Acorta ndi mankhwala omwe ali m'gulu la pharmacological lotchedwa statins. Nthawi zambiri, madokotala amauza anthu omwe ali ndi vuto la atherosulinosis kapena matenda aliwonse a lipid metabolism m'thupi. Mankhwalawa amapezeka mu mawonekedwe a mapiritsi ang'onoang'ono mu filimu yophimba. Mtundu wa mapiritsiwo ukhoza kukhala mkati mwa mithunzi yonse ya pinki. Amakhala ozungulira, owongoka mbali zonse, ndipo akaphwanyidwa mkati, amakhala oyera kapena oyera.
Chofunikira chachikulu cha Akorta ndi rosuvastatin. Kuphatikiza pa rosuvastatin, kapangidwe kamankhwala kamaphatikizira zinthu zothandiza monga lactose, cellulose, calcium, magnesium, crospovidone. Chigoba chophatikizika cha mapiritsi chokha chimakhala ndi lactose, hypromellose, titanium dioxide, triacetin ndi utoto womwe umakhala ngati chitsulo. Mapiritsi onse amapezeka m'mapaketi azithunzi 10.
Limagwirira ntchito
Akorta, kapena m'malo mwake, chopangira chake chachikulu, rosuvastatin, ndi chosankha chosankha mwanjira yapadera - hydroxymethylglutaryl-coenzyme A reductase, yomwe mwa mawonekedwe ofupikirako imamveka ngati HMG-CoA. HMG-CoA ndi enzyme yofunika kwambiri yomwe imayang'anira kusintha kwa hydroxy-3-methylglutaryl-coenzyme A ku chinthu chotchedwa mevalonate, kapena mevalonic acid.
Mevalonate ndiwotsogola mwachindunji kwa cholesterol, owonjezera omwe ali pachiwopsezo chachikulu cha atherosulinosis. Kuphatikizika kwa cholesterol ndi kusokonekera kwa otsika kachulukidwe lipoproteins (LDL) kumachitika m'chiwindi. Kuchokera apa zitha kunenedwa molondola kuti chiwindi ndicho chandamale kwambiri chochita ndi mankhwalawa.
Mankhwalawa amathandizira kukulitsa kuchuluka kwa zolandilira zam'mimba zowoneka bwino pamaselo a chiwindi, chifukwa zomwe zimapangitsa kuti zinthu zomwe zimawola ziyambe kwambiri, ndipo lipoproteins zaulere sizilowa m'magazi. Kuphatikiza apo, m'chiwindi, gulu lina la lipoproteins limapangidwanso - kachulukidwe kwambiri (VLDL). Ndi Akorta omwe amalepheretsa kaphatikizidwe kake ndipo amatsogolera kuchepa kwa mulingo wawo m'magazi a anthu.
Rosuvastatin amathandizira kuchepetsa kuchuluka kwa cholesterol wotsika kwambiri komanso wotsika kwambiri, ndipo nthawi yomweyo amawonjezera cholesterol "yabwino" - kuchokera ku HDL. Kuchuluka kwa cholesterol yathunthu, ma apolipoproteins B (koma, nawonso, kumakulitsa kuchuluka kwa apolipoproteins A), triglycerides imachepetsedwa kwambiri, kuchuluka kwa cholesterol ya "atherogenic" kwathunthu.
Njira iyi yochitira zinthu ikufotokoza zotsatira zazikulu za mankhwalawa - lipid-kutsitsa (kwenikweni - kuchepetsa kuchuluka kwa mafuta). Zotsatira zake mwachindunji zimatengera mlingo wa mankhwala omwe adokotala adapereka. Kuti mukwaniritse othandizira, ndiye kuti, mumathandizira ena, ndikofunikira kumwa mankhwalawo kwa sabata limodzi. Kuti mupeze kuchuluka kwakukulu, "mantha", kumatenga pafupifupi milungu inayi ya kudya pafupipafupi ndikukonzanso kwa mankhwalawo.
Kugwiritsa ntchito Akorta kumayenda bwino ndi mankhwala omwe amachokera ku pharmacological gulu la mankhwala opatsirana ndi lipid, komanso nicotinic acid, omwe amathandizira kukulitsa kuchuluka kwa lipoproteins yapamwamba.
Pharmacokinetics ndi pharmacodynamics Acorta
Pharmacokinetics ndizomwe zimachitika ndi mankhwalawo pawokha m'thupi la amene adamwa. Zotsatira zake zimangokhala 20% yokha ya mlingo womwe walandiridwa. Vutoli limatchedwa bioavailability. Ndi kuchuluka kwa mankhwala kumene kumafikira komwe mukupita. Kupezeka kwakukulu kwa Acorta kumawonedwa patatha maola 3-5 mutayamwa. Simuyenera kumwa mapiritsi ndi chakudya, chifukwa chakudya chilichonse chimathandiza kuchepetsa kuchuluka kwa mankhwalawa. Rosuvastatin amalowa bwino mu zotchinga za hematoplacental, zomwe zimayenera kuganizira nthawi zonse popereka mankhwalawa kwa amayi apakati.
