Ma Bacteriostatic maantibayotiki amagwiritsidwa ntchito mosiyanasiyana m'magulu osiyanasiyana azachipatala pochiza matenda omwe alibe. Mankhwalawa amapereka chithandizo chokwanira kwambiri ngakhale kuti thupi limateteza bwanji mwachilengedwe. Amikacin ali m'gulu la III m'badwo aminoglycosides, kugwiritsidwa ntchito komwe kumaloledwa ku matenda a kupuma, impso, genitourinary system, khungu ndi minofu yofewa. Mankhwalawa ayenera kugwiritsidwa ntchito pazolinga zake komanso malinga ndi chiwembu chosankhidwa payekha. Matenda omwe angakhalepo ndi zoyipa zimasonyezedwa muzowonjezera.
Dzinalo Losayenerana
Maina omwe siali eni ake kapena dzina la gulu ndi Amikacin.
Amikacin ali m'gulu la III m'badwo aminoglycosides, kugwiritsidwa ntchito komwe kumaloledwa ku matenda a kupuma, impso, genitourinary system, khungu ndi minofu yofewa.
Ath
Mankhwalawa ali ndi nambala ya ATX ya J01GB06 ndi nambala yolembetsa ya LSR-002156/09. Tsiku lokhala manambala - 03.20.09.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwala amagulitsidwa monga njira yothetsera jakisoni ndi lyophilisate. Mu kapangidwe ka mtundu uliwonse wamasulidwe mumakhala zinthu zina zapadera chifukwa chofunikira chothandizira. Mothandizirana, amatha kugawidwa m'magulu awiri: othandizira komanso othandiza.
Ufa
Lyophilisate ndi ufa wa zoyera, wosakonda chikasu, kulocha, kusungunuka mosavuta m'madzi. Zimapitilira kugulitsa m'mabotolo agalasi owonekera. Khosi limatsekedwa mwamphamvu ndi chipewa cha mphira. Chingwe cha foil chilipo.
Kuphatikizika kwa gawo lalikulu la lyophilisate ndi 500 mg. Amikacin 500 simalumikizana ndi zinthu zothandizira zinthu ngati okhazikika, chifukwa chosapezeka. Ufa umapitilira kugulitsidwa m'mabokosi amakatoni, mkati mwake mumakhala mabotolo 5 okhala ndi lyophilisate ndi malangizo ogwiritsira ntchito.
Njira Zothetsera
Mosiyana ndi lyophilisate, zinthu zothandizira zilipo mu yankho la jakisoni. Zomwe zili pazinthu zazikulu (amikacin) ndizotsika 2 - zosaposa 250 mg. Zowonjezera zotsatirazi zikuwonetsedwa mu malangizo omwe mungagwiritse ntchito:
- sodium pyrosulfite;
- mchere wa sodium wa citric acid;
- madzi a jakisoni;
- sulfuric acid (khazikika).
Njira yothetsera vutoli imakhala ya utoto kapena yowonekera kwathunthu. Pakupenyerera, palibe ma zakunja achilendo amene ayenera kupezeka m'madzi. Kukula, ngakhale kocheperako, kulibe. Njira yothirayo imathiridwa m'mbale zamagalasi, kuchuluka kwake komwe sikoposa 4 ml. Phukusi lam'manja lili ndi ma ampoules ochokera ku 5 mpaka 10 ndipo limagulitsidwa pabokosi lamatoni.
Zotsatira za pharmacological
Mankhwala olimbana ndi ma cell omwe ali m'gulu la peninsimate aminoglycosides ali ndi mphamvu yoteteza bacteria. Chomwe chimagwira ntchito pakupanga mtundu uliwonse wa mankhwalawa imatha kulowa mkati mwa cell ya michere ya pathogenic ndikuchepetsa kuchepa kwa mapuloteni.
Anti-wodziwika bwino ma antiotic ali m'gulu la peninimate aminoglycosides.
