NovoRapid Penfill ndi wopanga wopanga wa hypoglycemic wokhazikika pa insulin aspart. Yotsirizayi imasiyana ndi insulin yaumunthu yachilengedwe pakupezeka kwa Aspartic acid kuchokera ku yisiti yophika yomwe imalowa m'malo mwa proline. Kusintha kwa maselo kumeneku kwachepetsa nthawi yokwaniritsa komanso nthawi yayitali ya mankhwalawa, chifukwa chake amalimbikitsidwa kumwa mankhwalawa musanadye.
Dzinalo Losayenerana
Insulin.
ATX
A10AB05.
Mankhwalawa amapangidwa mwa njira yothetsera kuyendetsa mankhwalawa mozungulira komanso mkati mwamitsempha, makatiriji amayikidwa m'matumba a blister a 5 ma PC.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwala amapangidwa mu mawonekedwe a yankho la makonzedwe subcutanely ndi mtsempha wa magazi. Mowoneka, ndimadzimadzi omveka bwino, osanunkhira komanso opanda khungu. 1 ml ya mankhwalawa muli 100 IU yogwira ntchito, yomwe ikufanana ndi 3500 μg. Monga zina zomwe zimagwiritsidwa ntchito:
- glycerol;
- hydrochloric acid;
- sodium hydroxide;
- madzi osalala a jakisoni;
- phenol;
- zinc ndi sodium chloride;
- sodium hydrogen phosphate dihydrate;
- metacresol.
Mankhwala ali mu 3 ml galasi makatiriji. Makatoni amayikidwa mu zotumphukira zotulutsa 5 ma PC.
Zotsatira za pharmacological
Insulin aspart ndi chithunzi cha mahomoni amunthu omwe amapangidwa ndi maselo a beta a kapamba. Mukupanga kwa maselo a insulin, proline imasinthidwa ndi asidi wa aspartic, potero amachepetsa nthawi kuti akwaniritse zochizira.
NovoRapid Penfill ndi wopanga wopanga wa hypoglycemic wokhazikika pa insulin aspart.
Mahomoni ophatikizika amayanjana ndi ma receptor omwe ali kunja kwa membrane wa khungu. Ndi kuyanjana uku, insulin-receptor tata imapangidwa yomwe imalimbikitsa kupanga hexokinase, enzyme yomwe imayang'anira kapangidwe ka glycogen, ndi pyruvate kinase.
Zotsatira za hypoglycemic zimachitika chifukwa cha kuthamanga kwa magawo a shuga m'magazi komanso kuphatikizika kwa shuga ndi minofu, kuwonjezeka kwa lipogenesis ndi mapangidwe a glycogen, komanso kuchepa kwa gluconeogeneis mu hepatocytes a chiwindi. Mankhwala a cell yogwira ntchito ali ofanana ndi insulin yamunthu wachilengedwe. Koma nthawi yomweyo, kuthamanga kwa njira yochiritsira ku NovoRapid Penfill ndikweza kwambiri.
Madzi a insulin amatengedwa kuchokera ku mafuta osakanizira a dermis akaperekedwa mofulumira komanso amakwaniritsa zotsatira za hypoglycemic nthawi yochepa kwambiri kuposa insulle ya munthu.
Pharmacokinetics
Ndi kukhazikitsidwa kwa NovoRapid subcutaneously, nthawi yofika pazambiri za plasma m'magazi imachepetsedwa nthawi 2 poyerekeza ndi insulin ya insulin. Ma maadili apamwamba amalembedwa mkati mwa mphindi 40 pambuyo pobayira jakisoni. The kuchuluka kwa insulin m'magazi amabwerera zake zoyambirira pambuyo 4-6 mawola mankhwala. Odwala omwe samadwala matenda a shuga omwe amadalira insulin, kuchuluka kwa mayamwidwe kumakhala kotsika, chifukwa chake nthawi yoti ifikire kuchuluka kwambiri kwa plasma insulin imafika mphindi 60.
