Mphamvu ya mankhwala Victoza mu shuga komanso kuwonda

Victoza ndiye mndandanda woyamba komanso wokhawo wa glucagon-peptide. Thupi ili pafupifupi 100% limagwirizana ndi GLP yaumunthu. Monga chinthu chochokera ku chilengedwe, mankhwala a Victoza amalimbikitsa kutulutsa kwa insulin ndi mitundu yapadera yam'magazi ngati kuchuluka kwa glucose kudutsa mwazonse.

Masiku ano Viktoza wochepetsa thupi komanso ngati imodzi mwa mankhwala a odwala matenda ashuga, amagwiritsidwa ntchito m'maiko opitilira 35 padziko lonse lapansi, kuphatikiza m'maiko a America ndi Europe. Ofufuzawo amafufuza mosamalitsa mphamvu za GLP ndicholinga chofuna kuthetseratu matenda omwe ali m'magulu osiyanasiyana.

Mlingo wa mawonekedwe ndi kapangidwe kake

Mankhwala Victoza amaperekedwa ngati yankho la subcutaneous makonzedwe. Zomwe zimagwira ndi liraglutide. Madzi amadzimadzi amayikidwa mu cholembera chapadera ndi voliyumu ya 3 ml.

Njira yothetsera vuto siyopanda utoto, siyenera kukhala ndi zosayenera. Mtundu wamtundu wakuthupi kapena wopatsa chidwi uyenera kuchenjeza - mwina mankhwalawo afooka. Zithunzi zambiri za cholembera cha Victoza syringe zimatha kupezeka pazinthu zingapo za intaneti kuti mudziwe momwe mankhwalawa amayenera kuwonekera pasadakhale.

Mankhwala

Ma jakisoni a Victoza ndi othandizira amphamvu a hypoglycemic. Zotsatira zazikulu za mankhwala omwe amachititsa chidwi chenicheni kuchokera kwa akatswiri othandizira ndi ma endocrinologists:

1. Kukondoweza kwa shuga yemwe amadalira shuga;
2. Kuponderezedwa kwa shuga wamagulu opangidwa ndi shuga;
3. Chitetezo ku zovuta za hypoglycemic;
4. Kuwongolera m'mimba chifukwa kuchepa pang'ono kwa mphamvu ya m'magazi (kuyamwa kwa glucose mukatha kudya kumachepetsedwa pang'ono);
5. Kutsika kwakukulu kwa insulin yolimbana ndi zotumphukira;
6. Anachepetsa kupanga shuga mwa mapangidwe a hepatic;
7. Kuchita ndi nuclei ya hypothalamus kuti apange kumverera kogwira mtima komanso kuchepetsa nkhawa;
8. Kupititsa patsogolo kukhathamiritsa ndi ziwalo za mtima;
9. Kuthamanga kwa magazi;
10. Kupititsa patsogolo magazi.

Zambiri

Mankhwala Victoza, mogwirizana ndi malangizo ogwiritsira ntchito, amaperekedwa kamodzi patsiku. Mphamvu yayitali yogwira liraglutide imaperekedwa ndi njira zitatu:

1. Njira yochepetsera kuyamwa kwa mankhwala osokoneza bongo chifukwa cha mfundo zodziyanjana nawo;
2. Ligament ndi albhamuin;
3. Mulingo wambiri wosasunthika wa ma enzymes angapo, kuloleza kuchotsa zotsalira zamankhwala, bola ngati zingatheke.

Victoza yankho limakhudza pancreatic kapangidwe kake, kukonza magwiridwe antchito a maselo a beta. Komanso pali kutsika kwapang'onopang'ono pakubisika kwa glucagon. Njira yogwirizanitsira ntchito za ma enzymes ndikugwira ntchito kwa kapamba palokha ndi yangwiro.

Katundu Wocheperako

Victoza nthawi zambiri amagwiritsidwa ntchito ngati achepetsa thupi, ngati palibe matenda osokoneza bongo komanso zina mwa endocrine.

