Kuti mupeze chipukutiro cha matenda a shuga kwa nthawi yayitali, mitundu yambiri ya insulin imagwiritsidwa ntchito. Insulin Lizpro ndi mankhwala amakono kwambiri komanso otetezeka omwe amagwiritsa ntchito kagayidwe kazakumwa.
Chida ichi chikhoza kuwonetsedwa kuti chitha kugwiritsidwa ntchito ndi odwala matenda ashuga a mibadwo yosiyanasiyana. Insulin Lizpro imatha kuperekedwa kwa ana omwe ali ndi matenda ashuga.
Poyerekeza ndi ma insulin omwe amagwira ntchito mwachidule, Insulin Lizpro imachita zinthu mwachangu, chifukwa cholowa kwambiri.
Pharmacological zochita ndi zikuwonetsa
Lizpro biphasic insulin inapangidwa pogwiritsa ntchito ukadaulo wa DNA. Pali kulumikizana ndi cholandilira cha michere ya ma cell
Kuchepa kwa kuchuluka kwa shuga m'magazi kumafotokozedwa ndikuwonjezereka kwa kayendedwe kake ka chidwi, komanso kuchuluka kwa mayamwidwe ndi kuperewera kwa maselo. Shuga amatha kuchepa chifukwa chakuchepa kwa kuchuluka kwa kapangidwe kake ka chiwindi kapena kukondoweza kwa glycogenogeneis ndi lipogenesis.
Lyspro insulin ndi mtundu wina wa DNA womwe umasiyananso m'njira zotsalira za lysine ndi proline amino acid pamalo a 28 ndi 29 a insulin B. Mankhwalawa ali ndi 75% protamine kuyimitsidwa ndi 25% insulin lispro.
Mankhwalawa ali ndi zotsatira za anabolic komanso malamulo a shuga. Mu minofu (kupatula minyewa ya muubongo), kusintha kwa glucose ndi ma amino acid mu cell kumathandizira, zomwe zimapangitsa kuti glycogen ipangidwe ndi shuga mu chiwindi.
Mankhwalawa amasiyana ndi ma insulin ochiritsira omwe amapezeka mwachangu pakulimbikitsa thupi komanso zotsatira zoyipa zochepa.
Mankhwalawa amayamba kuchita pambuyo pa mphindi 15, zomwe zimafotokozedwa ndi kuyamwa kwambiri. Chifukwa chake, chitha kuperekedwa kwa mphindi 10-15 chakudya chisanafike. Insulin yokhazikika imayendetsedwa osakwana theka la ola.
Kuchuluka kwa mayamwidwe kumakhudzidwa ndi tsamba la jakisoni ndi zina. Pachimake pazochitikazo zimawonedwa mu maola 0,5 - 2,5. Insulin Lizpro amachita kwa maola anayi.
Lizpro insulin mmalo amasonyezedwa kwa anthu odwala mtundu 1 shuga, makamaka vuto la insulin. Kuphatikiza apo, imagwiritsidwa ntchito pazinthu zotere:
- postprandial hyperglycemia,
- subcutaneous insulin kukana mu pachimake mawonekedwe.
Mankhwalawa amagwiritsidwanso ntchito ngati mtundu wachiwiri wa matenda osokoneza bongo omwe ali ndi vuto lokhala ndi hypoglycemic.
Lizpro insulin imatha kupatsidwa mankhwala omwe amagwiritsa ntchito.
Malangizo ogwiritsira ntchito mankhwalawa
Malangizo ogwiritsira ntchito mankhwalawa akuwonetsa kuti Mlingo uyenera kuwerengera kutengera mtundu wa glycemia. Ngati ndi kotheka, mankhwalawa amaperekedwa limodzi ndi ma insulin omwe amakhala nthawi yayitali, kapena mankhwala amkamwa a sulfonylurea.
Jakisoni amachitidwa mosazindikira m'malo oterowo a thupi la wodwalayo:
- m'chiuno
- m'mimba
- matako
- mapewa.
Masamba obayira ayenera kusinthidwa kuti asagwiritsidwe ntchito koposa nthawi 1 pamwezi. Osapereka jakisoni m'malo omwe muli mitsempha yamagazi yomwe ili pafupi kwambiri.
Anthu omwe ali ndi vuto la kuchepa kwa magazi ndi impso amatha kukhala ndi insulini yambiri komanso kufunikira kwake. Izi zimafunikira kuwunikira glycemia ndi kukonza kwakanthawi kwamankhwala.
Pulogalamu ya Humalog syringe (Humapen) tsopano ikupezeka; ndiyosavuta kugwiritsa ntchito. Pali zosankha zingapo zamtunduwu, zochepa kwambiri zimamaliza mayunitsi 0,5.
Njira zoterezi zikugulitsidwa:
- "Humapen Luxura". Chogulitsirachi chimakhala ndi skrini yamagetsi yomwe imawonetsa nthawi ya jakisoni womaliza komanso kukula kwa mlingo womwe waperekedwa.
- Humapen Ergo. Peni ndi mtengo wapamwamba kwambiri wa ndalama.
Insulin Lizpro, ndi cholembera cha syapinge cha Humapen amagulitsidwa pamtengo wokwanira ndipo amawunikira zabwino.
Zotsatira zoyipa ndi contraindication
Insulin Lizpro ali ndi zotsutsana zotsatirazi:
- tsankho
- achina,
- insulinoma.
