Mankhwala opangidwa ku Russia pochiza kuthamanga kwa magazi komanso kulephera kwamtima. Zochitazo zimatengera vasodilation. Makulidwe azachipatala amakula patatha masabata awiri atatha chithandizo.
Dzinalo Losayenerana
Hinapril. Dzinalo la Chilatini ndi Chinaprilum.
Mankhwala opangidwa ku Russia pochiza kuthamanga kwa magazi komanso kulephera kwamtima.
ATX
C09AA06
Kutulutsa mafomu ndi kapangidwe kake
Amapezeka mu mawonekedwe a mapiritsi mu filimu yamafuta ndi mulingo wa 5.10, 20 kapena 40 mg yogwira ntchito. Mu 1 chithuza - mapiritsi 10. Matumba adadzaza mu katoni ka 3 ma PC.
Kuphatikizidwa kwa piritsi kumaphatikizapo chinthu chomwe chimagwira ndi dzina lomweli la mankhwala (ufa woyera, sungunuka m'madzi) ndi zina zowonjezera - zinthu zomangira, utoto, makola, ndi zina zambiri.
Zotsatira za pharmacological
Machitidwe a mankhwalawa amatengera mphamvu za quinapril zoletsa exopeptidase ndipo potero amachepetsa kaphatikizidwe ka mahomoni a oligopeptide omwe amachititsa vasoconstriction.
Chifukwa cha izi, zotumphukira zotumphukira zimakulira, kuthamanga kwa magazi kupita ku myocardium pambuyo pa ischemia kumayenda bwino, kutsika kwa magazi mu impso ndi ziwiya zam'mimba kumawonjezeka, kukana kutsutsana kwa thupi kumawonjezeka, kuchuluka kwa ma protein ochepa amachepetsa, kuthamanga kwa magazi komanso chiopsezo cha thrombosis kuchepa.
Pharmacokinetics
Mulingo wofika pakulimbikitsa kuchuluka kwa mankhwalawa m'magazi ndi ola limodzi pambuyo pokonzekera pakamwa. Chochitikacho chimatha molingana ndi mlingo womwe watengedwa.
Mulingo wofika pakulimbikitsa kuchuluka kwa mankhwalawa m'magazi ndi ola limodzi pambuyo pokonzekera pakamwa.
Mafuta ochokera m'mimba amakhala pafupifupi 60%, koma amatha kuvutika chifukwa cha kudya nthawi yomweyo zamafuta kwambiri.
Amapanga metabolites m'chiwindi, makamaka quinaprilat, yomwe imamangiriza mapuloteni a plasma ndioposa 90%.
Imafufutidwa kudzera mu impso ndi matumbo.
Zizindikiro zogwiritsidwa ntchito
Amagwiritsidwa ntchito onse ngati a monotherapy komanso ophatikiza matenda monga:
- matenda oopsa a arterial (pulayimale, kukonzanso, kusadziwika);
- kulephera kwa mtima (diastolic, zamtima, komanso kukomoka kwa diastoli, kusokonekera kwa diastoli, kulephera kwa mtima).
Ndi matenda oopsa, makonzedwe apanthawi yomweyo okonzanso ma potaziyamu ndi ma beta-blockers ndizotheka, komanso ndi mtima kulephera ndi mtima wa beta-blockers, etc.
Contraindication
Mankhwalawa amawonongeka pazochitika zotsatirazi:
- Hyperreaction kwa yogwira mankhwala kapena owonjezera magawo piritsi;
- mimba ndi mkaka wa m`mawere;
- ana ndi achinyamata (mpaka zaka 18);
- kukhalapo kwa mbiri ya angioedema;
- matenda ashuga nephropathy;
- aimpso kuwonongeka;
- ochepa hypotension;
- Hyperkalemia
Kusankhidwa ndikotheka, koma mosamala ndi kuyang'aniridwa kosalekeza kwa ogwira ntchito zamankhwala ngati kupezekapo:
- ngozi yamitsempha;
- atherosulinosis ya miyendo;
- mitral valavu stenosis;
- mtima wosokoneza ndi kusintha kwa hypertrophic;
- impso zosinthika;
- zosokoneza mu purine metabolism (gout);
- autoimmune systemic connective minofu matenda;
- matenda a shuga;
- kufunikira kwa ma MTOR ndi ma DPP-4 enzyme zoletsa;
- matenda opatsirana a bronchopulmonary dongosolo mu mawonekedwe.
Ndikwabwino kupewa kumwa mapiritsi awa kwa odwala omwe ali ndi chiwindi chambiri kuti mupewe kukula kwa chikondwerero cha hepatic.
Momwe mungatengere quinapril?
Tengani pakamwa, ngakhale chakudyacho. Piritsi imamezedwa popanda kutafuna, kutsukidwa ndi madzi pang'ono.
Ndi matenda oopsa, kupatsirana kopindulitsa ndikotheka, komanso kuphatikiza ndi othandizira ena.