Zizindikiro zogwiritsidwa ntchito
Mankhwalawa amagwiritsidwa ntchito kuti akwaniritse kuwongolera kwa glycemic komanso kuchepetsa matenda a shuga pamaso pa matenda amtundu 1 komanso matenda a shuga. Potsirizira pake, mankhwalawa amathandizidwa pokonzekera kukana kwathunthu kwa mankhwala amkamwa a hypoglycemic. Kukana pang'ono kumafuna kuphatikizidwa kwa NovoRapid mu mankhwala osakanikirana.
Mankhwala a NovoRapid ndi oletsedwa kwathunthu kwa ana osakwana zaka 2.
Mankhwalawa amagwiritsidwa ntchito ngati sikungatheke kupereka othandizira ena a hypoglycemic motsutsana ndi kukhazikika kwa matenda omwe amayambitsanso - njira yovuta yopanga mawonekedwe a yachiwiri.
Contraindication
Mankhwala ndi zoletsedwa pamaso pa hypoglycemia ndi kuchuluka kwa yogwira chigawo, ana osakwana zaka 2.
Ndi chisamaliro
Ndikulimbikitsidwa kusamala ndi anthu omwe ali ndi vuto lolakwika la chiwindi, pamaso pa neoplasms yoyipa, komanso kwa achikulire opitilira zaka 65.
Momwe mungatengere NovoRapid Penfill?
Mankhwalawa amaperekedwa mosavuta kapena m'mitsempha. Mlingo wa tsiku ndi tsiku wa NovoRapid umatsimikiziridwa ndi dokotala aliyense payekha malinga ndi kuchuluka kwa shuga ndi zofunikira za insulin tsiku lililonse. Ndikulimbikitsidwa kuti muphatikize mankhwalawa pophatikiza ndi mankhwala a hypoglycemic a nthawi yayitali kapena nthawi yayitali, omwe amatengedwa kamodzi patsiku.
Kuti mukwaniritse kuyang'anira glycemic koyenera, ndikofunikira kuyeza mayeso am'magazi a magazi, kutengera mtundu wa mankhwalawo.
Momwe mungapangire jakisoni?
Simungathe kulowa mankhwalawa intramuscularly. Ndikulimbikitsidwa kuti musinthe jekeseni ndi jekeseni aliyense kuti muchepetse zovuta zam'malo ndi zotupa.
Ndi chithandizo chokha, insulin imayang'aniridwa mosagwirizana. Kulowetsedwa kwa IV kumachitika moyang'aniridwa ndi katswiri wazachipatala. Kuti muchite jekeseni wa sc, ndikofunikira kutsatira algorithm yomwe yapangidwa kale:
- Ndikofunikira kugwira singano pansi pa khungu kwa masekondi osachepera 6 ndikanikizani batani loyambira (limamasulidwa mutachotsa singano). Njirayi imapereka kuperekera kwa 100% ya mlingo wa insulin ndipo imaletsa magazi kuti asalowe.
- Singano ndizongogwiritsa ntchito kamodzi. Mothandizidwa mobwerezabwereza insulin ndi singano imodzi, yankho limatulutsa kuchokera ku cartridge, chifukwa thupi limalandira mlingo woyenera wa mahomoni.
- Osadzazanso katoni.
Ndikulimbikitsidwa kuti nthawi zonse mumakhala ndi pobayira jakisoni wamphete ngati bokosi lamatayilo latayika kapena kuwonongeka.
Chithandizo cha matenda ashuga
Kufunika kwa insulin patsiku kwa odwala akuluakulu ndi ana kumasiyana kwa 0,5 mpaka 1 unit ya mankhwala pa 1 kg yolemera. Pogwiritsa ntchito mankhwalawa musanadye, thupi limalandira 50-70% ya mlingo wofunikira wa pancreatic hormone. Omwe amapangidwanso ndi thupi kapena mankhwala ena omwe amayamba kuchepa. Ndi kuwonjezeka kwa zolimbitsa thupi, kusintha kwa zakudya, kukhalapo kwa matenda achiwiri, kusintha kwa mlingo ndikofunikira.
