Metformin ndi njira yothandiza yolimbana ndi shuga wamagazi ambiri. Kuphatikiza pa kukonza mankhwalawa kwa odwala matenda ashuga, mankhwalawa amagwiritsidwa ntchito mwakhama kuchepetsa thupi. Katunduyu ndi wa gulu la Biguanides. Pali maphunziro angapo omwe amatsimikizira kuti, kuwonjezera pa malo ake a hypoglycemic, metformin hydrochloride imathandiza kuchepetsa chiopsezo cha khansa ya kapamba.
Dzinalo Losayenerana
Metformin.
Metformin ndi njira yothandiza yolimbana ndi shuga wamagazi ambiri.
ATX
A10BA02.
Kutulutsa mafomu ndi kapangidwe kake
Metformin Zentiva imapezeka m'mapiritsi okhala ndi filimu. The yogwira pophika mankhwala ndi metformin hydrochloride mu kuchuluka kwa:
- 500 mg;
- 850 mg;
- 1000 mg
Zotsatira za pharmacological
Zotsatira zazikulu za Metformin ndikuchepa kwa plasma glucose. Komabe, sizimalimbikitsa kupanga insulin, chifukwa cha ichi palibe chiopsezo cha hypoglycemia.
Achire zotsatira za mankhwalawa ndi chifukwa amatha kuyambitsa zotumphukira zolandilira, kukulitsa chidwi chawo ndi insulin. Kuphatikiza apo, metformin:
- amalepheretsa njira ya kupanga shuga m'magazi;
- amalepheretsa mayamwidwe a shuga m'matumbo;
- imathandizira kugwiritsidwa ntchito kwa shuga mkati ndi glycogen synthesis;
- kumawonjezera kuchuluka kwa shuga m'magulu amtundu wam'mimba;
- imayendetsa mafuta kagayidwe, kuchepetsa zomwe triglycerides, otsika osalimba lipoproteins ndi okwanira mafuta m'thupi.
Zotsatira zazikulu za Metformin ndikuchepa kwa plasma glucose. Komabe, sizimalimbikitsa kupanga insulin, chifukwa cha ichi palibe chiopsezo cha hypoglycemia.
Pharmacokinetics
Kumwa mankhwala pa chopanda kanthu m'mimba imathandizira kukwaniritsa pachimake mu ndende ya yogwira magazi m'magazi am'magazi. Izi sizikumanga m'mapuloteni amwazi, zimagawidwanso chimodzimodzi. Mpaka 20-30% ya mankhwalawa amamuchotsa m'matumbo, ena - ndi impso.
Zomwe zimayikidwa
Kuvomerezedwa kwa mankhwalawa kumasonyezedwa kwa mtundu wachiwiri wa matenda osokoneza bongo, makamaka zovuta kunenepa. Chifukwa chakutha kukonza njira za metabolic, mankhwalawa ndi chida chothandiza kuthana ndi kunenepa kwambiri.
Kugwiritsidwa ntchito kwa Trental 100 kumathandizira kutsegulira kwa magazi ndi kukonza mkhalidwe wamitsempha yamagazi.
Mu njira yotupa kuchokera ku mabakiteriya, mapiritsi a Gentamicin amagwiritsidwa ntchito. Werengani zambiri apa.
Mankhwala Victoza: malangizo ntchito.
Contraindication
Kumwa mankhwalawa ndi contraindised mu:
- kuchuluka kwa magawo ake;
- matenda ashuga ketoacidosis;
- matenda a shuga ndi chikomokere;
- olephera kapena aimpso kulephera;
- kuchepa madzi m'thupi ndi zinthu zina zomwe zingayambitse vuto laimpso;
- kulephera kupuma ndi zina zomwe zimayambitsa minyewa hypoxia;
- lactic acidosis;
- chiwindi kuwonongeka ntchito, pachimake kuledzera;
- uchidakwa komanso kugwiritsa ntchito mankhwala osokoneza bongo;
- mimba
- kuperewera kwa kalori (kudya zakudya zosakwana 1000 kcal / tsiku);
- kuchita opareshoni kapena maphunziro omwe amagwiritsa ntchito chinthu cha radiopaque.
