Ngakhale kuti asayansi adatha kubwereza molekyulu yonse ya insulin, yomwe imapangidwa m'thupi la munthu, zochita za timadzi za m'madzi zimachepetsedwa chifukwa cha nthawi yomwe amafunika kunyamulidwa m'magazi. Mankhwala oyamba osinthika anali insulin Humalog. Imayamba kugwira ntchito patangodutsa mphindi 15 jakisoni, choncho shuga yochokera m'mwazi imasamutsidwira minofu yake munthawi yake, ndipo ngakhale hyperglycemia yochepa siyimachitika.
Poyerekeza ndi ma insulins omwe adapangidwa kale, Humalog ikuwonetsa zotsatira zabwino: mwa odwala, kusinthasintha kwa tsiku ndi tsiku kwa shuga kumachepetsedwa ndi 22%, mawonekedwe a glycemic amayenda bwino, makamaka masana, ndipo mwayi wa kuchepa kwambiri kwa hypoglycemia umachepa. Chifukwa chachangu, koma chokhazikika, insulin iyi imagwiritsidwa ntchito kwambiri mu shuga.
Malangizo achidule
Malangizo ogwiritsira ntchito insulin Humalog ndiwosakhazikika, ndipo magawo omwe amafotokoza zoyipa ndi mayendedwe akugwiritsidwa ntchito amakhala ndi zigawo zingapo. Kufotokozera kwakutali komwe kumayendera limodzi ndimankhwala ena kumadziwika ndi odwala ngati chenjezo lokhuza kuwopsa kwawo. M'malo mwake, zonse ndizofanana: langizo lalikulu, latsatanetsatane - umboni wa mayesero ambirikuti mankhwalawa adapirira.
Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale
- Matenda a shuga -95%
- Kuthetsa kwa mitsempha thrombosis - 70%
- Kuthetsa kwa kugunda kwamtima kwamphamvu -90%
- Kuthana ndi kuthamanga kwa magazi - 92%
- Kuwonjezeka kwa mphamvu masana, kukonza kugona usiku -97%
Humalogue wavomerezedwa kuti agwiritse ntchito zaka 20 zapitazo, tsopano kuli bwino kunena kuti insuliniyi ndi yotetezeka pa mlingo woyenera. Imavomerezedwa kuti agwiritsidwe ntchito ndi akulu ndi ana onse;
Zambiri pa Humalogue:
| Kufotokozera | Yankho lomveka. Zimafunikira malo osungirako apadera, ngati aphwanyidwa, amatha kutaya katundu wake popanda kusintha mawonekedwe, chifukwa chake, mankhwalawo amatha kugulidwa m'masitolo ogulitsa mankhwala. |
| Mfundo yogwira ntchito | Amapereka glucose m'matipi, amathandizira kutembenuka kwa glucose m'chiwindi, komanso kupewa mafuta. Kutsitsa kwa shuga kumayamba m'mbuyomu kuposa kukhala ndi insulin yochepa, ndipo kumakhala kocheperako. |
| Fomu | Anakonza ndi kuchuluka kwa U100, makonzedwe - subcutaneous kapena mtsempha wa magazi. Atayikidwa m'makalata kapena pensulo zotayika. |
| Wopanga | Njira yothetsera vutoli imangopangidwa ndi Lilly France, France. Katemera amapangidwa ku France, USA ndi Russia. |
| Mtengo | Ku Russia, mtengo wa phukusi lomwe lili ndi ma cartridge 5 a 3 ml iliyonse ndi pafupifupi ma ruble 1800. Ku Europe, mtengo wa voliyumu yofanana ndi yofanana. Ku US, insulin iyi imakhala yokwera mtengo kwambiri maulendo 10. |
| Zizindikiro |
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| Contraindication | Zomwe zimachitika ndi insulin lyspro kapena zothandizira zina. Nthawi zambiri zimafotokozedwa m'mawonekedwe a jekeseni. Ndi kuchepa kwambiri, zimatha sabata pambuyo osinthana ndi insulin iyi. Milandu ingapo ndiyosowa, amafuna m'malo a Humalog ndi analogues. |
| Zomwe zasinthidwa ku Humalog | Pakusankhidwa kwa mlingo, pafupipafupi miyeso ya glycemia, kufunsa kwachipatala pafupipafupi kumafunikira. Monga lamulo, wodwala matenda ashuga amafunikira magawo ochepa a Humalog pa 1 XE kuposa insulin yochepa yamunthu. Kufunika kwakukulu kwa mahomoni kumawonedwa pamatenda osiyanasiyana, mantha ochulukirapo, komanso zochita zolimbitsa thupi. |
| Bongo | Kuonjezera mlingo kumabweretsa hypoglycemia. Kuti muthane ndi vuto lanu, muyenera kudya michere mwachangu. Milandu ingapo imafunika chisamaliro chamankhwala. |
| Kugwirizana ndi mankhwala ena | Humalog ikhoza kuchepetsa ntchito:
Limbikitsani izi:
Ngati mankhwalawa sangasinthidwe ndi ena, mlingo wa Humalog uyenera kusinthidwa kwakanthawi. |
| Kusunga | Mu firiji - zaka 3, kutentha firiji - milungu 4. |
Zina mwazotsatira zoyipa, hypoglycemia ndi thupi lawo siligwirizana nthawi zambiri zimawonedwa (1-10% ya odwala matenda ashuga). Osakwana 1% odwala amakhala ndi lipodystrophy pamalo opangira jekeseni. Makulidwe azinthu zina zoyipa amakhala ochepera 0.1%.
