Tresiba Flextach ndi mankhwala ochepetsa shuga. Ndi analogue ya anthu omwe akhala akuchita insulin. Chifukwa cha mawonekedwe ake a zamankhwala, Tresiba nthawi zambiri amagwiritsidwa ntchito ndi odwala omwe ali ndi vuto la matenda a shuga a insulin. Imagwiritsidwa ntchito ngati maziko osungitsa kuchuluka kwa insulin.
Mikhalidwe yosiyanasiyana imatha kudalira insulin. Mtundu woyamba wa matenda a shuga a mellitus, omwe ndi achinyamata, amathandizidwa ndi insulin kale. Popeza kapamba sangathe kutulutsa timadzi tomwe timalowa m'magazi chifukwa cha zovuta zina zamtundu.
Type 2 shuga mellitus, yomwe imakhala pakati pa theka lakale la anthu, imachitika motsutsana ndi maziko amasinthidwe amomwe amapezeka m'maselo a pancreatic ndi chitukuko cha kukana kwa cell receptors ku insulin. Matenda a shuga oterewa safuna mwachangu chithandizo ndi insulin. Pokhapokha ndi nthawi yomwe kusakwanira kwa zisumbu za Langerhans ndikutulutsidwa kwa mahomoni kumayamba, motero.
Tresiba Flextach ili ndi mawonekedwe apadera omwe amathandizira kwambiri moyo wa odwala matenda ashuga. Mankhwalawa amapezeka mu cholembera, omwe amachititsa kuti insulini ikhale yosavuta komanso yopweteka komanso imapangitsa kuti ikhale yosavuta kunyamula mankhwalawo.
Anagulitsa Tresiba mu phukusi la zolembera 5. Mtengo wapakatikati wozungulira umachokera ku 7600 - 8840 rubles. Izi ndizopindulitsa kwambiri, chifukwa mtengo umawonetsedwa nthawi yomweyo kwa zolembera 5.
Mawonekedwe ndi mawonekedwe a mankhwalawa
Mankhwala Tresiba Flextach amapezeka mu cholembera cholembera ndi makatoni ophatikizika. Mankhwalawa amapezeka mu 2 Mlingo, womwe ndi wofunikira kwambiri kwa odwala omwe ali ndi kulemera kwakukulu komanso njira yovuta ya matenda ashuga. Makilogalamu atatu aliwonse. Chifukwa chake, zolembera 300 ndi 600 za insulin zilipo.
Mu 1 ml yankho la jakisoni muli chinthu chachikulu cha insulin degludec 100 ndi magulu a 200.
Zofanana ndi izi:
- Glycerol - 19.6 / 19.6 mg;
- Metacresol - 1.72 / 1.72 mg;
- Phenol - 1.5 / 1.5 mg;
- Hydrochloric acid;
- Zinc - 32.7 / 71.9 mcg;
- Sodium hydroxide;
- Madzi a jakisoni - mpaka 1/1 ml.
Mankhwala akhoza kutumikiridwa muyezo wa 80/160 U / kg. Pankhaniyi, gawo la kusintha kwa mlingo ndi gawo limodzi kapena awiri. Gawo lililonse la insulin ya insludec limafanana ndi gawo limodzi la insulin yaumunthu.
Njira yamachitidwe
Limagwirira a zochita za mankhwala zachokera wathunthu agonism wa insulin degludec ndi amkati anthu. Ikamamwa, imamangilira ma insulin minofu yolumikizira, makamaka minofu ndi mafuta. Chifukwa cha zomwe, njira ya mayamwidwe a shuga m'magazi imayatsidwa. Palinso kutsika kwa Reflex pakupanga kwa glucose ndi ma cell a chiwindi kuchokera ku glycogen.