Mankhwala osokoneza bongo omwe ali mgululi amagwira ntchito motsutsana ndi tizilombo toyambitsa matenda angapo a pathologies omwe amakhudza ziwalo zamkati ndi minofu yofewa. Zochita zimawonedwa pokhudzana ndi tizilombo tina tosavomerezeka ta gramu komanso gramu. Mndandanda wa mabakiteriya osagwirizana ndi gramu:
- Providencia stuartii;
- Salmonella spp;
- Serratia spp;
- Enterobacter spp;
- Shigella spp;
- Escherichia coli;
- Pseudomonas aeruginosa;
- Klebsiella spp.
Mabakiteriya okhala ndi gramu, zomwe zimakhala zovulaza Amikacin:
- Streptococcus spp;
- Staphylococcus spp.
Mabakiteriya ambiri a anaerobic ndi mankhwala osokoneza bongo:
- Bacillus aerothermophilus;
- Bacillus coagulans;
- Candida lipolytica;
- Clostridium butyricum;
- Monilia Mycobacterium;
- Saccharomyces cerevisiae.
Pokhudzana ndi mabakiteriya okhala ndi gramu, mankhwalawa ndiwothandiza.
Pharmacokinetics
Mtundu uliwonse wa mlingo umalowetsedwa mwachangu m'magazi, mosasamala kanthu za kayendetsedwe ka kayendetsedwe. Pankhaniyi, kuchuluka kwambiri mu seramu ya magazi kumatha kutsimikiziridwa pambuyo maola 1-1,5 pambuyo pa ntchito koyamba. Mapuloteni a magazi amagwirizanitsidwa pang'ono ndi chinthu chogwira (zosaposa 10%). Imagona zotchinga za placental ndi BBB. Pazinthu zochepa zomwe zimakhala mkaka wa m'mawere.
The yogwira thunthu pambuyo ingestion sasintha. Amachoka kwathunthu m'thupi m'maola asanu ndi limodzi ndi asanu ndi limodzi, atachotsedwa ndi impso ndi mkodzo. Kuchotsa kumachitika osasinthika.
Chithandizo chogwira ntchito pambuyo polowa m'thupi sichisintha, koma chimachoka kwathunthu m'thupi kwa maola asanu ndi limodzi ndi asanu ndi limodzi, atachotseredwa kudzera impso ndi mkodzo.
Zizindikiro zogwiritsidwa ntchito
Chifukwa cha kuthekera kwa mankhwalawo kukhala ndi bacteriostatic kwambiri mthupi, kugwiritsidwa ntchito kwake kumachitika pozindikira wodwala yemwe ali ndi matenda osachiritsika. Chofunikira chachikulu pakumwa mankhwala ndi kupezeka kwa tizilombo toyambitsa matenda omwe amapezeka m'thupi la wodwalayo.
Zisonyezo zogwiritsa ntchito maantibayotiki:
- matenda a m'munsi ndi chapamwamba kupuma ziwalo (chibayo, pleural kupweteka, pachimake bronchitis, tonsillitis, pharyngitis, sinusitis);
- endocarditis ya matenda etiology;
- sepsis
- zotupa mu ubongo, kuphatikizapo meningitis;
- matenda a mafupa (osteomyelitis);
- kutupa mu ziwalo za m'chiuno (cystitis, urethritis);
- peritonitis ndi zina m'mimba matenda;
- zotupa pakhungu ndi matenda ena opatsirana a dermis (dermatitis, eczema).
Kutulutsa kwamtundu uliwonse kumaloledwa kugwiritsidwa ntchito munthawi yokonzanso pambuyo pakuchita opareshoni. Izi zimachepetsa chiopsezo cha matenda opweteka.
Contraindication
Aliyense mankhwala aminoglycoside ali ndi zotsutsana zingapo. Wodwalayo ayenera kuchenjeza adokotala pasadakhale kuti ali ndi vuto loti siligwirizana chifukwa cha zomwe ali ndi hypersensitivity (ngati alipo). Kugwiritsa ntchito mtundu uliwonse wa Mlingo wa prophylactic ndi mankhwala othandizira sikovomerezeka ngati wodwala azindikiritsa izi:
- yotupa njira ya wamva magazi;
- kwambiri aimpso kuwonongeka.
