Mikstard 30 NM ndi mankhwala osokoneza bongo. Zinapangidwa ndi ukadaulo wapadera wama DNA obwerezabwereza pogwiritsa ntchito mtundu wa Saccharomycescerevisiae. Imalumikizana kwambiri ndi ma receptor a membrane wakunja wa maselo ndipo potero imakwiyitsa maonekedwe a insulin receptor tata.
Mwa kuyambitsa biosynthesis m'maselo a mafuta ndi chiwindi kapena kulowa mkati mwaselo iliyonse, mankhwala a insulin receptor amakhudzanso zomwe zimachitika mkati, komanso kupanga ma enzymes ena, mwachitsanzo, pyruvate kinase, hexokinase, glycogen synthetase.
Kuchepa kwa kuchuluka kwa shuga m'magazi kumachitika chifukwa cha kuchuluka kwa kayendedwe ka intracellular, kuchuluka kwa mayamwidwe, komanso kuyamwa kwambiri ndi minofu.
Mphamvu ya mankhwala a Mikstard 30 NM imadziwika mphindi 30 pambuyo pa kuperekedwa. Kuchuluka kwambiri kumatheka pambuyo pa maola 2 mpaka 8, ndipo kutalika kwa nthawi yonse ya insulin ya mahomoni kumakhala maola 24.
Yemwe amawonetsedwa mankhwalawa ndi mlingo wake
Mikstard 30 NM ndikulimbikitsidwa kwa odwala matenda ashuga. Kukhazikitsidwa kwa mankhwalawa kudzachitika kawiri pa tsiku, kutengera kufunika kosakanikirana mwachangu komanso kwanthawi yayitali.
Mlingo wa mankhwalawa munthawi iliyonse amasankhidwa mosiyanasiyana, kutengera zosowa za wodwalayo. Nthawi zambiri, zofunika za insulini zimachokera pa 0,3 mpaka 1 IU pa kilogalamu ya odwala patsiku.
Omwe ali ndi insulin kukaniza angafunikire kuchuluka tsiku lililonse. Amatha kukhala odwala matenda ashuga, komanso onenepa kwambiri.
Mlingo wochepetsetsa ufunika kwa odwala omwe kapamba sanatheretu kutulutsa insulin.
Ngati wodwala wodwala matenda a shuga afika pamlingo wokwanira wa glycemia, ndiye kuti muzochitika zochulukirapo za matendawo. Poganizira izi, ndikofunikira kuyesa kukhathamiritsa kagayidwe kachakudya, makamaka kuwunika kuchuluka kwa shuga m'magazi.
Ikani Mikstard 30 NM theka la ola musanadye chakudya chomwe mukufuna.
Momwe mungagwiritsire ntchito?
Mankhwalawa adapangira ma subcutaneous management. Monga lamulo, izi ziyenera kuchitidwa m'chigawo cha khoma lakunja lam'mimba. Ndi malo olowera awa omwe angapangitse kuti amve zotsatira za mankhwalawa posachedwa.
Ngati wodwala matenda ashuga ali bwino, amathanso kubayidwa m'malo ena opindika, monga ntchafu, matako, kapena minofu ya m'mapewa.
Ndi oletsedwa kupereka mankhwala kuyimitsidwa.
Mukamapanga jekeseni pakhungu, mwayi wolowa m'matumbo umachepetsedwa kwambiri. Kuphatikiza apo, ziyenera kuzindikirika kuti ndibwino kusintha malo opangira jakisoni nthawi iliyonse. Izi zipangitsa kuti athe kuchepetsa chiopsezo cha lipodystrophy (kuwonongeka kwa khungu). Muyenera kudziwa momwe mungabayire insulin.
Ntchito Zowonetsera Mikstard
Muyenera kudziwa kuti simungagwiritse ntchito insulin pamapampu a insulin, komanso ndi chidwi chambiri ndi insulin ya anthu kapena chimodzi mwazinthu zake.
Kuphatikiza apo, mankhwalawa sangathe kugwiritsidwa ntchito pazinthu zotere:
- shuga wamagazi ochepa;
- insulin idasungidwa kapena kusungidwa;
- kapu yodzitetezera ikusowa kapena kumangiriridwa bwino botolo;
- thunthu limakhala inhomogeneous pambuyo kusakaniza.
Musanayambe kugwiritsa ntchito Mikstard 30 NM, onetsetsani kuti mawuwo ndi odalirika komanso onetsetsani kuti mankhwalawo amagwiritsidwa ntchito moyenera.
Momwe angakwire?
Musanalowe jakisoni, onetsetsani kuti syringe yapadera imagwiritsidwa ntchito, pomwe muyeso umayikidwa. Ndi iye yemwe amapangitsa kuti azitha kuyeza molondola momwe mulingo woyenera wa insulin angagwiritsire ntchito.
Chotsatira, muyenera kukoka mpweya mu syringe. Ili liyenera kukhala voliyumu yomwe izigwirizana ndi kuchuluka kofunikira.
Mankhwalawa musanatenge kumwa, ndikofunikira kuti mukupukutira botolo pakati pa manja kwanthawi yayitali. Izi zipangitsa kuti chinthucho chikhale mitambo komanso choyera. Mchitidwewo uthandizidwa pokhapokha ngati mankhwalawo adayatsidwa kale kutentha kwawindo m'chilengedwe (!) Njira.
Kuti mupeze insulin pansi pa khungu, muyenera kuwerengera molondola mayendedwe anu. Ndikofunika kugwira singano pansi pa khola la khungu mpaka insulin yonse itayilowetsedwa bwino.
