Insulin aspart ndi insulin yotsika mtengo yochepa yomwe imapezeka pogwiritsa ntchito njira zamtundu wa biotechnology ndi genetic. Amapangidwa ndi mitundu yosinthika ya Saccharomyces cerevisiae yisiti, yomwe imalimidwa pazolinga izi. Mankhwalawa amachepetsa shuga la magazi kwa odwala omwe ali ndi matenda amtundu woyamba, pomwe samayambitsa matupi awo komanso sachepetsa chitetezo cha m'thupi.
Mfundo yogwira ntchito
Mankhwalawa amamangirira ku insulin receptors mu adipose minofu ndi minofu minofu. Mlingo wa glucose m'magazi umachepetsedwa chifukwa minofu imatha kuyamwa kwambiri glucose, kuwonjezera apo, imalowa bwino m'maselo, pomwe kuchuluka kwa mapangidwe ake mu chiwindi, mosiyana, kumachepa. Ntchito yogawa mafuta m'thupi imakulirakulira komanso imathandizira kapangidwe ka mapuloteni.
Kuchita kwa mankhwalawa kumayamba pakadutsa mphindi 10 mpaka 20, ndipo kuchuluka kwake kwakukulu m'magazi kumadziwika pambuyo pa maola 1-3 (izi ndi maulendo awiri mwachangu poyerekeza ndi mahomoni amunthu wamba) Insulin yokhayo yotere imakhala yogulitsidwa pansi pa dzina la malonda la NovoRapid (pambali pake, palinso gawo la insulini lachiwiri, lomwe limasiyana pakapangidwe kake).
Biphasic insulin
Biphasic insulin aspart ili ndi mfundo imodzimodziyo yamatenda amthupi. Kusiyana kwake ndikuti imakhala ndi insulin yocheperako (kwenikweni aspart) ndi mahomoni ocheperako (protamine-insulin aspart). Kuwerengera kwa ma insulin mu mankhwalawa kuli motere: 30% ndi mahomoni othamanga ndipo 70% ndi mtundu wanthawi yayitali.
Mphamvu yayikulu ya mankhwalawa imayamba nthawi yomweyo pambuyo pakupita (mkati mwa mphindi 10), ndipo 70% ya mankhwala ena onse amapanga insulin pansi pa khungu. Amamasulidwa pang'onopang'ono ndikuchita pafupifupi maola 24.
Mankhwala osakanikirawa amapezeka pansi pa dzina la Novomix. Palibe fanizo mwachindunji la mankhwalawa, koma pali mankhwala ofanana ndi omwe achitapo kanthu
Palinso chithandizo chomwe chimagwirira ntchito mwachidule insulini (aspart) ndi mahomoni okhala ndi mphamvu yayitali kwambiri (degludec). Dzina lake lamalonda ndi Ryzodeg. Mankhwalawa, monga insulin iliyonse yofanana, imatha kuperekedwa pang'onopang'ono, kusinthanso malo a jakisoni (pofuna kupewa kukula kwa lipodystrophy). Kutalika kwa mankhwala mu gawo lachiwiri mpaka masiku awiri mpaka atatu.
Ngati wodwala nthawi zambiri amafunikira kubayitsa mitundu yosiyanasiyana ya mahomoni, ndiye kuti ndikofunikira kwambiri kuti agwiritse ntchito magawo awiri a insulin. Izi zimachepetsa kuchuluka kwa jakisoni ndikuthandizira kuyendetsa bwino glycemia. Koma ndi endocrinologist wokhayo amene angasankhe njira yolondola yochokera pazotsatira za kusanthula ndi kusanthula deta.
Ubwino ndi zoyipa
Insulin aspart (biphasic ndi single-gawo) imasiyana pang'ono ndi insulin wamba ya anthu. Mwanjira inayake, amino acid proline imasinthidwa mmalo mwake ndi aspartic acid (yomwe imadziwikanso kuti aspartate). Izi zimangotukula mphamvu za mahomoni ndipo sizikugwirizana mwanjira iliyonse kulekerera kwake bwino, ntchito komanso kutsika pang'ono. Chifukwa cha kusinthaku, mankhwalawa amayamba kugwira ntchito mwachangu kwambiri kuposa mawonekedwe ake.
Mwa zovuta za mankhwala omwe ali ndi mtunduwu wa insulin, ndizotheka kudziwa, ngakhale sizimachitika kawirikawiri, komabe zovuta zina zoyipa.
Amatha kudziwonetsa okha:
- kutupa ndi ululu pamalo a jekeseni;
- lipodystrophy;
- zotupa pakhungu;
- khungu louma;
- thupi lawo siligwirizana.
Izi insulini (gawo limodzi) lingathe kutumikiridwa osati kokha, komanso kudzera m'mitsempha. Koma izi zimayenera kuchitika kokha ndi akatswiri oyenerera kuchipatala
Contraindication
Mitundu ya insulin + tebuloContraindication kugwiritsa ntchito mankhwalawa munthu tsankho, chifuwa ndi magazi ochepa (hypoglycemia). Palibenso maphunziro owongoleredwa okhudza kugwiritsidwa ntchito kwa insulini iyi panthawi yoyembekezera komanso pakubala. Kuyesera kwanyama kwawoneka kwawonetsa kuti mu Mlingo womwe sunapitirire zomwe analimbikitsa, mankhwalawa amakhudza thupi chimodzimodzi ndi insulin yaumunthu wamba.
Nthawi yomweyo, pamene kutumikiridwa mlingo kudaposa nthawi 4-8 mwa nyama, zolakwika zimawonedwa koyambirira, kukulira kwa kusokonezeka kwa kubereka kwa ana ndi mavuto omwe amabwera pambuyo pake mtsogolo.
Sizikudziwika ngati mankhwalawa amalowera mkaka wa m'mawere, chifukwa chake sichikulimbikitsidwa kuti azimayi aziyamwitsa panthawi ya chithandizo. Ngati wodwala panthawi yoyembekezera afunika kubaya insulin, ndiye kuti mankhwalawo amasankhidwa nthawi zonse poyerekeza ndi mapindu omwe mayi amakhala nawo komanso zoopsa zake kwa mwana wosabadwayo.
Monga lamulo, kumayambiriro kwa kubereka, kufunika kwa insulin kumachepa kwambiri, ndipo chachiwiri ndi chachitatu, mankhwala angafunikenso. Ndi matenda a shuga, chida ichi sichikugwiritsidwa ntchito. Mulimonsemo, osati kokha endocrinologist, komanso katswiri wowonera-gynecologist amayenera kupereka mankhwala omwewo kwa mayi wapakati.
Homoni wamtunduwu nthawi zambiri umaloledwa bwino ndi odwala, ndipo zoyipa zake zimagwiritsidwa ntchito kawirikawiri.
Mankhwala osiyanasiyana omwe ali ndi mayina osiyanasiyana ogulitsa kutengera momwe amalola kuti musankhe jekeseni woyenera wodwala aliyense payekhapayekha. Pochita ndi mankhwalawa, ndikofunikira kuti muwone ma regimen omwe adokotala amawalimbikitsa kuti asayiwale za zakudya, masewera olimbitsa thupi komanso moyo wathanzi.
