Cocarboxylase ndi thiamine phosphate ester. Ili ndi ma synonyms ambiri, mwachitsanzo: Kotiamin, Berolase, etc. Vitamini B, yemwe amalowa m'thupi la wodwalayo, amamuika phosphorylated mu coenzyme yomwe ili ndi mphamvu yochizira.
Dzinalo
Mu Latin, mankhwalawa ali ndi mayina angapo: Cocarboxylasum, B-Neuran, Cocarbosyl, Cocarboxylase.
ATX
Mtundu wa anatomical komanso achire umafanana ndi code A11DA01.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapangidwa m'mitundu ingapo:
- ufa wokonza njira (0,05 g ampoules, 2 ml solvent);
- lyophilisate wa jekeseni wa i / m;
- Zinthu zouma zamankhwala amkati (ma ampoules a 0,025 ndi 0,005 g, zosungunulira za 2 ml).
Pali ma ampoules 10 mu paketi.
Mankhwalawa amakhudza bwino mkhalidwe wa wodwala yemwe wachitika ndi matenda osokoneza bongo.
Zotsatira za pharmacological
Mankhwala amachititsa kuti mapangidwe a ma nucleotide aphatikizidwe, zimakhudza kayendedwe ka metabolic m'thupi, zimapangitsa kuti magazi azithamanga. Zimathandizira kuchepetsa cholesterol m'magazi, zimachepetsa chiopsezo chokhala ndi atherosulinosis ndi matenda a mtima.
Pharmacokinetics
Maziko a mankhwalawo ndi chinthu chogwira ngati mawonekedwe a porous, youma ndi fungo lokomoka. Lyophilisate amasungunuka mosavuta m'madzi. Coenzyme thiamine ndi adsorbed m'mimba mwake.
Chofunika kwambiri ndi njira yogwiritsira ntchito kagayidwe kamankhwala mu chiwindi. Kamodzi mu impso, mankhwalawa amamuchotsa mkodzo pang'ono. Mankhwalawa ndi gulu la vitamini B, lomwe limakhudza kuchuluka kwa mphamvu myocardium, limateteza impso ku ischemia pakuchita opareshoni. Kuperewera kwa Coenzyme kumayambitsa acidosis.
Zomwe zimayikidwa
Mankhwalawa amakhudza mkhalidwe wa wodwala yemwe wakhala ndi myocardial infarction, amachepetsa acidosis, ndikubwezeretsa homeostasis. Odwala omwe amalandira mankhwalawa, mawonekedwe a kulephera kwa mtima amachepa, kulekerera zochitika zolimbitsa thupi kumawonjezeka.
Wodwala sayenera kumwa mankhwalawa mapiritsi.
Zochizira matenda a mtima, wodwala amadzipatsa metabolite wa vitamini B1, koma kuwonongeka kwake kumachitika patangodutsa mphindi zochepa kuti jakisoni.
Mwa zina mwazomwe mukulembera mankhwala, zotsatirazi ndizomwe zimasiyanitsidwa:
- matenda a shuga;
- aakulu kupuma kulephera;
- kwa ndani;
- arrhythmia;
- multiple sclerosis;
- mitsempha;
- eclampsia;
- sepsis
- acidosis mu akhanda;
- zovuta za endocrine.
Mankhwalawa amagwiritsidwa ntchito ngati antioxidant kuchiza odwala nthawi yoyamba ya ischemic stroke.
Mankhwala amatenga nawo mbali zotsatirazi:
- amalimbikitsa kutembenuka kwa lactic acid kukhala piritsi ya pyruvic;
- amatenga nawo gawo la decarboxylation;
- amachepetsa metabolic acidosis.
Mankhwala akuwonetsedwa kwa odwala omwe ali ndi matenda a shuga, chifukwa mankhwalawa amabwezeretsa kagayidwe kazakudya, amachepetsa mafuta, ndipo amayambitsa katulutsidwe ka bile.
Coenzyme thiamine ali ndi antioxidant.