Insulin aspart, mosiyana ndi insulin yaumunthu yosungunuka, imathamanga kwambiri komanso yochepa, motero mankhwalawa amalimbikitsidwa kuti aperekedwe asanadye. Chifukwa chochepa nthawi yochitapo kanthu, mwayi wa usiku hypoglycemia umachepetsedwa.
Kuti muthandizike pamitsempha yamagetsi, ndikofunikira kukonzekera dontho.
Kuti muthandizike pamitsempha yamagetsi, ndikofunikira kukonzekera dontho. Kukonzekera kwa kulowetsako kumakhala ndikuchepetsa 100 UNITS ya NovoRapid mu 0.9% isotonic yankho la Sodium chloride kotero kuti kuchuluka kwa insulini kumasiyana kuchokera pa 0.05 mpaka 1 UNITS / ml.
Zotsatira zoyipa NovoRapida Penfill
Zotsatira zoyipa zimayamba nthawi zambiri chifukwa cha regimen yolakwika. Kuti muchepetse chiopsezo cha hypoglycemia, ndikofunikira kusankha mtundu wa NovoRapid weniweni.
Kuchokera ku chitetezo chamthupi
Mwina mawonekedwe a urticaria, totupa pakhungu, anaphylactic zimachitika.
Pa gawo la kagayidwe ndi zakudya
Chiwopsezo chachikulu cha hypoglycemia ndi mlingo wosayenera.
Pakati mantha dongosolo
Nthawi zina, zotumphukira za mitsempha ya mitsempha zimachitika.
Pa mbali ya gawo la masomphenyawo
Zowonongeka zowonekera zimawonekera mu matenda okonzanso kapena kukula kwa matenda ashuga retinopathy.
Kuchokera ku kupuma
Nthawi zina, kupuma movutikira kumawonekera.
Pa khungu
Mwina kukula kwa lipodystrophy.
Matupi omaliza
Mwapadera, pali milandu yokhudzana ndi chifuwa, yomwe imayenda limodzi ndi totupa, kudzimbidwa, kuchuluka thukuta, edeme ya Quincke, tachycardia, hypotension. Zochita za Anaphylactoid zikuopseza wodwala.
Zokhudza mphamvu pakuwongolera njira
Ndi kuchepa kwa chiwongolero cha glycemic, limodzi ndi hypoglycemia kapena hyperglycemia, kuthekera kwambiri kwa zinthu kumalephera ndipo kuthamanga kwa mawonekedwe amatsika. Izi zimakhala zowopsa poyendetsa kapena kugwiritsa ntchito makina ovuta.
Kutenga NovoRapid Penfill kumakhala kowopsa poyendetsa.
Malangizo apadera
Ndi mlingo wotsika wa insulin kapena kusiya mankhwala, kukula kwa hypoglycemia ndi ketoacidosis ndikutheka motsutsana ndi kumbuyo kwa kuchuluka kwa ketone matupi ndi shuga m'magazi am'magazi, makamaka odwala omwe ali ndi vuto la matenda a shuga 1. Hyperglycemia imatha kuchitika pang'onopang'ono patatha sabata limodzi. Zizindikiro zoyambirira zakukula kwa matenda a pathological zidzakhala:
- kamwa yowuma
- kugona
- redness pakhungu;
- polyuria;
- njala yayikulu;
- kusanza, kusanza, ndi ludzu;
- kununkhira kwa acetone kuchokera mkamwa.
Chimodzi mwa ma pharmacokinetics a insulin yochepa ndikulimbikitsa kwambiri kukula kwa hypoglycemia, mosiyana ndi insulin yaumunthu.
