Biosynthetic insulin Humulin: mtengo wa mitundu yosiyanasiyana ya kumasulidwa kwa mankhwalawo komanso zovuta zomwe amagwiritsa ntchito

Pamaso pa matenda a shuga a shuga chifukwa chosakwanira kupanga mahomoni a kapamba ndi thupi lanu, muyenera kupeza m'malo mwake.

Chifukwa chaichi, insulin imagwiritsidwa ntchito, mawonekedwe ake omwe ali pafupi kwambiri ndi anthu. Chimodzi mwa izi ndi Humulin.

Ndi phata la biosynthetic lomwe ndi loyenera kwa thupi la munthu. Monga lamulo, madokotala amapereka mankhwala kwa odwala omwe ali ndi endocrine matenda.

Ndikofunikira kukhalabe ndi shuga mu magazi seramu. Mankhwalawa ali ndi mitundu ingapo yomwe imasiyana pakapita nthawi.

Humulin, mtengo womwe umapezeka kwa aliyense, ndi woyenera kukhazikika kwa zomwe wodwalayo ali nazo. Amawerengedwa kuti azithandizira azimayi onyamula mwana wosabadwa yemwe ali ndi matenda a shuga. Dziwani zambiri za mankhwalawa m'nkhaniyi.

Kutulutsa Fomu

Ndikofunikira kudziwa kuti insulin yachilengedwe yogwiritsira ntchito biamynthetic imagwira ntchito ngati mankhwala. Mankhwala amamasulidwa mu mawonekedwe a kuyimitsidwa kwa jakisoni ndi yankho lapadera la jakisoni. Mitundu iyi imatha kukhala muma cartridge, komanso mabotolo.

Insulin Humulin N

Wopanga

Choyamba muyenera kudziwa kuti ndi ndani yemwe akuwonetsa insulin? Chithandizo cha anthu omwe ali ndi mitundu iwiri yonseyo ya shuga sichingakhale chokwanira popanda analogue ya munthu. Zimafunikira kuti shuga ikhale m'magazi m'malo oyenera.

Mankhwala ena amagwiritsidwa ntchito pokonzanso wodwala omwe ali ndi matendawa. Ponena za maiko opanga, nthawi zambiri pamakhala atatu kapena anayi a iwo. Popeza pali mitundu ingapo ya mankhwalawa, iliyonse imapangidwa m'maiko osiyanasiyana.

Pakadali pano, mitundu yotsatirayi ya mankhwala omwe amafunsidwa amaperekedwa mumafakisi:

1. Humulin NPH (USA, France);
2. Humulin MZ (France);
3. Humulin L (USA);
4. Humulin Regular (France);
5. Humulin M2 20/80 (USA).

Zokonzekera zonse za insulin zakumwambazi (zotupa za pancreatic) zimakhala ndi mphamvu ya hypoglycemic (hypoglycemic). Mankhwalawa adapangidwa pamaziko a insulin yaumunthu.

Chochita chachikulu cha Humulin ndikuchepetsa kuchuluka kwa shuga mu seramu yamagazi. Chifukwa chake, mankhwalawa amapereka shuga wambiri pogwiritsa ntchito minyewa ndipo amawaphatikiza ndi zochita za metabolic zomwe zimachitika m'maselo a thupi.

Kutengera njira yakukonzekeretsa komanso njira yake, insulin iliyonse imakhala ndi zake, zomwe zimathandizidwanso poika chithandizo chapadera. Kuphatikiza pazomwe zimagwira ntchito kwambiri (insulin, yoyesedwa m'mayunitsi apadziko lonse - ME), mankhwalawa onse amaphatikiza mankhwala ena ophatikizika.

Monga lamulo, zosakaniza monga protamine sulfate, phenol, zinc chloride, glycerin, metacresol, sodium hydrogen phosphate, sodium hydroxide, hydrochloric acid, madzi a jakisoni ndi ena akhoza kuphatikizidwa mu mtundu uliwonse wa Humulin.

Mankhwalawa amathandiza kukwaniritsa zabwino kuchokera ku mankhwala. Izi ndichifukwa choti imatha kupanga kuperewera kwathunthu kapena pang'ono pang'ono kwa mphamvu ya insulin.

Nthawi zambiri kuikidwa kwa insulin yotchedwa Humulin kumakhala moyo wonse. Kwa nthawi yayitali imafotokozedwa pamaso pa matenda a shuga 1.

Nthawi zina (ndimatenda ophatikizika omwe amapezeka mu mawonekedwe owopsa kapena osachiritsika, komanso kuwonongeka pakulimbana ndi matenda ashuga ndi matenda amtundu wachiwiri), tikulimbikitsidwa kugwiritsa ntchito njira yochiritsira mosiyanasiyana.

Musaiwale kuti matenda ashuga amafunika kukhala mahomoni opanga ma pancreas.

Ichi ndichifukwa chake kukana kwake kumatha kukhala ndi zotsatira zosasintha pa thanzi la munthu.

Pakadali pano, omwe amagwiritsidwa ntchito kwambiri pamankhwala awa ndi mitundu monga Humulin Regular ndi Humulin NPH.

