Momwe mungagwiritsire ntchito mankhwala Zilt?

Zilt ndi mankhwala othandizira antiplatelet omwe amachedwa kuphatikizana kwa kuphatikizana kwa magazi. Akatswiri amaulembera odwala kuti ateteze matenda a thrombosis, stroko ndi mtima.

Dzinalo

Dzinalo Lachilatini ndi Zyllt. Mankhwala a INN: clopidogrel.

Zilt ndi mankhwala othandizira antiplatelet omwe amachedwa kuphatikizana kwa kuphatikizana kwa magazi.

ATX

B01AC04.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwalawa amapangidwa m'mapiritsi a 75 mg yogwira mankhwala (clopidogrel hydrosulfate). Zinthu zina ndi izi:

• MCC;
• propylene glycol;
• talc;
• utoto wachitsulo;
• pregelatinized osiyanasiyana wowuma;
• titanium dioxide;
• macrogol-6000;
• mawonekedwe amadzimadzi a lactose;
• hydrogenated castor mafuta;
• hypromellose.

Mankhwalawa amapangidwa m'mapiritsi a 75 mg yogwira mankhwala (clopidogrel hydrosulfate).

Mapiritsi amagulitsidwa m'matumba a 14, 28, 30, 56, 84 ndi 90 ma PC.

Zotsatira za pharmacological

Mankhwala ndi a gulu la mankhwala a clopidogrel. Amasankha mosavomerezeka kuti ADP iphatikizidwe ndi mapulateleti komanso kutsegulira kwina kwa GPIIb / IIIa tata (glycoprotein), yomwe imakwiyitsa kulepheretsa kuphatikizana kwa mapulateleti.

Njirayi imapitilira sabata 1-1.5. Metabolite yogwira imawoneka chifukwa cha kuyambitsa kwa CYP450 isoenzymes. Komabe, si wodwala aliyense yemwe ali ndi kutembenuka kokwanira, chifukwa ma isoenzymes ena amakhala ndi ma polymorphism, amasintha motsogozedwa ndi mankhwala ena, kapena ali ndi vuto lina la zoletsa ADP.

Mankhwala akuwonetsa mphamvu popewa zotsatira za atherothrombotic kwa odwala omwe amawonongeka chifukwa cha mitsempha yamagazi yamavuto osiyanasiyana, makamaka mu matenda amitsempha yamagazi, mafupa amitsempha yamagazi.

Mankhwala akuwonetsa mphamvu popewa zotsatira za atherothrombotic kwa odwala omwe amawonongeka chifukwa cha mitsempha yamagazi yamavuto osiyanasiyana.

Pharmacokinetics

Mankhwalawa amatengeka mwachangu pambuyo pakumwa pakamwa. Pazipita plasma ndende ya yogwira pophika zimatheka 40-45 mphindi mutamwa 75 mg.

Zigawo za mankhwala mkati mwa chiwindi zimapangidwa. Hafu ya moyo ndi pafupifupi maola 6. 46% ya mankhwalawa amachotsedwa m'matumbo, pomwe ena impso.

Zizindikiro zogwiritsidwa ntchito

Mankhwalawa amagwiritsidwa ntchito popewa zovuta za atherothrombotic mwa odwala akuluakulu omwe adapezeka ndi matendawa:

• myocardial infarction;
• ischemic stroke;
• matenda a mtima;
• occlusive ochepa matenda (zotumphukira);
• pachimake mawonekedwe a coronary syndrome (ndi kuchuluka kwa gawo la ST ndipo popanda iyo).

Mankhwalawa amagwiritsidwa ntchito mwa odwala omwe ali ndi vuto la misala.

Mankhwalawa amagwiritsidwa ntchito mwa odwala omwe ali ndi vuto la mtima.

Mankhwalawa amagwiritsidwa ntchito mwa odwala omwe ali ndi matenda a ischemic stroke.

Kuphatikiza apo, mankhwalawa amagwiritsidwa ntchito poletsa matenda a thromboembolic ndi atherothrombotic a atrial fibrillation, stroke.

