Ndemanga za odwala omwe adagwiritsa ntchito mtundu wa Glimecomb mu mtundu wachiwiri wa matenda a shuga a mellitus amawonetsa mphamvu ya mankhwalawa. Mankhwalawa amalola kuti mutha kuwongolera bwino kuchuluka kwa dzuwa mthupi la wodwala.
Glimecomb ndi mankhwala azachipatala, omwe amapezeka mwanjira ngati mapiritsi oyera kapena oyera-zonona okhala ndi zonona. Piritsi lirilonse limagawika pakati ndikuyika pachiwopsezo pamtunda ndipo limakhala ndi bevel. Popanga mankhwala, kupezeka kwa mapilitsi padziko lapansi ndi kololedwa.
Kuphatikizika kwa mankhwalawa kumaphatikiza metformin mu mawonekedwe a hydrochloride monga yogwira popanga mankhwala othandiza pang'onopang'ono 500 mg ndi glycoslide malinga ndi zinthu zabwino zomwe zili ndi 40 mg.
Zothandiza pazinthu za mankhwalawa ndi sorbitol, povidone, croscarmellose sodium ndi magnesium stearate.
Chida chimagwiritsidwa ntchito pakumwa pakamwa ngati mankhwala a hypoglycemic. Mankhwalawa amaphatikizidwa, chifukwa amaphatikiza mankhwala ophatikizana ndi biguanides ndi sulfonylureas.
Pharmacokinetics ya mankhwala mankhwala
Mankhwala amadziwika ndi kupezeka kwa pancreatic ndi extrapancreatic kwenikweni.
Gliclazide imathandizira njira ya insulin yopangidwira maselo a pancreatic beta ndipo imathandizira kukulitsa chidwi cha maselo otengera insulin. Kuphatikiza apo, pawiri imathandizira kukulitsa chidwi cha puloteni ya intracellular - synthease ya minofu ya glycogen. Kugwiritsidwa ntchito kwa gliclazide kumathandizira kubwezeretsa kutalika kwa insulin katulutsidwe ndikuchepetsa hyperglycemia ya postpradial.
Kuphatikiza pa kukopa njira za kagayidwe kazakudya, kugwiritsa ntchito pawiri kumakhudzanso kuchuluka kwa magazi, kutsitsa kuchuluka kwa zomatira ndi kuphatikizira kwa mapulateleti, kuchepetsa kuchepa kwa parietal thrombosis, kubwezeretsa kuvomerezeka kwa makoma amitsempha, kumachepetsa mayankho amitsempha yamagalasi kuti adrenaline ngati microangiopathy.
Kugwiritsa ntchito gliclazide kumathandiza kuti muchepetse kukula kwa matenda ashuga; komanso, pamaso pa nephropathy, kuchepa kwa proteinuria kumawonedwa.
Metformin ndi mankhwala omwe ali m'gulu la Biguanide. Pulogalamuyi imathandizira kuchepetsa shuga m'magazi a m'magazi. Zotsatira zake zimatheka mwa kulepheretsa njira ya gluconeogenesis m'maselo a chiwindi, komanso pochepetsa kuchuluka kwa glucose kuchokera ku lumen ya m'mimba, komanso mwa kupititsa patsogolo mayamwidwe a glucose ndi maselo a minyewa. Kugwiritsa ntchito metformin kumathandizira kuchepetsa serum triglycerides, cholesterol ndi otsika kachulukidwe lipoproteins. Kukhazikitsidwa kwa metformin m'thupi kumapereka kuchepa komanso kukhazikika kwa thupi.
Kugwiritsa ntchito metformin pakalibe insulini m'magazi sikuti kumawonetsa kuwonekera kwa chidziwitso chifukwa cha kuwonekera kwa hypoglycemic sikuchitika. Kugwiritsa ntchito metformin kumathandizanso kupanga michere ya magazi.
Izi zimatheka ndikapondaponda activate inhibitor ya minofu.
Zizindikiro ndi contraindication kugwiritsa ntchito mankhwalawa
Zizindikiro ntchito Glimecomb ndi mtundu 2 shuga mellitus Popeza kulibe ntchito ntchito zakudya mankhwala ndi zolimbitsa thupi, komanso popeza palibe zotsatira za zomwe kale kuchitira achire mothandizidwa ndi metaformine ndi glycazide.
Glimecomb imagwiritsidwa ntchito m'malo mwa mankhwala omwe kale anali ndi Metformin ndi Glycoside, malinga ndi momwe shuga ya magazi imakhazikika komanso yoyendetsedwa bwino.
Glimecomb imakhala ndi njira zosiyanasiyana zotsutsana ndi mankhwalawa.