Odwala omwe ali ndi vuto la chiwindi ndi impso, kuchuluka kwa mayamwidwe a insulin kumachepetsedwa.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
M'maphunziro azachipatala pazinyama, insulini aspart sanasonyeze embryotoxicity ndi teratogenicity. Popereka NovoRapid, amayi apakati amafunikira kuyang'anira kuchuluka kwa shuga m'magazi. Dokotala amayenera kuwunika momwe odwala aliri.
Mu trimester yoyamba yakukula kwa embryonic komanso nthawi yogwira ntchito, kufunika kwa insulini kumachepa, pomwe lachiwiri ndi lachitatu matenthedwe azida amawonjezeka.
Panthawi yoyamwitsa, ndikofunikira kusintha Mlingo wa insulin.
Kuyenderana ndi mowa
Ethanol imawonjezera mphamvu ya hypoglycemic ya insulin, motero, kumwa mowa munthawi ya mankhwala ndi koletsedwa. Mowa wa Ethyl umatha kubweretsa kukula kwa hypoglycemia ndi hypoglycemic coma.
Mankhwala ochulukirapo a NovoRapida Penfill
Hypoglycemia imayamba pang'onopang'ono motsutsana ndi maziko a kukhazikika kwa nthawi yayitali ya NovoRapid. Pankhaniyi, mlingo weniweni womwe ungayambitse chithunzi cha mankhwala osokoneza bongo sichinakhazikitsidwe, chifukwa dziko la hypoglycemic limadziwonetsa lokha malinga ndi zomwe wodwalayo ali nazo.
Wofatsa hypoglycemia, wodwalayo amatha kuthetsa yekha mwa kutenga zinthu zomwe zili ndi shuga wambiri kapena shuga mkati.
Hypoglycemia yayikulu imayendera limodzi ndi kusazindikira. Pankhaniyi, kugonekedwa kuchipatala, kuyambitsa intramuscularly kapena subcutaneally 0,5-1 mg wa glucagon. Kukhazikitsidwa kwa kulowetsedwa kwa shuga kumaloledwa. Ngati pambuyo pa mphindi 10-15 mutakhazikitsa Glucagon, chikumbumtima sichibwerera, muyenera kulowa mu 5% yankho la Dextrose. Mukabwezeretsa vutoli ndikudzutsa wodwalayo, ndikofunikira kupatsa wodwalayo chakudya ndi chakudya chochuluka. Izi ndizofunikira kupewa kuti zisayambenso.
Hypoglycemia yayikulu imayendera limodzi ndi kusazindikira.
Kuchita ndi mankhwala ena
Mankhwala ena amatha kupititsa patsogolo hypoglycemic ya NovoRapid:
- monoamine oxidase, ACE inhibitors, carbonic anhydrase inhibitors;
- mankhwala a lithiamu;
- osasankha beta-blockers;
- sulfonamides;
- Fenfluramine;
- okhala ndi ethanol ndi hypoglycemic;
- Bromocriptine;
- tetracycline mankhwala;
- Octreotide;
- Pyridoxine.
Kuchepa mphamvu kwa njira zochizira kumawonedwa ndi munthawi yomweyo ya NovoRapid ndi calcium njira blockers, diuretics, Heparin, antidepressants, glucocorticosteroids, Morphine, ndi othandizira okhala ndi mahomoni a chithokomiro.
Reserpine ndi salicylates zingayambitse kuchepa kwa glycemic control.
Kusuta chifukwa cha chikonga kumatha kuchepetsa zotsatira za hypoglycemic.
Mankhwala okhala ndi ziwengo ndi sulfite mukamayanjana ndi insulin amayambitsa kuwonongeka kwa otsirizawa.
