Formetin ndi mankhwala yogwira a metformin hydrochloride. Mlingo: 0,5 g; 0,85 g kapena 1 g. Analogs: Glformin, Metadiene, Nova Met, NovoFormin, Siofor, Sofamet.
Zinthu zothandiza: croscarmellose sodium; sing'anga yamphamvu povidone (polyvinylpyrrolidone), magnesium stearate yamafuta azamalonda.
Kutulutsidwa kwa mawonekedwe: mapiritsi ozungulira ozungulira amiyala yokhala ndi mawonekedwe ndi chiopsezo (mulingo wa 0,5 g) ndi mapiritsi oyera a biconvex oyera okhala ndi chiopsezo kumbali imodzi (Mlingo wa 0.85 g ndi 1.0 g).
Zizindikiro zamankhwala
Formethine amachepetsa kuyamwa kwa glucose kuchokera m'matumbo, amalepheretsa gluconeogeneis mu chiwindi, amalimbitsa zotulutsa zama glucose, zimapangitsa chidwi cha minofu kukonzekera insulin.
Pankhaniyi, formethine:
- Zilibe kukhudzana ndikupanga insulin ndi maselo a beta omwe amapezeka mu kapamba.
- Sizipangitsa kukhazikika kwa dziko la hypoglycemic.
- Amachepetsa kuchuluka kwa lipoprotein otsika ndi triglycerides m'magazi.
- Amachepetsa kunenepa kwambiri, amakhala olimba.
- Imakhala ndi fibrinolytic chifukwa chokakamira kwa minofu wa plasminogen activator.
Formaline, pambuyo pakamwa pakamwa, imatengedwa pang'onopang'ono kuchokera kumimba. Kuchuluka kwa mankhwala a bioavava mukatha kugwiritsa ntchito mlingo woyenera pafupifupi 60%.
Kuchuluka kwa mankhwalawa kwa magazi m'magazi kumachitika patatha maola 2,5 pambuyo pakugwiritsidwa ntchito kwamkati.
Forthine pafupifupi samamangiriza mapuloteni a plasma; amadziunjikira m'chiwindi, impso, minofu, ma cell a salivary; chofowoka ndi impso mu mawonekedwe osayenera. Hafu ya moyo wa chinthucho ndi maola 1.5 - 4.5.
Tcherani khutu! Ngati wodwalayo wasokoneza ntchito yaimpso, kudzikundikira kwa mankhwala m'thupi ndikotheka.
Zizindikiro zogwiritsidwa ntchito
Mankhwala amapatsidwa mtundu wa matenda a shuga 2, pamene chithandizo chamankhwala sichinabweretse zotsatira zabwino (mwa odwala omwe ali ndi kunenepa kwambiri), zonsezi zikuwonetsedwa ndi malangizo a mankhwalawa.
Mlingo wa mankhwalawa amatchulidwa ndi dokotala aliyense payekha kwa wodwala aliyense. Kusiyana kwa Mlingo kumachitika chifukwa cha kuchuluka kwa shuga m'magazi. Mapiritsi a Forethine ayenera kumwedwa panthawi yomwe wodwala watenga chakudya, osafuna kutafuna komanso kumwa madzi ambiri.
Pa gawo loyamba la chithandizo, mlingo uyenera kukhala 0,85g. 1 nthawi patsiku kapena 0.5g. 1-2 patsiku. Pang'onopang'ono onjezerani mlingo mpaka 3g. patsiku.
Zofunika! Kwa odwala okalamba, chizolowezi cha tsiku ndi tsiku sayenera kupitirira 1g. Chifukwa cha chiwopsezo chachikulu cha lactic acidosis, ndi metabolic yovuta kwambiri, mlingo uyenera kuchepetsedwa.
Malangizo apadera ogwiritsa ntchito
Malangizo: mankhwalawa, muyenera kugwiritsa ntchito bwino kuwongolera. Kamodzi miyezi isanu ndi umodzi komanso chitukuko cha myalgia, ndikofunikira kudziwa kuchuluka kwa lactate mu plasma.
Formetin angagwiritsidwe ntchito limodzi ndi zotumphukira za sulfonylurea. Potere, kuyang'anira mosamala kuchuluka kwa shuga m'magazi kumafunika.
Formetin panthawi ya monotherapy sizikhudza kuthekera kugwira ntchito ndi maginito ovuta komanso kuyendetsa magalimoto. Ngati mankhwalawa akuphatikizidwa ndi mankhwala ena a hypoglycemic, chitukuko cha hypoglycemia chimatheka, momwemo osatha kuyendetsa galimoto komanso kugwira ntchito ndi maumboni ovuta omwe amafunikira chidwi chachikulu.