Chofunikira kwambiri pa Humalog
Kunyumba, Humalog imayendetsedwa pang'onopang'ono pogwiritsa ntchito cholembera kapena pampu ya insulin. Ngati matenda oopsa a hyperglycemia atachotsedwa, opaleshoni ya intravenous ndiyotheka kuchipatala. Pankhaniyi, kuthana ndi shuga pafupipafupi ndikofunikira kupewa bongo.
Insulin Humalog
Chithandizo chogwira mankhwalawa ndi insulin lispro. Amasiyana ndi mahomoni amunthu pakupanga ma amino acid mu molekyulu. Kusintha koteroko sikulepheretsa ma cell receptors kuzindikira mahomoni, chifukwa chake amapatsira shuga mwa iwo okha. Chiwonetserochi chimangokhala ndi ma insulin monomers okha - mamolekyulu osalumikizana. Chifukwa cha izi, imakamizidwa mwachangu komanso moyenera, imayamba kugwira ntchito kuti muchepetse shuga mwachangu kuposa insulin yachilendo.
Humalog ndi mankhwala ofupikitsika kuposa, mwachitsanzo, Humulin kapena Actrapid. Malinga ndi gulu, amatchulidwa ndi ma insulin omwe ali ndi ultrashort action. Kukhazikika kwa ntchito yake kumachitika mwachangu, pafupifupi mphindi 15, kotero odwala matenda ashuga sayenera kudikirira mpaka mankhwalawo atagwira, koma mutha kukonzekera chakudya mukangobaya jakisoni. Chifukwa cha kusiyana kwakanthawi, kumakhala kosavuta kukonza zakudya, ndipo chiopsezo cha kuiwala chakudya jekeseni itachepa.
Kuti muthane ndi vuto labwino la glycemic, insulin yothamanga iyenera kuphatikizidwa ndi kuvomerezedwa kwa insulin yayitali. Chokha chosiyana ndi kugwiritsa ntchito pampu ya insulin nthawi zonse.
Sankhani
Mlingo wa Humalog umatengera zinthu zambiri ndipo umatsimikiziridwa payekhapayekha kwa aliyense wodwala matenda ashuga. Kugwiritsa ntchito njira zoyenera sikulimbikitsidwa, popeza zimakulitsa kubwezeretsanso shuga. Ngati wodwala amatsatira zakudya zamafuta ochepa, mlingo wa Humalog umakhala wocheperako kuposa momwe oyang'anira angapangire. Poterepa, tikulimbikitsidwa kugwiritsa ntchito insulin yofulumira.
Hormashort ya Ultrashort imapereka mphamvu kwambiri. Mukasinthira ku Humalog, mlingo wake woyambirira amawerengedwa ngati 40% ya insulin yayifupi yomwe kale idagwiritsidwa ntchito. Malinga ndi zotsatira za glycemia, mlingo umasinthidwa. Chofunikira pakukonzekera mkate uliwonse ndimagawo 1-1,5.
Ndondomeko ya jekeseni
Chakudya chimayalidwa chakudya chilichonse chisanachitike. osachepera katatu patsiku. Pankhani ya shuga wambiri, mawonekedwe okhathamira pakati pa jakisoni wamkulu amaloledwa. Malangizo ogwiritsira ntchito amalimbikitsa kuti muwerenge kuchuluka kwa insulini yoyenera malinga ndi zakudya zomwe zimapangidwira chakudya chotsatira. Pafupifupi mphindi 15 ayenera kuchokera jakisoni kupita chakudya.