Recombinant insulin degludec imapangidwa pogwiritsa ntchito ma genetic engineering, omwe amathandizira kupatula DNA ya mabakiteriya a Saccharomyces cerevisiae. Mtundu wawo wama genetic ndi wofanana kwambiri ndi insulin yaumunthu, yomwe imathandizira kwambiri komanso imathandizira kupanga mankhwala. Nkhumba insulin kale. Koma adayambitsa machitidwe ambiri ochokera mthupi.
Kutalika kwake kukhudzana ndi thupi komanso kukonza maselo a insulin kwa maola 24 kumatsutsidwa chifukwa chake zimayamwa mafuta ochepa.
Mothandizidwa ndi subcutaneally, insulin degludec imapanga malo owerengeka omwe amasungunuka ambiri. Mamolekyu amamanga maselo amafuta, omwe amachititsa kuti mankhwalawo amveke pang'onopang'ono m'magazi. Komanso, njirayi ili ndi gawo lathyathyathya. Izi zikutanthauza kuti insulini imamwilidwa chimodzimodzi kwa maola 24 ndipo silinasinthe.
Zizindikiro ndi contraindication
Chizindikiro chokhacho komanso chokhacho chogwiritsira ntchito insulin yayitali ndi mtundu 1 kapena mtundu 2 wa shuga. Degludec insulin imagwiritsidwa ntchito kusunga kuchuluka kwa mahomoni m'magazi kuti akhale ndi metabolism.
Main contraindication ndi:
- Kusalolera payekhapayekha magawo a mankhwala;
- Mimba komanso nthawi yakudya;
- Ana osakwana chaka chimodzi.
Malangizo ogwiritsira ntchito
Mlingo umasankhidwa kwa wodwala aliyense payekhapayekha ndi dokotala wopita. Mavoliyumu amadalira mtundu wa matendawa, kulemera kwa wodwala, moyo wokangalika, komanso zakudya zina zomwe zimatsatidwa ndi odwala.
Mankhwalawa angagwiritsidwe ntchito ngati monotherapy, komanso gawo la mankhwala osokoneza bongo pakukonzanso kosalekeza kwa insulin. Gwiritsani ntchito nthawi zonse nthawi yomweyo masana kuti muchepetse kukula kwa hypoglycemia.
Insulin yochulukirapo yowonjezera imaperekedwa pokhapokha, chifukwa njira zina zoyendetsera zimayambitsa zovuta. Malo abwino kwambiri a jakisoni wotsekemera: ntchafu, matako, phewa, minofu yolumikizana komanso khoma lakutsogolo kwam'mimba. Ndikusintha kwatsiku ndi tsiku m'dera la mankhwalawa.
Musanayambe kugwiritsa ntchito cholembera, muyenera kudziwa malamulo ogwiritsira ntchito chida ichi. Izi nthawi zambiri zimaphunzitsidwa ndi adokotala. Kapenanso wodwalayo amalowa m'makalasi a gulu kukonzekera moyo wokhala ndi matenda ashuga. M'magawo awa, amalankhula za magawo a mkate mu zakudya, mfundo zoyambirira zamankhwala zomwe zimadalira wodwala, komanso malamulo ogwiritsira ntchito mapampu, zolembera, ndi zina mwa zida zoperekera insulin.
Musanayambe njirayi, muyenera kuonetsetsa kuti cholembera sichitha. Pankhaniyi, muyenera kulabadira katiriji, mtundu wa yankho, moyo wa alumali ndi serviceability yamavalo. Kapangidwe ka syringe-cholembera Tresib ndi motere.
Kenako yambitsirani nokha.
Ndikofunika kulabadira kuti kugwiritsa ntchito moyenera ndikofunikira pakugwiritsa ntchito palokha. Wodwala ayenera kuwona bwino manambala omwe amawonetsedwa pa osankhayo posankha mlingo. Ngati izi sizingatheke, ndi bwino kutenga thandizo lina la munthu wina yemwe ali ndi masomphenya abwinobwino.