Izi ndichifukwa choti, motsutsana ndi maziko akumene kuchepa kwa milingo ya glycemia, kutaya kwa m'mimba kumachepera.

Chithandizo chogwira ntchito chimathandiza kuchepetsa thupi. Mafuta amatsitsidwa mwachilengedwe, ndipo zida zonse zomwe zimakhudzidwa ndi njirayi sizitha kuvulaza thupi. Kutentha kwamafuta kumachitika pochepetsa njala komanso kuchepetsa mphamvu zamagetsi.

Mankhwala Victoza kapena Saksenda (dzina lina la mankhwalawo lomwe cholinga chake nkulimbana ndi onenepa kwambiri mwa odwala omwe alibe matenda ashuga) amaperekedwa kwa odwala kuti akhazikitse kulemera ndikuwongolera mndandanda wa glycemic. Kuyeserera ndi mankhwalawa sikuyenera - musanagwiritse ntchito ndikofunikira kwambiri kuti muthandizidwe ndi akatswiri othandizira kapena azolimbitsa thupi.

Zokhudza matenda asanakwane shuga

Kafukufuku wokhudza nyama zokhala ndi prediabetes amati akuwonetsa kuti liraglutide amachepetsa kupanga matenda ashuga. Mwanjira zambiri, zotsatira zabwino zimachitika chifukwa cha kuchuluka kwa ma cell a beta. Mwachidule, chiwalo chimachira msanga, ndipo njira zakukonzanso zimapambana njira zowonongeka.

Udindo wofunikira umachitidwa ndi kutetezedwa kwa zinthu zakumaso ku zinthu zingapo zovuta:

• Kukhalapo kwa cytotoxins;
• Kukhalapo kwa mafuta achilengedwe aulere omwe amayambitsa kufa kwa maselo a beta a gland.
• Maselo olemera ochepa am'mimba, zomwe zimatsogolera thupi.

Zolemba za Pharmacokinetic

The kuyamwa kwa yogwira pang'onopang'ono, zomwe zimatsimikizira kukhalitsa kwa thupi.

Kuchuluka kwa plasma ndende kumachitika maola 8 mpaka 10 pambuyo pa kuperekera mankhwalawa.

Liraglutide amawonetsa kukhulupirika kwa odwala azaka zonse ndi magulu. Kafukufuku pomwe odzipereka kuyambira wazaka 18 mpaka 80 adatenga nawo zotsatirapo zotsimikizira izi.

Zisonyezo za kumwa mankhwalawa

Victoza, monga mawonekedwe ake, amawonetsedwa kwa odwala onse omwe ali ndi matenda amtundu wa 2. Kutengera zakudya zoyenera komanso kuchita masewera olimbitsa thupi nthawi zonse, mankhwalawa amawonetsa kugwira ntchito bwino. Malinga ndi ndemanga za odwala, Victoza amakulolani kuwongolera chisonyezo cha glycemic, mosasamala mbiri ndi mbiri yake.

Pali malo angapo osankhidwa a Victoza. Kuyang'ana kwa madokotala kuli ndi chiyembekezo chogwirizana ndi aliyense wa iwo:

1. Monotherapy (Victoza m'modzi yekha mu cholembera Amawalamulira kuti azilamulira anthu odwala matenda ashuga komanso kukhazikika m'thupi mwa odwala omwe ali ndi vuto la chakudya.
2. Kuphatikiza mankhwala ndi mankhwala amodzi kapena angapo a hypoglycemic omwe amatengedwa pakamwa. Nthawi zambiri tikulankhula za metformin ndi urea sulfinyl. Njira yochizira iyi ndiyothandiza kwa odwala omwe sanathe kukwaniritsa kuwongolera kuzowonetsa kwa glucose m'mbuyomu zochizira zam'mbuyomu.
3. Mankhwala ophatikizika ozikidwa pa insal insulin mwa odwala omwe sanamve zotsatira zoyenera mukamamwa mankhwalawa malinga ndi chiwembu chomwe chatchulidwa pamwambapa.

