Mankhwala a antidiabetesic Humulin NPH amapangidwa kuti azisungitsa shuga m'magazi pamlingo woyenera, amakhala ndi nthawi yotha kuchitapo kanthu.
Dzinalo Losayenerana
Humulin NPH, ngati mankhwala omwe ali ndi fomula yopanda tanthauzo, wapatsidwa International Nonpxpetary Name - Insulin-Isophan (Umisiri wa Majini a Anthu).
Komanso, mankhwalawa amafanana ndi dzina la malonda la Humulin® NPH ndi dzina lachi Latin lotchedwa Insulinum isophanum (humanum biosynt syntum).
Humulin NPH adapangidwa kuti azisungitsa glucose wamagazi nthawi yokhazikika ndipo amakhala ndi nthawi yayitali kuchitapo kanthu.
ATX
Mankhwalawa amafanana ndi code A10AC01, zomwe zikutanthauza kuti ndi m'gulu la anthu omwe amakhala ndi insulini.
Kutulutsa mafomu ndi kapangidwe kake
Kapangidwe ka mankhwala monga chinthu chachikulu kumaphatikizira insulin ya anthu pamlingo wa 100 IU / ml. Kuti muwonetse katundu wofunikira, mawonekedwe a mankhwalawa amathandizidwa ndi zinthu zothandizira: metacresol, phenol, glycerol, protamine sulfate, sodium hydrogen phosphate heptahydrate, zinc oxide, hydrochloric acid solution, sodium hydroxide solution ndi madzi a jakisoni.
Mankhwalawa amadzaza m'mbale (10 ml) ndi makatoni (3 ml) agalasi osalowerera. Mbale za 1 pc. anayikidwa m'makatoni, ndi makatoni 5 ma PC. kuyikidwa m'matumba. Kusintha komwe kuli kotheka momwe makatiriji amagulitsidwa asanakhaleko m'makola a ma syringe (m'makatoni 5 ma PC.).
Kuyimitsidwa
Kwa subcutaneous makonzedwe. Kuyimitsidwa koyera kumeneku kumatha kupanga mawonekedwe oyera oyera komanso oyera, opanda utoto kapena pafupifupi khungu. Musanagwiritse ntchito, gwiritsani ntchito mankhwala pang'onopang'ono mpaka madzi atapezeka.
Mankhwalawa amadzaza m'mabotolo (10 ml) ndi makatoni (3 ml) agalasi losalowerera, kapangidwe kake kamaphatikizira insulin ya anthu pamlingo wa 100 IU / ml.
Zotsatira za pharmacological
Mankhwalawa ndi mtundu wa DNA wobwerezabwereza anthu, umagwiritsidwa ntchito ngati chiwongolero cha glucose metabolism. Katundu wa anabolic amadziwika kuti ndiwowonjezera ku Humulin NPH. Insulin imathandizira kuyendetsa mwachangu ma glucose ndi ma amino acid m'thupi lathu (kupatula ubongo), komanso kuthamanga kwa mapuloteni a anabolism. Chifukwa cha insulin, glucose amasinthika m'chiwindi kukhala glycogen. Mankhwalawa amagwira ntchito monga choletsa gluconeogeneis ndipo amathandizira kusintha shuga wambiri kukhala mafuta.
Pharmacokinetics
Mankhwala amayamba kuchita mphindi 50-60 pambuyo pa kutsata, amagwira bwino kwambiri kuyambira nthawi ya 2 koloko itatha, nthawi yonse yowonekera ndi maola 18-20.
Kugwiritsa ntchito komanso kuyamwa kwa mankhwalawa kumakhudzidwa ndi malo a jekeseni, Mlingo ndi ndende. Amadziwika ndi kugawidwa kosasiyanako kwa zimakhala zathupi. Kafukufuku watsimikizira kusowa kwa Humulin NPH mkaka wa m'mawere ndikulephera kwake kuloza chitseko cha placental. 30-80% imachotsedwa impso.
Zizindikiro zogwiritsidwa ntchito
Mankhwalawa amalembera mtundu wa 2 komanso mtundu wachiwiri wa matenda ashuga, komanso nthawi ya pakati, yomwe imachitika ndi mtundu wachiwiri wa matenda a shuga.