Analogi
Ma analoguqu ake ndi mankhwala omwe ali ndi mankhwala ofanana a pharmacological amaphatikizapo:
- Actrapid;
- NovoRapid syringe cholembera;
- Apidra
- Biosulin;
- Gensulin;
- Insulin.
Kupita kwina mankhwala
Mankhwalawa amagulitsidwa pazifukwa zachipatala mwachindunji.
Kodi ndingagule popanda kulandira mankhwala?
Wothandizirana ndi glycemic, ngati agwiritsidwa ntchito molakwika, angayambitse hypoglycemia, yomwe imayamba kukhala kuphwanya kwa hypoglycemic. Matendawa ndi oopsa, chifukwa chake kugwiritsa ntchito mankhwalawa popanda mankhwala kuchipatala nkoletsedwa.
Mtengo wa NovoRapid Penfill
Mtengo wapakatikati wamakatoni ndi ma ruble 1850.
Zosungidwa zamankhwala
Ndikofunikira kusunga mankhwalawo pa kutentha kwa + 2 ... + 8 ° C. Ndikulimbikitsidwa kuti muzisunga mufiriji, koma osatha kuzizira. Makatoni amayenera kusungidwa pamatatoni kuti atetezedwe ndi dzuwa. Makatoni otseguka amasungidwa kutentha kwa + 15 ... + 30 ° C ndipo amagwiritsidwa ntchito kwa mwezi umodzi.
Mafuta a analogue akhoza kukhala mankhwala a Apidra.
Tsiku lotha ntchito
Miyezi 30
Wopanga
Novo Nordisk A / S, Denmark.
Ndemanga za NovoRapida Penfill
Mu nthawi yotsatsa itatha, insulin aspart idalimbikitsa zotsatira zake pamsika wa pharmacological, chifukwa chomwe pamakhala ndemanga zabwino kuchokera kwa odwala ndi madokotala omwe amapezeka pa intaneti.
Madokotala
Zinaida Siyuhova, endocrinologist, Moscow.
Mankhwalawa ali ndi njira yocheperako, yomwe imakupatsani mwayi kuti musalowe ndi mphindi 15 - 10 musanadye chakudya, komanso mukamadya komanso mukatha kudya. Kukwaniritsidwa mwachangu kwamankhwala othandizira ndikofunikira pazofunikira zadzidzidzi. Chifukwa cha insulin aspart, munthu yemwe ali ndi matenda a shuga a 2 kapena shuga wodalira insulin sangathe kuzolowera matenda, amasintha kadyedwe monga angafune.
Ignatov Konstantin, endocrinologist, Ryazan.
Monga zochita za insulin. M'mikhalidwe yovuta, zimathandiza kuchepetsa magazi.Nthawi yomweyo, wodwalayo ayenera kutsatira mlingo mosamalitsa malinga ndi malangizo, apo ayi chiopsezo chokhala ndi hypoglycemia chikuwonjezeka. Wodwalayo amatha kudzipatsa yekha kulowetsedwa mwa insulin.
Odwala
Artemy Nikolaev, wazaka 37, Krasnodar.
Ndili ndi matenda ashuga amtundu woyamba kuyambira ndili ndi zaka 18. Actrapid wamtengo, womwe sunathandize kukwaniritsa chiwongolero cha glycemic - shuga anakhalabe wokwera. Dotoloyu adalocha Actrapid ndi mankhwala ophatikiza ndi NovoRapid Penfill wocheperako komanso Levemir wakhalapo kwanthawi yayitali. NovoRapid amayenera thupi langa. Kuyamikira wopanga chifukwa cha insulin yabwino.
Sofia Krasilnikova, wazaka 24, Tomsk.
Ndakhala ndikugwiritsa ntchito makatiriji kwazaka zopitilira. Mlingo wa shuga nthawi zonse umakhala wolondola. Ikangotuluka, ndimabaya nthawi yomweyo. Kwa mphindi 10-15, amabwerera mwakale. Sindinazindikire zoterezi.
