C-peptide ya matenda ashuga - momwe mungayesedwe ndi chifukwa

Kuchuluka kwa glucose mu kuyezetsa magazi a labotale kumatilola kuti tiziwunika kuti kagayidwe kazakudya ka wodwala kamakhala kovuta, ndimatenda ambiri, chifukwa cha matenda a shuga. Kuti mumvetsetse chifukwa chake shuga adakula, kuyesa kwa C-peptide kumafunikira. Ndi chithandizo chake, ndizotheka kuyesa magwiridwe antchito a kapamba, ndipo kudalirika kwa zotsatira zoyeserera sikukhudzidwa ndi insulin kapena jakisoni womwe umapangidwa mthupi.

Kudziwa kuchuluka kwa C-peptide ndikofunikira kukhazikitsa mtundu wa matenda ashuga, kuyesa zotsalira za kapamba ndi matenda a mtundu 2. Kusanthula uku kudzakuthandizanso kudziwa zomwe zimayambitsa matenda a hypoglycemia mwa anthu omwe alibe shuga.

C-peptide - ndi chiyani?

Peptides ndi zinthu zomwe ndizomangira zotsalira zamagulu amino. Magulu osiyanasiyana a zinthuzi amakhudzidwa ndi zinthu zambiri zomwe zimachitika mthupi la munthu. C-peptide, kapena peptide yomangira, imapangidwa mu kapamba limodzi ndi insulin, chifukwa chake, pamlingo wophatikizika, munthu akhoza kuweruza kulowa kwa insulin ya wodwalayo m'magazi.

Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale

• Matenda a shuga -95%
• Kuthetsa kwa mitsempha thrombosis - 70%
• Kuthetsa kwa kugunda kwamtima kwamphamvu -90%
• Kuthana ndi kuthamanga kwa magazi - 92%
• Kuwonjezeka kwa mphamvu masana, kukonza kugona usiku -97%

Insulin imapangidwa m'maselo a beta kudzera pamafotokozedwe angapo azotsatira za mankhwala. Mukakwera gawo limodzi kuti mupeze molekyu yake, tiona proinsulin. Ichi ndi zinthu zopanda ntchito zomwe zimakhala ndi insulin ndi C-peptide. Zikondazo zimatha kusunga ngati masheya, osazitaya nthawi yomweyo m'magazi. Kuti ayambe kugwira ntchito yosamutsa shuga m'maselo, ma proinsulin adagawanika mu molekyulu ya insulin ndi C-peptide, palimodzi mofananamo amalowa m'magazi ndipo amayendetsedwa limodzi ndi njira. Chinthu choyamba chomwe amachita ndikulowa mu chiwindi. Ndi vuto la chiwindi, insulin imatha kupangika pang'ono, koma C-peptide imadutsa momasuka, chifukwa imakhudzidwa ndi impso zokha. Chifukwa chake, kuphatikiza kwake m'magazi kumawonetsa bwino momwe kaphatikizidwe ka timadzi timene timayambira mu kapamba.

Hafu ya insulin m'magazi imasweka patatha mphindi 4 atapanga, pomwe moyo wa C-peptide ndiwotalikirapo - pafupifupi mphindi 20. Kusanthula pa C-peptide kuti kuyesa kugwira ntchito kwa kapamba kumakhala kolondola, popeza kusinthasintha kwake ndikocheperako. Chifukwa cha moyo wosiyanasiyana, mulingo wa C-peptide m'mwazi ndi kuchuluka kwa insulin.

Pakadutsa matenda a shuga 1 am'magazi, ma antibodies omwe amawononga insulin nthawi zambiri amapezeka. Chifukwa chake, momwe zidapangidwira panthawiyi sizingatheke kuwerengeka. Koma ma antibodies awa samalabadira kwenikweni za C-peptide, chifukwa chake kuwunikira paulendowu ndi mwayi wokhawo womwe ungawerenge kutayika kwa maselo a beta.

Ndikosatheka kudziwa mwachindunji kuchuluka kwa mahomoni apakhungu ndi kapamba ngakhale mutagwiritsa ntchito mankhwala a insulin, popeza mu labotale ndikosatheka kupatulira insulini kuti ilowe mkati komanso kulowetsamo. Kutsimikiza kwa C-peptide pankhaniyi ndi njira yokhayo, chifukwa C-peptide sikuphatikizidwa pakukonzekera kwa insulin kwa odwala omwe ali ndi matenda a shuga.

Mpaka posachedwa, amakhulupirira kuti C-peptides sagwira ntchito kwachilengedwe. Kafukufuku waposachedwa adawulula udindo wawo woteteza poletsa angiopathy ndi neuropathy. Makina a zochita za C-peptides akuphunziridwa. Ndizotheka kuti mtsogolomu zidzawonjezeredwa kukonzekera kwa insulin.