Kusalolera kumafotokozedwa munthawi yomweyo:
- urticaria
- angioedema ndi malungo,
- kupuma movutikira
- kutsitsa magazi.
Maonekedwe a hypoglycemia amawonetsa kuti kuchuluka kwa mankhwalawa amasankhidwa molakwika kapena kulakwitsa ndiko kusankha kolakwika kwa malo kapena njira. Mtundu wa insulin suyenera kuperekedwa kudzera m'mitsempha, koma modumphira.
Nthawi zina mankhwalawa amatha.
Lipodystrophy imapangidwa ngati jakisoni wongoganiza unapangidwa molakwika.
Zizindikiro zotsatirazi za mankhwala osokoneza bongo amasiyana siyana:
- ulesi
- thukuta
- kugunda kwamtima
- njala
- nkhawa
- paresthesia mkamwa,
- khungu
- mutu
- kunjenjemera
- kusanza
- kuvutika kugona
- kusowa tulo
- Kukhumudwa
- kusakhazikika
- machitidwe osayenera
- zovuta zowoneka ndi zolankhula,
- glycemic chikomokere
- kukokana.
Ngati munthu akudziwa, ndiye kuti dextrose mkatimo akuwonetsedwa. Glucagon imatha kutumikiridwa kudzera m'mitsempha, subcutaneous ndi intramuscularly. Pamene hypoglycemic coma ikapangidwa, mpaka 40 ml ya 40% dextrose yothetsera imaperekedwa. Kuchiza kumapitirira mpaka wodwalayo atatuluka.
Nthawi zambiri, anthu amalolera Insulin Lizpro popanda zotsatira zoyipa.
Nthawi zina, phwando limatha kusiyanasiyana.
Zomwe zimayenderana ndi mankhwala ena
Lizpro insulin sayenera kugwiritsidwa ntchito ndi mankhwala ena. Hypoglycemic zotsatira za mankhwala kumatheka:
- Mao zoletsa
- androgens
- ACE
- mebendazole,
- sulfonamides,
- kaboni anhydrase,
- theofylline
- anabolic steroids
- Kukonzekera kwa lifiyamu
- NSAIDs
- chloroquinine,
- bromocriptine
- manzeru
- ketoconazole,
- onjezerani
- fenfluramine,
- quinine
- cyclophosphamide
- Mowa
- pyridoxine
- quinidine.
Mphamvu ya hypoglycemic imafooka ndi:
- estrogens
- glucagon,
- heparin
- somatropin,
- danazol
- GKS,
- kulera kwamlomo
- okodzetsa
- mahomoni a chithokomiro
- odana ndi calcium
- amphanomachul
- morphine
- clonidine
- mankhwala antidepressants,
- diazoxide
- chamba
- chikonga
- phenytoin
- BMKK.
Izi zitha kufooketsa ndikulimbikitsa:
- Octreotide
- beta blockers,
- yotsalira
- pentamidine.
Zambiri
M'pofunika kuyang'anitsitsa njira za kukhazikitsa mankhwala okhazikitsidwa ndi dokotala.
Posamutsa odwala kupita ku Insulin Lizpro yokhala ndi insulin yofulumira, kusintha kwa mlingo kungafunike. Pamene tsiku ndi tsiku mlingo wa munthu uposa mayunitsi 100, kusamutsa kuchokera ku mtundu wina wa insulini kupita kwina kumachitika pang'onopang'ono.
Kufunika kwa insulin yowonjezera kungathe kukhazikitsidwa chifukwa:
- matenda opatsirana
- kupsinjika mtima
- kuchuluka kwa chakudya chamagulu azakudya,
- mukamamwa mankhwala ndi ntchito ya hyperglycemic: mahomoni a chithokomiro, thiazide diuretics ndi mankhwala ena.
Kuchepetsa kufunika kwa insulini kungakhale ndi chiwindi kapena impso, kulephera zolimbitsa thupi, kapena kumwa mankhwala ndi ntchito ya hypoglycemic. Ndalamazi ndi monga:
- osasankha beta-blockers,
- Mao zoletsa
- sulfonamides.
Kuopsa kwa hypoglycemia kumachepetsa munthu kuyendetsa magalimoto komanso kukonza makina osiyanasiyana.
Anthu omwe ali ndi matenda ashuga amatha kupatulira hypoglycemia pakudya shuga kapena zakudya zopatsa mphamvu kwambiri.
Dokotala wopezekapo ayenera kudziwitsidwa za hypoglycemia, popeza mlingo uyenera kusintha.
Mtengo ndi fanizo la mankhwala
Pakadali pano, Insulin Lizpro imagulitsidwa pamtengo wa 1800 mpaka 2000 rubles.
Mndandanda wa mankhwala a insulin Lizpro ndi:
- Insulin Humalog Remix 25.
- Insulin Humalog Sakanizani 50.
Mtundu wina wa insulin yakunja ndi insulin aspar.
Ndikofunikira kukumbukira kuti simungagwiritse ntchito Insulin Lizpro pamtundu wa kusankha pawokha. Mankhwalawa amayenera kumwedwa pokhapokha ataikidwa ndi adokotala. Mlingo nawonso ndiudokotala.
Kufotokozera ndi malamulo ogwiritsa ntchito Lizpro insulin zimaperekedwa mu kanema munkhaniyi.