Malinga ndi ndemanga, nthawi ino nthawi zambiri zimakhala zochepa, makamaka masana, pomwe insulin kukana imakhala yotsika. Mlingo wa mayamwidwe ndi munthu payekhapayekha, umatha kuwerengeka pogwiritsa ntchito kuchuluka kwa shuga m'magazi pambuyo pobayidwa. Ngati zotsatira za hypoglycemic zimawonedwa mwachangu kwambiri kuposa malangizo, nthawi yakudya isanachepe.
Humalog ndi imodzi mwamankhwala omwe amafulumira kwambiri, motero ndikosavuta kugwiritsa ntchito ngati thandizo ladzidzidzi la matenda ashuga ngati wodwala akuwopseza kuti ali ndi vuto la hyperglycemic.
Nthawi yogwira (yochepa kapena yayitali)
Peak ya insulin ya ultrashort imawonedwa patatha mphindi 60 kuchokera pakukhazikitsa. Kutalika kwa zochita zimatengera mlingo; kukula kwake ndikutalika kwa shuga, pafupifupi - pafupifupi maola 4.
Kusakaniza kwa Humalog 25
Kuti muwone molondola momwe Humalog ikuyendera, shuga ayenera kuyesedwa pambuyo pa nthawi imeneyi, nthawi zambiri izi zimachitika chakudya chotsatira chisanachitike. Miyeso yoyambirira imafunikira ngati hypoglycemia ikayikiridwa.
Kutalika kwakanthawi kwa Humalog sikuli koyipa, koma mwayi wa mankhwalawa. Tikuthokoza, odwala omwe ali ndi matenda osokoneza bongo sakhala ndi vuto la hypoglycemia, makamaka usiku.
Kusakaniza Kwa Humalog
Kuphatikiza pa Humalog, kampani yopanga zamankhwala Lilly France imatulutsa Humalog Remix. Ndiosakanikirana kwa insulin lispro ndi protamine sulfate. Chifukwa cha kuphatikiza uku, nthawi yoyambira ya mahomoni imakhalabe mwachangu, ndipo nthawi yochitapo kanthu imawonjezeka kwambiri.
Kusintha kwa Humalog kumapezeka mu 2indi:
| Mankhwala | Mapangidwe,% | |
| Lyspro insulin | Kuyimitsidwa kwa insulin ndi protamine | |
| Kusintha kwa Humalog 50 | 50 | 50 |
| Kusintha kwa Humalog 25 | 25 | 75 |
Ubwino wokhawo wa mankhwalawa ndi regimen yosavuta. Kulipiritsa kwa odwala matenda a shuga pakagwiridwe ntchito koyipa kwambiri kuposa kugwiritsira ntchito njira zamankhwala amtundu wa insulin komanso kugwiritsa ntchito mtundu wina wa Humalog ana Humalog Mix sagwiritsidwa ntchito.
Insulin iyi imayikidwa:
- Anthu odwala matenda ashuga omwe sangathe kuwerengera pawokha kapena kuwabayira, mwachitsanzo, chifukwa cha kusaona bwino, ziwalo kapena kugwedezeka.
- Odwala omwe ali ndi matenda amisala.
- Okalamba okalamba omwe ali ndi zovuta zambiri za matenda a shuga komanso kuperewera koyipa kwa chithandizo ngati safuna kuphunzira malamulo owerengera insulin.
- Anthu odwala matenda ashuga omwe ali ndi matenda amtundu wa 2, ngati mahomoni awo akupangidwabe.
Kuchiza matenda a shuga ndi Humalog Remix kumafuna kudya mosasangalatsa yunifolomu, zakudya zazovutikira pakati pa chakudya. Amaloledwa kudya mpaka 3 XE pa chakudya cham'mawa, mpaka 4 XE pachakudya chamadzulo komanso chamadzulo, pafupifupi 2 XE pachakudya chamadzulo, ndi 4 XE asanagone.
Ma Analogi a Humalog
Lyspro insulin monga chinthu chogwira imangopezeka mu Humalog yoyambayo. Mankhwala osokoneza bongo ndi NovoRapid (kutengera aspart) ndi Apidra (glulisin). Zida izi ndizothandizanso pofupikitsa, zilibe kanthu kuti musankhe iti. Zonse zimalekeredwa bwino ndipo zimapereka shuga msanga. Monga lamulo, zokonda zimaperekedwa kwa mankhwalawa, omwe amatha kupezeka kwaulere kuchipatala.
Kusintha kuchokera ku Humalog kupita ku analogue yake kungakhale kofunikira pakakhala zovuta zina. Ngati wodwala matenda ashuga amatsatira zakudya zamafuta ochepa, kapena amakhala ndi hypoglycemia, ndizosavuta kugwiritsa ntchito anthu m'malo mwa insulin.