Kufunika kosanthula C-peptide

Kafukufuku wazomwe zili ndi C-peptide m'magazi nthawi zambiri amalembedwa ngati, atazindikira kuti ali ndi matenda ashuga, ndizovuta kudziwa mtundu wake. Matenda a shuga amtundu woyamba amayamba chifukwa cha kuwonongeka kwa maselo a beta ndi ma antibodies, zizindikilo zoyambirira zimawoneka pomwe maselo ambiri akhudzidwa. Zotsatira zake, kuchuluka kwa insulin kumachepetsedwa kale pazomwe zimadziwika. Maselo a Beta amatha kufa pang'onopang'ono, nthawi zambiri mwa odwala aang'ono, ndipo ngati chithandizo chinayamba nthawi yomweyo. Monga lamulo, odwala omwe ali ndi zotsalira pancreatic amamva bwino, pambuyo pake amakumana ndi zovuta. Chifukwa chake, ndikofunikira kusunga maselo a beta momwe ndingathere, zomwe zimafunikira kuwunika kawirikawiri pakupanga insulin. Ndi chithandizo cha insulin, izi ndizotheka pokhapokha mothandizidwa ndi C-peptide assays.

Matenda a 2 a shuga koyambirira amakhala ndi insulin yokwanira. Shuga amakwera chifukwa chakuti kugwiritsidwa ntchito kwake ndi minofu kumasokonekera. Kusanthula kwa C-peptide kumawonetsa chizolowezi kapena kuchuluka kwake, chifukwa zikondamoyo zimathandizira kutulutsidwa kwa mahomoni kuti athetse shuga wambiri. Ngakhale akupanga zochulukirapo, shuga mpaka insulin pazokwera azikhala apamwamba kuposa anthu athanzi. Popita nthawi, ndi matenda amtundu wa 2 shuga, kapamba amatuluka, kaphatikizidwe ka proinsulin kamachepa, motero C-peptide imayamba kuchepa ndipo zimayamba.

Komanso, kusanthula kumayikidwa pazifukwa zotsatirazi:

1. Pambuyo pakuyang'ananso kwa kapamba, kuti mupeze kuchuluka kwamagawo otsalira omwe angathe kupanga, komanso ngati insulini ikufunika.
2. Ngati periodic hypoglycemia imachitika, ngati matenda a shuga sawonekeranso, motero, chithandizo sichikuchitika. Ngati mankhwala ochepetsa shuga sagwiritsidwa ntchito, kuchuluka kwa glucose kumatha kutsika chifukwa chotupa chotulutsa insulin (insulinoma - werengani za izi apa //diabetiya.ru/oslozhneniya/insulinoma.html).
3. Kuti muthane ndi kufunika kosintha kwa jakisoni wa insulin yemwe ali ndi matenda a shuga a 2 apamwamba. Pakufika pamlingo wa C-peptide, munthu akhoza kuwunika kusungidwa kwa kapamba ndi kuneneratu kuwonongeka.
4. Ngati mukukayikira mawonekedwe achilengedwe a hypoglycemia. Anthu omwe adzipha kapena ali ndi matenda amisala amatha kupereka insulin popanda mankhwala. Kuchulukitsa kwakulu kwa mahomoni pamwamba pa C-peptide kumawonetsa kuti mahomoni adalowetsedwa.
5. Ndi matenda a chiwindi, kuyesa kuchuluka kwa kuchuluka kwa insulin mmenemo. Matenda otupa a hepatitis ndi cirrhosis amatsitsa kuchepa kwa insulin, koma sizingakhudze C-peptide.
6. Kuzindikiritsa kumayambiriro ndi nthawi yachikhululukiro cha matenda osokoneza bongo a achinyamata pamene zikondamoyo zimayamba kupanga zake zokha poyankha mankhwalawa ndi jakisoni wa insulin.
7. Ndi polycystic komanso kusabereka. Kuchulukitsa katemera wa insulini kungakhale chifukwa cha matenda amenewa, chifukwa kupanga androgens kumatheka chifukwa chakuwayankha. Nayo, imasokoneza kukula kwa follicles ndikuletsa ovulation.

Kusanthula kwa C-peptide

Mu kapamba, kupanga kwa proinsulin kumachitika nthawi yonseyi, ndipo jakisoni wamagazi m'magazi, amathandizira kwambiri. Chifukwa chake, zotsatira zolondola, zokhazikika zimaperekedwa ndi kafukufuku pamimba yopanda kanthu. Ndikofunikira kuti kuyambira nthawi yakudya yomaliza mpaka kuthira magazi osachepera 6, maola 8 apita.

Ndikofunikira kupatula pasadakhale kukhudzidwa kwa kapamba pazinthu zomwe zimatha kupotoza kapangidwe ka insulin:

• tsiku osamwa mowa;
• kuletsa maphunzirowo dzulo;
• Mphindi 30 magazi asanaperekedwe magazi musatope, yesani kuti musadandaule;
• musasute m'mawa wonse mpaka kusanthula;
• Osamamwa mankhwala. Ngati simungathe kuchita popanda iwo, kuchenjeza dokotala.

Mukadzuka komanso musanapereke magazi, madzi oyera okha ndi omwe amaloledwa popanda mpweya ndi shuga.