Pamene aorta ilowa m'thupi lathu, imakhudza chiwindi, ndipo imagwiritsidwa ntchito ndi iye, zomwe zimakhudza kapangidwe ka cholesterol ndi lipoproteins yotsika. Komanso rosuvastatin imagwirizanitsidwa bwino ndi mapuloteni amwazi. Mu kagayidwe, ndiye kuti, kusinthana kwa ma rosuvastatin, ma enzymes a hepatic amagwira ntchito mwachangu, makamaka - cytochrome P-450, yomwe ndi imodzi mwazinthu zazikulu zomwe zimapereka njira yopumira minofu.
Kuchulukitsa, kapena kuchotsedwa, kwa gawo lalikulu la mankhwalawa kumachitika kudzera m'matumbo, omwe kudzera m'matumbo. Gawo lotsala limachotsedwa ndi impso. Kuchepa kwa kuchuluka kwa mankhwala m'magazi ndi theka kumatchedwa theka-moyo. Hafu ya moyo wa Acorta ndi maola khumi ndi zisanu ndi zinayi, ndipo ndiwodziyimira payokha.
Kagayidwe kake ka rosuvastatin sikusintha mwanjira iliyonse ndipo sikudalira msinkhu komanso mtundu wa odwala, koma zimatengera ndi kukhalapo kwa ma concomitant pathologies monga aimpso ndi kulephera kwa chiwindi. Odwala omwe ali ndi vuto lalikulu laimpso, kuchuluka kwa mankhwalawa m'magazi kumakhala katatu kuposa momwe munthu wathanzi amakhala. Ndipo odwala omwe ali ndi vuto la chiwindi, kuwonjezereka kwa theka la moyo wa rosuvastatin kumadziwika.
Komanso, kagayidwe kazomwe amagwira ndi zotsatira za Acorta zimatengera zolakwika zamtundu kapena kungosiyana.
Malangizo ogwiritsira ntchito mankhwalawa
Aorta adalembedwa matenda osiyanasiyana a lipid metabolism.
Chizindikiro chachikulu ndicho kupezeka kwa atherosulinosis.
Mankhwala amagwiritsidwa ntchito ngati kuwonjezera pa zakudya kuti muchepetse mafuta m'thupi komanso otsika kwambiri.
Kuphatikiza pa izi, mankhwalawa amalembedwa:
- Monga Prophylactic wowonjezera matenda a mtima dongosolo odwala popanda matenda zizindikiro za matenda a mtima. Izi zimaphatikizapo infernation ya myocardial, stroke, matenda oopsa. Pankhaniyi, zaka za odwala ndizofunika - kwa amuna ndi okulirapo kuposa zaka 50, ndipo kwa akazi - opitilira 60. Ndikofunikanso kuganizira kuchuluka kochepa kwa matenda osalimba a lipoprotein cholesterol ndi kukhalapo kwa matenda a mtima apachibale abale apafupi;
- Hypercholesterolemia yoyamba malinga ndi Fredricksen kapena mtundu wosakanikirana ndikuwonjezereka kwa cholesterol popanda zifukwa zakunja. Mankhwala amatchulidwa ngati chida chowonjezera, makamaka ngati mankhwala ena, zakudya ndi zolimbitsa thupi sizinali zokwanira kukwaniritsa zotsatira zomwe mukufuna;
- Mtundu wachinayi wa hypertriglyceridemia malinga ndi Fredricksen monga gawo lina lophatikiza ndi mankhwala othandizira.
Contortindering Acorta zimatengera mlingo wa mankhwalawa. Kwa tsiku lililonse 10 mg 20 mg, matupi awo sagwirizana ndi contraindication; matenda pachimake chiwindi kapena aakulu pachimake, omwe mu biochemical kusanthula magazi amatchulidwa kuti kuwonjezeka katatu kwa zitsanzo za chiwindi poyerekeza ndi zizindikiro zowoneka bwino; kulephera kwambiri kwaimpso; munthu hypersensitivity kuti mkaka shuga (lactose), kuchepa kwake kapena kuphwanya njira mayamwidwe; kukhalapo kwa mbiri ya myopathy (kufooka kwa minofu); munthawi yomweyo mankhwala otchedwa cyclosporin; chibadwa tsogolo la myopathy; nthawi ya pakati ndi mkaka wa m`mawere akazi; zaka zazing'ono.
Pamene dort Akorta 40 mg patsiku, zotsatirazi contraindication ziyenera kuwonjezeredwa kwa contraindication pamwambapa:
- Kuperewera kwa chithokomiro - hypothyroidism;
- The kukhalapo kwa mbiri ya munthu kapena wotsatira wachibale wa matenda amisempha minofu;
- Kukula kwa myotoxicity pamene mumamwa mankhwala omwe ali ndi ofanana mawonekedwe a kanthu;
- Mowa wambiri
- Mulingo uliwonse womwe ungayambitse kuchuluka kwa rosuvastatin mthupi;
- Odwala a mtundu wa Mongoloid;
- Kugwiritsa ntchito mitundu ingapo;
Kuphatikiza apo, chosemphana ndi kupezeka kwa thupi la wodwalayo kuzungulira mwamphamvu kwa aimpso.