Contraindication

• Hypersensitivity kwa zosakaniza za mankhwala;
• mimba ndi mkaka wa m`mawere;
• magazi (pachimake);
• kwambiri ndi pachimake hepatic matenda;
• zaka zosakwana 18;
• GGM syndrome, lactose tsankho, kusowa kwa lactase.

Zilt imaphatikizidwa mwa amayi apakati.

Zilt imaphatikizidwa kwa anthu omwe ali ndi hypersensitivity kwa zosakaniza za mankhwala.

Zilt imaphatikizidwa kwa anthu osakwana zaka 18.

Ndi chisamaliro

• Mavuto olimba a chiwindi;
• aimpso kuwonongeka;
• mikhalidwe momwe mungathe kutuluka magazi;
• kuphatikiza ndi Heparin, Warfarin ndi glycoprotein othandizira;
• tsankho kwa thienopyridines ena (Prazogrel, Ticlopidine, etc.).

Mosamala, mankhwalawa amatengedwa limodzi ndi glycoprotein zoletsa othandizira.

Lozap Plus imaphatikizidwa kwambiri kuwonongeka kwa impso.

Mosamala, mankhwalawa amatengedwa pamavuto olimbitsa thupi komanso ofatsa a chiwindi.

Kutenga Zilt?

Mankhwalawa amayenera kuledzera 1 nthawi patsiku. Chakudya sichimayendetsa ntchito komanso kuyamwa kwa mankhwalawa.

Ndi ischemia, myocardial infarction ndi occlusive ochepa kwamitsempha yamagazi, pafupifupi pakati ndi 75 mg (piritsi 1) kamodzi patsiku.

Kwa odwala omwe ali ndi fibrillation ya atgency, mankhwalawa amadziwitsidwa muyezo wa 75 mg. Mlingo wambiri watsiku ndi tsiku ndi 300 mg. Pankhaniyi, asidi acetylsalicylic nthawi zina amagwiritsidwa ntchito mopambanitsa.

Ngati mungadumphe kugwiritsa ntchito mlingo wotsatira wa mankhwalawo, mutha kumwa nawo pasanathe maola 12. Pambuyo pa izi, ma regimen a chithandizo sayenera kuphwanyidwa. Musamachulukitse mlingo.

Mankhwalawa amayenera kuledzera 1 nthawi patsiku.

Kumwa mankhwala a shuga

Ngati muli ndi matenda ashuga, muyenera kumakambirana ndi katswiri wa zamankhwala musanamwe mankhwalawo.

Kutenga nthawi yayitali bwanji?

Kutalika kwa mankhwalawa sikuyenera kupitirira chaka chimodzi.

Zotsatira zoyipa

Mankhwala amatha kuyambitsa zosafunikira. Ngati izi zikuwonekera, muyenera kufunsa dokotala.

Matumbo

• kupweteka pamimba;
• kutsegula m'mimba ndi kudzimbidwa;
• mitengo;
• kapamba
• magazi m'magazi am'mimba (retroperitoneal hemorrhage);
• nseru
• kusanza
• dyspepsia.

Zotsatira zoyipa kuchokera m'mimba thirakiti ndi m'mimba.

Zotsatira zoyipa kuchokera m'matumbo am'mimba ndikusanza.

Zotsatira zoyipa za m'mimba thirakiti: kukokosera kwa chifuwa cham'mimba.

Hematopoietic ziwalo

• leukopenia;
• kuchepa magazi
• agranulocytosis;
• granulocytopenia;
• thrombocytopenia;
• neutropenia (nthawi zina).

Pakati mantha dongosolo

• mutu
• malungo
• kuzindikira kolakwika;
• kuyang'anira ndi kuwonera;
• Chizungulire
• kugwedezeka.

Zotsatira zoyipa za chapakati mantha dongosolo: chizungulire.

Zotsatira zoyipa za chapakati mantha dongosolo: kusazindikira bwino.