Mankhwala Humulin NPH ndi mankhwala a matenda a shuga 1.
Contraindication
Kugwiritsa ntchito Humulin NPH kumaphatikizidwa chifukwa cha hypoglycemia komanso kuwonjezeka kwa insulin komanso zilizonse zomwe zimaphatikizidwa ndikupanga mankhwala.
Ndi chisamaliro
Panthawi yapakati komanso yoyamwitsa, kufunika kwa kuchuluka kwa insulin kumatha kusintha, chifukwa chake, kumwa mankhwala kuyenera kuthandizidwa mosamala, kuyang'anira momwe zinthu zilili ndikusintha ngati pakufunika kutero.
Momwe mungatenge Humulin NPH
Mlingo wa mankhwalawa amatchulidwa ndi dokotala ndipo zimatengera zomwe zili m'magazi. Mgwirizano wamankhwala amathandizira kuloledwa, komabe, njira yayikulu ndi jakisoni pansi pakhungu matako, phewa, ntchafu, kapena pamimba. Ndizoletsedwa kulowa intraral.
Asanakhazikitsidwe, kutentha kwa kuyimitsidwa kumabwera ndi kutentha kwa firiji, malo omwe amaba jekeseni amasinthidwa osagwiritsa ntchito malo amodzi koposa nthawi 1 pamwezi. Ndi kayendetsedwe ka subcutaneous, ndikofunikira kuonetsetsa kuti mitsempha ya magazi siyikhudzidwa. Malowo a jekeseni pambuyo poti jakisoni sanatenthe.
Ndi matenda ashuga
Asanayambike, insulini iyenera kukhazikitsidwanso, komwe mabotolo amawagudubuza mobwerezabwereza m'manja, ndipo makatoni amagulitsidwa kanthawi kokwanira khumi m'manja, kenako ndikutembenuzidwenso kanthawi kokwanira ka 10 °. Kuphatikizikako kumawoneka ngati koyenda kwamadzi kofanana. Simungagwedezere chinthucho mwamphamvu kuti chithovu chisawonekere, chomwe chimasokoneza gawo lolondola. Asanalowetse jakisoni, wodwalayo ayenera kuphunzira malangizo othandizira insulin kudzera mu cholembera.
Maupangiri Ogwiritsira Ntchito Chingwe
Cholembera Chachangu ndichosavuta komanso chosavuta kugwiritsa ntchito. Kukhazikitsidwa kwa insulin kumachitika m'njira zingapo.
- Mukatha kusamba manja anu bwino, sankhani jakisoniyo ndikupukuta.
- Chotsani cholozera cha cholembera ndi kukoka, koma osazungulira. Osachotsa chizindikiro. Onetsetsani kuti insulin ikukwaniritsa zonse zofunikira (mtundu, tsiku, mawonekedwe). Bwezeretsani mankhwalawo.
- Konzani singano yatsopano pochotsa cholembera papepala lakunja. Pukutani chidutswa cha rabara pamphepete mwa bokosi la cartridge ndi mowa, ndiye kuti muveke singano, yomwe ili mumkono, ndendende ndi cholowera pa cholembera. Sungani singano mpaka ilumikizane kwathunthu.
- Chotsani kapu yakunja kumapeto kwa singano, koma osataya, ndikuchotsa kapu yamkati ndikuitaya.
- Onani kuchuluka kwa insulini kuchokera ku syringe yachangu.
- Ikani singano pansi pakhungu, kutsatira njira yolimbikitsidwa ndi adokotala. Limbani mwamphamvu batani la jakisoni wa mankhwala ndi chala chanu. Kuti mulowetse muyezo kwathunthu, batani limasungidwa kuti liwonjezeke 5.
- Mukachotsa singano, kanikizani bwino jakisoniyo ndi swab ya thonje, osalipaka.
- Tulutsani singano ndi kapu yoteteza ndi kutaya.
Humulin NPH jekeseni pansi pakhungu, kutsatira njira yomwe dokotala amakupangira, kanikizani mwamphamvu batani la jekeseni ndi chala.
