Diabetes ndi mankhwala omwe amathandizanso pa matenda a shuga a 2. Gawo lake lothandizira ndi gliclazide. Mankhwalawa amadziwika ndi kutulutsidwa mwachangu komanso mtengo wokwera, kotero odwala ambiri amafunafuna njira yotsika mtengo ya Diabeteson. Kudziyambitsa nokha kwa mankhwalawa ndizoletsedwa: Malangizo a akatswiri amafunikira.
Kufotokozera Kwazogulitsa
A diabetes ndi othandizira a hypoglycemic komanso achokera ku β-sulfonylurea, omwe amatengedwa pakamwa. Kusiyana kwake kufananizira ndi kukhalapo kwa mphete ya N-heterocyclic yokhala ndi chomangira cha endocyclic. Mankhwalawa amathandizira kupanga insulin ndi ma β-cell a islets a Langerhans ndikuchepetsa zomwe zili m'magazi.
Pambuyo pa zaka ziwiri zamankhwala, kuwonjezeka kwa C-peptide ndi insprandial insulin kumatsalira. Gawo lochita lachiwonetsero limawonetsa kukhudzika kwa mitsempha ndipo limakhudza kagayidwe kazakudya. Mtundu wachiwiri wa matenda ashuga, umawonjezera gawo lachiwiri la kutulutsidwa kwa insulini ndikubwezeretsanso nsonga zake zobisika kuti pakhale shuga. Njira izi zimawonedwa makamaka ndi kuyambitsa kwake komanso poyankha kukondoweza, komwe kumachitika chifukwa cha chakudya.
Mankhwalawa amachepetsa chiwopsezo cha thrombosis yaying'ono yamagazi ndi kukula kwa zovuta zomwe zimachitika chifukwa cha matenda ashuga. Pambuyo pa tsiku limodzi la mankhwalawa, kugwiritsa ntchito metabolites ndi pioglitazone mu seramu yamagazi kumakhalabe pamlingo wokwera.
Malangizo ogwiritsira ntchito
Mawuwo akuwonetsa zoletsa kumwa mankhwalawo. Milandu yake ikuluikulu zotsatirazi:
matenda ashuga okoma ndi matenda a mtima;- nthawi ya mkaka wa pakati ndi kubereka mwana;
- kukanika kwa chiwindi ndi impso;
- kuchuluka kwa matupi a ketone ndi shuga wamagazi;
- tsankho lactose, sulfanilamide, gliclazide.
matenda ashuga okoma ndi matenda a mtima;Mankhwalawa amaperekedwa kwa odwala akuluakulu okha. Piritsi imayenera kutengedwa kamodzi patsiku pakudya. Mlingo wambiri watsiku ndi tsiku ndi 120 mg. Mankhwalawa sangawonongeke komanso kutafunidwa, amayenera kutsukidwa ndi madzi osavuta. Ngati mungadumphe kumwa mankhwalawo, mulingo wachiwiri sugwiritsidwa ntchito.
Pa gawo loyambirira la mankhwala, mlingo ndi 30 mg. Ngati ndi kotheka, ukuwonjezeka ndi katswiri palibe kale kuposa masiku 40 atasankhidwa kale. Odwala a zaka zopitilira 65 safuna kusintha kwa Mlingo. Pa chithandizo, nthawi ya kuchotsedwa kwa mankhwala am'mbuyomu iyenera kuganiziridwa. Mukamamwa mankhwalawa, zimayambitsa mavuto ena. Izi zikuphatikiza:
kulephera kudziwa;- kugona kwambiri kapena kusowa tulo;
- chisangalalo chamanjenje;
- zosapweteketsa kuyipa;
- kukokana ndi kufooka wamba;
- Kuzindikira kwa vuto, chizungulire.
kulephera kudziwa;Analogs ndi choloweza mmalo mwa mankhwalawo
Mankhwala ali ndi mtengo wokwera kwambiri. Ma dialogon a diabetes ndi olowa m'malo amaimiridwa ndi mankhwala otsatirawa:
- Diabetesalong;
- Gliclazide;
- Glidiab;
- Diabefarm MV;
- Predian;
- Glucostabil;
- Piroglar.
Diabetesalong - Analogue yotsika mtengo ya Diabeteson, mawu ofanana omwe amawonjezera kupanga kwa insulini, chidwi cha zotumphukira zama cell ndikuchepetsa kuchuluka kwa shuga m'magazi. Osati osokoneza bongo ngakhale atatha zaka 3 akugwiritsidwa ntchito. Mankhwala amachepetsa postprandial hyperglycemia, kubwezeretsa koyamba kuchuluka kwa insulin, kumachepetsa nthawi pakati pakudya ndi insulin. Mu chiwindi, mankhwalawa amachepetsa mapangidwe a shuga ndikuwonjezera magwiridwe ake.