Zotsatira zoyipa
Kuchokera m'mimba:
- kulawa kwazitsulo;
- kusanza, kusanza
- chisangalalo, kutsekula m'mimba;
- kusowa kwa chakudya
- kupweteka kwam'mimba.
Kuchokera ku ziwalo za hemopoietic, nthawi zina meippbast anemia imawonedwa.
About metabolism:
- yofuna discontinuation chithandizo, lactic acidosis ndi osowa;
- ndi chithandizo cha nthawi yayitali, hypovitaminosis B12 imayamba.
Dongosolo la endocrine pamlingo wokwanira lingayankhe ndi hypoglycemia.
Mawonekedwe a mziwopsezo: zotupa pakhungu.
Kuchita ndi mankhwala ena
Hypoglycemic mphamvu ya metformin imatha kulimbikitsidwa ikagwiritsidwa ntchito pamodzi:
- insulin;
- zotumphukira sulfonylurea;
- oxytetracycline;
- acarbose;
- mankhwala osapweteka a antiidal;
- cyclophosphamide;
- angiotensin otembenuza enzyme zoletsa;
- monoamine oxidase zoletsa;
- β-blockers;
- zotumphukira za clofibrate.
Kutsika kwa hypoglycemic zotsatira za metformin kumawonedwa pogwiritsa ntchito munthawi yomweyo:
- loop ndi thiazide okodzetsa;
- kulera kwamlomo;
- glucocorticosteroids;
- glucagon;
- epinephrine;
- zotumphukira za phenothiazine;
- sympathomimetics;
- nicotinic acid zotumphukira;
- mahomoni a chithokomiro.
Contraindication
Osatenge FORMETINE ndi:
- kwambiri aimpso kuwonongeka;
- matenda ashuga ketoacidosis, precoma, chikomokere;
- kupuma komanso kulephera kwa mtima;
- kusowa kwamadzi;
- pachimake cerebrovascular ngozi;
- uchidakwa wambiri ndi zina zomwe zimapangitsa kuti lactic acidosis ipangidwe;
- pa mimba ndi mkaka wa m`mawere;
- Hypersensitivity zigawo zikuluzikulu za mankhwala;
- kuvulala komanso kulowererapo kwakukulu;
- matenda opatsirana opatsirana;
- pachimake mowa;
- lactic acidosis.
Langizo lomwe likutsatirapo likuti maphunziro a X-ray ndi radioisotope ndikukhazikitsa njira yokhala ndi ayodini sayenera kutsogoleredwa ndi kugwiritsa ntchito Formetin pasanathe masiku awiri.
Forethine sikulimbikitsidwa kuti igwiritsidwe ntchito ndi anthu opitilira 60 omwe amagwira ntchito zolimbitsa thupi. Ngati lamulo ili silinawonedwe, odwala otere amatha kukhala ndi lactic acidosis.
Zomwe malangizo osokoneza bongo amakamba
Malangizo a mankhwala a Formetin amachenjeza kuti ndi mankhwala osokoneza bongo, pali mwayi wokhala ndi lactic acidosis wokhala ndi zotsatira zakupha. Zomwe zimayambitsa vutoli zimatha kukhala kudzikundikira kwa mankhwala m'thupi chifukwa chazovuta aimpso.
Zizindikiro zotsatirazi ndizizindikiro zazikulu za lactic acidosis:
- Kusanza, kusanza.
- Kutsegula m'mimba, kupweteka kwam'mimba.
- Zofooka, hypothermia.
- Chizungulire
- Zowawa.
- Reflex bradyarrhythmia.
- Kutsitsa magazi.
- Kusokonezeka kwa chikumbumtima komanso kukula kwa chikomokere
Ngati wodwala ali ndi zizindikiro zoyambirira za lactic acidosis, Fomu liyenera kupatulidwa mwachangu kuchokera ku njira zochizira, wodwalayo amayenera kupita kuchipatala komwe dokotala angadziwe kuchuluka kwa lactate ndikupanga matenda osatsimikizika.
Njira yothandiza kwambiri yochotsa metformin ndi lactate kuchokera mthupi ndi hemodialysis, limodzi ndi chithandizo chamankhwala.
Fomu - yosungirako, mtengo
Alumali moyo wa mankhwalawa ndi miyezi 24, pambuyo pake mawonekedwe a Formetin sangagwiritsidwe ntchito. Mankhwalawa ndi a mndandanda B. Uyenera kusungidwa pamalo amdima osavomerezeka kwa ana pamtunda wa osaposa 25 ° C.
Wopanga - Mankhwala.
Kutulutsa mawonekedwe - mapiritsi a 850 mg. 60 zidutswa.
Mtengo - 177 ma ruble.
Wopanga - Mankhwala.
Kutulutsa mawonekedwe - mapiritsi 1gr. 60 zidutswa.
Mtengo - 252 rub.
Ma analogi ena ndi okwera mtengo kwambiri.