Contraindication
Malangizo ogwiritsira ntchito mankhwalawa salola kugwiritsa ntchito mankhwalawa ngati munthu ali ndi vuto lililonse. Mankhwala a metabolic samalimbikitsidwa kwa odwala omwe ali ndi angina pectoris.
Kugwiritsa ntchito mankhwalawa kumatha kuyambitsa mavuto osiyanasiyana.
Mtima wa postinfarction mtima umachiritsidwa ndi mankhwala a mtima, komanso coenzyme thiamine, ATP, Riboxin sanayimebe nthawi yayitali. Potengera momwe mankhwalawa amathandizira, kuperekedwa kwa mankhwalawa sikuti kumawonjezera kuleza mtima.
Pambuyo kugwiritsa ntchito coenzyme thiamine, wodwala nthawi zambiri amakula:
- thupi lawo siligwirizana;
- dyspepsia
- wokongola.
Ndi matenda a shuga a mtundu wachiŵiri, mtima wodziyimira payekha umachitika. Kugwiritsa ntchito zinthu za Vitamini mu odwala ena kumabweretsa kukulira, ndipo zizindikiritso zakuthanso kwamtima zimasintha pang'onopang'ono.
Sichikulimbikitsidwa kuperekera mankhwalawa kwa odwala omwe ali ndi vuto la kukomoka kwa hepatic ngati wodwalayo adakhudzidwa kale. Mu matenda a chiwindi, mankhwalawa amatchulidwa kuti ateteze glycemia komanso monga zakudya za makolo zokhala ndi 5% shuga.
Odwala omwe ali ndi matenda a hepatobiliary system ndi ziwengo safunika kumwa mankhwala, chifukwa mankhwalawa sasintha mosagwirizana ndi thupi popanda kusamalidwa kwambiri.
Kukonzekera yankho lomwe limayikidwa intramuscularly, zomwe zili 1 ampoule zimasungunuka ma milliliters angapo amadzi a jakisoni.
Momwe zimaswana
Kukonzekera yankho lomwe limayikidwa intramuscularly, zomwe zili 1 ampoule zimasungunuka ma milliliters angapo amadzi a jakisoni. Kwa kukapanda kuleka, zosungunulira zapadera zimagwiritsidwa ntchito - 0,9% sodium chloride solution. Nthawi zina, yankho la dextrose limagwiritsidwa ntchito.
Mulingo wambiri womwe uli ndi 2 ml ya madzi a jakisoni. Pa jakisoni wa jet, 10-20 ml ya yankho ndi yokwanira, chifukwa kulowetsedwa kwamkati kochitidwa ndi kukapumira, 200-400 ml amagwiritsidwa ntchito. Ufa wokonza njira umaperekedwa kwathunthu ndi ma ampoules okhala ndi sodium acetate. Phukusi limodzi limaphatikizapo ma seti atatu, iliyonse ili ndi ma ampoules a 0,05 g ndi 2 ml.
Momwe angatenge
Mankhwalawa amathandizidwa ndi intramuscularly, nthawi zina pansi pa khungu kapena kuwonjezeredwa kwa otsikira. Mu matenda a shuga, achire mlingo ndi 0.1-1.0 g patsiku. Kuchuluka kwa zinthu zoperekedwa kwa akuluakulu kumayambira 50 mg mpaka 1 g kamodzi patsiku. Njira ya maphunziro imatenga masiku 15 mpaka 30.
Mu chiwindi matenda, mankhwala ndi mankhwala kupewa glycemia.
Kwa ana
Jakisoni wa mankhwala wolembedwa ndi adotolo kuti atonthoze chitetezo cha mthupi mwa odwala omwe ali ndi zomatira otitis media amaphatikizidwa ndi zovuta panthawi imodzimodzi ndi chithandizo cha physiotherapy ndi mechanotherapy. Mankhwalawa amaperekedwa kudzera mu mnyezo wa 50-100 mg pa tsiku.
Zochizira hemolytic matenda a akhanda, mavitamini E, B1, B2, B6, thiamine phosphate ester amagwiritsidwa ntchito, omwe amasintha magwiridwe antchito a biliary thirakiti ndi kagayidwe kazinthu. Chithandizo cha matenda enaake mu ana zimaphatikizira kuikidwa kwa maphunziro angapo a vitamini.