Metformin akuwonetsedwa ngati mtundu wa 2 matenda a shuga, makamaka ovuta kunenepa.
Ndi chisamaliro
Mu milandu yotsatirayi, kugwiritsa ntchito mankhwalawa ndikovomerezeka, koma mkhalidwe wa wodwalayo uyenera kuyang'aniridwa ndi dokotala:
- nthawi ya mkaka wa m`mawere;
- zaka zopitilira 60;
- kulimbitsa thupi;
- zolimbitsa thupi aimpso.
Kuti muchepetse kunenepa, ndikofunikira kutenga Metformin katatu pa tsiku 500 mg kapena 2 kawiri pa tsiku pa 850 mg kwa masabata atatu.
Momwe mungatenge Metformin Zentiva
Asanadye kapena pambuyo chakudya
Ngakhale kuti akumwa pamimba yopanda kanthu, metformin hydrochloride imakamizidwa kwambiri, ndikofunikira kumwa mapiritsi pambuyo chakudya kapena pakudya. Kupanda kutero, chiopsezo chokhala ndi zizindikiro za dyspeptic chimachuluka.
Kuchepetsa thupi
Kuti muchepetse kunenepa, ndikofunikira kumwa mankhwalawa katatu patsiku 500 mg kapena 2 pa tsiku kwa 850 mg kwa masabata atatu. Pambuyo pa izi, yopuma pafupifupi mwezi umodzi uyenera kutengedwa.
Ndikofunikira kuti Metformin yokha isamayendetse kuchepa kwa thupi, chinthu choyambirira ndichakudya cham'mbuyo chamankhwala omwe amapezeka ndi mankhwalawa.
Ndi matenda ashuga
Mlingo woyambirira woperekedwa ndi wopanga matenda a shuga a 2 ndi piritsi limodzi lokhala ndi 500 mg ya metformin katatu patsiku. Kuchulukitsa kwa mankhwalawa kumatheka pambuyo masiku 10-15. Lingaliro loti muwonjezere liyenera kukhazikitsidwa pazotsatira za kuyezetsa magazi kwa shuga. Mulingo wovomerezeka wa tsiku ndi tsiku ndi 3 g, muyezo wowonjezera wowerengeka ndi 1.5-2 g. Kuchulukanso pang'onopang'ono kwa kuchuluka kwa mankhwalawo ndikugawika pawiri Mlingo wofunikira kuti muchepetse kusokonezeka kwa njira yogwirira ntchito.
Mlingo wophatikizira wa insulin umasankhidwa payekhapayekha kuti azikhala wathithithi shuga. Kuchuluka kwa Metformin kumakhalabe chimodzimodzi ndi monotherapy
Mlingo wophatikizira wa insulin umasankhidwa payekhapayekha kuti azikhala wathithithi shuga.
Zotsatira zoyipa za Metformin Zentiva
Mukamatenga Metformin, kupotoza kwamankhwala kosangalatsa ndikotheka, komanso:
- hepatitis;
- encephalopathy;
- hypomagnesemia;
- kuchepa magazi.
Kuphatikiza apo, chiwonetsero chomwe chimakhala chowoneka cha zoyipa zosiyanasiyana zamthupi.
Matumbo
Pa gawo loyamba la chithandizo nthawi zambiri kumachitika:
- nseru
- kutsegula m'mimba
- kupweteka kwam'mimba
- kuchepa kwamtima.
Zizindikiro izi nthawi zambiri zimazimiririka zokha pamene thupi lizolowera mankhwalawo.
Pa khungu
Nthawi zambiri sizingachitike:
- urticaria;
- erythema;
- kuyabwa
- kuchuluka kwa chidwi pakuwala.
Kuchokera kumbali ya kagayidwe
Nthawi zina, kukula kwa lactic acidosis komanso kuyamwa kwa vitamini B12 ndikotheka, komwe kumatha kuyambitsa kupuma kwa neuropathy.
Dongosolo la Endocrine
Mukamatenga Metformin, kuchepa kwa kuchuluka kwa mphamvu ya chithokomiro mu plasma ndikotheka.
Matupi omaliza
Thupi lawo siligwirizana limatha kukhala ngati zotupa pakhungu.
