwala.

Kupita kwina mankhwala

Mankhwalawa ndi mankhwala.

Kodi ndingagule popanda kulandira mankhwala?

Palibe zotheka.

Mtengo wa Akkuzid

Mtengo ku Russia ndi ma ruble 530.

Zosungidwa zamankhwala

Kutentha kovomerezeka kwa chipinda - mpaka + 25 ° С.

Tsiku lotha ntchito

Alumali moyo wa mankhwalawa salinso wopitilira zaka 3 kuyambira tsiku lopangidwa.

Wopanga

Pfizer Manufachering Deutschland GmbH, Germany.

Ndemanga za Accid

Veronika, wazaka 39, Novomoskovsk

Adatenga mitundu yosiyanasiyana ya mankhwala (komanso zowonjezera zakudya, kuphatikizapo). Koma chida ichi chimathandiza kuposa ena. Zotsatira zimatheka msanga, kupanikizika kumachitika pakatha maola awiri. Poyamba, sanafune kuzilandira, chifukwaNdamva za zoyipa (kuchokera ku chitetezo chamthupi, chitetezo cha mthupi, makamaka zochita za anaphylactic). Koma ine, mankhwalawo sanapite popanda zovuta.

Mikhail, wazaka 46, Kerch

Dotolo adalimbikitsa kusankha mitundu ingapo ya mankhwalawa oyenera kundipeza, koma sindinayime ku Accuid - Sindinakonde kuti pakati pazotsatira zake zili ndi chiopsezo chokhala ndi matenda a kubereka.