Kuti mulimbikitse chitetezo chamthupi, mankhwalawa amaperekedwa kwa mwana:
- Njira;
- riboflavin;
- folic acid.
Kuchitira cholowa nephritis mu mwana, mankhwala mankhwala intramuscularly. Mankhwalawa amagwiritsidwa ntchito popanga chithandizo cha mankhwala katatu pachaka. Ndi chitukuko cha matenda a meningococcal, thiamine coenzyme imathandizira kudzera m'mitsempha.
Odwala omwe ali ndi ziwengo sayenera kuloledwa kupaka jekeseni kuti apewe kukwiya komanso kuyamwa.
Akuluakulu
Pa kulowetsedwa, 100-150 mg ya mankhwalawa amagwiritsidwa ntchito katatu patsiku. Mukulephera kwa chiwindi, lyophilisate imayendetsedwa mu 5% dextrose solution. Chiwerengero chonse cha mankhwala osayenera sayenera kupitilira 150 mg / tsiku.
Kugwiritsa ntchito mankhwala cocarboxylase zotumphukira neuritis okalamba odwala zimaphatikizapo intramuscular makonzedwe a mankhwala pa mlingo wa 100 mg patsiku kwa masiku 30.
Zochizira kufinya kwa mabanja kwa Strumpel, mapiritsi a coenzyme amagwiritsidwa ntchito omwe ali ndi mphamvu yolimbitsa, kuphatikiza kayendetsedwe kake ndi ATP, Cerebrolysin, ndi Aminalon.
Mapiritsi a Thiamine phosphorous ester, mapiritsi a Panangin ndi Anaprilin amawonetsedwa chifukwa chophwanya njira zotsutsana ndi matenda a mtima. Zochizira hypovitaminosis pamlomo wamkati, ma ampoules a vitamini okhala ndi 0,05 g yogwiritsidwa ntchito pophika.
Mankhwalawa amathandizidwa ndi intramuscularly, nthawi zina pansi pa khungu kapena kuwonjezeredwa kwa otsikira.
Zotsatira zoyipa
Mavitamini omwe amaperekedwa kwa odwala ngati jakisoni amathanso kuyambitsa mavuto:
- redness la khungu pamalo jakisoni;
- kutupa
- kuyabwa
- kupweteka
Musanagwiritse ntchito mankhwalawa zochizira matenda oopsa monga metabolic acidosis, dokotala amazindikira kuchokera kwa wodwalayo ngati akudwala mphumu ya bronchial kapena atopic dermatitis.
Wodwala omwe ali ndi chifuwa samalimbikitsidwa kumwa mapiritsi; jakisoni wa yankho sayenera kuloledwa kupewa mawonekedwe a mkwiyo.
Matupi omaliza
Wodwala amatha kukhala ndi totupa zingapo pakhungu:
- mabingu;
- thovu lomwe ladzala ndi zowonekera.
Nthawi zambiri wodwalayo amadandaula zazing'ono malo ofiira. Ndi nthawi yayitali ya matendawa, kutupa kumakhudza mbali zikuluzikulu za khungu. Zomata zamatsenga zimayendera limodzi ndi kuyabwa kwambiri.
Zotupa zoyipa zomwe zimachitika pomwa mankhwalawa zimayendera limodzi ndi kuyabwa kwambiri.
Mukakana jakisoni wa mankhwalawa, kuchira kwathunthu ndikotheka. Kusokonezeka kwa mitsempha kumawonjezera ziwengo zomwe zimachitika pambuyo pakupereka mankhwala. Mwa ana, redness imafalikira m'malo akuluakulu khungu.
Malangizo apadera
Kumbukirani kuti cofactor dehydrogenase imakhudzanso mtima wa mtima wa glycosides. Mankhwala amathandizira kuti pakhale kulekerera bwino kwa Digoxin, Strofantin, Korglikon, amakhala ndi mphamvu mu metabolyo. Ndizosavomerezeka kuphatikiza ndi mankhwala okhala ndi paracetamol.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Poletsa toxosis ndi metabolic acidosis mu trimester yoyamba, mkazi amalembera deofrogenase cofactor, yomwe imakhudzidwa ndikupanga ma nucleic acids, acetylcholine, ndi nucleotides.