Nthawi yobala mwana, yotenga komanso yokhala ndi tsankho kwa munthu payekhapayekha (pulayimale ndi sekondale) monga mbali yamtundu uliwonse wamasulidwe imawerengedwa ngati milandu.
Momwe mungatenge Amikacin 500
Anti-sipekitiramu yothandizira imapangidwira makonzedwe amkati ndi mu mnofu. Mlingo wa makonzedwe a pakamwa sakusankhidwa ndi wopanga. Chiyeso choyambirira cha momwe matendawo angayambire pamafunika. Mlingo watsiku ndi tsiku umadalira thupi la wodwalayo.
Mlingo wapamwamba wa tsiku ndi tsiku kwa odwala akuluakulu ndi 15 mg / kg. Kwa ana akhanda ndi ana mpaka miyezi 12, njira ya kuchiritsi ndi 7.5-10 mg / kg. Malangizo ogwiritsira ntchito amaperekanso magawidwe a tsiku ndi tsiku kangapo. Njira yakugwiritsira ntchito mtundu uliwonse wa kumasulidwa nthawi zambiri ndi masiku 10. Pokhapokha pakuchitika zochizira pambuyo pa masiku 4-5 ogwiritsidwa ntchito pafupipafupi, mankhwala ochepetsa mphamvu ya mabakiteriya ayenera kuyimitsidwa ndikuwonetseratu koyenera kwa analogue.
Zomwe ndi kubereketsa
Lyophilisate imasungunulidwa ndi madzi a jakisoni. Novocaine, lidocaine sagwiritsidwa ntchito pazolinga izi. Chojambulacho ndi choyimira chopondera chimabayidwa ndi singano, zomwe zili mu syringe (madzi osungunuka) zimayambitsidwa pang'onopang'ono mu botolo la ufa. Chombocho chimagwedezeka mwamphamvu kwa masekondi 20-30 mpaka lyophilisate itasungunuka kwathunthu.
Kumwa mankhwala a shuga
Odwala omwe ali ndi matenda osokoneza bongo angafunike kusintha njira chifukwa mankhwalawa samagwirizana ndi mankhwala onse a hypoglycemic. Kuchiza ndi bwino kuyamba ndi theka.
Zotsatira zoyipa za Amikacin 500
Zotsatira zoyipa zimaphatikizapo zovuta zilizonse zomwe zimagwiritsidwa ntchito pakugwiritsa ntchito lyophilisate ndi jakisoni. Amawonedwa kuchokera:
- m'mimba thirakiti;
- dongosolo lamagazi;
- chapakati mantha dongosolo;
- kwamikodzo thirakiti ndi dongosolo la urogenital.
Wodwalayo amatha kuwonekera pakhungu lake.
Matumbo
Wodwalayo ali ndi kutsegula kwa magazi a chiwindi, kusanza, mseru, komanso kuchuluka kwa bilirubin m'magazi.
Hematopoietic ziwalo
Zotsatira zoyipa zimawonetsedwa mu mawonekedwe a leukopenia, kuchepa magazi, thrombocytopenia ndi granulocytopenia.
Pakati mantha dongosolo
Kuchokera kumbali yamanjenje yapakati pamakhala mutu, kugona, kusamva kwakanthawi, kumva misempha.
Pa gawo la hemopoietic ziwalo, mavuto akuwoneka mwa leukopenia, kuchepa magazi, thrombocytopenia ndi granulocytopenia.
Kuchokera ku genitourinary system
Pankhaniyi, wodwala amawoneka oliguria, crystalluria, proteinuria, mkhutu waimpso.
Matupi omaliza
Thupi lawo siligwirizana pa mankhwala opha maantibayotiki limawonekera ngati mawonekedwe totupa pakhungu, kusefukira kwa khungu, kumva koyaka ndi kuyabwa.
