Chizindikiro chachikulu cha kugwiritsidwa ntchito kwa Krestor ndi kuchuluka kwa cholesterol pochitika hypercholesterolemia, atherosulinosis ndi zina mtima.
Mapiritsi amaloledwa mosavuta ndi odwala, zovuta zimachitika kawirikawiri. Ngati ndi kotheka, katswiriyo amasankha masinthidwe (Rosuvastatin, Rosart, Mertinil) kapena analogues (Atoris, Vasilip, Zokor). Zambiri mwatsatanetsatane zimapezeka muzambiri.
Zambiri zamankhwala
Wopanga mankhwalawa ndi kampani ya zamankhwala AstraZeneca UK Limited, yomwe ili ku UK.
Crestor (dzina lachi Latin - Crestor) limatulutsidwa mu mawonekedwe a piritsi kuti mugwiritse ntchito mkati. Mlingo akhoza kukhala wosiyana - 5, 10, 20 kapena 40 mg yogwira ntchito. Makatoni ama CD, omwe amatha kuwoneka pazithunzi za intaneti, ali ndi matuza awiri okhala ndi mapiritsi 14.
Piritsi limodzi limakhala ndi kashiamu wogwira wa rosuvastatin calcium (rosuvastatin) ndi oikizidwa. Mapiritsi amapangidwa mozungulira kapena ozungulira, mtundu wawo umatengera mlingo - wachikasu (5 mg) ndi pinki (10, 20, 40 mg).
Mtanda umakhala ndi kutsitsa kwa lipid. Rosuvastatin, ikuchulukitsa kuchuluka kwa zolandilira chiwindi, kumachepetsa cholesterol "choyipa" (LDL ndi VLDL) m'magazi. Zotsatira zake, dissimilation (catabolism) ndi machitidwe a LDL amatenga mofulumira, ndipo kupanga "cholesterol" koyipa kumachepetsedwa.
Chifukwa chake, sabata limodzi atatha kulandira chithandizo, kuchepa kwa cholesterol yathunthu, LDL, VLDL, triglycerides, etc. Kutheka kwakukulu kogwiritsa ntchito mankhwalawa kumawonedwa pakatha masiku 14.
Mutatenga mapiritsi, ndende yolumikizidwa kwambiri imatha kufikira maola 5. Kuphatikiza apo, rosuvastatin amamangiriza bwino mapuloteni a plasma.
Kuchulukitsa kwa chigawo chachikulu kumachitika, monga lamulo, ndi ndowe komanso pang'ono ndi mkodzo. Kugwiritsa ntchito mankhwalawa kwakanthawi kwamatenda a chiwindi kungakhudze magawo a pharmacokinetic.
Zizindikiro ndi contraindication kuti mugwiritse ntchito
Dokotalayo amapereka mankhwala a hypolipidemic popewa matenda a homozygous hypercholesterolemia, atherosulinosis.
Kuphatikiza apo, mankhwalawa amagwiritsidwa ntchito pochiza matenda amkati, komanso mbali ya zovuta za mankhwala osakanikirana a hypercholesterolemia.
Malangizo ogwiritsira ntchito ali ndi mndandanda wowoneka bwino wa contraindication. Zimatengera mlingo wa mankhwalawo.
Sizoletsedwa kugwiritsa ntchito mitanda ya Mtanda 5.10.20 kwa anthu omwe:
- kukhala ndi chidwi chochulukirapo kuzinthu zomwe zimapanga kapangidwe kake;
- akudwala matenda akuluakulu a chiwindi, komanso kuwonjezeka kwa ntchito ya hepatic transaminases;
- nthawi yomweyo akudwala mankhwala a cyclosporin;
- kudwala matenda a impso;
- lactose tsankho kapena kuchepa kwa lactase;
- simunafikire zaka 18;
- akudwala myopathy (opita patsogolo mu mitsempha ya mitsempha);
- pakati kapena poyamwitsa.
Mlingo wa mamiligalamu 40 umayesedwa mwa anthu omwe:
- Imwani mowa.
- Matenda a chiwindi kapena aimpso kukanika.
- Ali ndi chiwopsezo chachikulu cha myopathy.
- Tengani ulusi mu zovuta.
- Anachitidwa opaleshoni yayikulu kwambiri posachedwapa.
- Pewani kugwidwa, khunyu.
- Khalani ndi hypothyroidism.
- Amakhala ndi kusowa kwa ma elekitirodi pamagazi.
- Posachedwa adalandira zovulala zazikulu.
- Muli ndi ochepa hypotension.
- Matenda opatsirana ndi septic.
- Matenda a metabolic.
- Kukhala wa liwiro la a Mongoloid.
Kalata yophunzirayo imanenanso kuti kwa anthu achikulire (zaka 60 ndi kupitirira), mankhwalawa amawunikira mosamala kwambiri.