Pankhani ya monotherapy, chithandizo chimayambika ndi mlingo wa 10 mg kamodzi ndipo pang'onopang'ono ukuwonjezeka mpaka 20 kapena 40 mg, kutengera kukwaniritsidwa kwa zotsatira zamankhwala.
Ndi matenda oopsa, kupatsirana kopindulitsa ndikotheka, komanso kuphatikiza ndi othandizira ena.
Kuphatikiza mankhwala ndi okodzetsa, kuyambira 5 mg patsiku amalembedwa kamodzi ndi kuwonjezeka kwa masiku otsatirawa mpaka zotsatira zomwe zikuyembekezeredwa zitheke, koma osapitirira mlingo womwe umalimbikitsa tsiku lililonse.
Onjezani mlingo wake kamodzi pamwezi. Pazololedwa tsiku lililonse sizoposa 80 mg ya mankhwalawa.
Kulephera kwa mtima kumafuna kuphatikiza. Pankhaniyi, mankhwalawa amayamba ndi 5 mg 1-2 kawiri patsiku, ndikutsatira kuwonjezeka kwa kulekerera kwabwino osapitirira 1 kuwonjezeka pa sabata.
Ndi vuto la aimpso, mlingo wa mankhwalawa umasankhidwa malinga ndi kuchuluka kwa chilolezo cha creatinine - chokwanira kwambiri, chomwe chikuwonetsa kuchuluka. Ndizotheka kuwonjezera kuchuluka kokha poganizira chipatalachi, kukhazikika kwa kuchuluka kwa magazi ndi ntchito ya impso.
Ndi matenda ashuga
Odwala omwe ali ndi matenda a shuga, atamwa mankhwala a antihypertensive, kuyang'aniridwa kosafunikira kwakanthawi kofunikira kwa kuchipatala kumafunikira ndikusankhidwa kwa mlingo woyenera wa mankhwala a hypoglycemic ndi insulin, chifukwa zotsatira zake zimawonjezereka.
Zotsatira zoyipa za hinapril
Pakhoza kukhala zovuta zina kuchokera ku hematopoiesis, chapakati mantha dongosolo, kupuma ndi kwamikodzo ziwalo, kugaya chakudya ndi mtima dongosolo, khungu, lomwe nthawi zambiri silitchulidwa kwambiri. Pa milandu 100 yolembetsa, pafupifupi 6% yokha ya milandu yochotsedwa yomwe imawerengedwa.
Nthawi zina pamakhala kuphwanya kwa kupumira ndi kuwona, kuchepa kwa potency, kupweteka kumbuyo ndi chifuwa, etc.
Matumbo
The mawonekedwe a nseru, kusanza, dyspepsia, kapamba, chiwindi chikomokere, chiwindi necrosis, angioedema wamatumbo.
Hematopoietic ziwalo
Matenda a anemia, thrombocytopenia, neutropenia, hyperkalemia, kuchuluka kwaini.
Pakati mantha dongosolo
Mutu wapafupipafupi komanso chizungulire. Nthawi zina paresthesia, kukhumudwa ndi kusowa tulo zimachitika.
Kuchokera kwamikodzo
Pachimake aimpso kulephera, kwamikodzo thirakiti matenda.
Pa khungu
Zotsatira zoyipa zimawonetsedwa ndi pemphigus, dazi, kutuluka thukuta, photosensitivity, ndi dermatitis.
Kuchokera pamtima
Hypotension, kukomoka, kusinthasintha kwa mtima, kugunda, kumasuka kwa makoma amitsempha yamagazi.
Matupi omaliza
Kugwedezeka kwa anaphylactic ndi edema ya Quincke ndizotheka.
Zokhudza mphamvu pakuwongolera njira
Kusamala ndikofunikira pakuyendetsa ndikugwira ntchito, kumafuna chisamaliro chachikulu, popeza pakati pazotsatira zoyipa - kutsika kwakuthwa kwa magazi komanso chizungulire.
Malangizo apadera
Ndi kuwonjezeka kwa kutentha kwa thupi kapena tonsillitis, kuyezetsa magazi kuyenera kuchitidwa kuti athe kupatula neutropenia.
Asanachite opareshoni, kuphatikizapo mano, dokotala ayenera kuchenjezedwa za kupatula ndalama zomwe zafotokozedwapo kale.
Gwiritsani ntchito mu ukalamba
Njira zopewera zimayikidwa mukakalamba chifukwa kuchepa kwake kumachotsedwa m'thupi.
Kupatsa ana
Sikugwira ntchito mpaka zaka 18.
Mosamala, hinapril amalembedwa mu ukalamba chifukwa cha kuchepa kwa zotulutsa za thupi.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Munthawi ya bere ndi pamene mukuyamwitsa mwana, kugwiritsa ntchito ma ACE zoletsa ndizoletsedwa. Imatha kusokoneza chitukuko ndikupangitsa imfa ya fetal. Nthawi yoyamwitsa, imatha kudutsa mkaka ndikuyambitsa zovuta mu khanda.