Zokhudza mphamvu pakuwongolera njira
Metformin monotherapy sikukhudza kuthekera koongolera njira. Mukatengedwa molumikizana ndi ma hypolytics ena, kukulitsa kwa hypoglycemia ndikotheka, zomwe zimayambitsa kuwonongeka mu ndende ndikuvuta pakugwiritsa ntchito njira.
Metformin monotherapy sikukhudza kuthekera koongolera njira.
Malangizo apadera
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Ngakhale kupezeka kwa umboni kuti mankhwala omwe ali ndi mankhwalawa samachulukitsa chiopsezo chakuchulukitsidwa kwa mwana wosabadwayo, amayi apakati amawonetsedwa kuti adye insulin.
Metformin hydrochloride imatha kudutsa mkaka wa m'mawere; palibe chidziwitso chodalirika chokhudza chitetezo chatsopano cha akhanda. Chifukwa chake, ngati kuli kotheka, ndikulimbikitsidwa kusiya kudya.
Kulembera Metformin Zentiva kwa ana
Ndi matenda a shuga a mellitus otsimikizika, onse monotherapy komanso kuphatikiza ndi insulin amaloledwa kwa ana ndi achinyamata. Mlingo woyambira komanso wowona ndi wofanana ndi omwe akulimbikitsidwa kwa akuluakulu. Pafupipafupi komanso chikhalidwe cha zoyipa zoyambitsidwa ndi mankhwalawa ndizosagwirizana ndi zaka.
Gwiritsani ntchito mu ukalamba
Mu ukalamba, chiopsezo chokhala ndi kulephera kwa impso, komwe kumatha kukhala asymptomatic, chikuwonjezeka. Chifukwa chake, ndikofunikira kusankha mankhwalawa ndikuwachitira chithandizo pafupipafupi, kuwunika momwe gululi limagwirira ntchito.
Mu ukalamba, chiopsezo chokhala ndi kulephera kwa impso, komwe kumatha kukhala asymptomatic, chikuwonjezeka.
The ntchito aimpso kuwonongeka
Mlingo wovomerezeka waukulu ndi 1 g patsiku. Ndi chithandizo cha Metformin, chilolezo cha creatinine chizilamuliridwa mpaka kanayi pachaka
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Malinga ndi malangizo a wopanga, mankhwalawa amadziphimba kuti agwiritse ntchito ngati chiwindi chayamba kugwira ntchito. Ngakhale kupezeka kwa chidziwitso kuti Metformin imatha kukonza vutoli ndi kuchepa kwamafuta a chiwalo ichi, zitha kutengedwa pokhapokha pokhapokha atakambirana ndi hepatologist.
Mankhwala ochulukirapo a Metformin Zentiva
Mankhwala osokoneza bongo a metformin hydrochloride angayambitse kukulitsa kwa zinthu monga lactic acidosis ndi kapamba. Zikaonekera, mankhwalawo ayenera kusiyidwa. Pochotsa mwachangu zomwe zimachitika m'thupi, hemodialysis akuwonetsedwa. Syndrome dalili zimalimbikitsidwanso.
Mankhwala osokoneza bongo a metformin hydrochloride angayambitse kukulitsa kwa zinthu monga lactic acidosis ndi kapamba.
Kuchita ndi mankhwala ena
Kuphatikiza ndi ayodini wokhala ndi zinthu za radiopaque ndizotsutsana. Munthawi ya mankhwala ndi Metformin, makonzedwe a mankhwala omwe ali ndi ethyl mowa sasankhidwa. Kuyang'anira bwino shuga ndi / kapena ntchito yaimpso ndikofunikira mukaphatikizidwa ndi zinthu monga:
- Danazole;
- Chlorpromazine;
- glucocorticosteroids;
- okodzetsa;
- estrogens ndi mahomoni a chithokomiro;
- bta2-adrenomimetics mu mawonekedwe a jakisoni;
- mankhwala opangidwa kuti achepetse kuthamanga kwa magazi, kupatula ACE inhibitors;
- aracbose;
- zotumphukira sulfonylurea;
- salicylates;
- Nifedipine;
- Mao zoletsa;
- Ibuprofen ndi ena NSAID
- Morphine ndi mankhwala ena a cationic.