Malangizo ogwiritsira ntchito mankhwalawa
Akuluakulu amatenga mankhwalawo mosasamala chakudya - m'mawa kapena madzulo. Mapiritsi sangathe kutafunidwa ndikusweka, amasambitsidwa ndi madzi pang'ono.
Mlingo ndi kutalika kwa mankhwala zimatsimikiziridwa ndi adokotala, poganizira zinthu monga kuopsa kwa matendawo ndi machitidwe a wodwala.
Malinga ndi malangizo, mlingo woyambirira ndi mamililita 5 mpaka 10. Njira ya chithandizo ndi masiku 21, yopuma sikofunikira. Ngati ndi kotheka, dokotala ali ndi ufulu kuwonjezera kuchuluka kwa mankhwalawa.
Ndikulimbikitsidwa kuti muwunikire thanzi la wodwala m'masiku ochepa, omwe asinthana ndi Krestor 40 milligrams. Chifukwa cha kuzolowera thupi kuzinthu zomwe zimagwira, kukulitsa mawonekedwe owoneka ndi kotheka.
Kwa anthu omwe ali ndi vuto la kufooka kwa impso, dokotalayo amapereka mlingo woyambirira wa 5 mg patsiku, pang'onopang'ono ukuwonjezeka mpaka 40 mg.
Chifukwa chakuti anthu amtundu wa Mongoloid ali ndi mawonekedwe ena a chiwindi, kutenga Krestor 20 ndi 40 mg ndizoletsedwa. Mlingo woyambirira ndi 5 mg, ndiye umakulitsidwa mpaka 10 mg.
Amapatsirana kuti apereke oposa 20 mg patsiku kwa odwala omwe amakonda myopathy.
Wothandizira kutsitsa lipid ayenera kusungidwa pamalo ozizira. Osalola kuti ma phukusi agwere m'manja mwa ana.
Moyo wa alumali ndi zaka zitatu, pambuyo pa nthawi ino, kumwa mankhwalawo ndizoletsedwa.
Zotsatira zoyipa ndi bongo
Nthawi zina, mukamagwiritsa ntchito Krestor, zotsatira zoyipa zitha kuoneka.
Monga lamulo, mankhwalawa amalekeredwa bwino, ndipo pakugwiritsa ntchito milingo yayikulu, zotsatirapo zoyipa zimatha kuthana palokha popanda kupempha thandizo la mankhwala.
Malangizo ogwiritsira ntchito ali ndi mndandanda wazotsatira zoyipa:
- thupi lawo siligwirizana - urticaria, totupa pakhungu, edema ya Quincke;
- matenda a dyspeptic - kuphwanya chopondapo, nseru, kusanza, kutulutsa;
- kuphwanya kwamanjenje - chizungulire ndi kupweteka m'mutu;
- kukhalapo kwa mapuloteni mu mkodzo, nthawi zina kumachitika kulephera kwa impso;
- kupweteka kwa minofu, kawirikawiri, kupezeka kwa myopathy;
- chitukuko cha osadalira insulini (mtundu 2) matenda a shuga;
- chiwindi kukanika, kuchuluka kwa kwa chiwindi transaminases.
Ndi mankhwala osokoneza bongo ambiri, mavuto amayamba. Amawonetsedwa ndikuphwanya ntchito ya mtima ndi kuletsa kwa impso ndi chiwindi.
Palibe mankhwala enieni, hemodialysis sikuthandiza. Pofuna kuthetsa bongo, mankhwalawa amachitika.
Kuphatikiza apo, kuwunika moyenera ma enzymes a chiwindi ndikofunikira.
Zochita zina zamankhwala
Kuyanjana kwa Krestor ndi magulu ena a mankhwala kungayambitse zotsatira zoyipa. Chifukwa chake, wodwalayo adziwitse adokotala ake za matenda onse othandizira kuti asathenso kutuluka mthupi.
Malangizowa akunena za kuphatikiza kosafunika kwa Krestor ndi Cyclosporin. Kugwiritsa ntchito mitundu yina yotsitsa lipid, mwachitsanzo, Hemifibrozil, amasintha ndende ya plasma yogwira ya rosuvastatin.
Krestor sagwirizana bwino ndi otsutsana ndi Warfarin ndi vitamini K, chifukwa zimakhudza index ya prothrombotic.
Sitikulimbikitsidwa kutenga Krestor ndi Ezetimibe nthawi imodzi, chifukwa izi zimatha kuwonjezera pafupipafupi komanso zovuta za zovuta.
Odwala omwe amakonda kuyambika kwa myopathy sayenera kugwiritsa ntchito hemofibrate, michere, nicotinic acid, komanso gemfibrozil wokhala ndi rosuvastatin.
Komanso, cholembedwacho chili ndi chidziwitso chokhudzana ndi zosavomerezeka munthawi yomweyo za ma antacid, kulera kwapakamwa, proteinase inhibitors. Zomwezi zimagwiranso ntchito ngati mankhwala monga Erythromycin, Lopinavir ndi Ritonavir.