Zomwe zili pakati pa zotsutsana ndi izi:
- Hypersensitivity ya thupi la wodwalayo pazotsatira za metformin, gliclazide kapena sulfonylureas ina. Kuphatikiza apo, mankhwalawa sayenera kugwiritsidwa ntchito pamaso pa hypersensitivity pazinthu zina zowonjezera za mankhwalawa.
- Kupezeka kwa matenda a shuga 1.
- Kukhalapo kwa matenda ashuga a ketoacidosis, matenda a shuga komanso matenda a chikomokere.
- Kukula kwambiri aimpso kuwonongeka.
- Kukhazikika kwa mikhalidwe yovuta kwambiri yomwe ingayambitse kusintha kwa impso, kukula kwa kusowa kwamadzi, matenda opatsirana ndikuwopseza.
- Kukula kwa matenda aakulu ndi pachimake, limodzi ndi kupezeka kwa minofu hypoxia.
- Kumachitika kwa aimpso kulephera.
- Porphyria.
- Nthawi ya bere ndi nthawi yoyamwitsa.
- Munthawi yomweyo makonzedwe a miconazole.
- Matenda opatsirana komanso kulowererapo kwa ma opaleshoni, kuwotcha kwakukulu ndi kuvulala kwakukulu, komwe panthawi yamankhwala kumafuna kugwiritsa ntchito insulin.
- Kukhalapo kwa uchidakwa woperewera ndi kuledzera.
- Kukula kwa lactic acidosis.
- Kutsatira zakudya zamafuta ochepa.
Kuphatikiza pa milandu iyi, mankhwalawa saloledwa kugwiritsa ntchito mankhwala osiyanitsa ayodini.
Osagwiritsa ntchito mankhwalawa pochiza odwala matenda ashuga omwe afika zaka 60, omwe akumana ndi zovuta zolimbitsa thupi. Izi zimachitika chifukwa chakukula kwakukulu kwa lactic acidosis mwa odwala.
Kusamala makamaka kuyenera kuchitika pakumwa mankhwala ngati wodwala ali ndi vuto losakhazikika, kuperewera kwa magwiridwe antchito a adrenal, kupezeka kwa hypofunction ya anterior pituitary, matenda a chithokomiro, omwe amayambitsa kuphwanya kwake ntchito.
Kugwiritsa ntchito mankhwala osokoneza bongo
Malangizo ogwiritsira ntchito Glimecomba amawongolera ndikufotokozera mwatsatanetsatane zochitika zonse momwe zimalimbikitsidwira kumwa mankhwalawa komanso ngati kugwiritsa ntchito mankhwalawo ndizoletsedwa. Malangizo tsatanetsatane wazotsatira zonse zomwe zimachitika mukamagwiritsa ntchito mankhwalawa komanso mulingo woyenera wogwiritsa ntchito.
Mankhwalawa amagwiritsidwa ntchito pakumwa pakudya kapena akangomaliza kudya. Mlingo wofunikira wovomerezeka umadziwika ndi dokotala malinga ndi zotsatira za mayeso ndi machitidwe a thupi la wodwalayo. Mlingo wa mankhwalawa umatsimikizika malinga ndi kuchuluka kwa shuga m'thupi la wodwalayo.
Nthawi zambiri, muyeso woyamba wa mankhwalawa omwe adokotala amuuza wodwala amakhala ndi mapiritsi atatu patsiku, ndi kusankha pang'onopang'ono kwa mankhwalawa kuti atsimikizire kuti pakubwezeredwa kwa shuga. Ngati simutsatira malangizowo, ndiye kuti matenda ashuga akhazikika.
Nthawi zambiri, mankhwalawa amayenera kumwa kawiri patsiku m'mawa ndi madzulo. Ndipo mulingo woyenera wa mankhwalawa ukhoza kukhala mapiritsi 5.
Pali malangizo apadera omwe akuyenera kutsatidwa pochita mankhwala a Glimecomb:
- mankhwalawa uyenera kuchitidwa pokhapokha ngati pali zakudya zochepa zama calori;
- odwala ayenera kulandira zakudya zabwino nthawi zonse, zomwe zimaphatikizapo chakudya cham'mawa;
- popewa kukula kwa zizindikiro za hypoglycemia, kusankha kwa munthu payekha kuyenera kupangidwa;
- Ngati kupsinjika kwakuthupi ndi kwamatenda kumachitika pathupi, kusintha kwa mankhwalawa kumayenera kuchitika;
Mukamachita mankhwala ndi mankhwala monga Glimecomb, muyenera kukana kumwa zakumwa zoledzeretsa ndi zakudya zomwe zimakhala ndi ethanol.