Zokhudza mphamvu pakuwongolera njira
Chifukwa chakuti kumbuyo kwa kugwiritsa ntchito pafupipafupi, kugona kungawoneke, muyenera kukana kuyendetsa galimoto ndi njira zina zoyendera.
Malangizo apadera
Kusamala ndikofunikira kwa anthu omwe ali ndi matenda a Parkinson. Zoyenera kudziwa kupezeka kwa creatinine ziyenera kuchitika pafupipafupi. Odwala omwe ali ndi vuto la chiwindi angafunike kusintha njira. Ndi zosavomerezeka zowonjezera zochiritsika zololedwa, chiopsezo chokhala ndi ototoxic ndi neurotoxic zotsatira zimawonjezeka.
Chifukwa chakuti kumbuyo kwa kugwiritsa ntchito pafupipafupi, kugona kungawoneke, muyenera kukana kuyendetsa galimoto ndi njira zina zoyendera.
Popanda chidziwitso chokwanira kwa wodwalayo, kudziyimira pawokha komanso kulowerera kwa antibayotiki ndikosavomerezeka. Potere, jakisoni amaperekedwa kuchipatala. Urinalosis ndi kugwiritsa ntchito mankhwalawa kwa nthawi yayitali mwina ndi yabodza.
Gwiritsani ntchito mu ukalamba
Odwala okalamba ayenera kugwiritsa ntchito mankhwala othana ndi mankhwalawa malinga ndi malangizo. Rimage regimen imasinthidwa ndikuchepa kwake. Kuyang'anira akatswiri ndikofunikira.
Kupangira Amikacin kwa ana 500
Mankhwalawo alibe zoletsa zaka. Kugwiritsa ntchito mankhwalawa kumachitika molingana ndi chiwembu chomwe chimasankhidwa.
Odwala okalamba ayenera kugwiritsa ntchito mankhwala othana ndi mankhwalawa malinga ndi malangizo.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Pankhaniyi, kugwiritsa ntchito mosamala ndikofunikira. Intramuscular management imakondedwa.
Mankhwala ochulukirapo a Amikacin 500
Kuchulukana kwambirimbiri kwakanthawi kovomerezeka kwamankhwala kumakhala kofupikika ndi kukula kwa zizindikiro za bongo. Izi zimaphatikizapo ludzu lakuya, kutulutsa mkodzo mkatikati, kupumira mwachangu, chisokonezo, kumva pang'ono pang'ono, kuona pang'ono, komanso kudontha.
Kuchiza kuyenera kukhala chizindikiro. Hemodialysis imagwira ntchito. Kugwiritsa ntchito kwamakina mpweya wabwino ndikotheka.
Kuchita ndi mankhwala ena
The munthawi yomweyo aminoglycoside ndi mankhwala ena amagwirizana ndi madokotala.
Kuphatikiza kophatikizidwa
Zowopsa za antibayotiki zitha kupitilizidwa ndi mankhwala awa:
- ascorbic acid;
- b mavitamini;
- ma penicillin maantibayotiki.
Kugwiritsa ntchito pamodzi mankhwala omwe ali pamwambawa ndi koletsedwa.
Osavomerezeka kuphatikiza
Ethacrine acid, Cisplatin, Furosemide osakanikirana ndi mankhwala antimicrobial amatha kuyambitsa mphamvu yotupa. Sikulimbikitsidwa kuphatikiza mankhwalawa.
Kuphatikiza komwe kumafunikira kusamala
Chithandizo cha bacteriostatic chitha kuphatikizidwa ndi mankhwala ena:
- Methoxyflurane;
- Cyclosporine;
- Vancomycin.
Kuphatikiza kuyenera kusamala.
Ndi zoletsedwa kumwa mowa panthawi yamankhwala ndikumwa mankhwala oletsa kuponderezana.
Kuyenderana ndi mowa
Ethanol amapezeka mu zakumwa zoledzeretsa, zomwe kuphatikiza ndi amikacin kumatha kubweretsa kupuma. Ndi zoletsedwa kumwa mowa panthawi yamankhwala ndikumwa mankhwala oletsa kuponderezana.