Chithandizo chogwira ntchito chimachepetsa kukoka kwam'mimba komanso chakudya cha metabolism, kumachepetsa chiopsezo cha thrombosis ndikuyambiranso ntchito ya minofu ya plasminogen activator.
Gliclazide - Uwu ndi mtundu wa mankhwala osokoneza bongo omwe umapangidwira mkati. Zimaphatikizira mphete ya heterocyclic yokhala ndi chomangira cha endocyclic. Mankhwala amathandizira kupanga insulin komanso amachepetsa kuchuluka kwa shuga. Pambuyo pa zaka zitatu zamankhwala, kuwonjezereka kwa ndende ya C-peptide ndi insprandial insulin kumatsalira. The yogwira mawonekedwe limawonetsa hemovascular zochita ndipo zimakhudza kagayidwe kachakudya metabolism. Kugwiritsa ntchito mankhwala kumachepetsa chiopsezo cha zovuta za matenda ashuga.
Glidiab Ndi mankhwala a 2-sulfonylurea ofanana ndi a hypoglycemic. Imakongoletsa ntchito ya glucose insulin-secretory, kupindika kwa minofu ndikuthandizira pakubisalira kwa insulin, imalimbikitsa zochita za minofu ya intracellular glycogen synthetase enzymes, ndikuchepetsa kuchuluka kwa hyperglycemia mutatha kudya. Kugwiritsa ntchito mankhwalawa kuyenera kuyambika motsutsana ndi zakudya zama calorie otsika zomwe zili ndi chakudya chamagulu ochepa.
Ndikulimbikitsidwa kuyang'anira kuchuluka kwa glucose m'magazi mutatha kudya komanso pamimba yopanda kanthu. Mlingo umasinthidwa kuti mukhale ndi nkhawa kapena thupi.
Diabefarm MV - Ichi ndi chithunzi cha Diabeteson 60, chomwe ndi mankhwala a hypoglycemic komanso chokhudzana ndi m'badwo wachiwiri wa zotumphukira za sulfonylurea. Imayambitsa kupanga insulin ndi maselo a kapamba ndi zochita za ma intracellular enzymes. Mankhwalawa ndi othandiza kwambiri ku mtundu wa 2 osagwiritsa ntchito insulin wodwala matenda ashuga okhala ndi matenda ashuga komanso ngati prophylactic ya michere ya cellcirculatory.
Predian - mankhwalawa opangidwa kuchokera. Itha kugulidwa ngati mapiritsi okhala ndi mulingo wa 0,08 g, yokhazikitsidwa pabokosi la makatoni. Chithandizo chogwira thupi chimachepetsa kugunda kwa magazi ndikuchepetsa kuchuluka kwa shuga. Mankhwalawa amayenera kuyamba ndi theka la mapiritsi. Mankhwalawa sangaphatikizidwe ndi acetylsalicylic acid, butadione, amidopyrine chifukwa chowopseza hypoglycemia.
Glucostabil bwino michere ya fibrinolytic, imachepetsa kukulitsa kwa thrombus ya parietal, kuphatikizika kwa maselo othandiza magazi komanso kupendekera. Mankhwala amawonjezera microcirculation, kuchuluka kwa HDL-C, kumachepetsa cholesterol, mphamvu yamitsempha yamagazi kupita ku adrenaline ndipo kumalepheretsa kukula kwa atherosulinosis ndi microthrombosis. Kutsika kwa proteinuria kwa nthawi yayitali kumadziwika motsutsana ndi komwe kugwiritsidwa ntchito kwa nthawi yayitali kwa gliclazide mu matenda ashuga.
Phuli - hypoglycemic mankhwala amkamwa komanso kusankha kwa gamma receptor agonist mwamphamvu. Gawo lolimbikira likuwonetsa kusintha kwa majini omwe akukhudzidwa ndi kuphulika kwa lipid ndi kayendedwe ka glucose. Mu chiwindi ndi zotumphukira zimakhala, amachepetsa kukana insulin. Ndi mtundu 2 shuga mellitus lowers glycated hemoglobin ndi insulin mu plasma.
Mutha kudziwa zomwe Diabeteson ikhoza kusintha ndi dokotala. Sitikulimbikitsidwa kugwiritsa ntchito mankhwalawa nokha, chifukwa izi zimabweretsa zotsatira zoyipa.