Zokhudza contraindication

Mtengo wovomerezeka wa Victoza ndi ndemanga zabwino zimapangitsa kuti mankhwalawa atchuka kwambiri. Komabe, ngakhale chitetezo chokwanira, njira yabwino yopangira mankhwala komanso kugwiritsa ntchito kwa onse mankhwala kwa odwala onse sikuti chifukwa chakuyiwala za contraindication:

1. Hypersensitivity to Victoza zigawo, mosasamala kanthu za wopanga (ichi ndi chovomerezeka muyezo, chofunikira pa mankhwala aliwonse a pharmacological);
2. Mbiri ya khansa ya chithokomiro yamtundu wa medullary (ngakhale mbiri ya banja);
3. Neoplasia wa endocrine chiyambi (zingapo);
4. Kulephera kwakukulu kwaimpso;
5. Pachimake chiwindi kulephera;
6. Kulephera kwamtima I-II gulu lothandiza.

Magulu apadera

Victoza, malinga ndi ndemanga, amakhala ngati mankhwala otetezeka komanso othandiza kwambiri. Komabe, pali mikhalidwe ina momwe sizingatheke kupereka mankhwala, chifukwa nthawi zina chinthucho sichigwira ntchito.

Tikulankhula za ma pathologies otsatirawa ndi mikhalidwe ina:

• Mtundu wa shuga wa mtundu woyamba;
• Ketoacidosis wa matenda ashuga;
• Mimba
• Nthawi yodzala;
• Kutupa kwa mucosa ya m'mimba yaying'ono kapena yayikulu;
• Zaka zosakwana zaka 18 (palibe chidziwitso pakuvomerezeka, popeza maphunziro omwe ali ndi odwala omwe sanakwanitse zaka zambiri sanachitike);
• Gastroparesis wa mtundu wa matenda ashuga.

Zotsatira zoyipa

Maphunziro azachipatala a mankhwalawa akhala akuchitika mobwerezabwereza. Akatswiri adatha kuphunzira zovuta zonse za Viktoza. Monga mankhwala ena aliwonse, mankhwala ozikidwa ndi liraglutide angayambitse mavuto. Mutha kudziwa zambiri pokhudzana ndi kusakhudzika kwa thupi powerenga zambiri zomwe zili patebulopo.

Zokhudza kuphatikiza kwa mankhwala

Wowonongera amachepetsa mphamvu ya digoxin mukamamwa mankhwalawa nthawi imodzi. Zofananazo zimawonedwa limodzi ndi lisinopril.

Mankhwala amatha kuphatikizidwa mosamala ndi mankhwala a antihypertensive, mapiritsi oletsa kubereka a mahomoni.

Malinga ndi ndemanga za madotolo, Viktoza wochepetsa thupi ayenera kumwedwa mosamala kwambiri osapatsidwa mankhwala ena omwe angakhudze kuchuluka kwa shuga mthupi.

Njira zotengera Victoza

Mankhwalawa amawathandizira ngati jekeseni wothira kamodzi patsiku. Kukhazikitsidwa kwa mankhwalawa sikumangidwa pazakudya zambiri. Ngati mukuvutikira kubaya, onani momwe mungagwiritsire ntchito cholembera ndi Viktoza, ndizotheka kwa asing'anga.

Chida chake chimagulitsidwa nthawi zonse pamiyeso ndi syringe, yabwino kugwiritsidwa ntchito mulimonse. Victoza ikhoza kuikidwa pa "mfundo" zotsatirazi:

• Belly
• Mchiuno
• Mapewa.

Ngati ndi kotheka, madera omwe mankhwalawa amaperekedwa, komanso nthawi ya jakisoni, amatha kusintha molingana ndi wodwala. Zotsatira zonse zochizira sizingasinthe. Mankhwala ndi osavomerezeka ntchito kwa mtsempha wa magazi.