Zotsatira zoyipa kuchokera ku dongosolo lamanjenje lam'mutu ndizakumutu.

Kuchokera kwamikodzo

• glomerulonephritis (nthawi zina);
• hematuria;
• aimpso kuwonongeka;
• kuchuluka plasma creatinine ndende.

Kuchokera ku kupuma

• magazi ochokera pamphuno;
• katulutsidwe a ntchofu ndi magazi kuchokera kupuma thirakiti;
• mawonekedwe a chibayo;
• spasms bronchial.

Zotsatira zoyipa zimatha kukhala mtundu wa chibayo.

Zotsatira zoyipa za kupuma zimatha kukhala ma sponms.

Zotsatira zoyipa za kupuma ndi magazi kuchokera pamphuno.

Pa mbali ya gawo la masomphenyawo

• kuchepa kumveka kwa kuzindikira;
• kuchuluka kwapakati pa intraocular;
• masomphenya apawiri.

Pa mbali ya chiwindi ndi biliary thirakiti

• Kuchulukitsa kulephera ndi chiwindi china chothina;
• chiwindi.

Kuchokera minofu ndi mafupa

• kukoka kwa minofu;
• hemarthrosis;
• myalgia;
• arthralgia;
• nyamakazi.

Zotsatira zoyipa kuchokera ku minculoskeletal ndi minofu yolumikizana: nyamakazi.

Zotsatira zoyipa kuchokera ku minculoskeletal ndi minofu yolumikizana: arthralgia.

Zotsatira zoyipa kuchokera ku minofu ndi mafupa.

Kuphatikiza apo, zimapangitsa anaphylactoid zimachitika pakumwa mapiritsi.

Malangizo apadera

Odwala omwe akhala akuchita zowagwirira ntchito ndikuchita opaleshoni amafunika kuwunika mosamala akumwa mankhwalawo kuti apewe zovuta chifukwa chotuluka mwadzidzidzi magazi.

Mankhwala amathandizira kutalika kwa magazi. Chifukwa chake, amalembedwa mosamala kwa odwala omwe ali pachiwopsezo chachikulu chotere.

Musanagwire ntchito yomwe munakonzekera, ngati antiplatelet zochita sikofunikira, mankhwalawa ayenera kusiyidwa osachepera masiku asanu ndi limodzi ndi asanu ndi mmodzi asanachitike opareshoni. Izi zimaphatikizapo njira zamano.

Kuyenderana ndi mowa

Kuphatikizidwa kwa mankhwalawa ndi mowa kumatha kusokoneza mtima, kusintha kwa tachycardia ndi bradycardia. Chifukwa chake, ndi mankhwala osokoneza bongo, kuphatikiza koteroko kuyenera kupewedwa.

Kuphatikizidwa kwa mankhwalawa ndi mowa kumatha kusokoneza mtima, kusintha kwa tachycardia ndi bradycardia.

Zokhudza mphamvu pakuwongolera njira

Mankhwala alibe phindu lililonse pa kuyendetsa galimoto ndi zochitika zomwe zimafunikira kuti anthu amve mwachangu komanso chisamaliro.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Munthawi ya bere, mankhwalawa amawonetsedwa pokhapokha ngati phindu lomwe likuyembekezeka limaposa zoopsa zomwe zingachitike.

Mukamayamwa ndi kumwa mankhwalawa, kuyamwitsa kuyenera kutayidwa.

Kukhazikitsidwa kwa Zilt kwa ana

Mankhwalawa sanapangidwire zochizira odwala ochepa.

Gwiritsani ntchito mu ukalamba

Kwa odwala okalamba, mlingo sasinthidwa. Komabe, ayenera kutaya muyeso wokweza.

Kwa odwala okalamba, mlingo sasinthidwa.

Bongo

Mu Mlingo wambiri, mankhwalawa angayambitse kuchuluka kwa kutalika kwa magazi ndi zotupa za hemorrhagic. Kuti athetse vuto la wozunzidwayo, kuikidwa magazi kumaundana ndi mankhwala. Mankhwala alibe mankhwala.