Zotsatira zoyipa za Humulin NPH
Dongosolo la Endocrine
Zotsatira zoyipa zomwe zimachitika chifukwa cha zotsatira zazikulu za mankhwalawa ndi hypoglycemia. Woopsa milandu, izi zimatha kudzetsa hypoglycemic chikomoka komanso kusazindikira, ndipo pabwino, kufa.
Matupi omaliza
Kuwonetsedwa kwa mayankho am'deralo, owonetsedwa ndi redness, kutupa ndi kuyabwa pamalowo jekeseni, ndizotheka. Pankhaniyi, muyenera kuwonetsetsa kuti zomwe zimachitika chifukwa cha mankhwalawo, osati chifukwa cha kutsutsana ndi woyeretsa kapena zina.
Nthawi zina, chiwonetsero cha zinthu zingapo zovuta zoyipa mothandizidwa ndi kuyabwa kambiri, kupuma movutikira, kufupika, kutsika kwa magazi, kuthamanga kwa mtima komanso kutuluka thukuta kumatheka. Izi zitha kukhala zowopsa m'moyo ndipo zimafunikira chithandizo chamanthawi. Mungafunike kusintha mankhwalawo kapena kuchita desensitization.
Osati kawirikawiri (ndi kuthekera kwa 0.001-0.01%) lipodystrophy imayamba.
Zokhudza mphamvu pakuwongolera njira
Kumwa mankhwalawa sikukhudza kasamalidwe ka kayendedwe kazinthu zina. Komabe, zotsatira zoyipa zimakhala ndi zotsatira zoyipa - hypoglycemia, yomwe imadziwika ndi chidwi chosokoneza, ngakhale kutaya chikumbumtima ndikotheka.
Malangizo apadera
Kusintha kwa Mlingo pakuwonjezeka kungafunike pakusintha kwa zakudya, kuwonjezeka kapena kuchepa thupi, kukhumudwa. Kusintha kwa mulingo wochepetsera kungachepetse vuto la chithokomiro, chithokomiro cha titu ndi tiziwalo tamadontho.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Nthawi zambiri kufunika kwa insulini kumachepetsedwa panthawi yoyambirira ndikuwonjezeka nthawi yachiwiri ndi yachitatu, motero ndikofunikira kuyang'anira mawonetsedwe. Funsani dokotala wanu kuti musinthe mankhwala onse. Mimba komanso kukonzekera kwake kuyenera kukambirana ndi katswiri posachedwa.
Panthawi yoyamwa, kusintha kwa mlingo kungakhale kofunikira.
The ntchito aimpso kuwonongeka
Kufunika kwa insulin kumatha kuchepa;
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Kufunika kwa insulin kumatha kuchepa;
Kuchuluka kwa Humulin NPH
Ngati kuchuluka kwa insulin m'magazi sikugwirizana ndi chakudya chovomerezeka komanso kugwiritsa ntchito mphamvu, hypoglycemia ikhoza kuchitika, yomwe ikuwonetsedwa ndi kupha, thukuta kwambiri, tachycardia, kufooka kwa khungu, kupweteka mutu, kunjenjemera, kusanza komanso kusokonezeka. Kuopsa kwake komanso kuzindikirika kwa zizindikiro zakutsogolo kwa hypoglycemia kumatha kusiyanasiyana kutengera nyengo.
Kuchita ndi mankhwala ena
Zotsatira za hypoglycemic of insulin zimatheka chifukwa cha mankhwala osokoneza bongo a hypoglycemic, ma inhibitors a MAO, ma inhibitors a carbonic anhydrase inhibitors, osasankha beta-adrenergic blocking agents, bromocriptine, okreotide, sulfanilamides, anabolic steroids, tetracyofinoforofidi, clofide, clofide, clofide. mankhwala okhala ndi Mowa.
Mphamvu ya hypoglycemic ya insulin imafooka ndi kulera kwapakamwa, glucocorticoids, mahomoni a chithokomiro, thiazide diuretics, heparin, tridclic antidepressants, sympathomimetics, danazole, clonidine, BKK, diazoxide, morphine, phenytoin ndi nikotini.
Reserpine ndi salicylates zimatha kufooketsa ndikuwonjezera zochita za Humulin NPH.