Kugwiritsa ntchito limodzi ndi mankhwalawa kungafune kuti musinthe mlingo wa Metformin.
Kuphatikiza apo, Metformin imachepetsa mphamvu ya Fenprocumone mankhwala.
Munthawi ya mankhwala ndi Metformin, makonzedwe a mankhwala omwe ali ndi ethyl mowa sasankhidwa.
Kuyenderana ndi mowa
Zomwe zimagwiritsidwa ntchito mankhwalawa sizigwirizana ndi ethanol.
Analogi
Analog ndi mankhwala aliwonse okhala ndi metformin hydrochloride kuchokera kwa opanga osiyanasiyana, monga:
- A George Richter;
- Izvarino Pharma;
- Akrikhin;
- LLC "Merk";
- Canon Pharma Production.
Mankhwala osokoneza bongo amatha kukhala ndi mayina osiyanasiyana ogulitsa, mwachitsanzo Glucofage kapena Siofor.
Kodi pali kusiyana kotani pakati pa Metformin ndi Metformin Zentiva
Kusiyana pakati pa Metformin Zentiva ndi Metformin ndi kampani yamapiritsi. Palibe kusiyana muyezo kapena mankhwala.
Kupita kwina mankhwala
Mankhwalawa ndi mankhwala, ndipo chofunika kuti amasulidwe ku mankhwala azisamba ayenera kukhala mankhwala, momwe, malinga ndi malamulowo, dzinalo limawonetsedwa m'Chilatini.
Kodi ndingagule popanda kulandira mankhwala?
Kugulitsa mankhwalawa osagwiritsa ntchito mankhwala ndikuphwanya, komabe, mankhwala ena azamankhwala pamfundoyi amakhala ndi makasitomala.
Mtengo wa Metformin Zentiva
Mtengo wa mankhwala aliwonse umatengera ndondomeko yamapulogalamu yomwe amagula. Mumafakitale opezeka pa intaneti, mitengo zotsatirazi:
- Ma PC 60. 1 g iliyonse - ma ruble 136.8;
- Ma PC 60. 0,85 g iliyonse - ma ruble 162.7;
- Ma PC 60. 1 g iliyonse - ruble 192.4.
Zosungidwa zamankhwala
Mankhwalawa safuna kuti pakhale zochitika zapadera. Mutha kuyisunga pamalo aliwonse osakwaniritsidwa ndi ana.
Tsiku lotha ntchito
Zaka zitatu
Wopanga
Kampani yopanga mankhwala ku Russia Sanofi.
Ndemanga za Metformin Zentiva
Madokotala
A Galina, a endocrinologist wa ana, wazaka 25, ku Moscow: "Ubwino wabwino wa Metformin ndikuti ndi koyenera kuthandizanso mwana. Choyambirira ndikudziwitsanso matenda musanayambe mankhwala."
Svetlana, endocrinologist, wazaka 47, Tyumen: "Ndikuganiza kuti Metformin ndiwothandiza kugwiritsira ntchito mankhwala a hypoglycemic. Komabe, ngakhale kutchuka kwake ngati njira yochepetsera thupi, ndikukhulupirira kuti mankhwalawa amayenera kumwa okhawo omwe amapezeka ndi matenda a shuga, ndipo ndibwino kuchepa thupi mothandizidwa ndi masewera komanso zakudya. "
Kuchepetsa thupi
Gulnaz, wazaka 26, a Kazan: "Katswiri wazakudya adalangiza kugwiritsa ntchito mankhwala omwe ali ndi Metformin kuti achepetse chidwi cha chakudya. Analimbikitsa kugula zogulitsa za wopanga uyu, kuti amakhulupirira kuti anali ndi mbiri komanso mbiri yake. Ndine wokondwa kuti ndinatsatira upangiri wake. Kufunika kwa chakudya kunachepa kwambiri. Sindinazindikire mankhwalawo. "
Venus, wazaka 37, Sterlitamak: "Matenda a Metformin adakulitsa kuchepa kwa thupi. Komabe, kuwonjezera pa kutaya mtima komwe kumachitika, palinso zotsatira zoyipa monga nseru."