Nthawi yomweyo konzekerani cholembera kuti mugwiritse ntchito. Kuti tichite izi, tiyenera kuchotsa kapu mu cholembera ndikuonetsetsa kuti pali yankho lomveka bwino lopanda mtundu pazenera la cartridge. Kenako tengani singano yotayika ndikuchotsera chizindikiro. Kenako ikani pang'onopang'ono singano ku dzanja ndipo, pang'onopang'ono.
Pambuyo poti takhutira kuti singanoyo imagwira zolimba mu cholembera, chotsani chida chakunja ndikuchiyika pambali. Singano nthawi zonse imakhala ndi chida chachiwiri choonda chamkati chomwe chimayenera kutayidwa.
Zida zonse za jekeseni zikakhala zokonzeka, timayang'ana kuchuluka kwa insulini komanso thanzi la dongosolo. Pazomwezi, mlingo wa mayunitsi awiri umayikidwa pa osankhidwa. chogwirira chimakweza singano ndikuyimirira. Ndi chala chanu, onetsetsani pang'onopang'ono kuti thupi lonse lizitha kusunthidwa kutsogolo kwa singano.
Kukanikiza piston njira yonse, kuyimba kuyenera kuwonetsa 0. Izi zikutanthauza kuti mlingo wofunikira watuluka. Ndipo kumapeto kwa kunja kwa singano dontho la yankho liyenera kuwoneka. Ngati izi sizingachitike, bwerezani zomwe zikuwonetsetse kuti dongosololi likugwira ntchito. Izi zimapatsidwa kuyesa 6.
Macheke atatha, timapitiriza kugwiritsa ntchito mankhwalawa mu mafuta obisika. Kuti muchite izi, onetsetsani kuti osankhidwa akuwonetsa "0". Kenako sankhani ufa wofunikira.
Ikani singano pansi pa khungu ndiukadaulo uliwonse womwe namwino adawonetsa pakuphunzitsidwa. Tsekani singano pamalowo. Popanda kukhudza wosankhayo kapena kusuntha mwanjira iliyonse, kanikizani batani loyambira njira yonse. Gwiritsani singano mu makulidwe ena amkati kwa masekondi ena 6, kuti mankhwalawo atulowe mu cholembera muyezo wathunthu, kenako muwatulutse. Malowo a jakisoni sayenera kutenthedwa kapena kusisita.
Kenako ikani chophimba chakunja pa singano kuti mumasulidwe kuchikuta, kenako ndikuitaya. Tsekani cholembera ndi cholembera chake.
Kusamalira chida sikutanthauza kuyesetsa kulikonse. Kuti muchite izi, muyenera kungopukuta zida zonse zowoneka bwino za cholembera ndi swab thonje yoviikidwa mu mowa.
Zotsatira zoyipa
Pa chithandizo, zimachitika zovuta. Chotsatira chovuta kwambiri ndi hypoglycemia. Amawonedwa, monga lamulo, mwa odwala omwe amapitilira mlingo womwe unawonetsedwa, amatsatira molondola zomwe zidalembedwa, kapena kuti mlingo unasankhidwa molakwika.
Hypoglycemia imawonetsedwa ndi zizindikiro zosiyanasiyana, zomwe pamlingo wina wake zimadalira kuperewera kwa ubongo ndi shuga m'magazi. Udindo wofunikira umachitidwanso ndi mulingo wamba wa shuga momwe thupi la wodwalayo limazolowera.
Mawonekedwe a thupi lawo amachitika kawirikawiri. Zotsatira zoyipa izi nthawi zambiri zimadziwika ndi zochita za anaphylactic zamtundu wapomwe, zomwe zimayamba chifukwa cha tsankho la munthu pazamankhwala.
Nthawi zambiri anaphylaxis amawonetsedwa mu mawonekedwe a:
- Urticaria;
- Kuyabwa
- Edema ya Quincke;
- Erythema;
- Kugwedezeka kwa anaphylactic.