Zomwe zimagwiritsidwa ntchito pa acorta mu ma pathologies osiyanasiyana
Mosamala kwambiri, Akorta ayenera kuikidwa muyezo wa 10 ndi 20 mg pamaso pa zina zomwe zimayenderana ndi ma pathologies m'thupi.
Chenjezo liyenera kuchitika mukamagwiritsa ntchito mankhwala ngati pali chiwopsezo cha matenda a minofu
Kuphatikiza apo, odwala omwe amamwa mankhwalawa amayenera kuyang'aniridwa mwapadera pamaso pa kulephera kwa impso kwa gawo lililonse mthupi la wodwalayo.
Kuphatikiza apo, kulondola komanso kusamala kuyenera kuchitika ngati wodwala wapezeka:
- chithokomiro;
- kukhalapo kwa mbiri ya munthu kapena wachibale wa matenda amisempha;
- kukula kwa myotoxicity pamene mumamwa mankhwala omwe ali ndi ofanana mawonekedwe a kuchitapo;
- kumwa mowa kwambiri;
- zochitika zilizonse zomwe zingapangitse kuchuluka kwa rosuvastatin mthupi;
- ukalamba - woposa zaka 65;
- matenda oyamba a chiwindi;
- zotupa za septic;
- kukakamizidwa kuchepetsedwa;
- opaleshoni yayikulu yochitidwa kale;
- kuvulala koopsa;
- zovuta zama metabolic, usawa-electrolyte wamadzi, kuchuluka kwa mahomoni;
- khunyu yosalamulirika.
Mlingo wa 40 mg patsiku, zoletsa zake zimakhala zofanana:
- Ukalamba - woposa zaka 65;
- Matenda a chiwindi cham'mbuyo;
- Chotupa cha Septic;
- Kusasunthika kochepetsa;
- Njira zopangira opaleshoni yofunika kale;
- Kuvulala koopsa;
- Matenda a metabolism, usawa-electrolyte wamadzi, kuchuluka kwa mahomoni;
- Khunyu yosalamulirika;
- Kulephera kwofatsa.
Muyenera kusamala mukamagwiritsanso ntchito mankhwalawa kuchiza anthu amtundu wa Mongoloid komanso kugwiritsa ntchito mitundu yambiri ya mafupa.
Zomwe zimayambitsa zovuta mukamamwa Acorta zimadalira mlingo.
Zotsatira zoyipa zimatha kuchitika mthupi osiyanasiyana.
Mitsempha yam'mimba - kupweteka m'mutu, kumva kuda nkhawa, kupweteka m'mitsempha, kusokonekera kwazowonongeka, kutayika kukumbukira.
M`mimba thirakiti - kuphwanya matumbo kuyenda, nseru, m'mimba, kutupa kwa kapamba, matenda am'mimba, gastroenteritis, poizoni.
Machitidwe opatsirana - kutukusira kwa pharynx, kupuma kwammphuno, mabodza, bronchi, mapapu, mphumu, kufupika kwa mpweya, chifuwa.
Matenda a mtima - angina pectoris (kupanikizika kupweteka kumbuyo kwa sternum), magazi ochulukirapo, khungu rede, kumva kugunda kwa mtima.
Musculoskeletal system - kupweteka kwa minofu, mafupa, kutupa kwa mafupa, matumbo a tendon, rhabdomyolysis.
Mawonekedwe a mziwopsezo - zotupa pakhungu, kuyabwa, zotupa pakhungu lofiyira bwino (urticaria), kutupa kwa khungu, Stevens-Johnson syndrome - machitidwe oyipa kwambiri.
Zosintha pakuwunika - kuchuluka kwa shuga m'magazi, bilirubin, zitsanzo za chiwindi, creatine phosphokinase.
Ena: lembani matenda ashuga a 2 shuga, mawonetseredwe am'magazi, kudekha kwamabele, kuchepetsa kupatsidwa zinthu za m'magazi, edema, kukulitsidwa kwa mabere mwa amuna.
Ngati bongo, kuchuluka kwa zoyipa zimadziwika. Kuti mupewe izi, muyenera kutsatira kwambiri malangizo.
Mtengo wa Akorta ku Russia umachokera ku ruble 500 mpaka 550, chifukwa chake mankhwalawa amawonedwa kuti ndi otsika mtengo. Zotsatira za Akorta zimaphatikizapo mankhwala monga Krestor, Rosuvastatin, Roxer, Tevastor, Fastrong, ndi mankhwala apakhomo sizingakhale zopanda ntchito kwenikweni. Ndemanga pakugwiritsa ntchito Akorta ndizabwino kwambiri.
Zambiri zokhudzana ndi ma statins zimaperekedwa kanema munkhaniyi.
