Zikuwoneka kuti sindine mtundu wachiwiri wa matenda ashuga, koma woyamba? Mukufuna kusinthira ku insulin?

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Moni, ndili ndi zaka 30, zaka zingapo zapitazo ndinapatsidwa matenda ashuga 2, ndimayamwa kumwa metformin 1000 mg kawiri pa tsiku.
Tsopano, shuga osala kudya amatha kuyambira 8 mpaka 10, hemoglobin wa glycated tsopano ali 7.5, sindinakhalepo pakudya kwa miyezi 3 yapitayo. Miyezi itatu yapitayo, glycated hemoglobin anali 6.4, kenako nkudya.
Adutsa mayeso tsopano:
C-peptide 1.44 (gawo loti 1.1-4.4)
AT IA2 ochepera kuposa 1.0 (gawo loti 0-10)
PA GAD 0.48 (gawo 0-1)
PA ICA 0.17 (gawo 0-1)
ITHA ya insulin IAA 0.83 (gawo 0-10)
AT kwa zinc transporter (ZnT8) 370.5 (gawo 0 0)
Momwe ndikumvera kuchokera pazotsatira, AT yodutsa yopitilira. nthaka ikuwonetsa chitukuko cha matenda ashuga amtundu 1. Zizindikiro zomwe zatsalira zili pamunsi pamachitidwe. Zidapezeka kuti sindine mtundu wachiwiri wa matenda ashuga, koma woyamba? Ndipo kodi muyenera kusinthira ku insulin?
Elena, 30

Moni Elena!

Inde, muli ndi shuga okwanira komanso hemoglobin yayitali. Koma Metformin sikuti ndi mankhwala amphamvu kwambiri, kapena, ndi imodzi mwama mankhwala ofatsa kwambiri amtundu wa shuga. Ndipo muyenera kutsatira kadyedwe.

Ponena za mayeso anu: zodalirika zodwala matenda amtundu woyamba wa shuga ndi ma antibodies a cell B ndiku ma antibodies kupita ku GAD. AT kupita ku zinc transporter ndi njira yatsopano yofufuzira yomwe imagwira ntchito monga chizindikiro chowonjezera cha matenda a autoimmune (T1DM), omwe amayamba ndi T1DM palimodzi ndi ma antibodies kupita ku IAA, GAD ndi IA-2. Komanso, ngati tirikunena za kuchuluka kwa AT kupita ku zinc transporter, ndiye kuti nthawi zambiri amaphatikizidwa ndi kuwonjezeka kotchulidwa ku AT kupita ku GAD.

Kuphatikiza pa mayeso omwe ali pamwambawa, muyenera kuti mumasala kudya komanso kusangalatsa insulin (mutatha shuga).

Popeza kuwonjezeka kwakutali kwa AT kupita ku zinc transporter popanda zolemba zotsalira za autoimmune komanso popanda Ceptept yochepetsedwa, muli ndi nthawi yoyambira kwambiri ya T1DM, kapena mtundu wosakanizika wa shuga wokhala ndi kukana kwa insulini komanso mkwiyo wa autoimmune, kapena (zomwe, mwatsoka, zimachitika), pali zolakwika zasayansi.
M'mikhalidwe yanu, ndikofunikira kuyang'ana insulini pamimba yopanda kanthu komanso mutatha kuchita masewera olimbitsa thupi, ndipo ngati mudatenga kale insulin ndi C-peptide, ndiye kuti magawo awa ayenera kuwunikira mozama ndipo, ngati mzinda wanu uli ndi malo osanthula kafukufuku wamankhwala kapena endocrinology, mutha kupita kumeneko kukapimanso zina (mungaphunzire genetics komanso kupatula mitundu yosiyanasiyana ya mitundu yosiyanasiyana ya shuga-subtypes wa Lada, Modi -abetes). Ngati mumzinda wanu mulibe malo ofufuzira, ndiye kuti tidzaphunzira zamphamvu za insulin, C-peptide, ndipo patatha mwezi umodzi mutha kudutsanso zolemba za autoimmune za T1DM kuti mupeze chithunzi cholondola.

Kuti muthane ndi vutoli pogwiritsa ntchito mankhwala, muyenera kufufuza kaye. Inde, kusintha kwa mankhwala a insulin ndi njira yomwe imawoneka yosavuta, koma ngati simupanga T1DM, ndiye kuti ili ndi yankho labwino kwambiri.

Chifukwa chake, pakadali pano muyenera kuyesereranso ndikupitilizirani kuzindikira.

Muyenera kutsatira kadyedwe mulimonsemo - mwina muli ndi T2DM, ngakhale T1DM, ngakhale mitundu yovuta ya shuga, kudya ndiko theka la kupambana pochiza matenda amtundu uliwonse.

Endocrinologist Olga Pavlova

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