Analogi
Zotsalira zambiri zimapezeka mwanjira ya ma lyophilisates ndi njira zovomerezeka. Aminoglycosides samatenga bwino chimbudzi, motero makapisozi, mapiritsi ndi zotayira sizikugulitsidwa. Ma Analogs akuphatikizapo:
- Loricacin. Aminoglycoside mibadwo itatu, yogwira motsutsana ndi zingapo zama gram-hasi ndi gram zabwino. Amapezeka mu mawonekedwe a jakisoni njira. Amatengedwa ngati njira zochizira matenda opatsirana komanso otupa a ziwalo zamkati. Mtengo - kuchokera ku ma ruble 24.
- Flexelitis. Mndandanda wapafupi kwambiri wapachiyambi, womwe ndi gawo lalikulu la amikacin. Njira yothetsera jakisoni idapangidwa kuti imitsetse misempha ndi mafupa. Ili ndi katundu wa bacteria. Mtengo - kuchokera ma ruble 45.
- Amikacin-Kredofarm. Zoyala m'malo mwa choyambirira. Chofunikira chachikulu ndi amikacin sulfate ndi 250 mg. Mtengo umayambira ku ma ruble 48.
Ma Analogs, ngati mankhwala oyambitsidwa, ndi mankhwala. Mankhwala aliwonse amakhala ndi zotsutsana.
Njira yothetsera jakisoni ndi lyophilisate iyenera kusungidwa pamalo otetezeka ana, kutali ndi moto ndikuwotcha dzuwa pamawonekedwe osaposa +25 ° C.
Kupita kwina mankhwala
Tchuthi chotsatsa. Chinsinsicho chidalembedwa mchilatini.
Mtengo wa Amikacin 500
Mankhwala ali mu mankhwala 34-75 ma ruble. (kutengera malo oyambira).
Zosungidwa zamankhwala
Njira yothetsera jakisoni ndi lyophilisate iyenera kusungidwa pamalo otetezeka ana, kutali ndi moto ndikuwotcha dzuwa pamawonekedwe osaposa +25 ° C.
Tsiku lotha ntchito
Osapitirira miyezi 36 kuchokera tsiku lopangira.
Wopanga
KRASFARMA OJSC, SINTEZ OJSC, Russia.
Ndemanga za Amikacin 500
Svetlana Aksionova, katswiri wamkulu, Yekaterinburg
Mankhwalawa amagwiritsidwa ntchito m'magawo ambiri azachipatala ngati wothandizira antimicrobial. Imalekereredwa bwino ndi odwala. Asanaikidwe, ndimafunsa mafunso ndi odwala zokhudzana ndi contraindication, pakuzindikiritsa komwe sindimaphatikizira mankhwalawa popanga mankhwala.
Zotsatira zoyipa sizimawonedwa nthawi zambiri. Zotsatira za thupi lawo zimapezeka mu 16% ya odwala. Ma antihistamines amathandizira kutulutsa, kuyabwa ndi kuwawa, ngakhale atamasulidwa bwanji. Kuphatikiza kumasankhidwa ndi dokotala wopezekapo.
Valentin, wazaka 36, mzinda wa St.
Zaka zingapo zapitazo anapezeka ndi matenda a shuga, ndipo amakakamizidwa kumwa mankhwala a hypoglycemic pafupipafupi. Kuntchito, adazizira kwambiri, sanayambire chithandizo panthawi ndipo "adapeza" bronchitis. Kunali kuguguda pachifuwa, kuzunza koopsa, kupuma kunali kovuta. Ndinaganiza zokaonana ndi dokotala.
Matendawa adathandizidwa ndi maantibayotiki amphamvu. Amikacin zopezeka ndi mankhwala, mu mawonekedwe a ufa pokonzekera njira. Analipira mankhwalawa kawiri pa tsiku kwa 1 ampoule. Zotsatira zoyipa sizinawonekere, kunalibe zovuta.
