Kodi lactic acidosis mu shuga ndi momwe angachiritsire

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Anthu omwe ali ndi matenda ashuga amafunika chisamaliro chapadera kuti asamalire thanzi lawo. Matendawa akuwopseza kuyambitsa zovuta zambiri. Zoopsa kwambiri ndi ketoacidotic, hyperosmolar ndi hyperlactacidemic coma.

A harbinger otheka ndi matendawa ndiwonjezere kuchuluka kwa lactic acid m'magazi, omwe amasintha pH yake kukhala mbali ya acidic, yotchedwa lactic acidosis.

Zomwe zimachitika

Kukula kwa lactic acidosis kumatheka osati kokha mu matenda a shuga, komanso matenda ena angapo omwe amatsatana ndi kuchepa kwa kuperekera kwa okisijeni ku minofu, pomwe kuwonongeka kwa glucose ndi metabolism yamphamvu kumachitika molingana ndi mtundu wa anaerobic. Amadziwika ndi kupangika kwakukulu kwa lactic acid, yomwe imatuluka m'magazi.

Komanso, pathological mkhalidwe umachitika pamaso pa matenda a ziwalo zomwe zimagwiritsa ntchito ndikuchotsa lactic acid. Izi zimachitika ndimatenda a impso ndi chiwindi, omwe amayenda limodzi ndi kulephera kugwira ntchito kwawo.

Etiology

Pali zinthu zingapo zomwe zimayambitsa kuphatikiza kwa lactic acid m'matupi amthupi, zomwe zimayambitsa lactic acidosis, omwe adatinso amapezeka.

Pulmonary kusowa

Pankhaniyi, pakuchepa kwa kuchuluka kwa mpweya wamagazi, mapapu sagwira ntchito ndi mphamvu yoyenera, ndipo ziwalo zonse zimayamba kudwala chifukwa cha kuchepa kwa mpweya. Kuti athe kulipira vutoli, maselo amayamba kuphwanya glucose mumtundu wa anaerobic, ndikamasulidwa kwa lactate.

Kulephera kwa mtima

Zimabweretsa mawonekedwe a lactic acidosis amtundu womwewo ngati kulephera kwa m'mapapo. Koma ndikuphwanya mtima, kumakhala kuchepa kwa kuchuluka kwa magazi omwe amachokera m'mitsempha yake, komwe kumabweretsa kuchuluka kwakukulu kwa atria. Izi zimadzetsa kuwonjezeka kwa kuthamanga mumagulu ang'onoang'ono amwazi ndikudutsa mu edema yovuta kwambiri yam'mapapo, komanso mapapo am'mimba omwe amakanika ndikulephera kwa mtima.

Kulephera kwina

Chofunikira kwambiri pa impso ndikumasulidwa kwa zinthu zonse zosafunikira ndi zakupha m'thupi. Impso zimayang'aniranso kuchuluka kwa zinthu zina mthupi, ngati zochuluka kwambiri za izo, impso zimayamba kuwakhwimitsa kwambiri, zomwe zimachitika ndi thupi lactic, lactic acid. Kulephera kwamkati sikubala zomwe mukufuna, ndipo lactic acid imadziunjikira m'thupi.

Matenda opatsirana komanso otupa

Ndi matenda opatsirana ambiri, kuwonongeka kwakukulu kwa magazi ndi mabakiteriya kumachitika, izi zimakwiyitsa kwambiri magazi.

Mikhalidwe imeneyi, kufalikira kwa magazi m'magulu ang'onoang'ono a m'magazi kumayima ndipo minofu imayamba kudwala hypoxia.

Zomwe zimathandizira kuwonjezeka kwa milingo ya lactate.

Kutaya magazi kwakukulu

Izi zimagwirizanitsidwa ndi kuchepa kwamphamvu kwamaselo am'magazi omwe amanyamula mpweya kupita nawo ku minofu, zomwe zimawapangitsa kukhala ndi vuto la hypoxia ndikupanga lactic acid ndi chidwi chowonjezeka.

Zodabwitsa

Pankhaniyi, kuphatikiza kwa lactic acid kumachitika ndi mpweya wamatenda a minofu chifukwa cha vasospasm. Izi zimachitika ngati chitetezo cha thupi ku chinthu chowonongeka cha pathogenic, chomwe chimapangitsa kutsika kwa magazi pazipazi, ndikuthandizira magazi kulowa ziwalo zamkati.

Uchidakwa komanso uchidakwa

Amathandizira kuwonjezera kuchuluka kwa poizoni m'magazi, amawononganso chiwindi ndi impso, ziwalo zomwe zimawononga ndikuchotsa poizoni wonse mthupi. Komanso, pakutha kwa mowa wa ethyl panthawi ya kagayidwe, zopangidwa ndi kuwonongeka kwake zimachitika, chimodzi mwazo ndi lactic acid.