Kuyenderana ndi mowa
Zakumwa zoledzeretsa ndizomwe zimawonjezera chizolowezi cha hypoglycemia, chifukwa chake, kuwunikira mosamala, upangiri waluso komanso, mwina, kusintha kwa Mlingo wothandizidwa kumafunika.
Nthawi zina, kumwa mowa ndimakonzedwe a insulin kumatha kuyambitsa lactic acidosis, ketoacidosis, komanso kusokonezeka kofanana ndi thupi.
Kumwa mowa ndi mankhwala a insulin kumatha kuyambitsa lactic acidosis ndi zovuta zina monga thupi.
Analogi
Mankhwalawa amatha kusintha pokhapokha atakumana ndi katswiri. Monga momwe ma analogues amatha kuperekera zida zotsatirazi:
- Insuman Bazal GT;
- Biosulin N;
- Protafan HM;
- Protafan HM Penfill.
Kupita kwina mankhwala
Kodi ndingagule popanda kulandira mankhwala?
Mankhwala ochokera ku Mndandanda B womwe sungagulidwe popanda mankhwala a dokotala.
Mtengo wa Humulin NPH
Mtengo umatengera mtundu wa kumasulidwa, kuchuluka kwa mabotolo kapena ma cartridge omwe ali phukusi. Mitengo yoyandikira ya Humulin NPH 100 IU / ml:
- 3 ml katoni, ma PC 5. pamtundu wa makatoni (ndi QuickPen) - kuchokera ma ruble 1107.;
- botolo la 10 ml, 1 pc. mu gulu la makatoni - kuchokera ma ruble 555.
Zosungidwa zamankhwala
Kuti musunge katunduyo mufunika kutentha kwa + 2 ... + 8 ° C ndi malo otetezedwa ndi dzuwa. Pasakhale zida zamagetsi pafupi. Sizoletsedwa kuti zizimitsidwa.
Analogue akhoza kukhala mankhwala a Insuman Bazal GT.
Pewani kufikira ana.
Tsiku lotha ntchito
Kuyimitsidwa mu mawonekedwe osatsimikizika kumakhalabe ndi zinthu zake zaka zitatu. Pambuyo pakuyamba kugwiritsa ntchito - masiku 28 (ku + 15 ... + 25 ° C).
Wopanga
Wogwirizira satifiketi yolembetsa mankhwalawo ndi kampani yaku Swiss "Eli Lilly Vostok S.A."
Mabotolo amapangidwa ku USA (Indianopolis), Eli Lilly ndi Company, ndi makatoni okhala ndi mapensulo a syringe - ku France, Lilly France.
Ndemanga za Humulin NPH
Madokotala
Anna, wazaka 45, Saratov
Ndakhala ndikugwira ntchito ya endocrinology kwazaka zopitilira 20. Ndimaona Humulin kukhala wothandiza nthawi zambiri, nthawi zambiri samayambitsa mavuto.
Andrey, 38, Kaliningrad
Mankhwala ali ndi fanizo lamphamvu kwambiri. Ndimamusankha ngati ali ndi vuto lililonse.
Odwala
Alexandra, 32, Moscow
Mwana wochokera ku Humulin amamva kuwawa pamasamba a jakisoni, ngakhale ndimayesetsa kupaka jekeseni pang'onopang'ono. Zomwezo, zisindikizo zimawonekera, zomwe zimatsimikiza mkati mwa masiku ochepa. Tiyenera kuyesa kusintha kukhala analogue, ngakhale palibe zodandaula zina.
Mikhail, 42, Kazan
Ndinayesetsa kusiya Humulin NPH m'malo mwa Biosulin, koma ndidazindikira kuti sizoyenera, chifukwa Mavuto a Mlingo adayamba kuoneka, mumachita bwino, ndipo mulingo wa shuga sunapereke zotsatira zomwe mukufuna. Izi sizinachitikepo ndi NPH.
Alexander, 52, Khanty-Mansiysk
Ndakhala ndikudwala matenda ashuga kwa zaka zoposa 10. Ndinagwiritsa ntchito Humulin NPH kumayambiriro kwa matendawa. Kuchuluka kwa shuga kunali kwabwinobwino, ndimangowona kuchuluka kwa zochita zake kukhala zokoka, ndinapeza zina zomwe nditha kusankha.