Mankhwalawa lipids yapamwamba, kumwa mowa kumaletsedwa.
Mtengo ndi lingaliro la ogula
Mutha kugula mankhwala a Krestor kokha ndi mankhwala a dokotala. Komanso, ndikotsika mtengo kuyitanitsa pa intaneti pa tsamba la woimira.
Mtengo umatengera kuchuluka kwa matuza ndi mlingo. Mtengo wamtengo waperekedwa pansipa:
- 5mg (No. 28) mtengo - 1835 rubles.
- Mtengo wa Krestor 10mg - ma ruble 2170.
- 20 mg - 4290 rub.
- 40 mg - 6550 rub.
Chifukwa chake, mankhwala omwe adagulitsidwa ku Krestor ndi okwera mtengo, chifukwa chake, sangakwanitse kugula odwala ochepa. Ichi ndiye chopanda chachikulu cha mankhwalawa.
Popeza Krestor adawonekera pamsika wama pharmacological osati kale kwambiri, palibe ndemanga zambiri za iye. Imagwiritsidwa ntchito mwachindunji kwa anthu ngati mankhwalawa a hyperlipidemia, makamaka atalimbidwa ndi stroko kapena mtima.
Ogula ena amachenjeza kuti kupweteka mutu ndi kugona kumawonekera nthawi yamankhwala. Akatswiri amawunika mosamala kapangidwe ka magazi a odwala, komanso kuchuluka kwa michere ya chiwindi.
Mwambiri, madokotala ndi odwala amakonda chithandizo cha Crestor.
Nthawi zambiri, ndemanga zabwino zimapezeka pa mankhwalawa.
Zizindikiro ndi fanizo la mankhwalawa
Ngati Krestor adatsutsana ndi wodwala, kapena ali ndi zovuta zake, dokotala amamuthandizira wogwirizira.
Izi zitha kukhala zofananira, mumapangidwe omwe mumakhala chinthu chimodzi chogwira ntchito, kapena analogue yomwe ili ndi zofanana zochizira, koma imakhala ndi zinthu zosiyanasiyana zogwira ntchito.
Pakati pazofanizira, zothandiza kwambiri komanso zotchuka ndiz:
- Mertenil ndi mankhwala otsika mtengo (450 rubles pakompyuta No. 30 kwa 5 mg), omwe amatsitsa cholesterol ku ndende yovomerezeka. Ilinso ndi zofananira ndi ma contraindication. Chenjezo limatengedwa kwa omwe ali pachiwopsezo chachikulu chotenga myopathy / rhabdomyolysis, hypothyroidism, ndi kulephera kwa aimpso.
- Rosart ndi mankhwala ena okwera mtengo kwa odwala omwe amapeza ndalama zochepa komanso apakati. Pakatikati, mtengo wa ma CD (No. 30 kwa 5 mg) ndi 430 rubles.
- Rosuvastatin, wokhala ndi dzina lomwelo ndi mankhwala othandizira. Wotchuka pakati pa odwala, chifukwa mtengo wa ma CD (No. 30 kwa 5 mg) ndi 340 rubles okha.
Zofananira zoyenera zikuphatikiza:
- Vasilip imakhala ndi lipid-yotsitsa, zake zomwe zimagwira ndi simvastatin. Wopanga amapanga mapiritsi okhala ndi mulingo wa 1020 ndi 40 milligrams. Mtengo wa ma CD (mapiritsi 28 pa 10 mg) ndi ma ruble 250.
- Atoris imaphatikizanso gawo logwira ntchito la atorvastatin, lomwe limapangitsa zochitika za LDL receptors mu chiwindi ndi minyewa yowonjezera. Pali contraindication ochepa: munthu hypersensitivity, chiwindi kukanika, kuchuluka transaminases, mkaka wa m`mawere ndi pakati. Mtengo wa Atoris (mapiritsi 30 pa 30 mg) ndi 330 rubles.
- Zokor imakhala ndi simvastatin, yomwe imachepetsa HMG-CoA reductase. Opanga ndi USA ndi Netherlands. Ili ndi zofanizira komanso ma contraindication monga mankhwala akale, kuphatikiza paubwana. Mtengo wa ma CD (mapiritsi 28 pa 10 mg) ndi 385 ma ruble.
Chifukwa chake, mutha kufananiza momwe achire amathandizira komanso mtengo wa mankhwala, posankha njira yoyenera kwambiri. Tisaiwale kuti popewa komanso kuchiza matenda a atherosulinosis ndi hypercholesterolemia, muyenera kuchita masewera olimbitsa thupi ndikutsatira zakudya.
Zakudya zopatsa thanzi sizimaphatikizapo kumwa mafuta, okazinga, zakudya, mchere, komanso mbale zomwe zimakhala ndi cholesterol yambiri. Popanda magawo awiriwa, mankhwala othandizira amatha kukhala osagwira ntchito.
Ma Statins akufotokozedwa mwatsatanetsatane mu kanema munkhaniyi.