Mlingo woyamba sayenera kupitirira 0,6 mg yogwira mankhwala patsiku. Pakati pa sabata yoyamba, mulingo wocheperako ungathe kuwonjezeka pang'onopang'ono mpaka 1.2 mg. Mtengo wokwanira wololedwa pamilandu yapadera ndi 1.8 mg pa kugogoda.

Momwe mungasungire syringe

Mankhwala amaperekedwa mu mawonekedwe a yankho (6 mg mu 3 ml yamadzimadzi), woyikidwa mu cholembera chosavuta. Algorithm yogwiritsira ntchito mankhwala opangidwa ndi mankhwala ndi motere:

1. Chipewa choteteza chimachotsedwa mosamala mu syringe.
2. Chophimba chimachotsedwa mu singano yotayika.
3. Singano ili bala pa syringe.
4. Chotsani kapu yoteteza ku singano, koma osayitaya.
5. Kenako ndikofunikira kuchotsa singano ya kapu wamkati (pansi pake ndi singano).
6. Kuyang'ana thanzi la syringe.
7. Chigoba chimakotchera modekha, kusankha mlingo. Chizindikiro cha mlingo uyenera kukhala wofanana ndi chekeni.
8. Srinjiyo imakokedwa ndi singano kumtunda, ndikukwapula mokoma cartridge ndi chala cholozera. Kuchita chinyengo kumafunika chifukwa kumakupatsani mwayi kuthamangitsa thovu lomwe limapeza mu yankho.
9. Syringe iyenera kusungidwa mu singano ndi kukanikiza kuti ayambe kangapo. Kudzimbidwa kumachitika mpaka "zero" utawonekera pachizindikirocho, ndipo dontho lamadzi liziwoneka kumapeto kwa singano.

Nthawi yomweyo jekeseni isanachitike, muyenera kuonetsetsa kuti mlingo woyenera wasankhidwa. Kupereka mankhwalawa, syringe imatembenuzidwa ndipo singano imayikidwa pansi pa khungu. Kanikizani batani loyambira pang'onopang'ono komanso pang'onopang'ono. Njira yothetsera vutoli iyenera kulowa pakhungu pakapita masekondi 5 mpaka 7.

Kenako singano imayamba kutulutsidwa pang'onopang'ono. Chipewa chakunja chimayikidwa. Ndizoletsedwa kukhudza singano ndi zala zanu. Kenako chinthucho chimasulidwa ndikuchotsedwa. Cholembera chimbale chokha chimatsekedwa ndi chipewa chapadera.

Lycumia ndi Victoza

Nthawi zambiri funso limabuka, pali kusiyana kotani pakati pa Lixumia ndi Viktoza, omwe mankhwalawa amasankha kuthana ndi kunenepa kwambiri komanso mawonekedwe a matenda ashuga. Viktoza mu mtengo amatanthauza mankhwala ena okwera mtengo omwe ndizovuta kugula kuti muzigwiritsa ntchito tsiku lililonse. Ichi ndi chimodzi mwazifukwa zomwe akuyesera kuloweza mankhwala othandiza komanso otetezeka kwathunthu pogwiritsa ntchito njira zina.

Lixumia ndi mankhwala omwe amalembera mankhwalawa mtundu wa matenda ashuga a 2 kuphatikiza ndi metformin. Ngati Victoza amawongolera kuchuluka kwa shuga ndi glucagon, ndiye kuti Lixumia amatha kugwira ntchito kumodzi mokha - posintha kuchuluka kwa shuga.

Kusiyananso kwina kwakukulu, komwe nthawi zina kumatha kuwonedwa ngati vuto lalikulu ndikubweretsa chakudya. Mankhwalawa amaperekedwa kwa ola limodzi asanadye m'mawa kapena madzulo, zomwe sizikhala bwino nthawi zonse. Pankhani ya Victoza, jakisoni itha kuchitika nthawi iliyonse yabwino.