Mankhwala osokoneza bongo a vutoli ndi ovuta kwa amayi apakati.
Kuthandizira kwa metabolism kumachepetsa mwayi wobadwa nthawi isanakwane komanso kubadwa kwa mwana wakhanda wokhala ndi thupi lochepa. Mankhwalawa amalepheretsa zovuta zina:
- preeclampsia;
- kukula kwa fetal;
- kukonzedwa kwa placenta asanachitike.
Kumwa mankhwala a shuga
Mankhwala a metabolic amachitidwa kwa matenda ashuga a polyneuropathy.
Mankhwala Kokarnit, kuwonjezera pa cocarboxylase, muli cyanocobalamin ndi nicotinamide pakapangidwe kake.
Wodwala amamulembera mankhwala a Kokarnit, omwe ali ndi 1 ampoule zinthu zotsatirazi:
- disodium triphosphadenine trihydrate - 10 mg;
- cyanocobalamin - 0,5 mg,
- nicotinamide - 20 mg.
Thiamine phosphate ester amachepetsa zomwe zimakhala ndi lactic ndi pyruvic acid mthupi, zimapangitsa thanzi la minofu.
Bongo
Okalamba odwala, mankhwala ndi mankhwala ochepetsa. Woponya dontho wokhala ndi mankhwala osagona nthawi yayitali nthawi zambiri amakhala ndi vuto lina.
Mu anthu okalamba, zovuta zowonongeka zimadziwonetsa mu mawonekedwe a kusokonezeka kwa ubongo, zovuta zamagulu, kufupika, kumva kusowa kwa mpweya, tachycardia. Nthawi zina wodwalayo amadandaula za kuwonekera kwa zizindikiro monga:
- kutopa
- Chizungulire
- tinnitus;
- wokongola.
Mu okalamba, zovuta zoyipa zimadziwonetsa mwa tachycardia ndi zovuta zina.
Ndikofunikira kuganizira mawonekedwe a thupi la wodwalayo pofuna kupewa mankhwala osokoneza bongo ambiri. Wothandizira kagayidwe kakang'ono Mlingo wowongoletsa matenda a neuropsychiatric.
Kuchita ndi mankhwala ena
Mankhwalawa amalimbikitsa mphamvu ya mankhwalawa omwe amagwiritsidwa ntchito pochiza kulephera kwa mtima. Digoxin osakanikirana ndi coenzyme thiamine amachepetsa kuyamwa kwa zinthu zomwe zimagwira komanso ma metabolites ake.
Musatchule mankhwala nthawi imodzi ndi njira zomwe zimakhala ndi zamchere kapena zosagwira nawo ntchito. Ma antidepressants osakanikirana ndi vitamini amawonjezera mphamvu zawo, zomwe zimapangitsa kuti azikhala ndi bongo wambiri ndikukula kwa zotsatira zoyipa.
Ndi obstetric peritonitis pambuyo nthawi yobereka, glycosides yamtima amagwiritsidwa ntchito kutulutsa hemodynamics. Mankhwala amalimbitsa machitidwe awo, amatha kutumikiridwa pamodzi ndi Trental.
Mankhwalawa amawononga ntchito yoletsa kubereka.
Ma antidepressants osakanikirana ndi Cocarboxylase amawonjezera mphamvu zawo, zomwe zimatha kuyambitsa bongo ndikukula kwa zovuta zoyipa.
Mankhwalawa alibe zotsatira zoyipa zamankhwala monga:
- Kanamycin;
- Glutamic acid;
- Prednisone;
- Chofunikira;
- Lactulose
Amalembera mankhwalawa kwa chiwindi. Thiamine diphosphate imatha kutengedwa ndi riboflavin, nicotinic acid, pyridoxine hydrochloride, Riboxin, vitamini C. Mankhwala amakulitsa zotsatira za Korglikon pochizira poyizoni ndi ma tranquilizer.