Njira za tumor

Pankhaniyi, pali kusintha kwa mtundu wa kagayidwe kachakudya kosinthika khansa, nthawi zambiri mtundu wa anaerobic wa kutulutsa kwa lactate umawonedwa mwa iwo. Ndipo chifukwa cha kukula kwa neoplasm, ziwiya zomwe zimapereka mitsempha yamagazi zimapanikizika, zomwe zimayambitsa kuperewera kwa mpweya chifukwa cha khansa komanso tinthu tating'ono.

Mwa anthu omwe ali ndi matenda ashuga, omwe ali ndi vuto la insulin, enzyme, pyruvate dehydrogenase, imayatsidwa.
Panthawi yamphamvu kagayidwe, mothandizidwa ndi chinthuchiwamoyo ichi, mitundu ya asidi ya pyruvic imawola kukhala zinthu zomaliza, zopangidwa ndi lactic acid. Izi zimabweretsa kuwonjezeka kwa kuchuluka kwa lactic acid m'magazi. Koma mukamamwa mankhwala a hypoglycemic, biguanides, pamakhala kuwonjezeka kwakukulu kwa kuchuluka kwa lactate. Izi ndichifukwa choti mankhwalawa a gululi amadziunjikira m'chiwindi ndi impso, zomwe zimalepheretsa chimbudzi ndikugwiritsa ntchito lactate ndi ziwalozi.

Zizindikiro

Mwa anthu omwe ali ndi matenda a shuga, matenda a lactic acidosis amakula msanga, pomwe kusintha kwina koyambira sikungawoneke. chinthu choyamba chomwe muyenera kulabadira ndikumakhala ndi mantha osamveka, chizungulire, lilime louma komanso chamkamwa, kumayamwa kummero. Kwa odwala matenda ashuga, awa ndi maumboni owopsa omwe akuchenjeza za kuthekera kwa ketoacidotic ndi hyperosmolar coma.

Zizindikiro zazikulu za lactic acidosis yomwe yakula ndikuwoneka ngati kupweteka kwakukulu komanso kusasangalala m'magulu onse a minofu, vutoli limafanana ndi kumverera kwa "mphamvu" pambuyo poti atopetse kupsinjika kwa thupi. Dyspnea imalumikizana ndi kupitilira kwa ululu, kupuma kumakhala kopanda phokoso, odwala amadandaula za kupweteka kwakukulu pamimba ndi kumbuyo kwa sternum, kumverera kolemetsa m'mimba, mawonekedwe a nseru, thukuta lozizira, ndi kusanza ndizotheka.

Ngati pa nthawi imeneyi matendawo sangathe, kuperewera kwa mtima kumalumikizana, komwe kumawonetsedwa ndi kusazindikira, minofu yotsikira, kutsekeka kwa khungu komanso mawonekedwe a mucous. Pophunzira ntchito zamtima, pamakhala mawonekedwe a chisokonezo chamtambo, kuchepa kwa mgwirizano. bradycardia.

Gawo lotsatira limadziwika ndi vuto lagalimoto. Wodwalayo amakhala wopanda chidwi, wamphamvu, chiwonetsero cha kuyang'ana kwamitsempha cham'mimba ndizotheka. Kupitilira apo, matendawo amayamba kuvuta, komanso kupatsirana kwakukulu kwa zombo zazing'ono (DIC). Thrombosis yotere imatsogolera pakupanga zotupa za ischemic mthupi lonse, ubongo, impso, chiwindi ndi mtima. Zonsezi pang'onopang'ono zimabweretsa imfa ya wodwalayo.

Ndi lactic acidosis chikomokere, palibe fungo la acetone kuchokera kwa wodwala, lomwe ndi lingaliro losiyanitsa ndi coma iyi kuchokera ku ketoacidotic.

Chithandizo

Ngati kuperewera kotereku kumachitika kapena kuipiraipira komwe kumakhalapo pakati pa thanzi lanu, muyenera kuyimbira foni ambulansi kapena kupita kuchipatala chachipatala chayandikira. Kuyesa kudziyimira pawokha kuchiza matenda kunyumba, nthawi zambiri, kumatha moipa. Chokhacho chomwe chingakuthandizeni ndi kumwa mokwanira.

Ku chipatala, chithandizo chachikulu cha kulowetsedwa chimagwiritsidwa ntchito pochotsa vutoli.

Choyamba, wodwalayo amapatsidwa mwayi wokhazikika, kulowa mkati mwa subclavian mtsempha, ndi awiri ozungulira. Adzakulitsa sodium bicarbonate, saline.

Mlingo wopanda insulin umathandizidwa nthawi ndi nthawi, zomwe zimapangitsa kuti magawo atsopano a lactic acid atulutsidwe.

Odwala amachita thrombolytic mankhwala popewa mwadzidzidzi kufalikira kwa kwapakati.
Komanso, gawo loyamba la lactic acidosis chikomokere, odwala amakakamizidwa kutenga anticoagulants ndi antiplatelet othandizira amoyo.

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