Zochita zakomweko pakukonzekera mankhwala nthawi zambiri zimawonedwa. Wodwalayo amadandaula za kutupa kwakomweko, kuyabwa, kuzimiririka pamalowo. Mchitidwe wofooka komanso kuwawa kwawoko ndi kakhalidwe.
Zochitika za lipodystrophy nthawi zambiri zimawonedwa pamene malangizo ogwiritsira ntchito satsatidwa. Mukamatsatira malamulowo, ndipo nthawi iliyonse mukasintha jakisoni, mwayi wokhala ndi milomo ya m'mimba umachepa.
Bongo
Chizindikiro chodziwika bwino cha mankhwala osokoneza bongo ndi hypoglycemia. Izi zimachitika chifukwa cha kuchepa kwa glucose m'magazi motsutsana ndi maziko a insulin. Hypoglycemia imatha kudziwonetsa ndi zizindikiro zosiyanasiyana, zomwe zimatengera kuopsa kwa vutolo.
Hypoglycemia ikhoza kukayikiridwa ngati zingapo mwa zotsatirazi zikuwoneka:
- Chizungulire
- W ludzu;
- Njala;
- Pakamwa pakamwa;
- Thukuta lozizira;
- Zingwe
- Kuyabwa
- Kutentha;
- Kumva palpitations;
- Kumva kuda nkhawa;
- Kuyankhula kosaoneka bwino ndi masomphenya;
- Kuzindikira koperewera mpaka kufa.
Thandizo loyamba la hypoglycemia wofatsa lingaperekedwe ndi achibale kapena wodwala. Kuti matenda asinthe, muyenera kubweretsanso kuchuluka kwa shuga m'magazi.
Ngati vutoli likukulirakulira ndipo likuyambitsa kuphwanya chikumbumtima, muyenera kuyimbira ambulansi nthawi yomweyo. Ndi hypoglycemia yayikulu, ndikofunika kukhazikitsa mankhwala a insulin - glucagon mu mlingo wa 0,5-1 mg intramuscularly kapena subcutaneally. Ngati glucagon kulibe pazifukwa zina, akhoza m'malo mwa ena odana ndi insulin. Mahomoni a chithokomiro, glucocorticoids, catecholamines, makamaka adrenaline, somatotropin angagwiritsidwe ntchito.
Mankhwala ena amakhala ndi kukokoloka kwa jekeseni wa shuga ndikuwonetsetsa popanga shuga. Komanso onjezerani ma elekitirodi ndi kuchuluka kwa madzi.
Migwirizano ndi magwiritsidwe akusungidwa
Sungani cholembera cha ana kuti chisafike kwa ana. Kutentha kosungirako kosungirako kosatseka makatiriji osavomerezeka ndi +2 - +8 madigiri. Amaloledwa kuti azisunga mufiriji pachipata, chomwe chili kutali ndi mufiriji. Osamawumitsa mankhwalawo!
Pewani kuwonetsedwa ndi dzuwa komanso kutentha kwambiri. Kuti muchite izi, sungani makatoni otsekedwa mu zojambulazo zapadera, zomwe zimalumikizidwa ngati chitetezo.
Sungani cholembera chotseguka pofunda m'chipinda chodetsa. Kutentha kwambiri sikuyenera kupitirira +30 degrees. Kuti muteteze poizungulira, tsegulani cartridge yotseguka nthawi zonse ndi chipewa.
Moyo wapamwamba kwambiri wa alumali ndi miyezi 30. Tsiku lotha litasonyezedwa phukusi, kugwiritsa ntchito mankhwalawa kumatsutsana. Makatoni otseguka okhala ndi cholembera amatha kugwiritsa ntchito milungu 8.
Tresiba insulin ndi njira yabwino kwambiri yopangira syringe, yomwe imapangitsa moyo kukhala wosavuta pazinthu zambiri za insulin.