Mankhwala ochulukirapo a quinapril
Mutatenga kuchuluka kopitilira muyeso waukulu, kuwonongeka kwa mawonekedwe, chidwi chachikulu komanso chizungulire chitha kuchitika. Chithandizo cha mankhwalawa chikufotokozedwa potengera zomwe zizindikirazo.
Kuchita ndi mankhwala ena
Kupititsa patsogolo antihypertensive zotsatira: analcics ya narcotic, kukonzekera golide, mankhwala oletsa kupweteka, okodzetsa, ACE zoletsa.
Imachepetsa mphamvu ya sodium chloride, estrogens, mankhwala osapweteka a antiidal.
Amachepetsa kuyamwa kwa tetracycline.
Pankhani yogwiritsidwa ntchito nthawi yomweyo ndi kukonzekera kwa lithiamu, kuledzera kwa lithiamu ndikotheka.
Imalimbikitsa zochita za insulin ndi mankhwala a hypoglycemic.
Hinapril amachepetsa mayamwidwe tetracycline.
Sitikulimbikitsidwa kuphatikiza ndi Aliskiren, immunosuppressants, mTOR kapena DPP-4 enhibme inhibitors, komanso mankhwala omwe amalepheretsa kugwira ntchito kwa mafupa.
Kuyenderana ndi mowa
Mowa umapangitsa kuti magazi azikhala oopsa, chifukwa chake, kugwiritsidwa ntchito mosiyanasiyana kumatsutsana.
Analogi
Momwemonso, mapiritsi okhala ndi mafilimu amathandizanso ndipo ali ndi zomwe zimapangidwira pophatikizira:
- Accupro - 5.10, 20 kapena 40 mg (Germany).
- Akkuzid - 10 kapena 20 mg (Germany). Mankhwala ophatikiza. Ili ndi chinthu chachiwiri yogwira - hydrochlorothiazide.
- Hinapril C3 - 5.10, 20 kapena 40 mg (Russia).
- Quinafar - 10 mg (Hungary).
Mapiritsi ofanana mu gulu la pharmacological:
- Amprilan - 1.25; 2,5; 5 ndi 10 mg (Slovenia).
- Vasolapril - 10 kapena 20 mg (Turkey).
- Diropress - 5, 10 kapena 20 mg (Slovenia).
- Captopril - 25 kapena 50 mg (Russia, India).
- Monopril - 20 mg (Poland).
- Perineva - 4 kapena 8 mg (Russia / Slovenia).
Ma Analogs amatha kukhala amitundu yamagulu osiyanasiyana.
Kupita kwina mankhwala
Kodi ndingagule popanda kulandira mankhwala?
Amangotulutsidwa pokhapokha ngati adokotala amapita.
Mtengo wa Hinapril
Mtengo wapakati.
Mtengo wake umachokera ku ruble 200 mpaka 250 phukusi lililonse, kutengera mlingo.
Zosungidwa zamankhwala
Sungani kutentha kwa chipinda (osapitirira + 25ºC) pamalo amdima, osatheka ndi ana ndi ziweto.
Tsiku lotha ntchito
Alumali moyo wazaka zitatu kuyambira tsiku lotuluka komanso tsiku lotha ntchito litayidwa.
Wopanga
Amapangidwa ku Russia ku kampani yopanga mankhwala ZAO Severnaya Zvezda.
Ndemanga za Hinapril
Madokotala
Irina, dotolo wabanja, Tver
Ndimapereka mankhwala kwa odwala omwe ali ndi matenda oopsa pambuyo potola anamnesis ndikuwunika kokwanira. Nthawi zambiri ndimaphatikizira ndi diuretics molingana ndi mawonekedwe. Mankhwala ndi othandizadi, koma muyenera kuyang'ana mosamala za kukhalapo kwa zotsutsana ndi munthu aliyense, chifukwa zovuta zoyipa ndizotheka.
Sergey, cardiologist, Astrakhan
Pakulephera kwa mtima, mankhwala oterewa amapereka chithandizo mwachangu, koma musanaperekedwe, muyenera kumayesa ndikuphunzira mbiri yachipatala.
Odwala
Anna, wazaka 52, Volgograd
Ndimamwa mapiritsi monga adanenera ndi adokotala ngati chida chothandizira pa matenda oopsa. Zotsatira zoyipa, ndimatha kudziwa kugona pang'ono koyambirira kwamankhwala.
Sophia, wazaka 39, Vologda
Osati kale kwambiri, mavuto opanikizika adayamba. Ndinapita kwa akatswiri ochiritsira ndipo atatha mayeso adandipatsa mankhwalawa. Tsopano kupsinjika kumakhala koyenera nthawi zonse, pokhapokha ngati pachitika zipwirikiti zazikulu, ndipo palibe zotsatira zosasangalatsa zomwe zimachitika.