Kulongedza

Kutengera ndi mitundu, mankhwalawa Humulin angagulidwe motere:

1. NPH. Imapezeka ngati kuyimitsidwa kwa kayendetsedwe ka subcutaneous, 100 IU / ml. Amadzaza mabotolo 10 ml m'magalasi osalowerera. Iliyonse ya iwo ili ndi katoni. Mankhwala amtunduwu amaphatikizidwanso m'mabokosi atatu a galasi yomweyo. Asanu mwa awa ayikidwa mu chithuza. Iliyonse ya iyo ili ndi ma CD apadera;
2. MH. Imapezeka mu mitundu yotulutsira iyi: kuyimitsidwa kwa jakisoni (3 ml) m'matumba apadera, kuyimitsidwa (10 ml) m'mbale, njira ya jekeseni (3 ml) m'makalata, yankho (10 ml) mu mbale;
3. L. Kuyimitsidwa kwa jekeseni 40 IU / ml kapena 100 IU / ml mu botolo la 10 ml, lomwe limayikidwa mu paketi ya makatoni;
4. Nthawi zonse. Momwemonso kwa chimodzi cham'mbuyomu, chimapangidwira mu mlingo, 1 ml yomwe muli 40 PISCES kapena 100 PISCES;
5. M2 20/80. Kuyimitsidwa kwa jakisoni kuli pafupifupi 40 kapena 100 IU / ml recombinant insulin ya anthu. Mankhwalawa amapezeka m'mabotolo ndi ma cartridge.

Mtengo

Zokhudza mtengo wake, mtundu uliwonse wa mankhwalawo womwe umaganiziridwa uli ndi mtengo wake.

Ngati mwatsatanetsatane, ndiye kuti mndandanda wa mtengo wa Humulin ndi motere:

1. NPH - kutengera mlingo, mtengo wamba ndi ma ruble 200;
2. MH - mtengo wokwanira umasiyanasiyana 300 mpaka 600 ma ruble;
3. L - mkati mwa ma ruble 400;
4. Nthawi zonse - mpaka ma ruble 200;
5. M2 20/80 - kuchokera ku ma ruble 170.

Njira yogwiritsira ntchito

Humulin nthawi zambiri imayendetsedwa mwanjira yoti idutse dongosolo la chimbudzi. Nthawi zambiri amapatsidwa jakisoni wamkati kapena wofikira.

Malinga ndi malamulo omwe alipo, wodwala wa endocrinologist ayenera kupita ku maphunziro apadera, mwachitsanzo, ku "sukulu ya shuga".

Kuchuluka kwa mankhwalawa kwa tsiku lililonse, ndi madokotala okha omwe ayenera kusankha. Mlingo wosankhidwa ungasiyane malingana ndi mtundu wa masewera olimbitsa thupi komanso zakudya. Ndikofunikira kwambiri kuti wodwala wa endocrinologist nthawi yomweyo azilamulira kuchuluka kwa glycemia.

Madokotala ati Humulin ikhoza kugwiritsidwa ntchito ndi ana. Inde, ngati glycemia imayendetsedwa panthawi yogwiritsa ntchito. Okalamba amafunika kuwunika mosamala momwe ziwalo zamagetsi zimakhalira. Monga lamulo, kwa odwala otere, madokotala amapatsidwa mankhwala ochepa.

Pa nthawi yoyembekezera, mankhwalawa amathanso kugwiritsidwa ntchito. Mankhwala ochulukirapo otengera insulin, yofanana ndi anthu, amaloledwa kugwiritsidwa ntchito poyamwitsa.

Zotsatira zoyipa

Humulin yamitundu yosiyanasiyana ili ndi zovuta zomwezo, zomwe zalembedwa m'malangizo ake.

Choyipa chachikulu ndichakuti kulowetsa insulin ya anthu kumatha kudzetsa lipodystrophy (pamalo omwe jakisoni idapangidwira).

Ngakhale odwala omwe ali ndi endocrinologists, motsutsana ndi kugwiritsa ntchito mankhwalawa, kukana insulini, chifuwa, kuchepa kwa potaziyamu m'magazi, ndi kuwonongeka kowonekera kumadziwika.

Thupi lawo siligwirizana angayambitse osati mahomoni a kapamba, koma ndi zina mankhwala.

Contraindication

Mankhwala omwe akufunsidwa ndi mankhwalawa amathandizira odwala matenda a shuga.

Ndikofunikira kusamala kwambiri, makamaka ngati hypoglycemia imawonedwa (shuga m'magazi).

Mankhwala ena amaletsedwa kugwiritsidwa ntchito pamaso pa tsankho la munthu aliyense (chifukwa maonekedwe amisala sangathe). Akatswiri amaletsa kumwa mowa pa nthawi ya mankhwalawa. Izi ndichifukwa choti kusintha kwamphamvu kwamagazi kumachitika.

Makanema okhudzana nawo

Pakugwiritsa ntchito kukonzekera Humalog, Novorapid, Lantus, Humulin R, Insuman-Rapid ndi Actrapid-MS wa mtundu woyamba wa shuga:

Nkhaniyi imawerengera mahomoni a kapamba omwe adachokera koyambira, omwe amafanana ndi insulin yaumunthu - Humulin. Iyenera kutengedwa pokhapokha ngati adayikidwa ndi dokotala pamaziko a kafukufuku.

Kugwiritsa ntchito mankhwalawa mosavomerezeka sikusiyidwa konse, chifukwa mawonekedwe osafunikira a thupi amatha kuonedwa. Kuphatikiza apo, mankhwalawa sagawidwa m'mafakisoni popanda mankhwala kuchokera kwa dokotala wothandizira.