Kusamala makamaka kuyenera kugwiritsidwa ntchito ngati mukugwiritsa ntchito mankhwalawa pogwira ntchito zamtunduwu zomwe zimafuna kuti anthu aziganiza mwachangu komanso mwachangu.
Zotsatira zoyipa
Mukamamwa mankhwalawo, wodwalayo amatha kukumana ndi mavuto ambiri.
Pazochita za metabolic, kuphwanya mlingo wa mankhwalawa kapena kugwiritsa ntchito chakudya chokwanira, mavuto amatha kuyambitsa hypoglycemia. Mkhalidwe wamtunduwu umayendetsedwa ndi mutu, kuwoneka ngati kutopa, kumva mwamphamvu njala, kuchuluka kwa mtima, mawonekedwe a chizungulire, komanso kulumikizana kwamiseche.
Kuphatikiza apo, ngati kuphwanya kwamiyeso kwa wodwala, mkhalidwe wa lactic acidosis ungayambike, kuwonetsedwa ndi kufooka kwa myalgia, kugona kwambiri, kupweteka m'mimba ndi kuchepa kwa kuthamanga kwa magazi.
Mavuto otsatirawa atha kupezeka m'matumbo a ziwalo:
- mawonekedwe akumva mseru;
- kukula kwa m'mimba;
- maonekedwe akumva kulemera kwa epigastrium;
- kuwoneka kwa kulawa kwazitsulo mkamwa;
- kuchepa kwa chakudya;
- Nthawi zina, kuwonongeka kwa chiwindi monga hepatitis, cholestatic jaundice ndipo ena amakula.
Ngati pali chiwindi pakhungu, mankhwalawa amayenera kuyimitsidwa nthawi yomweyo.
Kuphwanya Mlingo ndi mfundo za mankhwala, kukulitsa chopinga cha hematopoietic ntchito ndikotheka.
Zotsatira zake zoyipa, wodwalayo amatha kuyanjana ndi matendawa, wowoneka ngati kuyabwa, urticaria ndi zotupa za maculopapular.
Wodwala akayamba kudwala chifukwa chomwa mankhwalawo, muyenera kuchepetsa mankhwalawo kapena kusiya kugwiritsa ntchito mankhwalawo.
Fomu yotulutsidwa, malo osungira ndi mawu, analogi ndi mtengo
Mankhwala amapezeka mu mawonekedwe a mapiritsi m'mabotolo apulasitiki. Botolo limodzi lili, kutengera mapaketi, mapiritsi 30,60 kapena 120. Kuphatikiza apo, mankhwalawa amapezeka mu mawonekedwe a mapiritsi osindikizidwa ndikuyika matuza. Ndi mtundu uwu wamasulidwe, phukusi lililonse lili ndi mapiritsi 10 kapena 20.
Bokosi lirilonse limayikidwa mkatoni, momwe malangizo ogwiritsira ntchito mankhwalawa amadzitsekera. Mapulogalamu ama Cellular amakhalanso amakhadi amakalatoni. Kutengera ndi kuchuluka kwa magome omwe amapezeka phukusi la ma cell, kuchuluka kwa otsiriza mumphika kumasiyana. Chiwerengero chonse cha mapiritsi ndi 60 kapena 100 zidutswa.
Mankhwalawa ndi a mndandanda B. Mankhwala amayenera kusungidwa m'malo owuma komanso amdima pamawonekedwe osaposa 25 digiri Celsius.
Malangizo a Glimecomb amafunikira kuti asungidwe m'malo osavomerezeka ndi ana. Alumali moyo wa mankhwala 2 zaka.
Mankhwalawa amaperekedwa ku pharmacy mosamalitsa monga mankhwala.
Wopanga m'gawo la Russian Federation ndi JSC Chemical and Pharmaceutical Combine AKRIKHIN.
Zofanizira zapakhomo ndi Glidiab, Glidiab MV, Gliklazid MV, Gliformin, Glformin Prolong ndi Diabefarm ndi ena ambiri.
Mtengo wa Glimecomb m'masitolo osiyanasiyana ogulitsa mankhwala kuchokera ku 232 mpaka 600 rubles, kutengera dera la Russian Federation ndi othandizira. Mtengo wa analogues wa mankhwala omwe amapangidwa ku Russian Federation, kutengera dera, kuyambira 158 mpaka 300 rubles. Malinga ndi odwala, kufananiza kwa mankhwalawo sikuti kumakhala kotsika poyerekeza ndikuwonekera kwa wodwala matenda ashuga. Kanema yemwe ali munkhaniyi ayang'ana kwambiri za matenda a shuga.