Magazi kuti awasanthule amatengedwa kuchokera m'mitsempha ndikupanga chubu choyesera chomwe chimakhala ndi zoteteza. Centrifuge imalekanitsa plasma ndi zinthu zamagazi, ndikugwiritsa ntchito ma reagents kudziwa kuchuluka kwa C-peptide. Kuwunikaku ndikosavuta, sikuwonjezera 2 maola. M'malo ochitira malonda, zotsatira zake zimakhala zokonzekera tsiku lotsatira.

Kodi ndizowonetsa ziti?

Kuzungulira kwa C-peptide pamimba yopanda kanthu mwa anthu athanzi kuchokera pa 260 mpaka 1730 picomoles mu lita imodzi yamagazi. M'mabotolo ena, mayunitsi ena amagwiritsidwa ntchito: milionita imodzi pa lita imodzi kapena ma nanograms pa millilita.

Chikhalidwe cha C-peptide m'magawo osiyanasiyana:

Miyezo ingasiyane pakati pa labotoreti ngati zida za reagent zochokera kwa ena opanga zigwiritsidwa ntchito. Ziwerengero zenizeni zomwe zimakhazikika zimawonetsedwa pamapepala omaliza pazotsatira "zonena zabwino".

Kodi kukula kochuluka ndi chiyani

C-peptide yowonjezereka poyerekeza ndi yokhazikika imatanthawuza kuchuluka kwa insulin - hyperinsulinemia. Ndizotheka ndi kuphwanya zotsatirazi:

1. Hypertrophy yama cell a beta omwe amakakamizidwa kupanga mahomoni ambiri kuti achepetse shuga m'magazi a shuga.
2. Metabolic syndrome yokhala ndi insulin kukana ngati kusala kudya kwatsala pang'ono bwino.
3. Insulinoma ndi beta-cell neoplasm yomwe imatha kupanga payekha insulin.
4. Pambuyo pa opaleshoni chithandizo cha insulinomas, kuwonjezeka kwa metastasis kapena kuyambiranso kwa chotupa.
5. Somatotropinoma ndi chotupa chomwe chimapangidwa m'matumbo omwe amapanga timadzi timene timene timapanga. Kukhalapo kwa chotupacho kumapangitsa kuti zikondamoyo zizigwira ntchito mwachangu.
6. Kupezeka kwa ma antibodies ku insulin. Nthawi zambiri, kuwoneka kwa ma antibodies kumatanthauza kuwonongeka kwa matenda ashuga amtundu woyamba, wocheperako ndi matenda a Hirat ndi polyglandular insufficiency syndrome.
7. Kulephera kwamphamvu ngati mahomoni ndi abwinobwino ndipo C-peptide imakwezedwa. Zoyambitsa zake zimatha kukhala nephropathy.
8. Zolakwika pakuwonjezera kusanthula: kuyamwa kwa chakudya kapena mankhwala osokoneza bongo, ambiri mahomoni.

Kodi otsika amatanthauza chiyani?

Ngati kusanthula kunawonetsa kuchepa kwa C-peptide, izi zitha kuwonetsa zinthu monga:

• shuga wodalira insulin - mtundu 1 kapena mtundu wapamwamba 2;
• kugwiritsa ntchito insulin;
• utachepa shuga chifukwa cha kuledzera;
• kupsinjika kwaposachedwa;
• opaleshoni yamapazi ndi kutayika kwakanthawi kwa ntchito yake.

C-peptide pang'ono pansipa matchulidwe amtunduwu amatha kuchitika ngati chosiyana ndi chizolowezi mwa ana ndi achinyamata achichepere. Kuyeserera kwa shuga m'magazi ndi kuyeserera kwa glucose pankhaniyi kumapereka zotsatira zabwino. Ngati C-peptide ili yabwinobwino kapena yotsika pang'ono, ndipo shugayo ndikwezedwa, itha kukhala yofatsa 1 shuga (matenda a LADA) komanso kuyambika kwa kubwerezanso kwa cell ya beta ndi mtundu 2.

Kuti muwone kufunika kwa chithandizo cha insulin kwa matenda ashuga, kuwunikira komwe kumachitika kumachitika. Glycemia iyenera kusinthidwa masiku angapo magazi asanaperekedwe, apo ayi zotsatira zake zimakhala zosadalirika chifukwa cha zovuta za shuga m'maselo a beta.

Jakisoni wambiri wa 1 mg wa glucagon angagwiritsidwe ntchito polimbikitsa insulin. Mlingo wa C-peptide umatsimikiziridwa pamaso pa jekeseni ndi mphindi 6 pambuyo.

Njira ina yosavuta ndiyo kugwiritsa ntchito magawo awiri a mkate musanawunike mafuta, mwachitsanzo, tiyi wokhala ndi shuga ndi mkate. Mlingo wa pancreatic magawo ndikokwanira ngati C-peptide itatha kulimbikitsidwa kwazonse. Ngati kwambiri zochepa - insulin mankhwala chofunika.

Komanso werengani:

• Malamulo oyambira kuperekera magazi kwa shuga - //diabetiya.ru/analizy/analiz-krovi-na-sahar.html