Opanga
Mankhwalawa amapangidwa ndi makampani angapo:
- Lelfa S.A. Poland
- NPO Microgen Russia, Moskhimpharmpreparaty im. N.A. Semashko.
Analogue ya mankhwalawa ndi mankhwala a Milgamm.
Analogi
Mankhwala amakono amapereka mankhwala omwe ali ofanana ndikuwonetsa:
- Neurorubin;
- Magne Express;
- Milgamma
- Tsinsil-T;
- Laetrile B17;
- Demoton;
- Ziman;
- Neuromax;
- Neurobeks.
Riboxin muli zinthu zomwe zimapangitsa kupuma kwama cell. Mankhwala ali ndi zotsatirazi:
- kagayidwe
- antiarrhythmic;
- kumawonjezera kugunda kwa mtima
Mexicoidol, wopezeka mu ma ampoules ndi mapiritsi, amachepetsa kuchuluka kwa lipids mu minofu ndi madzi amthupi. Mankhwalawa ali ndi antioxidant momwe, amakhazikika m'magazi ofiira am'magazi panthawi ya hemolysis, komanso amachepetsa kuledzera kwa amkati.
Kupita kwina mankhwala
Mankhwalawa amagulitsidwa muma pharmacose onse. Kuti mugule, muyenera kuwonetsa wamankhwala mankhwala a dokotala.
Mtengo wa Cocarboxylase
Mtengo wokondedwa ukufanana ndi mtundu wapamwamba. Mankhwalawa atha kugulika ma ruble 123, koma mtengo wa mankhwalawo m'magulu osiyanasiyana amasiyana mankhwala.
Kusunga mankhwala Cocarboxylase
Mankhwalawa amasunga zinthu zonse zamankhwala, malinga ndi malamulo okhazikitsidwa osungirako - kutentha osaposa + 25 ° C.
Tsiku lotha ntchito
Chifukwa cha ma CD apadera, mankhwalawa amasungidwa zaka 3. Sungani kutali ndi ana.
Sizovomerezeka kuphatikiza mankhwalawa ndi mankhwala okhala ndi paracetamol.
Ndemanga pa Cocarboxylase
Akatswiri amagawana malingaliro awo okhudzana ndi mankhwalawa, chifukwa nthawi zambiri amathandizidwa pochizira matenda amitsempha. Madokotala ali ndi chidwi ndi kafukufuku wazachipatala komanso umboni. Malingaliro amakasitomala ndi awa:
Madokotala
Rodion, katswiri wa zamankhwala, Novgorod: "Ndimaona kuti mankhwalawa ndi osathandiza, osati kungogwiritsa mwala chabe. Nthawi zina ndimawalemba ngati mankhwala othandizirana muubongo. M'magwiridwe aposachedwa a mankhwala ofotokoza umboni, mankhwalawa amaikidwa pamndandanda wapadera ngati mankhwala osagwira ntchito mosavomerezeka."
Lyudmila, katswiri wa matenda otupa chiwindi, Vologda: "Mankhwalawa ankaperekedwa kwa odwala omwe ali ndi vuto la chidwi ndi chiwindi.
Odwala
Alexandra, wazaka 22, Sevastopol: "Ali ndi pakati, adayika dontho lokhala ndi Vitamini, Tivortin ndi Actovegin. Mwana wosabadwayo adavulala, mtsikanayo adasowa 20% ya khungu (mtundu wowotcha madigiri atatu). Ndikhulupirira kuti awa anali matenda a Stevens-Johnson. Sindikuwona phindu lililonse. ndikugwiritsa ntchito mankhwalawa. "
Grigory, wazaka 38, Arkhangelsk: "Mwana wanga wamwamuna anali ndi vuto la mseru, matendawa mkodzo. Kupumula kwa mwana kunayimitsidwa pambuyo pakupanga kwamphamvu kwa 150 mg ya kukonzekera kwa vitamini mg. Chifukwa cha maphunziro angapo, mankhwalawa mkodzo anatha."