Ngati wodwala matenda ashuga ali ndi mbiri yowonjezera matenda, ndiye kuti pamenepa kungafunike kusintha kwa Mikstard 30 NM. Tikulankhula za matenda otere:
- matenda, limodzi ndi malungo;
- pamaso pa zovuta ndi impso, chiwindi.
Ndikofunikira kusintha mlingo wa vuto la chithokomiro. Kusintha kwa Mlingo kuwonetsedwa ndi kusintha kwakukuru mthupi la odwala matenda ashuga, kadyedwe kake kakang'ono, komanso pochotsa mtundu wina wa insulin.
Kuwonetsedwa kwa zoyipa
Pa kugwiritsa ntchito mankhwalawa Mikstard, zovuta zina zimadziwika kwambiri mwa odwala ena. Kuchuluka kwake kumakhala kwa zokwanira Mlingo chifukwa cha kuphatikizika kwa ma cell insulin.
Zotsatira zamayesero azachipatala, zotsatirapo zoyipa sizinali zochepa, zosowa kwambiri komanso zodzipatula.
Nthawi zambiri, zovuta zotsatirazi zimawonedwa mwa odwala:
- mavuto mu kugwira ntchito kwa chitetezo chathupi;
- hypoglycemia.
Wotsirizirayi amapezeka poti kuchuluka kwa mankhwalawo kunaposa kwambiri kufunika kwake. Pankhani ya kwambiri hypoglycemia, kusazindikira, kukhudzika, komanso kusokonekera kwa ubongo ntchito (yosatha kapena kwakanthawi) ngakhale imfa idadziwika.
Zocheperazo ziyenera kuphatikizapo:
- matenda ashuga retinopathy;
- zotupa, urticaria;
- lipodystrophy;
- matenda a subcutaneous minofu ndi khungu;
- kutupa;
- zotumphukira neuropathy;
- zimachitika m'deralo komwe majekeseni adapangidwira.
Popitiliza kuyang'anira kuchuluka kwa shuga m'magazi, mwayi wokhala ndi matenda ashuga retinopathy utha kuchepetsedwa.
Ndikofunika kukumbukira kuti kukula kwa insulin hormone yotsutsana ndi maziko a kukonzanso kwakukulu kwa glycemia sikungakhale kwamuyaya. Kufanana kwa matenda ashuga a retinopathy kungokhala kwakanthawi.
Lipodystrophy imatha kuyamba kukula pomwe wodwalayo alowetsa mankhwalawo pamalo omwewo.
Zochita zam'deralo zimadziwika ndi kutupa, kuyabwa, kutupa, redness ndi hematomas pakhungu pamalowo. Monga lamulo, milandu iyi ndiyosakhalitsa, ndipo imatha kutha kwathunthu mukalandira chithandizo.
Edema nthawi zambiri amawonetsedwa koyambira kwenikweni kwa mankhwala a Mikstard 30 NM. Chizindikiro ichi ndichakanthawi.
Ngati kusintha kwa kayendetsedwe ka shuga m'magazi kumatheka mosavuta, ndiye kuti pamakhalanso vuto lakusintha kwa shuga.
Pakadwala, pakachitika zovuta zomwe zimachitika, komabe, sizinganyalanyazidwe. Izi zikuphatikiza:
- mavuto obwezera;
- anaphylactic mkhalidwe.
Milandu yovuta ya kukonzanso ilipo kumayambiriro kwa insulin hormone. Poyerekeza ndi ndemanga, Zizindikiro izi ndizakanthawi ndipo zikupita.
Kuwonetsedwa kwa hypersensitivity yotchuka ikhoza kukhala limodzi ndi zotupa pakhungu, kuyabwa, mavuto ammimba, kufupika, angioedema, kugunda kwa mtima, kuchepa kwamphamvu kwa magazi, kukomoka, komanso ngakhale kugona. Izi zitha kukhala chiwopsezo chachikulu pamoyo wa wodwalayo.
Contraindication ndi milandu yambiri
Izi zimaphatikizapo hypoglycemia, komanso kukhudzidwa kwa chidwi ndi insulin ya anthu kapena zigawo zina za mankhwala a Mikstard.
Mpaka pano, palibe deta pa milandu ya bongo chifukwa chogwiritsa ntchito mankhwalawa.
Mwachidziwitso, muzochitika zotere, kuyambika kwa hypoglycemia kwa zovuta zakusiyanasiyana ndikotheka. Ngati hypoglycemia ili yofatsa, ndiye kuti wodwalayo amatha kudzipatula yekha. Izi zitha kuchitika mwa kudya zakudya zochepa zotsekemera, zomwe odwala matenda ashuga ayenera kukhala nawo nthawi zonse. Tikulankhula zamaswiti aliwonse kapena zakumwa za shuga zazing'onozing'ono.
Mu hypoglycemia yayikulu, kuchipatala kwadzidzidzi kuchipatala kwasonyezedwa.
Muzochitika zovuta kwambiri (ngati chikumbumtima chatayika kale) kuchipatala, wodwalayo adzapatsidwa 40% yankho la glucose (dextrose) kudzera m'mitsempha. Monga analog, subcutaneous kapena intramuscular dongosolo la glucagon mu voliyumu ya 0,5 mpaka 1 mg angagwiritsidwe ntchito.
Munthu akachira, wodwala amalimbikitsidwa kudya zakudya zopatsa mphamvu. Izi zipangitsa kuti izi zitha kupewa kupewa kubwerezabwereza kwa hypoglycemia.
