Hyperinsulinism ndi matenda omwe amapezeka mwa mtundu wa hypoglycemia, omwe ndiwowonjezera pazachilendo kapena kuwonjezeka kwathunthu kwa insulin m'magazi.
Kuchuluka kwa timadzi timeneti kumapangitsa kuchuluka kwa shuga, komwe kumapangitsa kuti shuga achepetse, komanso kumayambitsa kuperewera kwa mpweya waubongo, komwe kumayambitsa kuphwanya kwamanjenje.
Zochitika ndi zizindikiro
Matendawa amafala kwambiri mwa akazi ndipo amapezeka azaka za 26 mpaka 55. Kuukira kwa hypoglycemia, monga lamulo, kumawonekera m'mawa pambuyo pothamanga mokwanira. Matendawa amatha kuthandizika ndikuwonekera nthawi yomweyo patsiku, mutatha kumwa chakudya.
Sikuti kusala kudya kwanthawi yayitali kumayambitsa matenda a hyperinsulinism. Zina zofunika pakuwonetsa matendawa zimatha kukhala zochitika zosiyanasiyana zolimbitsa thupi komanso zokumana nazo m'maganizo. Mwa akazi, zizindikiro zobwereza za matendawa zimachitika pokhapokha ngati nthawi yotsala isanakwane.
Zizindikiro za Hyperinsulinism zili ndi izi:
- kumangokhalira kumva njala;
- thukuta;
- kufooka kwathunthu;
- tachycardia;
- womvera
- paresthesia;
- diplopia;
- kumverera kosawerengeka kwamantha;
- kusokonezeka kwa malingaliro;
- kugwedezeka kwa manja ndi miyendo yanjenjemera;
- zochita zosakhudzidwa;
- dysarthria.
Komabe, zizindikirazi ndi zoyambira, ndipo ngati simungazichiritse ndikupitiliza kunyalanyaza matendawa, zotsatira zake zimakhala zokulirapo.
Mtheradi hyperinsulinism imawonetsedwa ndi zizindikiro zotsatirazi:
- kulephera kwadzidzidzi;
- chikomokere ndi hypothermia;
- chikomokere ndi hyporeflexia;
- tonic kukokana;
- kukokana kwamankhwala.
Zovuta ngati izi zimachitika pambuyo poti mwadzidzidzi watha kuzindikira.
Asanayambe kuukira, zizindikiro zotsatirazi zimawonekera:
- utachepetsa kukumbukira;
- kusakhazikika mtima;
- kusayanja kwathunthu kwa ena;
- kutayika kwa maluso aukadaulo;
- paresthesia;
- Zizindikiro za kuperewera kwa piramidi;
- zamatsenga.
Zomwe zimachitika
Zomwe zimayambitsa hyperinsulinism mwa akulu ndi ana zimagawidwa m'njira ziwiri zamatendawa:
- kapamba. Matenda amtunduwu amakhala ndi hyperinsulinemia yokwanira. Amapezeka mu zilonda zonse komanso chosaopsa neoplasms, komanso pancreatic beta cell hyperplasia;
- osakhala kapamba. Matenda amtunduwu amachititsa kuchuluka kwa insulini.
Mawonekedwe osapindika amapezeka mumikhalidwe yotere:
- matenda endocrine. Amatsogolera kutsika kwa mahomoni a contrainsulin;
- chiwindi kuwonongeka kwa zosiyanasiyana etiologies. Matenda a chiwindi amatsogolera kutsika kwa milingo ya glycogen, komanso kusokoneza njira zama metabolic ndipo zimagwirizanitsidwa ndi kukula kwa hypoglycemia;
- kusowa kwa micherezomwe zimakhudzidwa mwachindunji ndi njira zomwe zimayambitsa matenda a shuga. Zimatengera hyperinsulinism;
- kudya mankhwala osafunikiraCholinga chofuna kuchepetsa kuchuluka kwa shuga mu shuga. Zitha kuyambitsa hypoglycemia;
- mavuto azakudya. Vutoli limaphatikizapo: nthawi yayitali yanjala, kuchepa kwamadzi ndi glucose (chifukwa cha kusanza, mkaka wa m'mimba, kutsekula m'mimba), kuwonjezera zolimbitsa thupi osadya zakudya zam'thupi, zomwe zimayambitsa kuchepa msanga m'magazi, kudya zakudya zopatsa mphamvu zambiri , yomwe imachulukitsa shuga.
Pathogenesis
Glucose mwina ndiye gawo lofunikira kwambiri lazinthu zam'madzi zamagetsi amkati ndikuwonetsetsa momwe ubongo umagwirira ntchito moyenera.
Hypoglycemia ikhoza kuyambitsa zoletsa za metabolic komanso njira zamagetsi.
Chifukwa chophwanya machitidwe a redox mthupi, kuchepa kwa kugwiritsa ntchito kwa okosijeni ndi maselo a chithokomiro chotupa, komwe kumayambitsa hypoxia.