Kuchita ndi mankhwala ena

Sikoyenera kuphatikiza mankhwalawa ndi anticoagulants pamlomo chifukwa choopsa cha kuchuluka kwa magazi.

Zimatanthawuza zomwe zimalepheretsa ntchito za pampu ya proton kukhala ndi mphamvu yochepa pa isoenzyme CYP2C19 - Lansoprazole ndi Pantoprazole. Amatha kuphatikizidwa ndi mankhwalawo omwe amafunsidwa.

Yogwira pophika mankhwala sizikhudza pharmacokinetic katundu wa warfarin. Koma kuphatikiza koteroko kumawonjezera mwayi wokhetsa magazi chifukwa cha kuwonongeka kwa magazi.

Mankhwala akaphatikizidwa ndi Theophylline ndi Digoxin, ma pharmacokinetics awo sasintha.

Ndi bwino kupewa kugwiritsa ntchito nthawi yomweyo ndi omeprazole.

Sikoyenera kuphatikiza mankhwalawa ndi anticoagulants pamlomo chifukwa choopsa cha kuchuluka kwa magazi.

Analogi

• Aterocardium;
• Areplex;
• Agrel;
• Brilinta;
• Deplatt;
• Avix;
• Diloxolum;
• Jendogrel;
• Clopact;
• Klopigrel.

Kupita kwina mankhwala

Kodi ndingagule popanda kulandira mankhwala?

Mankhwala sangatheke popanda kulandira mankhwala.

Mtengo Wopanda

Mtengo wa mankhwalawa umayambira pa ma ruble 120 a mapiritsi 14 a 75 mg a chinthu chogwiritsidwa ntchito pabokosi la makatoni.

Mankhwala sangatheke popanda kulandira mankhwala.

Zosungidwa zamankhwala

Ndikofunika kusunga mankhwalawo pamtunda wosaposa + 20 ° C, pamalo abwino komanso owuma pomwe dzuwa sililowa.

Tsiku lotha ntchito

Miyezi 24.

Ndemanga za Sylt

Madokotala

Igor Kvashnin (wochiritsa), wazaka 40, Barnaul.

Wothandizira komanso wamphamvu kuchokera pagulu la antiplatelet agents. Zinthu zomwe zimagwiritsidwa ntchito pakupangika kwake zimatha kuchepetsa AT. Gwiritsani ntchito mapiritsiwa pazifukwa zachipatala komanso mogwirizana ndi malangizo a dokotala. Ngati izi zikanyalanyazidwa, ndiye kuti munthu angakumane ndi zovuta komanso zovuta zina.

Odwala

Anton Wigman, wazaka 45, Moscow.

Kwa zaka zambiri akuvutika ndi angina pectoris. Pafupifupi zaka 3 zapitazo ndidakhala ndikuluma. Pambuyo pa njirayi, ndimamwa piritsi limodzi la mankhwalawa tsiku lililonse. Posachedwa omwe adachita mayeso, adotowo sanaulule zakuphwanya kulikonse, m'malo mwake, adawonetsa kuwongolera kwakukulu. Thanzi lake lidakulirakonso, ndipo ziwopsezo za angina sizidonekanso.

Vladimir Dubov, wazaka 47, Lipetsk.

Ndidadabwitsidwa kwambiri ndi ukadaulo wa akatswiri mu chipatala chathu omwe adazindikira mwachangu momwe ndilili ndisanalowe matenda ndikuwapulumutsa moyo wanga. Ndidayenera kupita kwa madotolo pafupifupi miyezi 12. Dokotala wamtimayu wandichenjeza za kuopsa kogwiritsa ntchito mankhwalawa ndikulimbikitsa kugwiritsa ntchito mankhwalawa chifukwa amadziwika bwino ndi thupi ndipo nthawi zambiri samakwiyitsa. Tsopano ziwiya zanga ndi mitsempha ndizabwinobwino.