Mwambiri, zomwe zikuwonetsa, contraindication, kusungirako ndi magwiritsidwe a kukonzekera ndizofanana. Kope yopanga ya GLP imagwiritsidwa ntchito kuchepa thupi mu mono-achire regimens. Pazonse, Liksumia ikhoza kusinthidwa ndi Victoza, koma m'malo mwake simudzakhala chilungamo. Kwa magawo ambiri, mankhwalawa omaliza amakhala okongola kwambiri kuthetsa mavuto achire.

Baeta kapena Victoza: kusankha

Funso lina lodziwikiratu ndi liti kuposa Bayet kapena Viktoza. Baeta ndi amino acid aminopeptide. Amasiyana kwambiri mu chikhalidwe cha mankhwala kuchokera ku Victoza wogwira ntchito, koma amatsimikizira kwathunthu mankhwalawa. Pofufuza "Victoza yaulere," aminopeptide sangatchulidwe njira yabwino kwambiri. Zimatenga ndalama zambiri kuposa mankhwala opatsirana ndi liraglutide.

Komabe, pali zosiyana pazomwe zimayenera kuyang'anira mwapadera. Mankhwala a Baeta amafunika kuperekedwa kawiri pa tsiku.

Patangotha ​​ola limodzi, munthu ayenera kugona pansi, ndipo mankhwalawo amapaka jekeseni pansi pakhungu pang'onopang'ono.

Ichi ndi lingaliro lofunikira lomwe liyenera kukumbukiridwa posankha chithandizo chachikulu cha odwala omwe ali ndi matenda a shuga a 2.

Victoza ndi wotsika mtengo kuposa Baeta, ndipo imayambitsidwanso mosavuta.

Kukhazikitsa aminopeptide m'malo mwa liraglutide ndi kofunikira pokhapokha thupi la wodwalayo litaona chithandizo ndi mankhwala okwera mtengo kwambiri, kunyalanyaza Victoza.

Viktoza ndi mowa

Kuphatikiza kwa mankhwala aliwonse a mankhwala ndi mowa nthawi zambiri sikofunikira. Kwa odwala matenda ashuga, momwe amapangira matendawa ndi gawo limodzi lamoyo. Muyenera kuthana ndi glucose wosakhazikika nthawi zonse, zomwe zikutanthauza kuti muyenera kumadziletsa zakudya komanso zakumwa zoledzeretsa.

Zakumwa zoledzeretsa za mtundu wa 2 matenda a shuga ndizofanana makamaka. Kumwa mowa kumatha kudzetsa kuti wodwalayo adzakumana ndi zizindikiro za hypoglycemic - kuchuluka kwa glucose m'magazi kumatsika kwambiri.

Izi zimatchulidwa makamaka ngati mowa umamwa pamimba yopanda kanthu, ndi chakudya chochepa, kapena kuchuluka kwa mowa palokha kumakhala kosangalatsa.

Zinthu zilizonse zokhala ndi mowa zimathandizira kuti pakhale mankhwala okhala ndi insulin ndi mapiritsi omwe amachepetsa insulin. Kuphatikiza apo, zinthu zingapo zomwe zili ndi zakumwa zimakhudzanso chiwindi - zimachepetsa kaphatikizidwe ka shuga.

Chiwopsezo cha hypoclycemia (ngakhale mpaka kukomoka kwa hypoglycemic) chikuwonjezeka kwambiri ngati, atamwa mowa ndi kudziletsa pakudya, wodwalayo amakumana ndi zovuta zolimbitsa thupi. Ndi zoletsedwa kumwa mitundu yayikulu yamadzulo madzulo ndikupereka mankhwala aliwonse kuti muchepetse shuga. Pogona.

Ngakhale mankhwala a Victoza amasiyanitsidwa ndi mtundu wina wapadera wa zamankhwala ndipo "mwanzeru" amawongolera njira zonse mthupi, munthu sayenera kuyiwala kuti kuphatikiza kwa mankhwala ndi mowa kumakhala koopsa.

Ndemanga za Victoza