Hypoxia ya ubongo yowonetsedwa ngati: kuchuluka kugona, kusamva bwino ndi kuletsa. Mtsogolomo, chifukwa cha kuchepa kwa glucose, pali kuphwanya njira zonse za metabolic mthupi la munthu, komanso kuwonjezeka kwakukulu kwa magazi kupita ku ubongo, kupindika kwa zotumphukira za m'mitsempha kumachitika, komwe nthawi zambiri kumayambitsa vuto la mtima.
Gulu la matenda
Hyperinsulinism syndrome imatchulidwa potengera zomwe zimachitika:- choyambirira. Ndizotsatira za chotupa, kapena hyperplasia ya maselo a beta ya islet zida za kapamba. Chifukwa cha kuchuluka kwakukulu kwa insulin, ma benign neoplasms amapangidwa, ndipo nthawi zina ovulaza nawonso amawoneka. Ndi hyperinsulinemia yayikulu, nthawi zambiri pamakhala kuukira kwa hypoglycemia. Mbali yodziwika ndi kuchepa kwa shuga m'magazi, omwe nthawi zambiri amalumikizidwa ndi kudumpha chakudya;
- sekondale. Ndi kuchepa kwamahomoni olimbana ndi mahomoni. Zomwe zimayambitsa matenda a hypoglycemia ndi: kusala kudya kwa nthawi yayitali, kuchuluka kwa mankhwala osokoneza bongo a hypoglycemic, kulimbitsa thupi kwakukulu, kugwedezeka kwa psychoemotional. Kuchulukitsa kwa matendawa kumatha kuchitika, komabe, sikukugwirizana ndi chakudya cham'mawa.
Mavuto
Zoyambirira zimachitika pakadutsa kanthawi kochepa kuchokera kuukira, zimaphatikizapo:
- sitiroko;
- myocardial infaration.
Izi zimachitika chifukwa chakuchepa kwambiri kwa kagayidwe kamunthu ka mu mtima ndi ubongo wa munthu. Mlandu woopsa ukhoza kubweretsa kukula kwa hypoglycemic coma.
Pambuyo pake zovuta zimayamba kuonekera patapita nthawi yayitali. Nthawi zambiri pakatha miyezi yochepa, kapena patatha zaka ziwiri kapena zitatu. Zizindikiro zodziwika za zovuta zakumapeto ndi parkinsonism, encephalopathy, kusokonezeka kukumbukira ndi kuyankhula.
Hyperinsulinism: chithandizo ndi kupewa
Kutengera zifukwa zomwe zinayambitsa kuwonekera kwa hyperinsulinemia, njira zochizira matendawa zimatsimikizika. Chifukwa chake, pankhani ya organic genesis, mankhwala othandizira opaleshoni ndi mankhwala.
Muli mukuwonjezeka kwa neoplasms, pang'ono pancreas, kapena kwathunthu kapamba.
Monga lamulo, atachitapo kanthu pakuchita opaleshoni, wodwalayo amakhala ndi kuchepa kwa magazi (hyperglycemia), chifukwa chake, mankhwala omwe amadza pambuyo pake komanso zakudya zotsika zamoto zimachitika. Matendawa amatenga mwezi pambuyo pa opareshoni.
Pankhani ya zotupa zosagwiritsidwa ntchito, palliative mankhwala ndi mankhwala, omwe umalimbana ndi kupewa hypoglycemia. Ngati wodwala ali ndi neoplasms yoyipa, ndiye kuti amafunikira chemotherapy.
Ngati wodwala ali ndi hyperinsulinism yothandiza, ndiye kuti chithandizo choyambirira chimakhala ndi matenda omwe adayambitsa.
Odwala onse amathandizidwa kuti azikhala ndi zakudya zamagulu ochepa. Kufunsirana ndi katswiri wama psychologist amakhazikikanso.
Woopsa zigawo zikuluzikulu za kukula kwa chikomokere, chithandizo chikuchitika mu malo osamalira odwala kwambiri, kulowetsedwa ndi kulowetsedwa kwachilombo kumachitika, adrenaline ndi glucocorticoids amathandizidwa. Panthawi yogwidwa komanso ndi psychomotor overexcation, kusintha ndi jakisoni wa ma tranquilizer amasonyezedwa.
Makanema okhudzana nawo
Kodi hyperinsulinism ndi njira yochotsera nthawi zonse njala, mutha kudziwa kanema uyu:
Titha kunena za hyperinsulinism kuti uwu ndi matenda omwe ungayambitse zovuta zazikulu. Amakhala ngati mtundu wa hypoglycemia. M'malo mwake, matendawa ndi omwe amasiyana kwambiri ndi matenda ashuga, chifukwa ndi omwe amapanga insulin kapena kupezeka kwake kwathunthu, ndipo ndi hyperinsulinism imachulukitsidwa kapena yopanda tanthauzo. Kwenikweni, kuzindikira kumeneku kumapangidwa ndi gawo la akazi.
